Solanesol
Based on 2 publication(s) in Google Scholar
Solanesol is an orally active aliphatic terpene alcohol. Solanesol is mainly found in tobacco and other Solanaceae plants. Solanesol induces HO-1 and Hsp70 expression, activates p38 and Akt signaling pathways, and inhibits Apoptosis (reduces caspase-3 and PARP cleavage). Solanesol has antioxidant, anti-inflammatory, and neuroprotective activities. Solanesol can be used in the research of Huntington's disease, alcoholic liver disease, chronic inflammatory pain, anxiety, Alzheimer's disease, and bipolar disorder.
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- Pureza: 98.0%
- No. CAS: 13190-97-1
- Fòrmula: C45H74O
- Peso molecular:631.07
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Help & FAQs
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Apoptosis Compound Library
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Publications Citing Use of MedChemExpress (MCE) Solanesol
MoreVer todos los productos específicos de isoformas Endogenous Metabolite
MoreVer todos los productos específicos de isoformas Caspase
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Actividad biológica
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Caspase-3 |
HSP70 |
HO-1 |
Solanesol (40 μM; 0-24 h) induces HO-1 mRNA and protein expression in RAW264.7 cells[2].
Solanesol (10-80 μM; 12–24 h) upregulates HO-1 and Hsp70 expression in human hepatic L02 cells, protecting against ethanol-induced oxidative injury by enhancing Nrf2 and HSF1 nuclear translocation[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 murine macrophage-like cells
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Concentration:5 μM, 10 μM, 20 μM, 40 μM
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Incubation Time:12 h
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Result:Enhanced phosphorylated p38 and Akt levels.
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Cell Line:RAW264.7 murine macrophage-like cells
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Concentration:80 μM
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Incubation Time:12 h
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Result:Inhibited apoptosis by decreasing caspase-3 and PARP cleavage.
Solanesol (50 mg/kg, i.p.) alleviates CFA (HY-153808)-induced chronic inflammatory pain in C57BL/6 mice, reducing mechanical and thermal hypersensitivity and suppressing spinal glial cell activation[5].
Solanesol (50 mg/kg; i.p.; 1 week) ameliorates CFA-induced anxiety-like behaviors in mice by downregulating TIA1, inhibiting the expression of pro-inflammatory factors IL-1β and TNF-α, and reducing microglial/astrocytic activation in the anterior cingulate cortex[6].
Solanesol (40-80 mg/kg, p.o.) activates SIRT-1 signaling in Ouabain (HY-B1457)-induced bipolar disorder rats, improving neurobehavioral deficits and restoring Na+/K+-ATPase activity[8].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult C57BL/6 mice (6-8 weeks old, 15-25 g), CFA-induced chronic inflammatory pain model[5]
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Dosage:50 mg/kg
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Administration:Intraperitoneal injection
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Result:Reduced pro-inflammatory cytokines (TNF-α, IL-1β) in spinal cord.
Suppressed microglial and astrocytic activation (Iba-1 and S100β).
Improved mechanical allodynia and thermal hyperalgesia.
Chemical Information
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No. CAS 13190-97-1
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Appearance Solid
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Peso molecular 631.07
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Fòrmula C45H74O
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Color Off-white to light yellow
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SMILES
C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CO
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Heliyon
Solanesol alleviates CFA-induced chronic inflammatory pain via inhibition of proinflammatory cytokines in spinal glial cells. [Abstract]Heliyon. 2024 Jul 18;10(15):e34870. PMID: 39157324
Solvente y solubilidad
DMSO : 100 mg/mL (158.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (3.96 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (3.96 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Yan N, et al. Bioactivities and Medicinal Value of Solanesol and Its Accumulation, Extraction Technology, and Determination Methods. Biomolecules. 2019 Aug 2;9(8):334. [Content Brief]
[2]. Yao X, et al. Solanesol induces the expression of heme oxygenase-1 via p38 and Akt and suppresses the production of proinflammatory cytokines in RAW264.7 cells. Food Funct. 2017 Jan 25;8(1):132-141. [Content Brief]
[3]. Mehan S, et al. Neuroprotective effect of solanesol against 3-nitropropionic acid-induced Huntington's disease-like behavioral, biochemical, and cellular alterations: Restoration of coenzyme-Q10-mediated mitochondrial dysfunction. Indian J Pharmacol. 2018 Nov-Dec;50(6):309-319. [Content Brief]
[4]. Yao X, et al. Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70. Toxicol In Vitro. 2015 Apr;29(3):600-8. [Content Brief]
[5]. Wang YY, et al. Solanesol alleviates CFA-induced chronic inflammatory pain via inhibition of proinflammatory cytokines in spinal glial cells. Heliyon. 2024 Jul 18;10(15):e34870. [Content Brief]
[6]. Ding S, Li Y, et al. Solanesol Ameliorates Anxiety-like Behaviors via the Downregulation of Cingulate T Cell-Restricted Intracellular Antigen-1 in a Complete Freund's Adjuvant-Induced Mouse Model. Int J Mol Sci. 2024 Sep 21;25(18):10165. [Content Brief]
[7]. Wang C, et al. Natural Bioactive Compounds Solanesol and Chlorogenic Acid Assembled Nanomicelles for Alzheimer's Disease Therapy. ACS Appl Mater Interfaces. 2025 Mar 5;17(9):14591-14603. [Content Brief]
[8]. Rajkhowa B, et al. Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder. Pharmaceuticals (Basel). 2022 Aug 2;15(8):959. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5846 mL | 7.9231 mL | 15.8461 mL | 39.6153 mL |
| 5 mM | 0.3169 mL | 1.5846 mL | 3.1692 mL | 7.9231 mL | |
| 10 mM | 0.1585 mL | 0.7923 mL | 1.5846 mL | 3.9615 mL | |
| 15 mM | 0.1056 mL | 0.5282 mL | 1.0564 mL | 2.6410 mL | |
| 20 mM | 0.0792 mL | 0.3962 mL | 0.7923 mL | 1.9808 mL | |
| 25 mM | 0.0634 mL | 0.3169 mL | 0.6338 mL | 1.5846 mL | |
| 30 mM | 0.0528 mL | 0.2641 mL | 0.5282 mL | 1.3205 mL | |
| 40 mM | 0.0396 mL | 0.1981 mL | 0.3962 mL | 0.9904 mL | |
| 50 mM | 0.0317 mL | 0.1585 mL | 0.3169 mL | 0.7923 mL | |
| 60 mM | 0.0264 mL | 0.1321 mL | 0.2641 mL | 0.6603 mL | |
| 80 mM | 0.0198 mL | 0.0990 mL | 0.1981 mL | 0.4952 mL | |
| 100 mM | 0.0158 mL | 0.0792 mL | 0.1585 mL | 0.3962 mL |
Solanesol Related Classifications
HY-N0576 Related Classifications
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