Cdk6 - cyclin-dependent kinase 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114483

About Cdk6

Primary_assembly 4: 30,646,460-30,829,634 reverse strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 199 orthologues, 24 paralogues and is associated with 24 phenotypes. Biased expression in Thymus (RPKM 15.7), Kidney (RPKM 87.) and 9 other tissues.

Summary

Enables cyclin binding activity. Predicted to be involved in several processes, including negative regulation of cellular senescence; negative regulation of osteoblast differentiation; and regulation of myeloid cell differentiation. Predicted to act upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of hematopoietic stem cell differentiation. Predicted to be located in several cellular components, including centrosome; nucleoplasm; and ruffle. Predicted to be part of cyclin D2-CDK6 complex and mediator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in high grade glioma; lung non-small cell carcinoma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Orthologous to human CDK6 (cyclin dependent kinase 6). [provided by Alliance of Genome Resources, Apr 2022]

Cdk6 Products (1)

mRNA Protein Name
NM_001191861.2 NP_001178790.1 cyclin-dependent kinase 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
15809057 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
19151707 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk6 Protein Structure

STKc_CDK6

STKc_CDK6: cd07862 (10 - 299)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 6

  • cell division protein kinase 6

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50767 Palbociclib Inhibitor 99.94% Unkown
HY-16297A Abemaciclib Inhibitor 99.97% Yes
HY-15777 Ribociclib Inhibitor 99.94% Unkown
HY-50767C Palbociclib hydrochloride Inhibitor 99.96% Unkown
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% Unkown
HY-A0065 Palbociclib isethionate Inhibitor 99.98% Unkown
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-15777B Ribociclib succinate Inhibitor 99.93% Unkown
HY-15777A Ribociclib hydrochloride Inhibitor 99.95% Unkown
HY-114338 Dalpiciclib Inhibitor 99.70% Unkown
HY-101467A Trilaciclib hydrochloride Inhibitor 99.69% Unkown
HY-B0877 Halcinonide Activator 98.29% Unkown
HY-15777C Ribociclib succinate hydrate Inhibitor 99.94% Unkown
HY-50767B Palbociclib dihydrochloride Inhibitor / Unkown
HY-50767D Palbociclib orotate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-125101A Rafutrombopag diolamine Agonist / Phase 4
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-101563 GSK3326595 99.83% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-114177 Ebvaciclib Inhibitor 99.98% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-12624 Narazaciclib Inhibitor 98.66% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-45661 Inixaciclib Inhibitor 99.93% Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-15504 RGB-286638 Inhibitor 99.67% Phase 1
HY-111361 FN-1501 Inhibitor 98.72% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.26% Phase 1
HY-172234 PF-06842874 Inhibitor / Phase 1
HY-153336 PRT3645 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (135)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Unkown
HY-103248 Toyocamycin Inhibitor 99.27% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.39% Unkown
HY-136250 BSJ-03-204 Inhibitor 99.76% Unkown
HY-116035 Nimbolide Inhibitor 99.79% Unkown
HY-138946 XY028-140 Inhibitor 98.52% Unkown
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Unkown
HY-N0404 Sinigrin Inhibitor 99.97% Unkown
HY-111556 BSJ-03-123 Inhibitor 99.19% Unkown
HY-114338A Dalpiciclib hydrochloride Inhibitor 99.41% Unkown
HY-136252 BSJ-04-132 Inhibitor 99.07% Unkown
HY-122620 Rafutrombopag (tautomerism) Agonist 98.33% Unkown
HY-144117 GFB-12811 Inhibitor 98.04% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-N0805 Alisol B 23-acetate Inhibitor 99.65% Unkown
HY-12422 Voruciclib Inhibitor 99.76% Unkown
HY-128669 Abemaciclib metabolite M2 Inhibitor 99.75% Unkown
HY-103712 Samuraciclib Inhibitor 99.55% Unkown
HY-126534A Abemaciclib metabolite M18 hydrochloride Inhibitor 98.18% Unkown
HY-16559 Riviciclib hydrochloride 99.08% Unkown
HY-148530 YX-2-107 Degrader 98.60% Unkown
HY-163786 PROTAC CDK4/6 degrader 1 Degrader 98.88% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.93% Unkown
HY-119940 MC180295 Inhibitor 98.07% Unkown
HY-112272 Lerociclib Inhibitor 96.42% Unkown
HY-125835 CP-10 Inhibitor 98.41% Unkown
HY-129336 Abemaciclib metabolite M20 Inhibitor 95.92% Unkown
HY-129180 XY028-133 Inhibitor 99.07% Unkown
HY-151071 TMX-3013 Inhibitor 98.02% Unkown
HY-15889 AMG 925 Inhibitor 99.02% Unkown
HY-126534 Abemaciclib metabolite M18 Inhibitor 98.01% Unkown
HY-50943 AT7519 Hydrochloride Inhibitor 99.16% Unkown
HY-50767S Palbociclib-d8 Inhibitor 99.84% Unkown
HY-144995 BSJ-02-162 Degrader 98.07% Unkown
HY-15504A RGB-286638 free base Inhibitor 98.09% Unkown
HY-148214 CDK2/4/6-IN-2 Inhibitor 98.20% Unkown
HY-151069 TMX-2039 Inhibitor 99.42% Unkown
HY-142076 CDK4/6-IN-15 Inhibitor 99.32% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-148070 FLT3-IN-17 99.11% Unkown
HY-164129 CDK4-IN-3 Inhibitor 98.07% Unkown
HY-152263 HEMTAC CDK4/6 degrader 1 Inhibitor 98.18% Unkown
HY-153894 SRX3177 Inhibitor 99.33% Unkown
HY-148062 RSS0680 99.85% Unkown
HY-114339 CDK4/6-IN-2 Inhibitor 99.67% Unkown
HY-16942 Damulin B Inhibitor 96.62% Unkown
HY-126251 CDK9-IN-7 Inhibitor 98.05% Unkown
HY-148063 DB0614 99.92% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.88% Unkown
HY-129336S Abemaciclib metabolite M20-d8 Inhibitor 99.26% Unkown
HY-155787 SHR5428 Inhibitor 99.80% Unkown
HY-136726 CGP-82996 Inhibitor 98.12% Unkown
HY-50940A AT7519 TFA Inhibitor 99.75% Unkown
HY-108420 INK4C-IN-2 Activator 98.35% Unkown
HY-115992 CDK4/6-IN-9 Inhibitor 99.46% Unkown
HY-146213 CDK4/6-IN-12 Inhibitor 99.76% Unkown
HY-168996 LA-CB1 Degrader 98.20% Unkown
HY-142696A CDK6/PIM1-IN-1 hydrochloride Inhibitor 99.38% Unkown
HY-145589 Rafutrombopag Agonist 95.29% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-185121 PROTAC CDK2/4/6 Degrader-2 Degrader 97.22% Unkown
HY-168440 Aurora-A ligand 1 Ligand 98.75% Unkown
HY-123535 P18IN003 Activator 99.49% Unkown
HY-112243A Cimpuciclib tosylate Inhibitor 99.65% Unkown
HY-181490 WWZ-11-098 Degrader / Unkown
HY-164906 TMX-2138 Degrader 98.99% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-180277 PROTAC CDK6 Degrader 1 Degrader 98.89% Unkown
HY-112418 CDK4/6-IN-18 Inhibitor 98.9% Unkown
HY-161708 PROTAC FLT3/CDKs degrader-1 Degrader / Unkown
HY-112346 RGB-286147 Inhibitor 98.60% Unkown
HY-176713 KWZY-11 Inhibitor / Unkown
HY-15889A AMG 925 (HCl) Inhibitor / Unkown
HY-N2423 Sinigrin hydrate Inhibitor 99.92% Unkown
HY-112243 Cimpuciclib Inhibitor / Unkown
HY-126244 CDK4/6-IN-3 Inhibitor / Unkown
HY-131063 CDK6/9-IN-1 Inhibitor / Unkown
HY-184911 CDK6 ligand-3 Degrader / Unkown
HY-153088 CDK4/6-IN-16 Inhibitor / Unkown
HY-178168 ARUK2010694 Inhibitor / Unkown
HY-184910 JHK-02-108-2 Degrader / Unkown
HY-182071 MG16 Inhibitor / Unkown
HY-179375 LCI133 Inhibitor / Unkown
HY-180279 CDK6 ligand-Linker Conjugate 1 Inhibitor / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-181501 CDK2/4/6-IN-3 Inhibitor / Unkown
HY-161709 FLT3/CDKs ligand-1 Degrader / Unkown
HY-143258 CDK4/6-IN-8 Inhibitor / Unkown
HY-182036 KWZL-7f15 Inhibitor / Unkown
HY-179452 KRAS G13D-IN-2 Inhibitor / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-185487 CDK4/6-IN-27 Inhibitor / Unkown
HY-172899 Carbonic anhydrase inhibitor 33 Inhibitor / Unkown
HY-162529 CDK4/6-IN-19 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-179151 CDK4/6-IN-26 Inhibitor / Unkown
HY-183771 CDK4/6-IN-28 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-171656 G721-0282 Inhibitor 99.96% Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-181999 PC8 Inhibitor / Unkown
HY-178171 ARUK2010489 Inhibitor 96.64% Unkown
HY-171826 PROTAC CDK2/4/6 Degrader-1 Inhibitor / Unkown
HY-162530 CDK4/6-IN-20 Inhibitor / Unkown
HY-114338B Dalpiciclib isethionate Inhibitor / Unkown
HY-182986 LS-Q2 Inhibitor / Unkown
HY-162619 CDK9-IN-33 Inhibitor / Unkown
HY-181729 PROTAC BET Degrader-15 Inhibitor / Unkown
HY-163787 YY173 Inhibitor / Unkown
HY-172128 NUAK1-IN-2 Inhibitor / Unkown
HY-175013 CDK6/9-IN-2 Inhibitor / Unkown
HY-181483 CDK6-IN-2 Inhibitor / Unkown
HY-176718 VEGFR-2-IN-69 Inhibitor / Unkown
HY-134303 CST651 Degrader / Unkown
HY-164376 CDK4/6-IN-21 Inhibitor / Unkown
HY-184707 CDK4/6-IN-29 Inhibitor / Unkown
HY-178112 CDK2-IN-47 Inhibitor / Unkown
HY-143257 CDK4/6-IN-7 Inhibitor / Unkown
HY-180262 PROTAC CDK6 Degrader 2 Degrader / Unkown
HY-148213 CDK2/4/6-IN-1 Inhibitor / Unkown
HY-178516 PROTAC CDK4/6/9 degrader 2 Degrader / Unkown
HY-173237 CDK4/6/BRD4-IN-1 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-180278 CDK6 ligand 1 Inhibitor / Unkown
HY-115993 CDK4/6-IN-10 Inhibitor / Unkown
HY-178452 PROTAC CDK4/6/9 degrader 1 Degrader / Unkown
HY-176365 Palbociclib-C4-Boc Inhibitor / Unkown
HY-170651 CDK4/6/HDAC-IN-1 Inhibitor / Unkown
HY-183571 JD128 Inhibitor / Unkown
HY-168444 CDK4/6-IN-23 Inhibitor / Unkown
HY-164376A CDK4/6-IN-21 maleate Inhibitor / Unkown
HY-102088 P18IN011 Inhibitor / Unkown
HY-N11852 Momilactone B Inhibitor 99.47% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk6 NCBI NCBI:1021