Tlr7 - toll-like receptor 7 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170743

About Tlr7

Chromosome X: 166,087,925-166,113,554 reverse strand.GRCm39:CM001013.3

This gene has 6 transcripts (splice variants), 197 orthologues, 23 paralogues and is associated with 14 phenotypes. Low expression observed in reference dataset.

Summary

Enables siRNA binding activity and single-stranded RNA binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; response to virus; and Toll-like Receptor 7 signaling pathway. Acts upstream of or within positive regulation of interleukin-6 production and regulation of protein phosphorylation. Located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Is expressed in brain and liver. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in COVID-19 and X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Tlr7 Products (5)

mRNA Protein Name
NM_001290757.1 NP_001277686.1 toll-like receptor 7 isoform a precursor
NM_001290756.1 NP_001277685.1 toll-like receptor 7 isoform a precursor
NM_001290755.1 NP_001277684.1 toll-like receptor 7 isoform a precursor
NM_001290758.1 NP_001277687.1 toll-like receptor 7 isoform b
NM_133211.4 NP_573474.1 toll-like receptor 7 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17452530 MGI
enables siRNA binding IMP
IMP: Inferred from mutant phenotype
15723075 MGI
enables single-stranded RNA binding IMP
IMP: Inferred from mutant phenotype
14976262 MGI
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
18802055 MGI
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
18802055 MGI
involved in cellular response to virus IMP
IMP: Inferred from mutant phenotype
18802055 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
14976261 MGI
acts upstream of interleukin-6 production IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of macrophage cytokine production IDA
IDA: Inferred from direct assay
18261938 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
12032557 MGI
involved in positive regulation of interferon-alpha production IMP
IMP: Inferred from mutant phenotype
14976261 MGI
acts upstream of or within positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
18261938 MGI
acts upstream of or within positive regulation of macrophage cytokine production IDA
IDA: Inferred from direct assay
18261938 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18802055 MGI
acts upstream of or within regulation of protein phosphorylation IGI
IGI: Inferred from genetic interaction
24740015 MGI
involved in toll-like receptor 7 signaling pathway IMP
IMP: Inferred from mutant phenotype
14976261 MGI
involved in toll-like receptor 8 signaling pathway IDA
IDA: Inferred from direct assay
12032557 MGI
Cellular Component GO Annotation Evidence References Source
located in early phagosome IDA
IDA: Inferred from direct assay
18305481 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18305481 MGI
located in endosome IDA
IDA: Inferred from direct assay
18305481 MGI
located in lysosome IDA
IDA: Inferred from direct assay
18305481 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tlr7 Protein Structure

PRK15370

PRK15370: cl33128 (31 - 242)

LRR_RI

LRR_RI: sd00033 (47 - 68)

LRR_RI

LRR_RI: sd00033 (69 - 89)

LRR_RI

LRR_RI: sd00033 (90 - 127)

LRR_RI

LRR_RI: sd00033 (128 - 151)

LRR_RI

LRR_RI: sd00033 (173 - 204)

PLN00113

PLN00113: cl33413 (173 - 785)

LRR_RI

LRR_RI: sd00033 (205 - 225)

LRR_RI

LRR_RI: sd00033 (226 - 249)

LRR_RI

LRR_RI: sd00033 (250 - 290)

LRR_RI

LRR_RI: sd00033 (291 - 314)

LRR_RI

LRR_RI: sd00033 (315 - 340)

LRR_RI

LRR_RI: sd00033 (341 - 397)

LRR_RI

LRR_RI: sd00033 (398 - 421)

LRR_RI

LRR_RI: sd00033 (496 - 518)

LRR_RI

LRR_RI: sd00033 (519 - 543)

LRR_RI

LRR_RI: sd00033 (544 - 567)

LRR_RI

LRR_RI: sd00033 (568 - 597)

LRR_RI

LRR_RI: sd00033 (598 - 620)

LRR_RI

LRR_RI: sd00033 (621 - 651)

LRR_RI

LRR_RI: sd00033 (652 - 676)

LRR_RI

LRR_RI: sd00033 (677 - 700)

LRR_RI

LRR_RI: sd00033 (701 - 724)

LRR_RI

LRR_RI: sd00033 (749 - 774)

PCC

PCC: cl28216 (753 - 837)

TIR

TIR: smart00255 (890 - 1035)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1050 a.a.
Protein Preferred Names Protein Names

toll-like receptor 7

  • Toll like receptor 7

Recombinant Tlr7 Proteins

Cat. No. Product Name Accession Purity
HY-P79405 TLR7 Protein, Mouse (His, Myc) P58681 (F27-S348) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0180 Imiquimod Agonist 99.96% Unkown
HY-B1370 Hydroxychloroquine sulfate Inhibitor 99.99% Yes
HY-B0180A Imiquimod hydrochloride Agonist 99.77% Yes
HY-B0180B Imiquimod maleate Agonist 99.92% Yes
HY-B1370A (S)-Hydroxychloroquine Inhibitor / Unkown
HY-B1370B (R)-Hydroxychloroquine Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-W008634 Bropirimine Agonist 99.94% Phase 3
HY-13740 Resiquimod Agonist 99.95% Phase 2
HY-134581 Enpatoran Inhibitor 99.80% Phase 2
HY-15601 Vesatolimod Agonist 99.90% Phase 2
HY-134581A Enpatoran hydrochloride Inhibitor 99.42% Phase 2
HY-13740G Resiquimod (GMP) Agonist / Phase 2
HY-108472 Loxoribine Agonist 99.94% Phase 2
HY-111269 AZD8848 Agonist 99.14% Phase 2
HY-100176 PF-4878691 Agonist 99.89% Phase 2
HY-118250 GSK2245035 Agonist 99.79% Phase 2
HY-139575 Guretolimod Agonist / Phase 2
HY-177617 Bazlitoran Agonist 95.30% Phase 2
HY-177617A Bazlitoran sodium Agonist 95.30% Phase 2
HY-13655A Isatoribine Agonist / Phase 2
HY-109104 Telratolimod Agonist 98.85% Phase 1
HY-111786 LHC-165 Agonist 98.0% Phase 1
HY-178166 ETI41 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (92)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0201 Atractylenolide I Antagonist 99.98% Unkown
HY-124603 AT791 Inhibitor 98.77% Unkown
HY-128799 CL097 Agonist 99.90% Unkown
HY-160229 ssRNA40 sodium Activator 98.34% Unkown
HY-12756 E6446 Antagonist 98.78% Unkown
HY-12756A E6446 dihydrochloride Antagonist 99.29% Unkown
HY-103697 Gardiquimod 99.91% Unkown
HY-103698 TLR7/8 agonist 1 Agonist 98.42% Unkown
HY-139323 TLR7/8-IN-1 Inhibitor 99.92% Unkown
HY-135905 CL264 Inhibitor 98.63% Unkown
HY-103698A TLR7/8 agonist 1 dihydrochloride Agonist 99.70% Unkown
HY-110120 DSR-6434 Agonist 99.32% Unkown
HY-128799A CL097 hydrochloride Agonist 99.96% Unkown
HY-111582 BBIQ Agonist 99.81% Unkown
HY-B1370R Hydroxychloroquine sulfate (Standard) Inhibitor 99.96% Unkown
HY-160227A ORN 06 sodium Activator 95.05% Unkown
HY-130797 TLR7/8 agonist 3 Agonist 99.96% Unkown
HY-153879 C12-TLRa Ligand 99.71% Unkown
HY-111358 TLR7 agonist 1 Agonist 98.19% Unkown
HY-159102 PVP-037.2 Agonist 99.18% Unkown
HY-156174 E104 Inhibitor 99.38% Unkown
HY-117602 TLR7 agonist 3 Agonist 99.90% Unkown
HY-13740S Resiquimod-d5 Agonist 98.33% Unkown
HY-115400 1V209 Agonist 99.67% Unkown
HY-150736 ODN 20844 Inhibitor 96.14% Unkown
HY-139017 TLR7/8 agonist 4 Agonist 99.18% Unkown
HY-138139B AXC-715 trihydrochloride Agonist 99.76% Unkown
HY-131945 CU-115 Antagonist 99.63% Unkown
HY-103697A Gardiquimod diTFA 99.0% Unkown
HY-138139A AXC-715 hydrochloride Agonist 99.89% Unkown
HY-110207 SM-324405 Agonist 98.52% Unkown
HY-145885 TLR7/8 agonist 6 Agonist 98.93% Unkown
HY-156693A MTvkPABC-P5 TFA Agonist 98.78% Unkown
HY-176774 L07-2 Agonist 99.83% Unkown
HY-157793 SMU-L11 Agonist 99.64% Unkown
HY-158694A TLR7 agonist 20 hydrochloride Agonist 99.86% Unkown
HY-145960A MC-Val-Cit-PAB-Amide-TLR7 agonist 4 formic Agonist 97.70% Unkown
HY-164485 INI-4001 Activator / Unkown
HY-145961 TLR7 agonist 4 Agonist 98.87% Unkown
HY-150158 TMX-201 ≥95.0% Unkown
HY-150744 ODN 24888 Inhibitor / Unkown
HY-10018 Toll-like receptor modulator Modulator 99.36% Unkown
HY-153543 TLR7/8 agonist 8 Agonist 98.69% Unkown
HY-178037 TLR9 antagonist 1 Antagonist / Unkown
HY-179474 TSI-13-57 Inhibitor 98.73% Unkown
HY-153071 TLR7 agonist 6 Agonist 98.08% Unkown
HY-145960 MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Agonist 99.39% Unkown
HY-101589 Sotirimod Agonist 99.90% Unkown
HY-139017A TLR7/8 agonist 4 TFA Agonist / Unkown
HY-147215 UC-1V150 Agonist / Unkown
HY-141454A TLR8 agonist 2 hydrochloride Agonist / Unkown
HY-141454 TLR8 agonist 2 Agonist / Unkown
HY-162845 TLR7/8 agonist 11 Agonist / Unkown
HY-176553 KBD4466 Inhibitor / Unkown
HY-175782 SMU-R39 Antagonist / Unkown
HY-181796 TLR7 antagonist-1 Antagonist / Unkown
HY-160227 ORN 06 Activator / Unkown
HY-169017 MTT5 Agonist 98.49% Unkown
HY-153072 TLR7 agonist 7 Agonist / Unkown
HY-162115 TLR7 agonist 17 Agonist / Unkown
HY-169057 BI1543673 Inhibitor / Unkown
HY-178169 ETI60 Inhibitor 99.51% Unkown
HY-173070 TLR7 agonist 29 Agonist / Unkown
HY-152726 TLR7 agonist 9 Agonist / Unkown
HY-117686 AZ12441970 Agonist / Unkown
HY-179336 TLR7/8 agonist 14 Agonist / Unkown
HY-179047 SMU-L11-R Agonist / Unkown
HY-170899 TLR7 agonist 28 Agonist / Unkown
HY-162725 TLR7 agonist 24 Agonist / Unkown
HY-158694 TLR7 agonist 20 Agonist / Unkown
HY-179209 TLR9-IN-2 Inhibitor / Unkown
HY-145886 TLR7/8 antagonist 1 Antagonist / Unkown
HY-163670 TLR7 agonist 21 Inhibitor / Unkown
HY-175421 ArMan Activator / Unkown
HY-168159 TLR7 agonist 27 Agonist / Unkown
HY-153544 TLR7/8 agonist 9 Inhibitor / Unkown
HY-121496 3M-011 Agonist / Unkown
HY-179007 TLR7 agonist 31 Agonist / Unkown
HY-183079 ENDO12 Inhibitor / Unkown
HY-153070 TLR7 agonist 5 Agonist / Unkown
HY-156175 TLR7 agonist 14 Agonist / Unkown
HY-153073 TLR7 agonist 8 Agonist / Unkown
HY-159916 AYK004 Agonist / Unkown
HY-159914 AYK004-B1 Agonist / Unkown
HY-163398 TLR7-IN-1 Inhibitor / Unkown
HY-168157 TLR7 agonist 26 Agonist / Unkown
HY-177300 TLR7/8 agonist 13 Agonist / Unkown
HY-165632 Creatine ethyl ester Activator / Unkown
HY-183400 BIM-46174 Inhibitor / Unkown
HY-159919 UM-3006 Agonist / Unkown
HY-131920 Poly(U) Agonist / Unkown
HY-111582G BBIQ (GMP) Agonist / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992348 DS-7011a Inhibitor / Unkown
HY-P991956 ABB071 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tlr7 NCBI NCBI:51284