Tlr4 - toll-like receptor 4 Gene

Rattus norvegicus

Gene ID: 29260 | Gene type: protein coding

About Tlr4

Primary_assembly 5: 80,145,826-80,159,628 forward strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 127 orthologues, 26 paralogues and is associated with 182 phenotypes. Biased expression in Lung (RPKM 171.1), Spleen (RPKM 11.9) and 9 other tissues.

Summary

Enables lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; immune response-regulating signaling pathway; and response to steroid hormone. Located in cell surface and cytoplasm. Colocalizes with membrane raft. Used to study several diseases, including carotid stenosis; ileitis; neuropathy (multiple); obesity; and renal fibrosis. Biomarker of several diseases, including kidney failure (multiple); pancreatitis (multiple); perinatal necrotizing enterocolitis; pulpitis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Tlr4 Products(1)

mRNA	Protein	Name
NM_019178.2	NP_062051.2	toll-like receptor 4 precursor

Tlr4 Protein Structure

PLN00113

LRR_RI

LRR_8

LRR_RI

TIR

0
200
400
600
835 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 4

toll4

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130320	Monophosphoryl lipid A	Agonist	≥99.0%	Unkown
HY-107352	Fosfenopril	Inhibitor	99.89%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-D1056	Lipopolysaccharides	Activator	/	Phase 4
HY-N8277	Kdo2-Lipid A ammonium	Activator	≥95.0%	Phase 4
HY-11109	Resatorvid	Inhibitor	99.95%	Phase 3
HY-105070	Eritoran	Antagonist	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107575	TLR4-IN-C34	Inhibitor	99.85%	Unkown
HY-U00435	Neoseptin 3	Agonist	99.57%	Unkown
HY-N0703	Schaftoside	Inhibitor	99.67%	Unkown
HY-N0774	Isofraxidin	Inhibitor	99.00%	Unkown
HY-116213	Sparstolonin B	Antagonist	99.54%	Unkown
HY-N1346	Robinin	Inhibitor	98.77%	Unkown
HY-135042	CAY10614	Antagonist	98.04%	Unkown
HY-125171	IAXO-102	Antagonist	≥98.0%	Unkown
HY-N6673	Okanin	Inhibitor	98.64%	Unkown
HY-124750	NecroX-7	Inhibitor	99.69%	Unkown
HY-126154	L48H37	Inhibitor	97.05%	Unkown
HY-W082785A	L6H21	Inhibitor	99.46%	Unkown
HY-18325	AN-3485	Inhibitor	95.63%	Unkown
HY-146195	MAPK-IN-1	Inhibitor	95.85%	Unkown
HY-N0392	Polygalasaponin F	Inhibitor	99.74%	Unkown
HY-145245	TLR4-IN-C34-C2-amide-C6-OH	Inhibitor	≥95.0%	Unkown
HY-P10208A	RKH acetate	Antagonist	99.45%	Unkown
HY-145253	Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH	Inhibitor	/	Unkown
HY-162004	NF-κB-IN-14	Inhibitor	/	Unkown
HY-145255	Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH	Inhibitor	/	Unkown
HY-146560	Xanthine oxidase-IN-6	Inhibitor	/	Unkown
HY-N8903	Mumefural	Inhibitor	/	Unkown
HY-Y0278	Chloranil	Inducer	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr4	NCBI	NCBI:7099
Mus musculus	Tlr4	NCBI	NCBI:21898

Name
Email *

	Sorry, but the email address you supplied was invalid.