2. Gene
  3. CDK4 - cyclin dependent kinase 4 Gene

CDK4 - cyclin dependent kinase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Canis lupus familiaris (sub-species: familiaris)
Gene ID: 481131 | Gene type: protein coding

About CDK4

Primary_assembly 10: 1,822,136-1,825,057 reverse strand.ROS_Cfam_1.0:CM025109.1

This gene has 1 transcript (splice variant), 214 orthologues and 25 paralogues.

CDK4 Products(1)

mRNA Protein Name
XM_038679138.1 XP_038535066.1 cyclin-dependent kinase 4

CDK4 Protein Structure

PKc_like

PKc_like: cl21453 (4 - 294)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 4

Related Agents

Approval
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50767 Palbociclib Inhibitor 99.94% Unkown
HY-16297A Abemaciclib Inhibitor 99.97% Yes
HY-15777 Ribociclib Inhibitor 99.94% Unkown
HY-50767C Palbociclib hydrochloride Inhibitor 99.96% Unkown
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% Unkown
HY-A0065 Palbociclib isethionate Inhibitor 99.98% Unkown
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-15777A Ribociclib hydrochloride Inhibitor 99.95% Unkown
HY-15777B Ribociclib succinate Inhibitor 99.93% Unkown
HY-114338 Dalpiciclib Inhibitor 99.70% Unkown
HY-101467A Trilaciclib hydrochloride Inhibitor 99.69% Unkown
HY-15777C Ribociclib succinate hydrate Inhibitor 99.94% Unkown
HY-50767B Palbociclib dihydrochloride Inhibitor / Unkown
HY-50767D Palbociclib orotate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (31)
Cat. No. Product Name Effect
Purity Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.73% Phase 4
HY-114338A Dalpiciclib hydrochloride Inhibitor 98.22% Phase 4
HY-122620 Rafutrombopag (tautomerism) Agonist 98.33% Phase 4
HY-145589 Rafutrombopag Agonist 95.29% Phase 4
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-112272 Lerociclib Inhibitor 98.35% Phase 3
HY-175538 USP10-IN-4 Inhibitor / Phase 3
HY-10005 Flavopiridol Inhibitor 99.72% Phase 2
HY-101563 GSK3326595 99.83% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-10006 Flavopiridol Hydrochloride Inhibitor 99.73% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Phase 2
HY-10424 Milciclib Inhibitor 99.89% Phase 2
HY-103712 Samuraciclib Inhibitor 99.55% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.16% Phase 2
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Phase 2
HY-50940A AT7519 TFA Inhibitor 99.75% Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10008 SNS-032 Inhibitor 99.91% Phase 1
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-15504 RGB-286638 Inhibitor 99.70% Phase 1
HY-12624 Narazaciclib Inhibitor 98.66% Phase 1
HY-12422 Voruciclib Inhibitor 99.76% Phase 1
HY-111361 FN-1501 Inhibitor 98.72% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.09% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.26% Phase 1
Pre-clinical Phase
Bioactive Molecules (162)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103248 Toyocamycin Inhibitor 99.27% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.39% Unkown
HY-15339 CVT-313 Inhibitor 99.90% Unkown
HY-136250 BSJ-03-204 Inhibitor 99.76% Unkown
HY-114177 Ebvaciclib Inhibitor 99.98% Unkown
HY-116035 Nimbolide Inhibitor 99.79% Unkown
HY-122609 XO44 99.38% Unkown
HY-18299A Purvalanol A Inhibitor 98.61% Unkown
HY-138946 XY028-140 Inhibitor 98.52% Unkown
HY-15275 BMS-265246 Inhibitor 99.59% Unkown
HY-N0404 Sinigrin Inhibitor 99.97% Unkown
HY-13914 Roniciclib Inhibitor 98.00% Unkown
HY-15878 LDC000067 Inhibitor 99.00% Unkown
HY-136252 BSJ-04-132 Inhibitor 99.07% Unkown
HY-11009 CGP60474 Inhibitor 98.90% Unkown
HY-18629 SU9516 Inhibitor 99.85% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-N0805 Alisol B 23-acetate Inhibitor 99.65% Unkown
HY-128669 Abemaciclib metabolite M2 Inhibitor 99.75% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-168664 CPD-39 Degrader 98.06% Unkown
HY-119940 MC180295 Inhibitor 98.07% Unkown
HY-126534A Abemaciclib metabolite M18 hydrochloride Inhibitor 98.18% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.93% Unkown
HY-147007 β-catenin-IN-3 Inhibitor 95.64% Unkown
HY-163786 PROTAC CDK4/6 degrader 1 Degrader 98.88% Unkown
HY-129336 Abemaciclib metabolite M20 Inhibitor 95.92% Unkown
HY-16559 Riviciclib hydrochloride 99.08% Unkown
HY-129180 XY028-133 Inhibitor 98.62% Unkown
HY-N1431 Tabersonine Inhibitor 98.13% Unkown
HY-15889 AMG 925 Inhibitor 99.02% Unkown
HY-126534 Abemaciclib metabolite M18 Inhibitor 98.01% Unkown
HY-100624 Ryuvidine Inhibitor 99.23% Unkown
HY-168660 CPD-10 Degrader 98.59% Unkown
HY-163640 CDK4 degrader 1 Degrader 99.83% Unkown
HY-151071 TMX-3013 Inhibitor 98.02% Unkown
HY-50767S Palbociclib-d8 Inhibitor 99.84% Unkown
HY-148214 CDK2/4/6-IN-2 Inhibitor 98.20% Unkown
HY-151069 TMX-2039 Inhibitor 99.42% Unkown
HY-142076 CDK4/6-IN-15 Inhibitor 99.32% Unkown
HY-107419 NU6140 Inhibitor 99.53% Unkown
HY-148061 DB1113 99.86% Unkown
HY-153894 SRX3177 Inhibitor 99.33% Unkown
HY-164129 CDK4-IN-3 Inhibitor 98.07% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-152263 HEMTAC CDK4/6 degrader 1 Inhibitor 98.18% Unkown
HY-150280 Ironomycin Inhibitor 97.04% Unkown
HY-114339 CDK4/6-IN-2 Inhibitor 99.67% Unkown
HY-N7045 Isosilybin B Inhibitor 99.32% Unkown
HY-123045 PNU-292137 Inhibitor 99.95% Unkown
HY-100429 CAN508 Inhibitor 99.71% Unkown
HY-126251 CDK9-IN-7 Inhibitor 98.05% Unkown
HY-129336S Abemaciclib metabolite M20-d8 Inhibitor 99.26% Unkown
HY-112822 ON-013100 Inhibitor 99.66% Unkown
HY-119715 AG-012986 Inhibitor 99.78% Unkown
HY-45661 Inixaciclib Inhibitor 99.93% Unkown
HY-136726 CGP-82996 Inhibitor 98.12% Unkown
HY-155787 SHR5428 Inhibitor 98.97% Unkown
HY-103380 NSC 625987 Inhibitor 98.01% Unkown
HY-148365 NecroIr1 Inhibitor 98.53% Unkown
HY-16942 Damulin B Inhibitor 97.89% Unkown
HY-168996 LA-CB1 Degrader 98.20% Unkown
HY-142696A CDK6/PIM1-IN-1 hydrochloride Inhibitor 99.38% Unkown
HY-146213 CDK4/6-IN-12 Inhibitor 99.76% Unkown
HY-115992 CDK4/6-IN-9 Inhibitor 99.46% Unkown
HY-112328 Fascaplysin Inhibitor 95.64% Unkown
HY-182468 OP-3136 / Unkown
HY-115909 ZDLD20 Inhibitor 99.84% Unkown
HY-148366 NecroIr2 Inhibitor 98.02% Unkown
HY-108420 INK4C-IN-2 Activator 98.10% Unkown
HY-168440 Aurora-A ligand 1 Ligand 98.75% Unkown
HY-123535 P18IN003 Activator 99.49% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-201330 GDC-4198 Inhibitor / Unkown
HY-112243A Cimpuciclib tosylate Inhibitor 99.65% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-112418 CDK4/6-IN-18 Inhibitor 98.9% Unkown
HY-147125 DDO-6600 Inhibitor / Unkown
HY-N2423 Sinigrin hydrate Inhibitor 99.92% Unkown
HY-185121 PROTAC CDK2/4/6 Degrader-2 Degrader / Unkown
HY-112346 RGB-286147 Inhibitor 98.60% Unkown
HY-15889A AMG 925 (HCl) Inhibitor / Unkown
HY-179688 PROTAC CDK2/4 Degrader-1 Degrader / Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-111207 CA224 Inhibitor 99.94% Unkown
HY-112243 Cimpuciclib Inhibitor / Unkown
HY-126244 CDK4/6-IN-3 Inhibitor / Unkown
HY-159155 CDK2/4-IN-1 Inhibitor / Unkown
HY-181062 VWK147 Inhibitor / Unkown
HY-146253 CDK1/2/4-IN-1 Inhibitor / Unkown
HY-182752 CDK1-IN-9 Inhibitor / Unkown
HY-163787 YY173 Inhibitor / Unkown
HY-178516 PROTAC CDK4/6/9 degrader 2 Degrader / Unkown
HY-176365 Palbociclib-C4-Boc Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-176718 VEGFR-2-IN-69 Inhibitor / Unkown
HY-111932 Indirubin-5-sulfonate Inhibitor / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-164376A CDK4/6-IN-21 maleate Inhibitor / Unkown
HY-141685 3-Methylthienyl-carbonyl-JNJ-7706621 Inhibitor / Unkown
HY-178452 PROTAC CDK4/6/9 degrader 1 Degrader / Unkown
HY-134303 CST651 Degrader / Unkown
HY-170651 CDK4/6/HDAC-IN-1 Inhibitor / Unkown
HY-164376 CDK4/6-IN-21 Inhibitor / Unkown
HY-183297 CDK4-IN-5 Inhibitor / Unkown
HY-115993 CDK4/6-IN-10 Inhibitor / Unkown
HY-115904 FLT3/CDK4-IN-1 Inhibitor / Unkown
HY-172128 NUAK1-IN-2 Inhibitor / Unkown
HY-128491 UNC10112785 Inhibitor / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-185487 CDK4/6-IN-27 Inhibitor / Unkown
HY-168444 CDK4/6-IN-23 Inhibitor / Unkown
HY-143258 CDK4/6-IN-8 Inhibitor / Unkown
HY-155602 CDK2-IN-18 Inhibitor / Unkown
HY-170992 Autophagy agonist-1 Inhibitor / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-172234 PF-06842874 Inhibitor / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-172127 NUAK1-IN-1 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-148213 CDK2/4/6-IN-1 Inhibitor / Unkown
HY-182447 Contragestazol Inhibitor / Unkown
HY-183571 JD128 Inhibitor / Unkown
HY-143257 CDK4/6-IN-7 Inhibitor / Unkown
HY-W1047040 CDK2/4 ligand 1 Inhibitor / Unkown
HY-183854 AG-12286 Inhibitor / Unkown
HY-171740 CDK4-IN-4 Inhibitor / Unkown
HY-153336 PRT3645 Inhibitor / Unkown
HY-172198 GSK3-IN-10 Inhibitor / Unkown
HY-182470 AG-012986 dihydrochloride Inhibitor / Unkown
HY-171656 G721-0282 Inhibitor 99.96% Unkown
HY-173237 CDK4/6/BRD4-IN-1 Inhibitor / Unkown
HY-164906 TMX-2138 Degrader / Unkown
HY-162619 CDK9-IN-33 Inhibitor / Unkown
HY-153088 CDK4/6-IN-16 Inhibitor / Unkown
HY-179151 CDK4/6-IN-26 Inhibitor / Unkown
HY-162530 CDK4/6-IN-20 Inhibitor / Unkown
HY-150609 SHP2/CDK4-IN-1 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-182044 MRTX849-amide-C4-(o)-carborane Inhibitor / Unkown
HY-178168 ARUK2010694 Inhibitor / Unkown
HY-115908 ZDLD13 Inhibitor / Unkown
HY-171826 PROTAC CDK2/4/6 Degrader-1 Inhibitor / Unkown
HY-181501 CDK2/4/6-IN-3 Inhibitor / Unkown
HY-114338B Dalpiciclib isethionate Inhibitor / Unkown
HY-178112 CDK2-IN-47 Inhibitor / Unkown
HY-179375 LCI133 Inhibitor / Unkown
HY-182734 BMS-357075 Inhibitor / Unkown
HY-183771 CDK4/6-IN-28 Inhibitor / Unkown
HY-182986 LS-Q2 Inhibitor / Unkown
HY-123034 CDKI-83 Inhibitor / Unkown
HY-170815 CDK4/9-IN-1 Inhibitor / Unkown
HY-178171 ARUK2010489 Inhibitor 96.64% Unkown
HY-160941 CDK2-IN-29 Inhibitor / Unkown
HY-171481 Thio-acridone Inhibitor / Unkown
HY-123859 SR-2890 Inhibitor / Unkown
HY-162529 CDK4/6-IN-19 Inhibitor / Unkown
HY-173172 MG-002 Inhibitor / Unkown
HY-112450 Olomoucine II Inhibitor / Unkown
HY-N1431A Tabersonine hydrochloride Inhibitor 98.55% Unkown
HY-183529 Antitrypanosomal agent 31 Inhibitor / Unkown
HY-118447 RO0505124 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CDK4 NCBI NCBI:1019