JAK2 - Janus kinase 2 Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 484185

About JAK2

Primary_assembly 1: 93,877,224-93,990,814 forward strand.ROS_Cfam_1.0:CM025100.1

This gene has 1 transcript (splice variant), 265 orthologues, 32 paralogues and is associated with 1 phenotype.

JAK2 Products (6)

mRNA Protein Name
XM_038655369.1 XP_038511297.1 tyrosine-protein kinase JAK2 isoform X2
XM_038655371.1 XP_038511299.1 tyrosine-protein kinase JAK2 isoform X1
XM_038655370.1 XP_038511298.1 tyrosine-protein kinase JAK2 isoform X3
XM_038655369.1 XP_038511297.1 tyrosine-protein kinase JAK2 isoform X2
XM_038655370.1 XP_038511298.1 tyrosine-protein kinase JAK2 isoform X3
XM_038655371.1 XP_038511299.1 tyrosine-protein kinase JAK2 isoform X1

JAK2 Protein Structure

FERM_F1

FERM_F1: pfam18379 (38 - 133)

FERM_F2

FERM_F2: pfam18377 (142 - 260)

FERM_C_JAK2

FERM_C_JAK2: cd13333 (265 - 385)

SH2_Jak2

SH2_Jak2: cd10379 (385 - 480)

PTK_Jak2_rpt1

PTK_Jak2_rpt1: cd05078 (544 - 805)

PTKc_Jak2_rpt2

PTKc_Jak2_rpt2: cd14205 (843 - 1126)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1132 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase JAK2

  • Janus kinase 2 (a protein tyrosine kinase)

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (25)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50856 Ruxolitinib Inhibitor 99.99% Yes
HY-40354 Tofacitinib Inhibitor 99.99% Yes
HY-19569 Upadacitinib Inhibitor 99.98% Yes
HY-15315 Baricitinib Inhibitor 99.97% Yes
HY-10409 Fedratinib Inhibitor 99.87% Yes
HY-50858 Ruxolitinib phosphate Inhibitor 99.97% Yes
HY-40354A Tofacitinib citrate Inhibitor 99.94% Yes
HY-16379 Pacritinib Inhibitor 99.93% Yes
HY-107429 Abrocitinib Inhibitor 99.26% Unkown
HY-18300 Filgotinib Inhibitor 99.77% Yes
HY-19568 Peficitinib Inhibitor 99.43% Yes
HY-15315A Baricitinib phosphate Inhibitor 99.97% Yes
HY-10409A Fedratinib hydrochloride hydrate Inhibitor 99.92% Yes
HY-109053 Delgocitinib Inhibitor 99.61% Unkown
HY-13577 Oclacitinib Inhibitor 99.03% Unkown
HY-50867 Lestaurtinib Inhibitor 99.66% Unkown
HY-13577A Oclacitinib monomaleate Inhibitor 99.87% Unkown
HY-15728 Radotinib Inhibitor 99.19% Yes
HY-50856S Deuruxolitinib Inhibitor 99.18% Unkown
HY-18300A Filgotinib maleate Inhibitor 99.88% Yes
HY-50859 Ruxolitinib sulfate Inhibitor / Unkown
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / Unkown
HY-19568A Peficitinib hydrobromide Inhibitor / Unkown
HY-16379A Pacritinib hydrochloride Inhibitor / Unkown
HY-19568B Peficitinib hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name Effect
Purity Phase
HY-155785 MTP Inhibitor / Phase 4
HY-10961 Momelotinib Inhibitor 98.93% Phase 3
HY-112708 Brepocitinib Inhibitor 99.97% Phase 3
HY-50514 AT9283 Inhibitor 99.67% Phase 3
HY-15999 Cerdulatinib Inhibitor 99.06% Phase 3
HY-12469 Decernotinib Inhibitor 99.91% Phase 3
HY-10962 Momelotinib sulfate Inhibitor 98.63% Phase 3
HY-112724 Ivarmacitinib Inhibitor 99.62% Phase 3
HY-13775 XL019 Inhibitor 99.65% Phase 3
HY-15999A Cerdulatinib hydrochloride Inhibitor 98.96% Phase 3
HY-109038 Mocravimod Activator 98.39% Phase 3
HY-10963 Momelotinib mesylate Inhibitor / Phase 3
HY-15312 WP1066 Inhibitor 99.53% Phase 2
HY-10193 AZD-1480 Inhibitor 99.74% Phase 2
HY-13034 Gandotinib Inhibitor 99.86% Phase 2
HY-130247 Flonoltinib Inhibitor 99.48% Phase 2
HY-15270 BMS-911543 Inhibitor 98.23% Phase 2
HY-19631A Ilginatinib Inhibitor 99.81% Phase 2
HY-156961 Cadefrecitinib Inhibitor 99.81% Phase 2
HY-112708A Brepocitinib P-Tosylate Inhibitor 99.99% Phase 2
HY-15163 Zotiraciclib Inhibitor 99.88% Phase 2
HY-109179 Itacnosertib Inhibitor 99.06% Phase 2
HY-19631B Ilginatinib hydrochloride Inhibitor 98.92% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.33% Phase 2
HY-130247A Flonoltinib TFA Inhibitor 98.94% Phase 2
HY-10058 AT9283 lactic acid Inhibitor / Phase 2
HY-15504 RGB-286638 Inhibitor 99.67% Phase 1
HY-101024 PF-06263276 Inhibitor ≥99.0% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.09% Phase 1
HY-112809 GSK2646264 Inhibitor 99.74% Phase 1
HY-124067 EC-70124 Inhibitor / Phase 1
HY-16449 SB1578 Inhibitor / Phase 1
HY-16021 AC-430 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (133)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148748 Butyzamide Activator 99.83% Unkown
HY-18960 CHZ868 Inhibitor 98.69% Unkown
HY-N1405 Cucurbitacin I Inhibitor 99.60% Unkown
HY-14435 Pyridone 6 Inhibitor 98.20% Unkown
HY-15480 NSC 42834 Inhibitor 96.85% Unkown
HY-15166 (E/Z)-Zotiraciclib Inhibitor 99.96% Unkown
HY-15343 CEP-33779 Inhibitor 99.23% Unkown
HY-145551 Atinvicitinib Inhibitor 98.62% Unkown
HY-145696 SJ10542 Inhibitor 99.32% Unkown
HY-151902 SJ988497 Degrader 99.03% Unkown
HY-N0885 Telocinobufagin Inhibitor 99.93% Unkown
HY-N2963 Broussonin E Activator 98.11% Unkown
HY-113573 Protosappanin A 99.95% Unkown
HY-10411 AZ960 Inhibitor 97.08% Unkown
HY-14722 NVP-BSK805 Inhibitor 99.30% Unkown
HY-10410 TG101209 Inhibitor 98.81% Unkown
HY-100895 SAR-20347 Inhibitor 97.27% Unkown
HY-108264 TCS 21311 Inhibitor 99.49% Unkown
HY-137756 JAK2-IN-6 Inhibitor 97.07% Unkown
HY-113787 (R)-9b Inhibitor 99.51% Unkown
HY-15166A (E/Z)-Zotiraciclib hydrochloride Inhibitor 99.90% Unkown
HY-N1356 Reticuline Inhibitor 98.89% Unkown
HY-N0918 Desmethoxyyangonin Inhibitor 99.00% Unkown
HY-151262 JAK-IN-23 Inhibitor 98.88% Unkown
HY-146186 JAK2 JH2 binder-1 Modulator 95.40% Unkown
HY-153701S Envudeucitinibum Inhibitor 99.56% Unkown
HY-115452 G5-7 Inhibitor 98.45% Unkown
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% Unkown
HY-19544 JAK3-IN-1 Inhibitor 99.31% Unkown
HY-15166B (E/Z)-Zotiraciclib citrate Inhibitor 99.83% Unkown
HY-131906 JAK2-IN-7 Inhibitor 98.31% Unkown
HY-124858 SC99 Inhibitor 98.90% Unkown
HY-N3239 Mulberrofuran G Inhibitor 97.86% Unkown
HY-150720 TYK2-IN-12 Inhibitor 98.81% Unkown
HY-109179A Itacnosertib hydrochloride Inhibitor 99.43% Unkown
HY-179715 PROTAC JAK1/2 degrader-1 Degrader 99.47% Unkown
HY-169326S JAK2-IN-11 Inhibitor 98.03% Unkown
HY-147330B SJ1008030 formic Inhibitor 98.91% Unkown
HY-162248 JAK1/2-IN-1 Inhibitor 98.36% Unkown
HY-147330A SJ1008030 TFA Inhibitor 98.12% Unkown
HY-153440 Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate Inhibitor 98.01% Unkown
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 99.80% Unkown
HY-139423 JAK1-IN-8 Inhibitor 95.0% Unkown
HY-143444 JAK-IN-20 Inhibitor 99.63% Unkown
HY-111750 JAK-IN-3 Inhibitor 98.92% Unkown
HY-N0143A Phlorizin dihydrate Antagonist 99.51% Unkown
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.63% Unkown
HY-167846 YLIU-4-105-1 Inhibitor 99.39% Unkown
HY-124727 ZT55 Inhibitor 99.51% Unkown
HY-13961 GLPG0634 analog Inhibitor 98.07% Unkown
HY-164393 ON044580 Inhibitor 99.11% Unkown
HY-152080 Blovacitinib Inhibitor 99.71% Unkown
HY-100849 JAK 3i Inhibitor 99.81% Unkown
HY-116505 JAK1-IN-4 Inhibitor 99.26% Unkown
HY-120692 Cyclanoline chloride Inhibitor 96.27% Unkown
HY-179716 JAK1/2 ligand 1 Ligand 99.91% Unkown
HY-112391 SD-1029 Inhibitor 88.8% Unkown
HY-161684 JAK2-IN-10 Inhibitor 97.97% Unkown
HY-159536 Frevecitinib Inhibitor 99.42% Unkown
HY-125542 DCZ3301 Inhibitor 99.73% Unkown
HY-148060 JAK-IN-21 Inhibitor 99.72% Unkown
HY-170772 Dual Cathepsin L/JAK-IN-1 Inhibitor 98.47% Unkown
HY-161618 MJ04 Inhibitor 98.08% Unkown
HY-143884 JAK2/TYK2-IN-1 Inhibitor 99.94% Unkown
HY-107595 SD-1008 Inhibitor 99.10% Unkown
HY-181929 RAI-20 Inhibitor 98.66% Unkown
HY-14722C NVP-BSK805 trihydrochloride Inhibitor / Unkown
HY-184063 Vexicitinib Inhibitor / Unkown
HY-151259 TK4b Inhibitor / Unkown
HY-175684 JAK2-IN-14 Inhibitor / Unkown
HY-115541 BRD4-IN-41 / Unkown
HY-149296 JAK1-IN-12 Inhibitor / Unkown
HY-151256 JAK-2/3-IN-2 Inhibitor / Unkown
HY-177131 Soficitinib Inhibitor / Unkown
HY-156959 Ovalicin Inhibitor / Unkown
HY-151285 JAK-2/3-IN-3 Inhibitor / Unkown
HY-143885 JAK1/TYK2-IN-3 Inhibitor / Unkown
HY-180766 JAK2-IN-19 Inhibitor / Unkown
HY-136734 JAK2-IN-5 Inhibitor / Unkown
HY-183272 PI3K/Akt/mTOR-IN-7 Inhibitor / Unkown
HY-146727 JAK3-IN-11 Inhibitor / Unkown
HY-178936 JAK2-IN-15 Inhibitor / Unkown
HY-W064657 Momelotinib dihydrochloride Inhibitor / Unkown
HY-161967 JAK2/FLT3-IN-3 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-177006 JAK1/2-IN-2 Inhibitor / Unkown
HY-144440 JAK1-IN-9 Inhibitor / Unkown
HY-174428 PROTAC JAK2 degrader-1 Degrader / Unkown
HY-18293 NSC 33994 Inhibitor / Unkown
HY-155951 JAK3-IN-14 Inhibitor 99.32% Unkown
HY-161139 JAK1-IN-14 Inhibitor / Unkown
HY-175611 FLT3/JAK2/BRD4 ligand-1 Ligand / Unkown
HY-178448 EGFR-IN-178 Inhibitor / Unkown
HY-179687 JAK2-IN-18 Inhibitor / Unkown
HY-147975 JAK3-IN-12 Inhibitor / Unkown
HY-178282 JAK1-IN-19 Inhibitor / Unkown
HY-170723 JAK-IN-39 Inhibitor / Unkown
HY-108342 PF-00956980 Inhibitor / Unkown
HY-162885 YSY01A Degrader / Unkown
HY-180274 JAK1/2-IN-3 Inhibitor / Unkown
HY-10652 JAK-2/3-IN-1 Inhibitor / Unkown
HY-179428 JAK2-IN-17 Inhibitor / Unkown
HY-182430 NVP-BVB808 Inhibitor / Unkown
HY-151258 TK4g Inhibitor / Unkown
HY-154994 JAK-IN-30 Inhibitor / Unkown
HY-181691 JAK2-IN-20 Inhibitor / Unkown
HY-147754 JAK3/BTK-IN-6 Inhibitor / Unkown
HY-117810 JAK2-IN-1 Inhibitor / Unkown
HY-P10840 Tkip Inhibitor 95.16% Unkown
HY-174430 WWQ-131 Inhibitor / Unkown
HY-174999 JAK3-IN-18 Inhibitor / Unkown
HY-175610 PROTAC FLT3/JAK2/BRD4 Degrader-1 Degrader / Unkown
HY-183670 JAK2-IN-21 Inhibitor / Unkown
HY-N14094 Tubulosine Inhibitor / Unkown
HY-129341 WP1193 Inhibitor / Unkown
HY-176793 JAK1-IN-18 Inhibitor / Unkown
HY-N13352 Bufothionine Inhibitor / Unkown
HY-155746 JAK2-IN-9 Inhibitor / Unkown
HY-183370 JAK2/STAT3-IN-2 Inhibitor / Unkown
HY-174988 JAK2-IN-13 Inhibitor / Unkown
HY-160919 JAK2-IN-16 Inhibitor / Unkown
HY-168269 Tyk2-IN-20 Inhibitor / Unkown
HY-123939 JAK1/3-IN-1 Inhibitor / Unkown
HY-123187 AS2553627 Inhibitor / Unkown
HY-162862 JAK-IN-38 Inhibitor / Unkown
HY-129679 NMS-P953 Inhibitor / Unkown
HY-119009 TM-233 Inhibitor / Unkown
HY-N8098 Pulchinenoside E2 Inhibitor 99.28% Unkown
HY-130247B Flonoltinib monomaleate Inhibitor / Unkown
HY-157121 JAK-IN-34 Inhibitor / Unkown
HY-183519 AH057 Inhibitor / Unkown
HY-162862 JAK-IN-38 Inducer / Unkown
HY-124595 MPT0B098 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens JAK2 NCBI NCBI:3717