2. Gene
  3. ALK - ALK receptor tyrosine kinase Gene

ALK - ALK receptor tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Macaca mulatta
Gene ID: 704823 | Gene type: protein coding

About ALK

Primary_assembly 13: 78,995,892-79,753,056 forward strand.Mmul_10:CM014348.1

This gene has 1 transcript (splice variant), 195 orthologues and 53 paralogues.

ALK Products(3)

mRNA Protein Name
XM_015112031.2 XP_014967517.2 ALK tyrosine kinase receptor isoform X1
XM_028831808.1 XP_028687641.1 ALK tyrosine kinase receptor isoform X2
XM_028831809.1 XP_028687642.1 ALK tyrosine kinase receptor isoform X3

ALK Protein Structure

MAM

MAM: cl27660 (265 - 423)

LDLa

LDLa: smart00192 (440 - 466)

MAM

MAM: pfam00629 (479 - 634)

PTKc_ALK_LTK

PTKc_ALK_LTK: cd05036 (1108 - 1384)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1620 a.a.
Protein Preferred Names Protein Names

ALK tyrosine kinase receptor

anaplastic lymphoma kinase (Ki-1)

anaplastic lymphoma receptor tyrosine kinase

Related Agents

Approval
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50878 Crizotinib 99.97% Yes
HY-15656 Ceritinib Inhibitor 99.98% Yes
HY-12215 Lorlatinib 99.92% Yes
HY-12678 Entrectinib 99.87% Yes
HY-13011 Alectinib Inhibitor 99.59% Yes
HY-12857 Brigatinib Inhibitor 99.98% Yes
HY-13011A Alectinib Hydrochloride Inhibitor 99.93% Yes
HY-15656A Ceritinib dihydrochloride Inhibitor 99.57% Yes
HY-50878A Crizotinib hydrochloride 99.86% Yes
HY-103714A Ensartinib dihydrochloride Inhibitor 99.53% Unkown
HY-100375 Diroximel fumarate 99.90% Yes
HY-123689 Samidorphan / Unkown
HY-103714 Ensartinib Inhibitor / Unkown
HY-50878B Crizotinib acetate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Phase
HY-16590 X-376 Inhibitor 98.37% Phase 3
HY-19928 Vactosertib Inhibitor 99.58% Phase 2
HY-103022 Repotrectinib Inhibitor 99.90% Phase 2
HY-139279 Zotizalkib Inhibitor 95.73% Phase 2
HY-103021 LY3200882 Inhibitor 99.86% Phase 2
HY-19928A Vactosertib Hydrochloride Inhibitor 99.09% Phase 2
HY-109084 Conteltinib Inhibitor 99.54% Phase 2
HY-136788 ALK4290 Inhibitor 99.21% Phase 2
HY-109179 Itacnosertib Inhibitor 99.77% Phase 2
HY-17603 Belizatinib Inhibitor 99.64% Phase 2
HY-15841 CEP-37440 Inhibitor 99.58% Phase 1
HY-13326 ASP3026 99.73% Phase 1
HY-142287 Con B-1 Inhibitor / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99353 Ascrinvacumab Inhibitor 97.45% Phase 2
HY-P99752 Nemvaleukin alfa 99.50% Phase 2
Pre-clinical Phase
Bioactive Molecules (151)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10431 SB-431542 Inhibitor 99.89% Unkown
HY-13418A Dorsomorphin Inhibitor 99.91% Unkown
HY-10432 A 83-01 Inhibitor 99.41% Unkown
HY-13418 Dorsomorphin dihydrochloride Inhibitor 99.91% Unkown
HY-12071 LDN193189 Inhibitor 99.48% Unkown
HY-13012 RepSox Inhibitor 99.93% Unkown
HY-12273 DMH-1 Inhibitor 99.95% Unkown
HY-12043 SB 525334 Inhibitor 99.97% Unkown
HY-12071A LDN193189 Tetrahydrochloride Inhibitor 99.86% Unkown
HY-10432A A 83-01 sodium Inhibitor ≥98.0% Unkown
HY-13521 SB-505124 Inhibitor 99.99% Unkown
HY-10192 NVP-TAE 684 99.27% Unkown
HY-W040304 Alkynyl Palmitic Acid ≥97.0% Unkown
HY-13020 GSK1838705A Inhibitor 99.14% Unkown
HY-10326 GW788388 Inhibitor 99.92% Unkown
HY-112155 MS4078 Inhibitor 99.63% Unkown
HY-15609 AZD-3463 99.58% Unkown
HY-15897 LDN-212854 Inhibitor 99.70% Unkown
HY-13227 SD-208 Inhibitor 99.87% Unkown
HY-12274 ML347 Inhibitor 99.89% Unkown
HY-12953 R-268712 Inhibitor 99.78% Unkown
HY-16712 LDN-214117 Inhibitor 99.92% Unkown
HY-12071B LDN-193189 dihydrochloride Inhibitor 99.75% Unkown
HY-12278 K02288 Inhibitor 99.73% Unkown
HY-18758 IN-1130 99.79% Unkown
HY-111482 SM 16 Inhibitor 99.88% Unkown
HY-19628 OD36 Inhibitor 98.70% Unkown
HY-13464 ALK-IN-1 Inhibitor 99.94% Unkown
HY-145574 Iruplinalkib Inhibitor 99.29% Unkown
HY-15358 ALK inhibitor 2 Inhibitor 99.57% Unkown
HY-12331 KRCA-0008 98.88% Unkown
HY-122856 AZ12601011 Inhibitor 99.88% Unkown
HY-18766 EW-7195 Inhibitor 99.20% Unkown
HY-78349 A 77-01 Inhibitor 99.68% Unkown
HY-112156 MS4077 Inhibitor 99.49% Unkown
HY-123919 TL13-112 Inhibitor 98.15% Unkown
HY-118528A TP0427736 hydrochloride Inhibitor 99.22% Unkown
HY-144043 ALK5-IN-8 Inhibitor 98.06% Unkown
HY-136773 KER047 Inhibitor 99.35% Unkown
HY-153386 CPD-1224 Inhibitor 99.24% Unkown
HY-19990 ALK kinase inhibitor-1 Inhibitor 99.85% Unkown
HY-135366 HPN-01 Inhibitor 98.40% Unkown
HY-13012G RepSox (GMP) Inhibitor / Unkown
HY-145608 Zilurgisertib Inhibitor 99.77% Unkown
HY-112815 ALK2-IN-2 Inhibitor 99.56% Unkown
HY-15357 ALK inhibitor 1 Inhibitor 99.62% Unkown
HY-15801 HG-14-10-04 Inhibitor 99.09% Unkown
HY-50878S Crizotinib-d5 ≥99.0% Unkown
HY-136773A KER047 succinate Inhibitor 98.93% Unkown
HY-148234 M4K2234 Inhibitor 98.71% Unkown
HY-155163 APG-2449 Inhibitor 98.86% Unkown
HY-18030A CEP-28122 mesylate salt Inhibitor 99.08% Unkown
HY-112801 F-1 Inhibitor 98.65% Unkown
HY-122582 TL13-12 Inhibitor 98.06% Unkown
HY-152845 Ficonalkib Inhibitor 98.55% Unkown
HY-151289 ALK5-IN-34 Inhibitor 98.21% Unkown
HY-N4126 6-Demethoxytangeretin Inhibitor 99.37% Unkown
HY-156467A ALK-IN-27 TFA Inhibitor / Unkown
HY-145566 Envonalkib Inhibitor 99.73% Unkown
HY-10327 GW-6604 Inhibitor ≥98.0% Unkown
HY-12678S Entrectinib-d4 Inhibitor / Unkown
HY-13783 BIBF0775 Inhibitor 99.53% Unkown
HY-160520 ALK-IN-28 Inhibitor / Unkown
HY-13521A SB-505124 hydrochloride Inhibitor 99.34% Unkown
HY-125851 TP-008 Inhibitor / Unkown
HY-10432G A 83-01 (GMP) Inhibitor / Unkown
HY-111752 EML4-ALK kinase inhibitor 1 Inhibitor 98.49% Unkown
HY-112140 JH-VIII-157-02 Inhibitor 99.67% Unkown
HY-117887 Fidrisertib Inhibitor 96.72% Unkown
HY-147219 SIAIS164018 / Unkown
HY-147219A SIAIS164018 hydrochloride 99.84% Unkown
HY-147413 Unecritinib Inhibitor 98.83% Unkown
HY-109179A Itacnosertib (hydrocholide) Inhibitor 98.98% Unkown
HY-135887 ZX-29 99.52% Unkown
HY-156467 ALK-IN-27 Inhibitor 98.01% Unkown
HY-15656S Ceritinib-d7 Inhibitor 98.00% Unkown
HY-160506 PRO-6E / Unkown
HY-18030 CEP-28122 Inhibitor / Unkown
HY-111416 WY-135 Inhibitor / Unkown
HY-128569 ALK-IN-5 Inhibitor / Unkown
HY-128596 ALK-IN-6 Inhibitor / Unkown
HY-129171 TGFBR1-IN-1 Inhibitor / Unkown
HY-132229 LPM4870108 Inhibitor / Unkown
HY-131909 CJ-2360 Inhibitor / Unkown
HY-145566A Envonalkib citrate Inhibitor / Unkown
HY-108230 ALK-IN-12 Inhibitor / Unkown
HY-110347 Mps1-IN-1 dihydrochloride Inhibitor / Unkown
HY-112877 ALK-5-IN-1 Inhibitor / Unkown
HY-12678S1 Entrectinib-d8 / Unkown
HY-12857S Brigatinib-13C6 Inhibitor / Unkown
HY-12973 ALK-IN-13 Inhibitor / Unkown
HY-13011S Alectinib-d8 Inhibitor / Unkown
HY-13011S1 Alectinib-d6 Inhibitor / Unkown
HY-130794 ALK/ROS1-IN-1 Inhibitor / Unkown
HY-131244 ALK-IN-9 Inhibitor / Unkown
HY-136194 TL13-22 Inhibitor / Unkown
HY-136195 TL13-110 Inhibitor / Unkown
HY-136788A ALK4290 dihydrochloride Inhibitor / Unkown
HY-142949 ALK5-IN-7 Inhibitor / Unkown
HY-142950 ALK5-IN-6 Inhibitor / Unkown
HY-143557 Trk-IN-7 Inhibitor / Unkown
HY-144423 Trk-IN-10 Inhibitor / Unkown
HY-144437 ALK5-IN-9 Inhibitor / Unkown
HY-144732 TRK/ALK-IN-1 Inhibitor / Unkown
HY-145855 J-1063 Inhibitor / Unkown
HY-146022 SIAIS117 Inhibitor / Unkown
HY-146408 ALK-IN-21 Inhibitor / Unkown
HY-146694 RIPK2-IN-1 Inhibitor / Unkown
HY-146780 TGFβRI-IN-4 Inhibitor / Unkown
HY-147206 Biotin-PEG-Alk (MW 600) / Unkown
HY-147206A Biotin-PEG-Alk (MW 1000) / Unkown
HY-147206B Biotin-PEG-Alk (MW 2000) / Unkown
HY-147206C Biotin-PEG-Alk (MW 3400) / Unkown
HY-147206D Biotin-PEG-Alk (MW 5000) / Unkown
HY-147206E Biotin-PEG-Alk (MW 10000) / Unkown
HY-147206F Biotin-PEG-Alk (MW 20000) / Unkown
HY-147833 ALK-IN-22 / Unkown
HY-148246 MU1700 Inhibitor / Unkown
HY-149403 J-1048 Inhibitor / Unkown
HY-150169 THRX-144644 Inhibitor / Unkown
HY-151155 ALK-IN-23 Inhibitor / Unkown
HY-151233 ALK5-IN-10 Inhibitor / Unkown
HY-151270 ALK5-IN-25 Inhibitor / Unkown
HY-151272 ALK5-IN-26 Inhibitor / Unkown
HY-151273 ALK5-IN-27 Inhibitor / Unkown
HY-151275 ALK5-IN-28 Inhibitor / Unkown
HY-151277 ALK5-IN-29 Inhibitor / Unkown
HY-151279 ALK5-IN-30 Inhibitor / Unkown
HY-151281 ALK5-IN-31 Inhibitor / Unkown
HY-151282 ALK5-IN-32 Inhibitor / Unkown
HY-151283 ALK5-IN-33 Inhibitor / Unkown
HY-153246 ALK2-IN-5 Inhibitor / Unkown
HY-155227 ALK/EGFR-IN-1 / Unkown
HY-155227A ALK/EGFR-IN-2 Inhibitor / Unkown
HY-155227B ALK/EGFR-IN-3 Inhibitor / Unkown
HY-155939 M4K2163 dihydrochloride Inhibitor / Unkown
HY-156432 ALK-IN-26 / Unkown
HY-156470 Multi-kinase-IN-6 / Unkown
HY-157391 ALK/ROS1-IN-3 Inhibitor / Unkown
HY-161350 ALK/HDAC-IN-1 Inhibitor / Unkown
HY-161376 M4K2281 Inhibitor / Unkown
HY-161377 M4K2306 Inhibitor / Unkown
HY-163429 J-1149 Inhibitor / Unkown
HY-19628A OD36 hydrochloride Inhibitor / Unkown
HY-RS00598 ALK Human Pre-designed siRNA Set A / Unkown
HY-RS00599 Alk Mouse Pre-designed siRNA Set A / Unkown
HY-RS00600 ALK Rat Pre-designed siRNA Set A / Unkown
HY-118528 TP0427736 Inhibitor / Unkown
HY-160172 ALK/ROS1-IN-4 Inhibitor / Unkown
HY-160172A ALK/ROS1-IN-4 hydrate Inhibitor / Unkown
HY-18030B CEP-28122 mesylate hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ALK NCBI NCBI:238
Canis familiaris ALK NCBI NCBI:483021
Macaca fascicularis ALK NCBI NCBI:102128455
Mus musculus ALK NCBI NCBI:11682
Rattus norvegicus ALK NCBI NCBI:266802