CDKi free base
CDKi free base is a CDK inhibitor. CDKi free base induces morphological changes, DNA fragmentation, and cell death in vestibular schwannoma cells. CDKi free base downregulates pRb, EGF-R, PI3K, NF-κB, and Shh levels, while upregulating JNK, ASK1, Caspase 3, and p21, and induces PARP-1 cleavage. CDKi free base can be used in research related to vestibular schwannoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 70035-83-5
- 分子式: C4H6N4O
- 分子量:126.12
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
CDKi (0.5-5.0 nM; 24-72 h) free base induces extensive DNA fragmentation in primary human vestibular schwannoma tumor cell cultures, with a greater degree of fragmentation than other tested treatments[1].
CDKi (0.5-5.0 nM; 24-72 h) free base decreases total pRb and phosphorylated pRb levels in primary human vestibular schwannoma tumor cell cultures[1].
CDKi (0.5-5.0 nM; 24-72 h) free base modulates key cell survival and death-related proteins in primary human vestibular schwannoma tumor cell cultures, including eliminating EGF-R expression, decreasing PI3K, NF-kB, Shh, and S100A2 levels, and increasing JNK, ASK1, Caspase-3, and p21cip1/waf1 levels, while triggering PARP-1 cleavage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 70035-83-5
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分子量 126.12
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分子式 C4H6N4O
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SMILES
OC1=CN=C(N=C1N)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CDKi free base 関連分類
HY-W259575 関連分類
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