CDKi free base
CDKi free base is a CDK inhibitor. CDKi free base induces morphological changes, DNA fragmentation, and cell death in vestibular schwannoma cells. CDKi free base downregulates pRb, EGF-R, PI3K, NF-κB, and Shh levels, while upregulating JNK, ASK1, Caspase 3, and p21, and induces PARP-1 cleavage. CDKi free base can be used in research related to vestibular schwannoma.
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- CAS No.: 70035-83-5
- Formule: C4H6N4O
- Masse moléculaire:126.12
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
CDKi (0.5-5.0 nM; 24-72 h) free base induces morphological changes in primary human vestibular schwannoma tumor cell cultures, causing over 90% of the cells to aggregate together[1].
CDKi (0.5-5.0 nM; 24-72 h) free base induces extensive DNA fragmentation in primary human vestibular schwannoma tumor cell cultures, with a greater degree of fragmentation than other tested treatments[1].
CDKi (0.5-5.0 nM; 24-72 h) free base decreases total pRb and phosphorylated pRb levels in primary human vestibular schwannoma tumor cell cultures[1].
CDKi (0.5-5.0 nM; 24-72 h) free base modulates key cell survival and death-related proteins in primary human vestibular schwannoma tumor cell cultures, including eliminating EGF-R expression, decreasing PI3K, NF-kB, Shh, and S100A2 levels, and increasing JNK, ASK1, Caspase-3, and p21cip1/waf1 levels, while triggering PARP-1 cleavage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 70035-83-5
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Masse moléculaire 126.12
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Formule C4H6N4O
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SMILES
OC1=CN=C(N=C1N)N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDKi free base Related Classifications
HY-W259575 Related Classifications
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