Jak2 - Janus kinase 2 Gene

Also Known as Fd17

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16452

About Jak2

Chromosome 19: 29,229,228-29,290,480 forward strand.GRCm39:CM001012.3

This gene has 4 transcripts (splice variants), 265 orthologues, 32 paralogues and is associated with 50 phenotypes. Ubiquitous expression in bladder adult (RPKM 6.6), CNS E18 (RPKM 6.3) and 28 other tissues.

Summary

Enables interleukin-12 receptor binding activity and protein tyrosine kinase activity. Involved in several processes, including hemopoiesis; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to lipid; and regulation of apoptotic process. Located in caveola and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and musculoskeletal system. Used to study essential thrombocythemia; myelofibrosis; myeloproliferative neoplasm; and polycythemia vera. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Jak2 Products (2)

mRNA Protein Name
NM_001048177.3 NP_001041642.1 tyrosine-protein kinase JAK2
NM_008413.4 NP_032439.2 tyrosine-protein kinase JAK2

Jak2 Protein Structure

FERM_F1

FERM_F1: pfam18379 (38 - 133)

FERM_F2

FERM_F2: pfam18377 (142 - 260)

FERM_C_JAK2

FERM_C_JAK2: cd13333 (265 - 385)

SH2_Jak2

SH2_Jak2: cd10379 (385 - 481)

PTK_Jak2_rpt1

PTK_Jak2_rpt1: cd05078 (544 - 805)

PTKc_Jak2_rpt2

PTKc_Jak2_rpt2: cd14205 (843 - 1126)

  • 0
  • 200
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  • 1000
  • 1132 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase JAK2

  • JAK-2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (26)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50856 Ruxolitinib Inhibitor 99.99% Yes
HY-40354 Tofacitinib Inhibitor 99.99% Yes
HY-19569 Upadacitinib Inhibitor 99.98% Yes
HY-15315 Baricitinib Inhibitor 99.97% Yes
HY-10409 Fedratinib Inhibitor 99.87% Yes
HY-50858 Ruxolitinib phosphate Inhibitor 99.92% Yes
HY-40354A Tofacitinib citrate Inhibitor 99.94% Yes
HY-16379 Pacritinib Inhibitor 99.93% Yes
HY-10961 Momelotinib Inhibitor 98.93% Unkown
HY-107429 Abrocitinib Inhibitor 99.26% Unkown
HY-18300 Filgotinib Inhibitor 99.77% Yes
HY-19568 Peficitinib Inhibitor 99.43% Yes
HY-15315A Baricitinib phosphate Inhibitor 99.97% Yes
HY-10409A Fedratinib hydrochloride hydrate Inhibitor 99.92% Yes
HY-109053 Delgocitinib Inhibitor 99.61% Unkown
HY-13577 Oclacitinib Inhibitor 99.03% Unkown
HY-50867 Lestaurtinib Inhibitor 99.66% Unkown
HY-13577A Oclacitinib monomaleate Inhibitor 99.87% Unkown
HY-15728 Radotinib Inhibitor 99.19% Yes
HY-50856S Deuruxolitinib Inhibitor 99.18% Unkown
HY-18300A Filgotinib maleate Inhibitor 99.88% Yes
HY-50859 Ruxolitinib sulfate Inhibitor / Unkown
HY-19569A Upadacitinib tartrate tetrahydrate Inhibitor / Unkown
HY-19568A Peficitinib hydrobromide Inhibitor / Unkown
HY-16379A Pacritinib hydrochloride Inhibitor / Unkown
HY-19568B Peficitinib hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Phase
HY-112724 Ivarmacitinib Inhibitor 99.62% Phase 4
HY-155785 MTP Inhibitor / Phase 4
HY-50514 AT9283 Inhibitor 99.67% Phase 3
HY-15999 Cerdulatinib Inhibitor 99.06% Phase 3
HY-12469 Decernotinib Inhibitor 99.91% Phase 3
HY-13775 XL019 Inhibitor 99.65% Phase 3
HY-112708A Brepocitinib P-Tosylate Inhibitor 99.99% Phase 3
HY-130247A Flonoltinib TFA Inhibitor 98.94% Phase 3
HY-15312 WP1066 Inhibitor 99.53% Phase 2
HY-10193 AZD-1480 Inhibitor 99.74% Phase 2
HY-13034 Gandotinib Inhibitor 99.86% Phase 2
HY-15270 BMS-911543 Inhibitor 98.23% Phase 2
HY-156961 Cadefrecitinib Inhibitor 99.81% Phase 2
HY-15163 Zotiraciclib Inhibitor 99.88% Phase 2
HY-109179A Itacnosertib hydrochloride Inhibitor 99.43% Phase 2
HY-19631 Ilginatinib maleate Inhibitor 99.33% Phase 2
HY-159536 Frevecitinib Inhibitor 99.42% Phase 2
HY-15504 RGB-286638 Inhibitor 99.67% Phase 1
HY-101024 PF-06263276 Inhibitor ≥99.0% Phase 1
HY-179715 PROTAC JAK1/2 degrader-1 Degrader 99.47% Phase 1
HY-112809 GSK2646264 Inhibitor 99.74% Phase 1
HY-16021 AC-430 Inhibitor / Phase 1
HY-124067 EC-70124 Inhibitor / Phase 1
HY-16449 SB1578 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (146)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148748 Butyzamide Activator 99.83% Unkown
HY-112708 Brepocitinib Inhibitor 99.95% Yes
HY-18960 CHZ868 Inhibitor 98.69% Unkown
HY-N1405 Cucurbitacin I Inhibitor 99.60% Unkown
HY-14435 Pyridone 6 Inhibitor 98.20% Unkown
HY-15480 NSC 42834 Inhibitor 96.85% Unkown
HY-15166 (E/Z)-Zotiraciclib Inhibitor 99.96% Unkown
HY-130247 Flonoltinib Inhibitor 99.48% Unkown
HY-145696 SJ10542 Degrader 99.32% Unkown
HY-15343 CEP-33779 Inhibitor 99.23% Unkown
HY-145551 Atinvicitinib Inhibitor 98.62% Unkown
HY-10962 Momelotinib sulfate Inhibitor 98.63% Yes
HY-151902 SJ988497 Degrader 99.03% Unkown
HY-N0885 Telocinobufagin Inhibitor 99.93% Unkown
HY-N2963 Broussonin E Activator 98.11% Unkown
HY-113573 Protosappanin A 99.95% Unkown
HY-10411 AZ960 Inhibitor 97.08% Unkown
HY-14722 NVP-BSK805 Inhibitor 99.30% Unkown
HY-10410 TG101209 Inhibitor 98.81% Unkown
HY-19631A Ilginatinib Inhibitor 99.81% Unkown
HY-100895 SAR-20347 Inhibitor 97.27% Unkown
HY-108264 TCS 21311 Inhibitor 99.49% Unkown
HY-113787 (R)-9b Inhibitor 99.51% Unkown
HY-137756 JAK2-IN-6 Inhibitor 97.07% Unkown
HY-N1356 Reticuline Inhibitor 98.89% Unkown
HY-15166A (E/Z)-Zotiraciclib hydrochloride Inhibitor 99.90% Unkown
HY-N0918 Desmethoxyyangonin Inhibitor 99.00% Unkown
HY-151262 JAK-IN-23 Inhibitor 98.88% Unkown
HY-15504A RGB-286638 free base Inhibitor 98.09% Unkown
HY-146186 JAK2 JH2 binder-1 Modulator 95.40% Unkown
HY-109179 Itacnosertib Inhibitor 99.06% Unkown
HY-153701S Envudeucitinibum Inhibitor 99.56% Unkown
HY-115452 G5-7 Inhibitor 98.45% Unkown
HY-14722A NVP-BSK805 dihydrochloride Inhibitor 99.36% Unkown
HY-19544 JAK3-IN-1 Inhibitor 99.31% Unkown
HY-15166B (E/Z)-Zotiraciclib citrate Inhibitor 99.83% Unkown
HY-15999A Cerdulatinib hydrochloride Inhibitor 98.96% Yes
HY-131906 JAK2-IN-7 Inhibitor 98.31% Unkown
HY-180561 WWQ-03-012 Inhibitor 98.04% Unkown
HY-N3239 Mulberrofuran G Inhibitor 97.86% Unkown
HY-150720 TYK2-IN-12 Inhibitor 98.81% Unkown
HY-124858 SC99 Inhibitor 98.90% Unkown
HY-19631B Ilginatinib hydrochloride Inhibitor 98.92% Unkown
HY-120469 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide Inhibitor 99.80% Unkown
HY-139423 JAK1-IN-8 Inhibitor 95.0% Unkown
HY-169326S JAK2-IN-11 Inhibitor 98.03% Unkown
HY-147330B SJ1008030 formic Inhibitor 98.91% Unkown
HY-153440 Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate Inhibitor 98.01% Unkown
HY-143444 JAK-IN-20 Inhibitor 99.63% Unkown
HY-162248 JAK1/2-IN-1 Inhibitor 98.36% Unkown
HY-147330A SJ1008030 TFA Inhibitor 98.12% Unkown
HY-111750 JAK-IN-3 Inhibitor 98.92% Unkown
HY-167846 YLIU-4-105-1 Inhibitor 99.39% Unkown
HY-N0143A Phlorizin dihydrate Antagonist 99.51% Unkown
HY-124727 ZT55 Inhibitor 99.51% Unkown
HY-169853 M351-0056 Inhibitor 99.48% Unkown
HY-164393 ON044580 Inhibitor 99.11% Unkown
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.63% Unkown
HY-13961 GLPG0634 analog Inhibitor 98.07% Unkown
HY-161684 JAK2-IN-10 Inhibitor 97.97% Unkown
HY-120692 Cyclanoline chloride Inhibitor 96.27% Unkown
HY-116505 JAK1-IN-4 Inhibitor 99.26% Unkown
HY-179716 JAK1/2 ligand 1 Ligand 99.91% Unkown
HY-100849 JAK 3i Inhibitor 99.81% Unkown
HY-112391 SD-1029 Inhibitor 88.8% Unkown
HY-152080 Blovacitinib Inhibitor 99.71% Unkown
HY-109038 Mocravimod Activator 98.39% Yes
HY-125542 DCZ3301 Inhibitor 99.73% Unkown
HY-170772 Dual Cathepsin L/JAK-IN-1 Inhibitor 98.47% Unkown
HY-148060 JAK-IN-21 Inhibitor 99.72% Unkown
HY-143884 JAK2/TYK2-IN-1 Inhibitor 99.94% Unkown
HY-161618 MJ04 Inhibitor 98.08% Unkown
HY-107595 SD-1008 Inhibitor 99.10% Unkown
HY-181929 RAI-20 Inhibitor 98.66% Unkown
HY-14722C NVP-BSK805 trihydrochloride Inhibitor / Unkown
HY-184063 Vexicitinib Inhibitor / Unkown
HY-10058 AT9283 lactic acid Inhibitor / Unkown
HY-177131 Soficitinib Inhibitor 98.54% Unkown
HY-136734 JAK2-IN-5 Inhibitor / Unkown
HY-188002 JAK2-IN-23 Inhibitor / Unkown
HY-115541 BRD4-IN-41 / Unkown
HY-156959 Ovalicin Inhibitor / Unkown
HY-143885 JAK1/TYK2-IN-3 Inhibitor / Unkown
HY-181691 JAK2-IN-20 Inhibitor / Unkown
HY-151285 JAK-2/3-IN-3 Inhibitor / Unkown
HY-147754 JAK3/BTK-IN-6 Inhibitor / Unkown
HY-177006 JAK1/2-IN-2 Inhibitor / Unkown
HY-174999 JAK3-IN-18 Inhibitor / Unkown
HY-183670 JAK2-IN-21 Inhibitor / Unkown
HY-178936 JAK2-IN-15 Inhibitor / Unkown
HY-117810 JAK2-IN-1 Inhibitor / Unkown
HY-155951 JAK3-IN-14 Inhibitor 99.10% Unkown
HY-144440 JAK1-IN-9 Inhibitor / Unkown
HY-W064657 Momelotinib dihydrochloride Inhibitor 99.56% Unkown
HY-155746 JAK2-IN-9 Inhibitor / Unkown
HY-176793 Embricitinib Inhibitor / Unkown
HY-147975 JAK3-IN-12 Inhibitor / Unkown
HY-174988 JAK2-IN-13 Inhibitor / Unkown
HY-161139 JAK1-IN-14 Inhibitor / Unkown
HY-178282 JAK1-IN-19 Inhibitor / Unkown
HY-160919 JAK2-IN-16 Inhibitor / Unkown
HY-151259 TK4b Inhibitor / Unkown
HY-188001 JAK2-IN-22 Inhibitor / Unkown
HY-178448 EGFR-IN-178 Inhibitor / Unkown
HY-179428 JAK2-IN-17 Inhibitor / Unkown
HY-151258 TK4g Inhibitor / Unkown
HY-149296 JAK1-IN-12 Inhibitor / Unkown
HY-151256 JAK-2/3-IN-2 Inhibitor / Unkown
HY-182430 NVP-BVB808 Inhibitor / Unkown
HY-108342 PF-00956980 Inhibitor / Unkown
HY-183272 PI3K/Akt/mTOR-IN-7 Inhibitor / Unkown
HY-180274 JAK1/2-IN-3 Inhibitor / Unkown
HY-162885 YSY01A Degrader / Unkown
HY-180766 JAK2-IN-19 Inhibitor / Unkown
HY-10652 JAK-2/3-IN-1 Inhibitor / Unkown
HY-154994 JAK-IN-30 Inhibitor / Unkown
HY-P10840 Tkip Inhibitor 95.16% Unkown
HY-146727 JAK3-IN-11 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-174430 WWQ-131 Inhibitor / Unkown
HY-161967 JAK2/FLT3-IN-3 Inhibitor / Unkown
HY-18293 NSC 33994 Inhibitor / Unkown
HY-175610 PROTAC FLT3/JAK2/BRD4 Degrader-1 Degrader / Unkown
HY-183370 JAK2/STAT3-IN-2 Inhibitor / Unkown
HY-N13352 Bufothionine Inhibitor / Unkown
HY-N14094 Tubulosine Inhibitor / Unkown
HY-175611 FLT3/JAK2/BRD4 ligand-1 Ligand / Unkown
HY-174428 PROTAC JAK2 degrader-1 Degrader / Unkown
HY-129341 WP1193 Inhibitor / Unkown
HY-175684 JAK2-IN-14 Inhibitor / Unkown
HY-179687 JAK2-IN-18 Inhibitor / Unkown
HY-170723 JAK-IN-39 Inhibitor / Unkown
HY-168269 Tyk2-IN-20 Inhibitor / Unkown
HY-188034 JAK-IN-44 Inhibitor / Unkown
HY-123187 AS2553627 Inhibitor / Unkown
HY-123939 JAK1/3-IN-1 Inhibitor / Unkown
HY-183519 AH057 Inhibitor / Unkown
HY-N8098 Pulchinenoside E2 Inhibitor 99.28% Unkown
HY-130247B Flonoltinib monomaleate Inhibitor / Unkown
HY-162862 JAK-IN-38 Inhibitor / Unkown
HY-119009 TM-233 Inhibitor / Unkown
HY-157121 JAK-IN-34 Inhibitor / Unkown
HY-129679 NMS-P953 Inhibitor / Unkown
HY-162862 JAK-IN-38 Inducer / Unkown
HY-10963 Momelotinib mesylate Inhibitor / Unkown
HY-124595 MPT0B098 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jak2 NCBI NCBI:3717