1. Gene
  2. Tert - telomerase reverse transcriptase Gene

Tert - telomerase reverse transcriptase Gene

Mus musculus

Also known as TR; TP2; TRT; EST2; TCS1

Gene ID: 21752 | Gene type: protein coding

About Tert

Chromosome 13: 73,775,030-73,797,962 forward strand.GRCm39:CM001006.3

This gene has 7 transcripts (splice variants), 188 orthologues and is associated with 33 phenotypes. Broad expression in limb E14.5 (RPKM 4.7), adrenal adult (RPKM 3.6) and 25 other tissues.

Summary

Enables Telomerase RNA binding activity; Telomerase activity; and transcription coactivator binding activity. Involved in positive regulation of Wnt signaling pathway; positive regulation of hair cycle; and positive regulation of stem cell proliferation. Acts upstream of or within positive regulation of glucose import. Located in mitochondrion and plasma membrane. Part of Telomerase catalytic core complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; liver; and vibrissa follicle. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Orthologous to human TERT (telomerase Reverse Transcriptase). [provided by Alliance of Genome Resources, Apr 2022]

Tert Products(3)

mRNA Protein Name
NM_001362387.1 NP_001349316.1 telomerase reverse transcriptase isoform 2
NM_001362388.1 NP_001349317.1 telomerase reverse transcriptase isoform 3
NM_009354.2 NP_033380.1 telomerase reverse transcriptase isoform 1

Tert Protein Structure

Telomerase_RBD

Telomerase_RBD: pfam12009 (449 - 581)

TERT

TERT: cd01648 (814 - 928)

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  • 1122 a.a.
Protein Preferred Names Protein Names

telomerase reverse transcriptase

telomerase catalytic subunit

telomerase reverse transcriptase beta

Orthologs Information

Species Symbol Source ID
Homo sapiens Tert NCBI NCBI:7015