Il10 - interleukin 10 Gene

Also Known as If2a; IL10X

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25325

About Il10

Primary_assembly 13: 42,472,839-42,477,313 forward strand.mRatBN7.2:CM026986.1

This gene has 1 transcript (splice variant), 193 orthologues, 3 paralogues and is associated with 243 phenotypes. Biased expression in Spleen (RPKM 3.6), Thymus (RPKM 1.9) and 7 other tissues.

Summary

Enables interleukin-10 receptor binding activity. Involved in several processes, including cellular response to estradiol stimulus; liver regeneration; and negative regulation of nitric oxide biosynthetic process. Located in extracellular space. Used to study several diseases, including lung disease (multiple); perinatal necrotizing enterocolitis; sciatic neuropathy; toxic encephalopathy; and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); decubitus ulcer; lung disease (multiple); obstructive sleep apnea; and postpartum depression. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system Cancer (multiple); and hematologic Cancer (multiple). Orthologous to human IL10 (interleukin 10). [provided by Alliance of Genome Resources, Apr 2022]

Il10 Products (1)

mRNA Protein Name
NM_012854.2 NP_036986.2 interleukin-10 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables interleukin-10 receptor binding IDA
IDA: Inferred from direct assay
12405978 RGD
enables interleukin-10 receptor binding IMP
IMP: Inferred from mutant phenotype
19428551 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
20735828 RGD
involved in immune response IMP
IMP: Inferred from mutant phenotype
8484757 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
11813605 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19395591 RGD
involved in negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
8484757 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
28753520 RGD
involved in negative regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
17017555 RGD
involved in negative regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
17017555 RGD
involved in positive regulation of macrophage activation IDA
IDA: Inferred from direct assay
25837415 RGD
involved in regulation of synapse organization IDA
IDA: Inferred from direct assay
24278397 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
19424714 RGD
involved in response to carbon monoxide IEP
IEP: Inferred from expression pattern
20622590 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
16827395 RGD
involved in response to inactivity IEP
IEP: Inferred from expression pattern
17033197 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
18791499 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18791499 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19419978 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
18787467 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il10 Protein Structure

IL10

IL10: cl02501 (13 - 125)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

interleukin-10

  • CSIF

  • IL-10

  • cytokine synthesis inhibitory factor

  • interferon 2a

Recombinant Il10 Proteins

Cat. No. Product Name Accession Purity
HY-P7098 IL-10 Protein, Rat P29456 (S19-N178) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7098A IL-10 Protein, Rat (CHO) P29456 (S19-N178) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1829A Dexamethasone phosphate disodium 99.94% Yes
HY-B0809 Theophylline 99.97% Yes
HY-B1051 Flumethasone 99.84% Unkown
HY-B0809R Theophylline (Standard) 99.99% Unkown
HY-B0809A Theophylline monohydrate 99.93% Yes
HY-B1829AR Dexamethasone phosphate disodium (Standard) 99.88% Unkown
HY-B0327 Irsogladine 99.88% Unkown
HY-107909 Theophylline (sodium glycinate) / Unkown
HY-B0809B Theophylline sodium acetate / Unkown

Clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Phase
HY-13743 Roquinimex Inhibitor 99.69% Phase 3
HY-160040A Cobitolimod sodium Agonist / Phase 3
HY-13743R Roquinimex (Standard) Inhibitor / Phase 3
HY-110133 JTE-607 Inhibitor 99.27% Phase 2
HY-135317 Emavusertib 99.97% Phase 2
HY-101019 Ossirene Inhibitor 98.0% Phase 2
HY-135317B Emavusertib hydrochloride / Phase 2
HY-111167 AN-2898 Inhibitor / Phase 2
HY-19307 SB-273005 99.94% Phase 1
HY-107390 AX-024 Inhibitor 99.73% Phase 1
HY-107390A AX-024 hydrochloride Inhibitor 99.23% Phase 1
HY-101757 NO-prednisolone Agonist ≥99.0% Phase 1
HY-15507 VGX-1027 Inhibitor 99.67% Phase 1
Bioactive MoleculesInhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P990561 BT-063 Inhibitor 99.51% Phase 2
HY-P991659 SCH708980 Inhibitor / Phase 2
HY-P99390 Tepoditamab Inducer ≥99% Phase 1
HY-P991257 MK-1966 Inhibitor 96.17% Phase 1

Pre-clinical Phase

Bioactive Molecules (117)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141537 ABR-238901 Inhibitor 98.92% Unkown
HY-N0405 Orientin Inhibitor 99.89% Unkown
HY-A0103 Xanthan gum / Unkown
HY-110353 CU-T12-9 Agonist 99.96% Unkown
HY-23119 Sodium thiocyanate, GR, 99% Inhibitor 99.2% Unkown
HY-N6607 Tryptanthrin 99.89% Unkown
HY-130321 Lauroyl-L-carnitine chloride Activator 99.92% Unkown
HY-N0493 Pectolinarigenin 99.98% Unkown
HY-W013579 (S)-(+)-Carvone 99.26% Unkown
HY-113494 Sitostanol Activator 99.0% Unkown
HY-N0818 Chikusetsusaponin Iva Inhibitor 99.61% Unkown
HY-109540 Perfluorohexane Activator 98.62% Unkown
HY-122586 BRD6989 99.54% Unkown
HY-N0695 Schisantherin B 99.75% Unkown
HY-N4087 Platycodin D2 Inducer 99.84% Unkown
HY-N15135 Arabinoxylan (Medium viscosity) 95.0% Unkown
HY-124344 Avenanthramide C Activator 99.13% Unkown
HY-147105 LRH-1 agonist-2 98.58% Unkown
HY-W668775 Quin-C7 Antagonist 99.76% Unkown
HY-N0600 Ginsenoside F3 99.84% Unkown
HY-P1194 Spantide I Antagonist 99.64% Unkown
HY-161440 SIK-IN-1 Inhibitor 98.91% Unkown
HY-173679 RBN012811 98.79% Unkown
HY-175479 GLPG4970 99.60% Unkown
HY-N1940 β-Anhydroicaritin Inhibitor 99.69% Unkown
HY-D1056C1 Lipopolysaccharides, from S. enterica serotype enteritidis Activator / Unkown
HY-159657 PF-07899895 98.83% Unkown
HY-130321S Lauroyl-L-carnitine-d3 chloride Activator 99.95% Unkown
HY-130321S1 Lauroyl-L-carnitine-d9 chloride Activator 98.0% Unkown
HY-165613 Pam2Cys 99.82% Unkown
HY-172590 LZ-07 98.27% Unkown
HY-14837 Amizon Inhibitor 99.92% Unkown
HY-N14039 Pinus pinaster bark extract Activator 95.79% Unkown
HY-N2492 (E)-Methyl 4-coumarate 99.87% Unkown
HY-155520 Antileishmanial agent-19 Inhibitor 99.45% Unkown
HY-147105A (+)-LRH-1 agonist-2 Modulator 99.38% Unkown
HY-150232 MALT1-IN-11 Inhibitor / Unkown
HY-160040 Cobitolimod Agonist 97.14% Unkown
HY-N4267 Yangambin 98.27% Unkown
HY-N8249 Cynandione A Activator 99.6% Unkown
HY-NP134 Flagellin from S. typhimurium 95% Unkown
HY-P1194A Spantide I TFA Antagonist 99.32% Unkown
HY-W145695 Chitoheptaose ≥98.0% Unkown
HY-117123 Convulxin / Unkown
HY-171591 SIK2-IN-4 Inhibitor 99.06% Unkown
HY-B1829 Dexamethasone phosphate 98.89% Yes
HY-W041608 Methylchloroisothiazolinone / Unkown
HY-110067 VO-OHPic / Unkown
HY-111164 CBS-3595 Inhibitor / Unkown
HY-113494R Sitostanol (Standard) Activator / Unkown
HY-117461 Y 25510 Activator / Unkown
HY-124665 LMP-420 / Unkown
HY-130054 Theophylline L-lysine / Unkown
HY-143422 MALT1-IN-3 Inhibitor / Unkown
HY-143422A (R)-MALT1-IN-3 Inhibitor / Unkown
HY-143683S Theophylline-13C2,d6 / Unkown
HY-147527 CDK8-IN-5 Inhibitor / Unkown
HY-149365 SIKs-IN-1 Inhibitor / Unkown
HY-160844 CT-133 / Unkown
HY-161441 SIK-IN-2 Inhibitor / Unkown
HY-161442 SIK-IN-3 Inhibitor / Unkown
HY-162600 CDK8-IN-15 Inhibitor / Unkown
HY-167153 PNA5 / Unkown
HY-168091 YM-I-26 Inhibitor / Unkown
HY-168846 CDK8/19-IN-3 Inhibitor / Unkown
HY-172632 Resolvin D3 methyl ester Inducer / Unkown
HY-174395 CD-10 / Unkown
HY-175073 Ganglioside GT1b (bovine) trisodium / Unkown
HY-178144 FPR2 agonist 5 / Unkown
HY-178240 rel-(1S,2R)-Dihydro bupropion Inhibitor / Unkown
HY-178913 Tyk2-IN-23 Inhibitor / Unkown
HY-178945 KOR agonist 7 / Unkown
HY-181822 BMS-986331 / Unkown
HY-182469 FuBIG / Unkown
HY-183074 RO8323 / Unkown
HY-185709 2-ARA-LysoPtdEtn / Unkown
HY-B0809S1 Theophylline-d3 / Unkown
HY-N17685 Pseudoginsenoside RT4 / Unkown
HY-N18367 Lemairamin / Unkown
HY-N19801 N-Palmitoyl-D-glucosamine / Unkown
HY-N9980 Antcin K Inhibitor / Unkown
HY-P11004 A3-APO Inhibitor / Unkown
HY-P3483 Maxadilan / Unkown
HY-RS06670 IL10 Human Pre-designed siRNA Set A / Unkown
HY-RS06671 Il10 Mouse Pre-designed siRNA Set A / Unkown
HY-RS06672 Il10 Rat Pre-designed siRNA Set A / Unkown
HY-RS06673 IL10RA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06674 IL10RB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W338346 Salicylate choline Inhibitor / Unkown
HY-110133A JTE-607 free base Inhibitor / Unkown
HY-123625 R-348 choline Inhibitor / Unkown
HY-135317C Emavusertib tosylate / Unkown
HY-135317D Emavusertib mesylate / Unkown
HY-135317E Emavusertib maleate / Unkown
HY-135317F Emavusertib phosphate / Unkown
HY-168384 M04 / Unkown
HY-174614 Human IL26 mRNA / Unkown
HY-174615 Human IL24 mRNA / Unkown
HY-174620 Human IL22 mRNA / Unkown
HY-174629 Human IL19 mRNA / Unkown
HY-174645 Human IL10RA mRNA / Unkown
HY-174646 Human IL10 mRNA 90% Unkown
HY-174657 Human IFNLR1 mRNA / Unkown
HY-174658 Human IFNL3 mRNA / Unkown
HY-174659 Human IFNL2 mRNA / Unkown
HY-174660 Human IFNL1 mRNA / Unkown
HY-177608 Rat IL10 mRNA / Unkown
HY-B1829R Dexamethasone phosphate (Standard) / Unkown
HY-N0493R Pectolinarigenin (Standard) / Unkown
HY-N0976 1,11b-Dihydro-11b-hydroxymedicarpin Activator / Unkown
HY-N15347 Talaromyketide B Inhibitor / Unkown
HY-N7697C Chitohexaose hexahydrochloride 95.0% Unkown
HY-RS17431 Il10ra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23886 Il10ra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W553071 Cytoxazone Inhibitor / Unkown
HY-W745349 rel-(1S,2R)-Dihydro bupropion-d9 hydrochloride Inhibitor / Unkown
HY-W777138 rel-(1S,2R)-Dihydro bupropion-d9 Inhibitor / Unkown
Bioactive MoleculesInhibitory Antibodies (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990001 Anti-Mouse IL-10 Antibody (JES5-2A5) Inhibitor 98.666% Unkown
HY-P990228 Anti-Mouse IL-10R/CD210 Antibody (1B1.3A) Inhibitor 99.08% Unkown
HY-P991400 GSK1995057 99.09% Unkown
HY-P990776 Vimekofusp / Unkown
HY-P991760 Anti-IL-10 Antibody (JES3-19F1) Inhibitor / Unkown
HY-P992037 Anti-IL-10Rα Antibody Inhibitor / Unkown
HY-P992038 Anti-IL-10RB Antibody Inhibitor / Unkown
HY-P992153 Serrumab Inhibitor / Unkown
HY-P992370 HPN601 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il10 NCBI NCBI:3586
Canis familiaris Il10 NCBI NCBI:403628
Macaca fascicularis Il10 NCBI NCBI:102133450
Mus musculus Il10 NCBI NCBI:16153
Susscrofa domestica Il10 NCBI