Kit - KIT proto-oncogene receptor tyrosine kinase Gene

Rattus norvegicus

Gene ID: 64030 | Gene type: protein coding

About Kit

Primary_assembly 14: 32,548,877-32,624,652 reverse strand.mRatBN7.2:CM026987.1

This gene has 2 transcripts (splice variants), 206 orthologues, 54 paralogues and is associated with 72 phenotypes. Biased expression in Lung (RPKM 35.8), Brain (RPKM 125.4) and 9 other tissues.

Summary

Enables protein tyrosine kinase activity. Involved in several processes, including gamete generation; positive regulation of gastro-intestinal system smooth muscle contraction; and protein phosphorylation. Located in acrosomal vesicle; cytoplasmic side of plasma membrane; and external side of plasma membrane. Used to study aplastic anemia and male infertility. Biomarker of acute pancreatitis and gastroschisis. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell Cancer (multiple); piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Kit Products(1)

mRNA	Protein	Name
NM_022264.2	NP_071600.1	mast/stem cell growth factor receptor Kit precursor

Kit Protein Structure

Ig_3

IgI_4_SCFR

PKc_like

0
200
400
600
800
978 a.a.

Protein Preferred Names

Protein Names

mast/stem cell growth factor receptor Kit

Kit oncogene	c-kit receptor tyrosine kinase
protein kinase	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Recombinant Kit Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74337	CD117/c-kit Protein, Rat (HEK293, His)	Q63116 (M1-T522)	≥95%
HY-P74338	CD117/c-kit Protein, Rat (HEK293, Fc)	Q63116 (M1-T522)	≥95%

Related Agents

Approval

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10201	Sorafenib		99.92%	Yes
HY-10981	Lenvatinib	Inhibitor	99.84%	Yes
HY-16749	Pexidartinib		99.64%	Yes
HY-10331	Regorafenib		99.93%	Yes
HY-15463	Imatinib		99.95%	Yes
HY-13016	Cabozantinib		99.96%	Yes
HY-10230	Midostaurin		99.95%	Yes
HY-10208	Pazopanib		99.91%	Yes
HY-10201A	Sorafenib Tosylate		99.91%	Yes
HY-50946	Imatinib Mesylate		99.98%	Yes
HY-101561	Avapritinib	Inhibitor	99.94%	Yes
HY-112306	Ripretinib		99.33%	Yes
HY-10209	Masitinib		99.98%	Yes
HY-10981A	Lenvatinib mesylate	Inhibitor	99.86%	Yes
HY-16749A	Pexidartinib hydrochloride		99.86%	Yes
HY-12009	Pazopanib Hydrochloride		99.88%	Yes
HY-12044	Cabozantinib S-malate		99.90%	Yes
HY-13308	Regorafenib Hydrochloride		99.58%	Yes
HY-10331A	Regorafenib monohydrate		99.96%	Yes
HY-13904	Flumatinib	Inhibitor	99.94%	Unkown
HY-10209A	Masitinib mesylate		99.83%	Yes
HY-10330A	Toceranib phosphate	Inhibitor	98.54%	Unkown
HY-10330	Toceranib	Inhibitor	96.86%	Unkown
HY-B1684	Mebrofenin		99.88%	Unkown
HY-10331B	Regorafenib mesylate		/	Unkown
HY-13016A	Cabozantinib hydrochloride		/	Unkown
HY-50946R	Imatinib Mesylate (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13905	Flumatinib mesylate	Inhibitor	99.87%	Phase 4
HY-50905	Dovitinib	Inhibitor	99.94%	Phase 3
HY-10205	Cediranib		99.58%	Phase 3
HY-16961	Sitravatinib	Inhibitor	99.59%	Phase 3
HY-145557	Bezuclastinib	Inhibitor	98.59%	Phase 3
HY-13049	Cediranib maleate		99.95%	Phase 3
HY-10228	Motesanib	Inhibitor	99.96%	Phase 3
HY-124526	Chiauranib	Inhibitor	99.28%	Phase 3
HY-10207	Dovitinib lactate	Inhibitor	99.62%	Phase 3
HY-108713	Famitinib		98.43%	Phase 3
HY-152839	Elenestinib	Inhibitor	98.82%	Phase 3
HY-10229	Motesanib Diphosphate	Inhibitor	99.64%	Phase 3
HY-16961A	Sitravatinib malate	Inhibitor	/	Phase 3
HY-B0062	Dovitinib lactate hydrate	Inhibitor	/	Phase 3
HY-108713A	Famitinib malate		/	Phase 3
HY-13024	Rebastinib		99.91%	Phase 2
HY-109086	Edicotinib	Inhibitor	98.78%	Phase 2
HY-10206	Amuvatinib		99.47%	Phase 2
HY-136256	Vimseltinib	Inhibitor	99.08%	Phase 2
HY-10202	Tandutinib		99.48%	Phase 2
HY-109190	Seralutinib	Inhibitor	99.77%	Phase 2
HY-10527	Telatinib	Inhibitor	99.60%	Phase 2
HY-10202A	Tandutinib hydrochloride		99.78%	Phase 2
HY-10527C	Telatinib mesylate	Inhibitor	99.46%	Phase 2
HY-10206A	Amuvatinib hydrochloride	Inhibitor	/	Phase 2
HY-10204	OSI-930		98.57%	Phase 1
HY-12010	BMS-599626 Hydrochloride	Inhibitor	99.68%	Phase 1
HY-10251	BMS-599626	Inhibitor	/	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99462	Barzolvolimab	Inhibitor	99.78%	Phase 2

Pre-clinical Phase

Bioactive Molecules (84)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10514	BX795		99.06%	Unkown
HY-101443	ISCK03	Inhibitor	99.50%	Unkown
HY-131339	SP-96	Inhibitor	99.42%	Unkown
HY-132166	M4205	Inhibitor	99.47%	Unkown
HY-10501	SU14813	Inhibitor	99.63%	Unkown
HY-112802	AZD3229	Inhibitor	99.83%	Unkown
HY-13894	Tyrphostin AG1296		99.69%	Unkown
HY-13838	PLX647	Inhibitor	99.79%	Unkown
HY-G0017	N-Desmethyl imatinib		99.16%	Unkown
HY-10873	N-Desethyl Sunitinib		99.63%	Unkown
HY-10408	Ki20227	Inhibitor	99.17%	Unkown
HY-15240	c-Kit-IN-1	Inhibitor	98.83%	Unkown
HY-I0678	Regorafénib N-oxyde (M2)		98.27%	Unkown
HY-10501A	SU14813 maleate	Inhibitor	99.04%	Unkown
HY-112452	SU11652		99.06%	Unkown
HY-101219	VEGFR-IN-1		98.42%	Unkown
HY-103274	PD180970		99.27%	Unkown
HY-15463S1	Imatinib-d4		99.97%	Unkown
HY-15813	FIIN-1	Inhibitor	99.11%	Unkown
HY-148794	Risvodetinib	Inhibitor	99.21%	Unkown
HY-13493	AC710	Inhibitor	98.56%	Unkown
HY-112615	NAMPT inhibitor-linker 1		98.08%	Unkown
HY-112616	NAMPT inhibitor-linker 2	Inhibitor	98.11%	Unkown
HY-13016S	Cabozantinib-d6		98.14%	Unkown
HY-103032	Multi-kinase inhibitor 1	Inhibitor	99.34%	Unkown
HY-10981S	Lenvatinib-d4	Inhibitor	99.59%	Unkown
HY-138813	N-Desethyl Sunitinib hydrochloride		99.77%	Unkown
HY-18302	c-Kit-IN-5-1	Inhibitor	98.16%	Unkown
HY-18179	AZD2932	Inhibitor	99.04%	Unkown
HY-112802A	AZD3229 Tosylate	Inhibitor	99.80%	Unkown
HY-10208S	Pazopanib-d6		≥98.0%	Unkown
HY-10230S	Midostaurin-d5	Inhibitor	≥98.0%	Unkown
HY-123450	S116836		99.65%	Unkown
HY-133980	O-Demethyl Lenvatinib		/	Unkown
HY-133980A	O-Demethyl Lenvatinib hydrochloride		95.54%	Unkown
HY-136201	Sodium Glucoheptonate		≥98.0%	Unkown
HY-15198	KG5	Inhibitor	99.79%	Unkown
HY-15463S	Imatinib-d8		99.85%	Unkown
HY-15463S2	Imatinib-d3 hydrochloride		95.19%	Unkown
HY-156619	Labuxtinib	Inhibitor	99.76%	Unkown
HY-18317	JNJ-38158471	Inhibitor	97.02%	Unkown
HY-128589	CHMFL-KIT-033	Inhibitor	/	Unkown
HY-128602	c-Kit-IN-2	Inhibitor	/	Unkown
HY-10873S	N-Desethyl Sunitinib-d5		/	Unkown
HY-10201S2	Sorafenib-13C,d3		98.35%	Unkown
HY-10208S1	Pazopanib-13C,d3		/	Unkown
HY-10331S1	Regorafenib-13C,d3		/	Unkown
HY-10981S1	Lenvatinib-d5	Inhibitor	/	Unkown
HY-110071	APcK110	Inhibitor	/	Unkown
HY-110272	Vatalanib succinate	Inhibitor	/	Unkown
HY-111947	c-Fms-IN-6	Inhibitor	/	Unkown
HY-117873	KBP-7018	Inhibitor	/	Unkown
HY-12009S	Pazopanib-13C,d3 hydrochloride		/	Unkown
HY-13016S1	Cabozantinib-d4		/	Unkown
HY-131275	Imatinib Impurity E		96.05%	Unkown
HY-132451S	(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit		/	Unkown
HY-13342AS	Apatinib-d8 free base		92.56%	Unkown
HY-13645	Henatinib	Inhibitor	/	Unkown
HY-13838A	PLX647 dihydrochloride	Inhibitor	/	Unkown
HY-13904S	Flumatinib-d3	Inhibitor	/	Unkown
HY-139996	Pomalidomide-C5-Dovitinib		/	Unkown
HY-143894	FLT3-IN-11	Inhibitor	/	Unkown
HY-143895	FLT3-IN-12	Inhibitor	/	Unkown
HY-147864	c-Fms-IN-12		/	Unkown
HY-149019	Antitumor agent-70		/	Unkown
HY-149415	Multi-kinase-IN-5	Inhibitor	/	Unkown
HY-150026	Multi-kinase-IN-2		/	Unkown
HY-156470	Multi-kinase-IN-6		/	Unkown
HY-15814	HG-7-85-01		99.94%	Unkown
HY-160689	GW694590A	Inhibitor	/	Unkown
HY-160765	WNTinib		/	Unkown
HY-50905S	Dovitinib-d8	Inhibitor	/	Unkown
HY-G0017A	N-Desmethyl imatinib mesylate		/	Unkown
HY-G0017S1	N-Desmethyl imatinib-d4		/	Unkown
HY-I0678S	Regorafénib N-oxyde-d3 (M2)		/	Unkown
HY-I0678S1	Regorafénib N-oxyde (M2)-13C,d3		/	Unkown
HY-RS07319	KIT Human Pre-designed siRNA Set A		/	Unkown
HY-RS07320	Kit Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS07321	Kit Rat Pre-designed siRNA Set A		/	Unkown
HY-10330S	Toceranib-d8	Inhibitor	/	Unkown
HY-116116	Tafetinib	Inhibitor	/	Unkown
HY-13493A	AC710 Mesylate	Inhibitor	/	Unkown
HY-101034	CHMFL-ABL/KIT-155		/	Unkown
HY-18949	JI6		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kit	NCBI	NCBI:3815
Mus musculus	Kit	NCBI	NCBI:16590
Macaca mulatta	Kit	NCBI	NCBI:696759

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