Kit - KIT proto-oncogene receptor tyrosine kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 64030

About Kit

Primary_assembly 14: 32,548,877-32,624,652 reverse strand.mRatBN7.2:CM026987.1

This gene has 2 transcripts (splice variants), 206 orthologues, 54 paralogues and is associated with 72 phenotypes. Biased expression in Lung (RPKM 35.8), Brain (RPKM 125.4) and 9 other tissues.

Summary

Enables protein tyrosine kinase activity. Involved in several processes, including gamete generation; positive regulation of gastro-intestinal system smooth muscle contraction; and protein phosphorylation. Located in acrosomal vesicle; cytoplasmic side of plasma membrane; and external side of plasma membrane. Used to study aplastic anemia and male infertility. Biomarker of acute pancreatitis and gastroschisis. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell Cancer (multiple); piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Kit Products (1)

mRNA	Protein	Name
NM_022264.2	NP_071600.1	mast/stem cell growth factor receptor Kit precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7536501	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	12821048	RGD
involved in germ cell migration	IMP IMP: Inferred from mutant phenotype	9283007	RGD
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7536501	RGD
involved in positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	15302600	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	9283007	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	7536501	RGD
involved in positive regulation of colon smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	17322067	RGD
involved in positive regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11112797	RGD
involved in positive regulation of pseudopodium assembly	IMP IMP: Inferred from mutant phenotype	9283007	RGD
involved in positive regulation of pyloric antrum smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	9832052	RGD
involved in positive regulation of small intestine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	7542218	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	7536501	RGD
involved in regulation of bile acid metabolic process	IMP IMP: Inferred from mutant phenotype	7542218	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	24462979	RGD
involved in somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	15302600	RGD
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	12932303	RGD
involved in tongue development	IEP IEP: Inferred from expression pattern	10908606	RGD
involved in visual learning	IMP IMP: Inferred from mutant phenotype	11112797	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	9123725	RGD
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	11383883	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	7536501	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kit Protein Structure

Ig_3

IgI_4_SCFR

PKc_like

0
200
400
600
800
978 a.a.

Protein Preferred Names	Protein Names
mast/stem cell growth factor receptor Kit	Kit oncogene c-kit receptor tyrosine kinase protein kinase v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Recombinant Kit Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74337	CD117/c-kit Protein, Rat (HEK293, His)	Q63116 (Q26-T522)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74338	CD117/c-kit Protein, Rat (HEK293, Fc)	Q63116 (M1-T522)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10981	Lenvatinib	Inhibitor	99.75%	Yes
HY-16749	Pexidartinib		99.64%	Yes
HY-15463	Imatinib		99.95%	Yes
HY-10331	Regorafenib		99.97%	Yes
HY-13016	Cabozantinib		99.97%	Yes
HY-13001	Quizartinib		99.08%	Yes
HY-10230	Midostaurin		99.89%	Yes
HY-10208	Pazopanib		99.91%	Yes
HY-101561	Avapritinib	Inhibitor	99.85%	Yes
HY-10981A	Lenvatinib mesylate	Inhibitor	99.91%	Yes
HY-50946	Imatinib Mesylate		99.97%	Yes
HY-16749A	Pexidartinib hydrochloride		99.82%	Yes
HY-112306	Ripretinib		98.90%	Yes
HY-10209	Masitinib		99.94%	Yes
HY-136256	Vimseltinib	Inhibitor	99.94%	Unkown
HY-12044	Cabozantinib S-malate		99.90%	Yes
HY-10331A	Regorafenib monohydrate		99.94%	Yes
HY-12009	Pazopanib Hydrochloride		99.99%	Yes
HY-13904	Flumatinib	Inhibitor	99.94%	Unkown
HY-10209A	Masitinib mesylate		99.98%	Yes
HY-14217	Quizartinib dihydrochloride		99.81%	Unkown
HY-15240	c-Kit-IN-1	Inhibitor	98.26%	Unkown
HY-13308	Regorafenib Hydrochloride		99.58%	Yes
HY-10201R	Sorafenib (Standard)		99.71%	Unkown
HY-10330A	Toceranib phosphate	Inhibitor	99.23%	Unkown
HY-13905	Flumatinib mesylate	Inhibitor	99.80%	Unkown
HY-50946R	Imatinib Mesylate (Standard)		99.98%	Unkown
HY-10331B	Regorafenib mesylate		/	Unkown
HY-13016A	Cabozantinib hydrochloride		/	Unkown
HY-10201AR	Sorafenib tosylate (Standard)		/	Unkown
HY-13001R	Quizartinib (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10201S4	Sorafenib-d3 tosylate	Inhibitor	/	Phase 4
HY-10205	Cediranib		99.87%	Phase 3
HY-16961	Sitravatinib	Inhibitor	99.57%	Phase 3
HY-132166	Velzatinib	Inhibitor	99.40%	Phase 3
HY-145557	Bezuclastinib	Inhibitor	98.81%	Phase 3
HY-10228	Motesanib	Inhibitor	99.96%	Phase 3
HY-108713	Famitinib		98.13%	Phase 3
HY-109190	Seralutinib	Inhibitor	99.94%	Phase 3
HY-152839	Elenestinib	Inhibitor	98.68%	Phase 3
HY-124526	Chiauranib	Inhibitor	98.97%	Phase 3
HY-13024	Rebastinib		99.84%	Phase 2
HY-10501	SU14813	Inhibitor	99.11%	Phase 2
HY-10206	Amuvatinib		99.40%	Phase 2
HY-109086	Edicotinib	Inhibitor	99.68%	Phase 2
HY-10202	Tandutinib		99.48%	Phase 2
HY-10527	Telatinib	Inhibitor	99.57%	Phase 2
HY-10501A	SU14813 maleate	Inhibitor	99.04%	Phase 2
HY-171544	AGS-16C3F		99.81%	Phase 2
HY-10251	BMS-599626	Inhibitor	98.56%	Phase 2
HY-10501B	(Z)-SU14813		/	Phase 2
HY-10204	OSI-930		98.33%	Phase 1
HY-177578	NN3201		99.15%	Phase 1
HY-B1684	Mebrofenin		99.91%	Phase 1
HY-116116	Tafetinib	Inhibitor	96.20%	Phase 1
HY-13645A	Henatinib maleate	Inhibitor	/	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99462	Barzolvolimab	Inhibitor	99.83%	Phase 3
HY-P99488	Briquilimab		99.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (161)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10514	BX795		99.84%	Unkown
HY-50905	Dovitinib	Inhibitor	99.88%	Yes
HY-13894	Tyrphostin AG1296		99.69%	Unkown
HY-10330	Toceranib	Inhibitor	97.41%	Unkown
HY-112452	SU11652		99.18%	Unkown
HY-101443	ISCK03	Inhibitor	98.30%	Unkown
HY-10408	Ki20227	Inhibitor	99.51%	Unkown
HY-I0678	Regorafénib N-oxyde (M2)		98.15%	Unkown
HY-15813	FIIN-1	Inhibitor	99.04%	Unkown
HY-112802	AZD3229	Inhibitor	99.42%	Unkown
HY-N0419	Quercimeritrin		99.48%	Unkown
HY-18302	c-Kit-IN-5-1	Inhibitor	98.03%	Unkown
HY-112616	NAMPT inhibitor-linker 2	Inhibitor	99.35%	Unkown
HY-112440	HZX-02-059	Inhibitor	99.40%	Unkown
HY-13049	Cediranib maleate		99.68%	Yes
HY-160765	WNTinib		99.95%	Unkown
HY-131339	SP-96	Inhibitor	99.65%	Unkown
HY-103274	PD180970		99.27%	Unkown
HY-13838	PLX647	Inhibitor	99.74%	Unkown
HY-10229	Motesanib Diphosphate	Inhibitor	99.86%	Unkown
HY-15814	HG-7-85-01		98.14%	Unkown
HY-112615	NAMPT inhibitor-linker 1		99.27%	Unkown
HY-156619	Labuxtinib	Inhibitor	99.76%	Unkown
HY-10207	Dovitinib lactate	Inhibitor	99.75%	Yes
HY-12010	BMS-599626 Hydrochloride	Inhibitor	98.90%	Unkown
HY-13342AS	Apatinib-d8 free base		92.5%	Unkown
HY-15463S1	Imatinib-d4		99.82%	Unkown
HY-10202A	Tandutinib hydrochloride		99.29%	Unkown
HY-103032	Multi-kinase inhibitor 1	Inhibitor	99.05%	Unkown
HY-110293	CHMFL-FLT3-122		98.47%	Unkown
HY-133980A	O-Demethyl Lenvatinib hydrochloride		97.08%	Unkown
HY-15463S	Imatinib-d8		99.88%	Unkown
HY-101219	VEGFR-IN-1	Inhibitor	99.07%	Unkown
HY-10981S	Lenvatinib-d4	Inhibitor	99.59%	Unkown
HY-170517	PKMYT1-IN-8	Inhibitor	99.31%	Unkown
HY-W143698	PDGFRα kinase inhibitor 2	Inhibitor	98.95%	Unkown
HY-10201S2	Sorafenib-13C,d3		98.35%	Unkown
HY-123450	S116836		99.78%	Unkown
HY-13904S	Flumatinib-d3	Inhibitor	99.9%	Unkown
HY-18179	AZD2932	Inhibitor	98.16%	Unkown
HY-13016S	Cabozantinib-d6		98.14%	Unkown
HY-13016S1	Cabozantinib-d4		99.04%	Unkown
HY-136201	Sodium Glucoheptonate		98.0%	Unkown
HY-185750	c-Kit-IN-16	Inhibitor	99.45%	Unkown
HY-10230S	Midostaurin-d5	Inhibitor	98.0%	Unkown
HY-10527C	Telatinib mesylate	Inhibitor	99.74%	Yes
HY-112802A	Ubavitinib tosylate	Inhibitor	98.83%	Unkown
HY-128589	CHMFL-KIT-033	Inhibitor	99.74%	Unkown
HY-10873S	N-Desethyl Sunitinib-d5		99.9%	Unkown
HY-10208S	Pazopanib-d6		98.0%	Unkown
HY-10331S	Regorafenib-d3		98.0%	Unkown
HY-12009S	Pazopanib-13C,d3 hydrochloride		97.51%	Unkown
HY-133980	O-Demethyl Lenvatinib		/	Unkown
HY-138813	N-Desethyl Sunitinib hydrochloride		99.14%	Unkown
HY-15198	KG5	Inhibitor	99.79%	Unkown
HY-15463S2	Imatinib-d3 hydrochloride		95.19%	Unkown
HY-178219	Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE		97.88%	Unkown
HY-18317	JNJ-38158471	Inhibitor	97.02%	Unkown
HY-132451S	(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit		95.0%	Unkown
HY-13493	AC710	Inhibitor	99.57%	Unkown
HY-16961A	Sitravatinib malate	Inhibitor	/	Unkown
HY-B0062	Dovitinib lactate hydrate	Inhibitor	/	Unkown
HY-101034	CHMFL-ABL/KIT-155		/	Unkown
HY-10206A	Amuvatinib hydrochloride	Inhibitor	/	Unkown
HY-13001S	Quizartinib-d8		/	Unkown
HY-176266	KIT-13	Activator	/	Unkown
HY-108713A	Famitinib malate		/	Unkown
HY-128602	c-Kit-IN-2	Inhibitor	/	Unkown
HY-152839A	Elenestinib phosphate	Inhibitor	/	Unkown
HY-10208S1	Pazopanib-13C,d3		/	Unkown
HY-10330S	Toceranib-d8	Inhibitor	99.08%	Unkown
HY-10331S1	Regorafenib-13C,d3		/	Unkown
HY-10638	AP23464		/	Unkown
HY-10873S2	N-Desethyl Sunitinib-d5 hydrochloride		/	Unkown
HY-109086A	Edicotinib hydrochloride	Inhibitor	/	Unkown
HY-10981S1	Lenvatinib-d5	Inhibitor	/	Unkown
HY-10981S2	Lenvatinib-15N,d4	Inhibitor	98.01%	Unkown
HY-110071	APcK110	Inhibitor	/	Unkown
HY-110272	Vatalanib succinate	Inhibitor	/	Unkown
HY-111947	c-Fms-IN-6	Inhibitor	/	Unkown
HY-113157	Estrone 3-glucuronide		/	Unkown
HY-117873A	KBP-7018 hydrochloride	Inhibitor	/	Unkown
HY-121708	KI-328	Inhibitor	/	Unkown
HY-121874	EP009	Inhibitor	/	Unkown
HY-122849	CHMFL-KIT-031	Inhibitor	/	Unkown
HY-131275	Imatinib Impurity E		96.05%	Unkown
HY-13645	Henatinib	Inhibitor	/	Unkown
HY-138032	SU11657	Inhibitor	/	Unkown
HY-13838A	PLX647 dihydrochloride	Inhibitor	/	Unkown
HY-143894	FLT3-IN-11	Inhibitor	/	Unkown
HY-143895	FLT3-IN-12	Inhibitor	/	Unkown
HY-146579S	Estrone-3-glucuronide-d4 lithium		/	Unkown
HY-147864	c-Fms-IN-12		/	Unkown
HY-149019	Antitumor agent-70		/	Unkown
HY-149415	Multi-kinase-IN-5	Inhibitor	/	Unkown
HY-150026	Multi-kinase-IN-2		/	Unkown
HY-156470	Multi-kinase-IN-6		/	Unkown
HY-160689	GW694590A	Inhibitor	/	Unkown
HY-168579	c-Kit-IN-6	Inhibitor	/	Unkown
HY-168580	c-Kit-IN-7	Inhibitor	/	Unkown
HY-168581	c-Kit-IN-8	Inhibitor	/	Unkown
HY-170228	c-Kit-IN-9	Inhibitor	/	Unkown
HY-170911	KIT/PDGFRA-IN-1	Inhibitor	/	Unkown
HY-175281	SJ11646		/	Unkown
HY-177275	c-Kit Receptor modulator-1	Modulator	/	Unkown
HY-177286	c-Kit-IN-11	Inhibitor	/	Unkown
HY-177287	c-Kit-IN-10	Inhibitor	/	Unkown
HY-177821	CD117/c-Kit aptamer sodium		/	Unkown
HY-179382	HSB401		/	Unkown
HY-179497	FLT3-IN-37		/	Unkown
HY-180652	c-Kit-IN-13	Inhibitor	/	Unkown
HY-180653	c-Kit-IN-14	Inhibitor	/	Unkown
HY-181518	c-Kit-IN-15	Inhibitor	/	Unkown
HY-181886	AK177		/	Unkown
HY-182043	BLU-654	Inhibitor	/	Unkown
HY-182354	VEGFR2-IN-84	Inhibitor	/	Unkown
HY-184327	Anti-inflammatory agent 117	Inhibitor	/	Unkown
HY-18949	JI6	Inhibitor	/	Unkown
HY-50905S	Dovitinib-d8	Inhibitor	/	Unkown
HY-D3463	Vari Fluor 520 TSA, 200× (same as mIHC kit)		/	Unkown
HY-D3464	Vari Fluor 540 TSA, 200× (same as mIHC kit)		/	Unkown
HY-D3465	Vari Fluor 570 TSA, 200× (same as mIHC kit)		98%	Unkown
HY-D3466	Vari Fluor 620 TSA, 200× (same as mIHC kit)		/	Unkown
HY-D3467	Vari Fluor 650 TSA, 200× (same as mIHC kit)		/	Unkown
HY-D3468	Vari Fluor 690 TSA, 200× (same as mIHC kit)		98%	Unkown
HY-D3469	Vari Fluor 700 TSA, 200× (same as mIHC kit)		/	Unkown
HY-D3470	Vari Fluor 780 TSA, 200× (same as mIHC kit)		/	Unkown
HY-D3471	Vari Fluor 480 TSA, 200× (same as mIHC kit)		98%	Unkown
HY-E70734	KIT A829P Recombinant Human Active Protein Kinase		/	Unkown
HY-E70735	KIT D816H Recombinant Human Active Protein Kinase		/	Unkown
HY-E70736	KIT D816V Recombinant Human Active Protein Kinase		/	Unkown
HY-E70737	KIT T670I Recombinant Human Active Protein Kinase		/	Unkown
HY-E70738	KIT V559D Recombinant Human Active Protein Kinase		/	Unkown
HY-E70739	KIT V559D/T670I Recombinant Human Active Protein Kinase		/	Unkown
HY-E70740	KIT V559D/V654A Recombinant Human Active Protein Kinase		/	Unkown
HY-E70741	KIT V560G Recombinant Human Active Protein Kinase		/	Unkown
HY-E70742	KIT V654A Recombinant Human Active Protein Kinase		/	Unkown
HY-E70840	KIT Recombinant Human Active Protein Kinase		/	Unkown
HY-I0678S	Regorafénib N-oxyde-d3 (M2)		/	Unkown
HY-I0678S1	Regorafénib N-oxyde (M2)-13C,d3		/	Unkown
HY-RS07319	KIT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07320	Kit Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07321	Kit Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W706452	Cabozantinib-d4 S-malate		/	Unkown
HY-W751179	Midostaurin-13C6		/	Unkown
HY-10202B	Tandutinib sulfate		/	Unkown
HY-10208S2	Pazopanib-d3		/	Unkown
HY-107458	AP23848	Inhibitor	/	Unkown
HY-112350	AGL 2043	Inhibitor	/	Unkown
HY-117873	KBP-7018	Inhibitor	/	Unkown
HY-13493A	AC710 Mesylate	Inhibitor	/	Unkown
HY-15463S3	Imatinib-13C,d3		/	Unkown
HY-169517	Protein kinase inhibitor 10	Inhibitor	/	Unkown
HY-179563	c-Kit-IN-12	Inhibitor	/	Unkown
HY-179563A	(S)-c-Kit-IN-12	Inhibitor	/	Unkown
HY-18187	Ki 23057	Inducer	/	Unkown
HY-184786	Tyk2-IN-14	Inhibitor	/	Unkown
HY-184955	c-Met/c-Kit/Flt-3-IN-1	Inhibitor	/	Unkown
HY-18909	Multi-kinase-IN-11	Inhibitor	/	Unkown
HY-W705479	Pazopanib-d3 hydrochloride		/	Unkown
HY-W754911	Avapritinib-d3	Inhibitor	/	Unkown

Inhibitory Antibodies (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990615	Anti-c-Kit Antibody (LMJ729)	Inhibitor	98.39%	Unkown
HY-P990002	Anti-Mouse CD117/c-Kit Antibody (2B8)	Inhibitor	≥95.0%	Unkown
HY-P991293	NN-2101	Inhibitor	99.38%	Unkown
HY-P990754	Opelkibart	Inhibitor	99.93%	Unkown
HY-P992509	CDX-0158	Inhibitor	/	Unkown
HY-P990020	Eglatoprutug	Inhibitor	96.00%	Unkown
HY-P990851	Anti-c-Kit/CD117 Antibody (SR-1)	Inhibitor	≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kit	NCBI	NCBI:3815