Cat. No.: HY-N0621

Morin

10 Cited Publications

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Based on 10 publication(s) in Google Scholar

Morin is an orally active plant-derived flavonoid. Morin inhibits ROS generation. Morin induces Apoptosis. Morin inhibits PTP1B (IC₅₀ of 15 μM) and activates the insulin receptor. Morin has a detoxifying effect. Morin can be used in diabetes, leukemia, colon cancer, cervical cancer, Parkinson's disease and hypertension research.

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Pureté: 97.43%
CAS No.: 480-16-0
Formule: C₁₅H₁₀O₇
Masse moléculaire:302.24

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Morin Chemical Structure

CAS No.: 480-16-0

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Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (10)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
H9	EC₅₀	>331 μM Compound: 15	Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay	[PMID: 8158164]
H9	IC₅₀	>331 μM Compound: 15	Cytotoxicity against human H9 cells after 3 days Cytotoxicity against human H9 cells after 3 days	[PMID: 8158164]
HEK293	IC₅₀	12.3 μM Compound: Morin	Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay	[PMID: 21511472]
HEK293	IC₅₀	2 μM Compound: morin	Inhibition of human URAT1-mediated urate uptake in HEK293 cells Inhibition of human URAT1-mediated urate uptake in HEK293 cells	[PMID: 17325024]
HT-29	EC₅₀	1.33 μM Compound: Morin	Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay	[PMID: 24900447]
HT-29	IC₅₀	1.6 μM Compound: Morin	Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins	[PMID: 24900447]
Huh-7	CC₅₀	>50 μM Compound: 38	Cytotoxicity against human Huh7.5.1 cells by MTT assay Cytotoxicity against human Huh7.5.1 cells by MTT assay	[PMID: 22445328]
L929	EC₅₀	115 μM Compound: morin	Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by [methyl-3H]thymidine incorporation assay Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by [methyl-3H]thymidine incorporation assay	[PMID: 9287415]
L929	EC₅₀	120 μM Compound: morin	Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining	[PMID: 9287415]
MCF7	IC₅₀	49 μM Compound: 14	Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining	[PMID: 21354800]
MDCK	IC₅₀	21 μM Compound: 14	Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining	[PMID: 21354800]
U2OS	EC₅₀	11.2 μM Compound: Morin	Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay	[PMID: 24900447]

In Vitro

Morin (25 μM, 1 h) protects V79-4 cells from hydrogen peroxide-induced damage by inhibiting ROS generation and by inducing catalase activation^[3].
Morin (100-500 μM, 6-48 h) inhibits the growth of human leukemia HL-60 cells via cell cycle arrest and induction of apoptosis through mitochondria dependent pathway^[4].
Morin (50 μM, 0-70 h) inhibits growth and activates the insulin metabolic pathway in HepG2 cells^[5].
Morin (100-500 μM, 48 h) shows anti-cancerous activity against HeLa cells at an IC₅₀ of 214.28 μM and causes morphological changes^[6].
Morin (5-50 μM, 24 h) exerts neuroprotective actions in PC12 cells, with attenuating loss of cell viability^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:

HL-60
Concentration:

100, 200, 300, 400, 500 μM
Incubation Time:

6 h, 12 h, 24 h, 48 h
Result:

Decreased the percentage of viable cells at a dose- and time-dependent manner.

Apoptosis Analysis^[4]

Cell Line:

HL-60
Concentration:

100, 200, 300, 400, 500 μM
Incubation Time:

6 h, 12 h, 24 h, 48 h
Result:

Induced apoptosis in a dose-dependent manner.
Promoted the activation of caspase-3.

Cell Cycle Analysis^[4]

Cell Line:

HL-60
Concentration:

100, 200, 300, 400, 500 μM
Incubation Time:

6 h, 12 h, 24 h, 48 h
Result:

Induced G2/M arrest.

In Vivo

Morin (5-100 mg/kg, i.p., daily, 5 days) exerts neuroprotective actions in Parkinson disease mice^[7].
Morin (10-150 mg/kg, i.p., 30 min prior to γ-irradiation) shows anticlastogenic activity against whole body gamma irradiation in Swiss albino mice^[8].
Morin (100 mg/kg, intragastrically, 10 days) exacerbates Cyclophosphamide (HY-17420)-induced suppression of body weight gain in rats^[9].
Morin (Morin hydrate form, 100 mg/kg, p.o., 10 days) attenuates Doxorubicin (HY-15142A)-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis in rats^[10].
Morin (50 mg/kg, p.o., everyday for a total period of 30 weeks) could exert a significant chemopreventive effect on colon carcinogenesis induced by DMH in rats^[11].
Morin (25-75 mg/kg, p.o., 6 weeks) exhibits strong antihypertensive effect against DOCA-salt induced hypertension in rats^[12].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 480-16-0
Appearance Solid
Masse moléculaire 302.24
Formule C₁₅H₁₀O₇
Color Light yellow to yellow
SMILES

O=C1C(O)=C(C2=CC=C(O)C=C2O)OC3=CC(O)=CC(O)=C13
Structure Classification
- Flavonoids
- Flavonols
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (10)

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Journal Impact Factor

Nat Commun

Discovery of senolytics using machine learning. [Abstract]

2023 Jun 10;14(1):3445. PMID: 37301862
J Pharm Anal

A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance. [Abstract]

2023 May;13(5):514-522. PMID: 37305785

Morin purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522. [Abstract]

A dose-response experiment further confirmed the AAG inhibitory activity of sunitinib, which showed even greater inhibition of AAG activity (81.2% at 10 μM) compared to the positive control Morin.

Morin purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522. [Abstract]

Steady-state emission spectra of the probe with AAG (100 U/mL), AAG (100 U/mL) + 10 μM Morin, or AAG (100 U/mL) + 10 μM sunitinib. With excitation at 355 nm, the intensity of the luminescence emission was measured between 450 and 700 nm.

Morin purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):514-522. [Abstract]

DNA assay reaction products were subjected to polyacrylamide gel electrophoresis analysis and silver staining regardless of the presence of Sunitinib or Morin.
Phytomedicine

Morin exhibits a neuroprotective effect in MPTP-induced Parkinson's disease model via TFEB/AMPK-mediated mitophagy. [Abstract]

2023 Jul 25:116:154866. PMID: 37209604

Morin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Jul 25:116:154866. [Abstract]

Morin (6.25, 12.5, 25, 50 μM; 24 h) decreases the expression of p-TFEB (ser142) and cytoplasm TFEB (Flag-TFEB) dose-dependently in Hela cells.

Morin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Jul 25:116:154866. [Abstract]

Morin (25 μM; 24 h) significantly promotes TFEB nuclear translocation in CF7 cells.
Free Radic Biol Med

Bisphenol A drives thyroid carcinogenesis through oxidative stress-lipid metabolic reprogramming via the PTEN/PI3K/AKT axis: Therapeutic reversal by a curcumin-modified quercetin nanomicelle system. [Abstract]

2026 Aug 1:251:276-292. PMID: 41985638
Plant Physiol

Melatonin promotes Al3+ compartmentalization via H+ transport and ion gradients in Malus hupehensis. [Abstract]

2023 Aug 31;193(1):821-839. PMID: 37311207
Plant J

Strigolactones alleviate AlCl3 stress by vacuolar compartmentalization and cell wall blocking in apple. [Abstract]

2024 Jul;119(1):197-217. PMID: 38565306
Plant Cell Rep

MsDUF3700 overexpression enhances aluminum tolerance in alfalfa shoots. [Abstract]

2024 Dec 4;43(12):301. PMID: 39630276
ACS Omega

Unveiling Natural Power: Morin and Myricetin as Potent Inhibitors of Histidinol-Phosphate Aminotransferase in Drug-Resistant Acinetobacter baumannii. [Abstract]

2025 Feb 20;10(8):7920-7936. PMID: 40060852

Morin purchased from MedChemExpress. Usage Cited in: ACS Omega. 2025 Feb 20;10(8):7920-7936. [Abstract]

Intrinsic fluorescence quenching of AbHPA by different concentrations of Morin ranging from 0 to 48 μM (0, 6, 12, 24 and 48 μM) in the Tris-HCl buffer and pH 8.0 at 25 ℃.

Morin purchased from MedChemExpress. Usage Cited in: ACS Omega. 2025 Feb 20;10(8):7920-7936. [Abstract]

SPR sensograms showing the direct binding of morin and myricetin to AbHPA immobilized on the CM5 chip.
J Integr Med

Morin inhibits ubiquitination degradation of BCL-2 associated agonist of cell death and synergizes with BCL-2 inhibitor in gastric cancer cells. [Abstract]

2025 Apr 22:S2095-4964(25)00050-0. PMID: 40319008
J Mol Histol

Morin induces ferroptosis in endometrial cancer cells by down-regulating FTH1. [Abstract]

2026 Feb 4;57(1):69. PMID: 41636890

Solvant et solubilité

In Vitro:

DMSO : 250 mg/mL (827.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3086 mL

16.5431 mL

33.0863 mL

5 mM

0.6617 mL

3.3086 mL

6.6173 mL

10 mM

0.3309 mL

1.6543 mL

3.3086 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (6.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (6.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
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MS (2659 KB)
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IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
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Instruction de manipulation (2659 KB)

Références

[1]. Duthie G, et al. Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo. Oxid Med Cell Longev. 2012;2012:165127. [Content Brief]

[2]. Lian HZ, et al. Morin applied in speciation of aluminium in natural waters and biological samples by reversed-phase high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem. 2003 Jun;376(4):542-8. Epub 2003 May 9. [Content Brief]

[3]. Zhang R, et al. Cellular protection of morin against the oxidative stress induced by hydrogen peroxide. Chem Biol Interact. 2009 Jan 15;177(1):21-7. [Content Brief]

[4]. Kuo HM, et al. Morin inhibits the growth of human leukemia HL-60 cells via cell cycle arrest and induction of apoptosis through mitochondria dependent pathway. Anticancer Res. 2007 Jan-Feb;27(1A):395-405. [Content Brief]

[5]. Paoli P, et al. The insulin-mimetic effect of Morin: a promising molecule in diabetes treatment. Biochim Biophys Acta. 2013 Apr;1830(4):3102-11. [Content Brief]

[6]. Zhang Q, et al. Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells. Food Chem Toxicol. 2018 Feb;112:466-475. [Content Brief]

[7]. Zhang ZT, et al. Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo. Acta Pharmacol Sin. 2010 Aug;31(8):900-6. [Content Brief]

[8]. Parihar VK, et al. Anticlastogenic activity of morin against whole body gamma irradiation in Swiss albino mice. Eur J Pharmacol. 2007 Feb 14;557(1):58-65. [Content Brief]

[9]. Merwid-Ląd A, et al. The effects of morin, a naturally occurring flavonoid, on cyclophosphamide-induced toxicity in rats. Advances in Clinical and Experimental Medicine, 2011, 20(6): 683-690.

[10]. Kuzu M, et al. Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis. Biomed Pharmacother. 2018 Oct;106:443-453. [Content Brief]

[11]. Sreedharan V, et al. Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis. Invest New Drugs. 2009 Feb;27(1):21-30. [Content Brief]

[12]. Prahalathan P, et al. Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study. Asian Pac J Trop Biomed. 2012 Jun;2(6):443-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3086 mL	16.5431 mL	33.0863 mL	82.7157 mL
	5 mM	0.6617 mL	3.3086 mL	6.6173 mL	16.5431 mL
	10 mM	0.3309 mL	1.6543 mL	3.3086 mL	8.2716 mL
	15 mM	0.2206 mL	1.1029 mL	2.2058 mL	5.5144 mL
	20 mM	0.1654 mL	0.8272 mL	1.6543 mL	4.1358 mL
	25 mM	0.1323 mL	0.6617 mL	1.3235 mL	3.3086 mL
	30 mM	0.1103 mL	0.5514 mL	1.1029 mL	2.7572 mL
	40 mM	0.0827 mL	0.4136 mL	0.8272 mL	2.0679 mL
	50 mM	0.0662 mL	0.3309 mL	0.6617 mL	1.6543 mL
	60 mM	0.0551 mL	0.2757 mL	0.5514 mL	1.3786 mL
	80 mM	0.0414 mL	0.2068 mL	0.4136 mL	1.0339 mL
	100 mM	0.0331 mL	0.1654 mL	0.3309 mL	0.8272 mL

Keywords

Morin

10 Cited Publications

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Morin

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

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Publications Citing Use of MedChemExpress (MCE) Morin

Activité biologique

Chemical Information

Publications (10)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Morin Related Classifications

HY-N0621 Related Classifications