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Paclitaxel

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Based on 388 publication(s) in Google Scholar

Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.

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  • Pureté: 99.97%
  • CAS No.: 33069-62-4
  • Formule: C47H51NO14
  • Masse moléculaire:853.91
  • Stockage:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Paclitaxel Chemical Structure
    Paclitaxel Chemical Structure
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
  • Experimental Validation Results for Paclitaxel
CAS No.: 33069-62-4
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  • Paclitaxel Chemical Structure
    Paclitaxel Chemical Structure
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    Paclitaxel purchased from MedChemExpress. Usage Cited in: Nat Med. 2024 Mar;30(3):749-761. [Abstract]

    Customer Validation
     The relative cell viability of shCtl-, shNDUFB8-, and shCEMIP2-transfected cells was detected by XTT assay after paclitaxel (50 nM) plus gemcitabine treatment (A+G), single-agent 5-Fu (5-FU), and the FOLFIRINOX chemotherapy cocktail [FU+IRI+OXA: 5-FU+Irinotecan (SN-38) +Oxaliplatin] for 48h.

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2024 May 11:38:384-398. [Abstract]

    Customer Validation
     Paclitaxel (10 μM; 3–5 days) reduced the activity of lung cancer organoid-3 (LCO-3) with no significant effect on the activity of LCO-1 and LCO-2.

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Jun 18;18(24):15864-15877. [Abstract]

    Customer Validation
     Paclitaxel (PTX, 0.1-1 μM; 24 h) ​​increases​​ COX-2 mRNA expression in 4T1 cells in a dose-dependent manner and ​​induces​​ elevated PGE2 release in the culture medium.

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Mar 7;134(10):e172716. [Abstract]

    Customer Validation
     The given cell lines were treated with 250 nM osimertinib (Osim), 1.25 μM Etoposide (VP-16), 125 nM Doxorubicin (DXR), 5 nM Paclitaxel, 10 μM Cisplatin, 25 μM Carboplatin, 25 nM Gemcitabine, 20 nM 5-Fluorouracil (5-FU), 25 μM Cyclophosphamide, 25 μM Capecitabine, or 10 nM Vincristine alone or in combination for 3 days. Cell numbers were then measured using the SRB assay.

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2024 Oct:491:117066. [Abstract]

    Customer Validation
     WB images of SIRT3, AcK68-MnSOD and AcK122-MnSOD expressions in DRG tissues. Quantification of SIRT3, AcK68-MnSOD and AcK122-MnSOD expressions normalized with β-actin expressions and the Saline+Saline treated samples was set to 1 (NR (Nicotinamide riboside chloride); PTX (4 mg/kg, i. p.) Group, PTX (4 mg/kg, i.p.) + NR (400 mg/kg, i.g.) Group, PTX (4 mg/kg, I.P.) + NR (400 mg/kg, i.g.) +3-TYP (50 mg/kg, i.p.) group, NR (400 mg/kg, i.p.) group, 3-TYP (50 mg/kg, i.p.) group in SIRT3 WT mice)

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2024 Oct:491:117066. [Abstract]

    Customer Validation
     The representative images depicting the expression of AcK68-MnSOD in each group were utilized for immunohistochemical detection (NR (Nicotinamide riboside chloride); PTX (4 mg/kg, i. p.) Group, PTX (4 mg/kg, i.p.) + NR (400 mg/kg, i.g.) Group, PTX (4 mg/kg, I.P.) + NR (400 mg/kg, i.g.) +3-TYP (50 mg/kg, i.p.) group, NR(400 mg/kg, i.p.) group, 3-TYP (50 mg/kg, i.p.) group in SIRT3 WT mice)

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: Mar Drugs. 2023 Apr 23;21(5):259. [Abstract]

    Customer Validation
     Paclitaxel (PTX; 3.125, 6.25, 12.5, 25, 50, 100 nM; 48 h) reduces the viability of Hela, SiHa, and C33A cells in a dose-dependent manner.(3.125 nM for Hela cells, 100 nM for SiHa and C33A cells)

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: Mar Drugs. 2023 Apr 23;21(5):259. [Abstract]

    Customer Validation
     Paclitaxel (PTX; 50 nM; 48 h) increases the expression of Cleaved-caspase-9 and Cleaved-caspase-3 in Hela cells.

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2023 Aug 20:669:61-67. [Abstract]

    Customer Validation
     Paclitaxel (25, 50 μM; 24 h) significantly increases the expression of caspase-3 in PK-15 cells.

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: Oncol Lett. 2023 Feb 15;25(4):134. [Abstract]

    Customer Validation
     Paclitaxel (PTX; 0‑100 nM; 72 h) inhibits the viability of MDA‑MB‑231cells.

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: Arch Cancer Res. 2023 Jan 30.

    Customer Validation
     Paclitaxel (CPT; 10-6 -12-10 M; 72 h) demonstrates a strong antitumor activity and an inhibitory of proliferation (IC50 = 6.28 nM) in U937 cells.

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: Gastroenterology. 2021 Nov;161(5):1601-1614.e23. [Abstract]

    Customer Validation
     Bar graphs show the GI50 of 5-fluoruracil (48 h), irinotecan (48 h), gemcitabine (48 h), paclitaxel (48 h), and oxaliplatin (48 h) in PDAC cells in combination with bioactive hexapeptides (NTAIYY and PTTIYY) or controls (saline and NTAIYA).

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2019 Feb 13;67(6):1656-1665. [Abstract]

    Customer Validation
     Western blot image and statistical analysis of phosphorylated γH2AX levels in HT-29 cells with different treatments after 48 h. Myricetin and PTX used are 32 μM and 100 nM, respectively.

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Gen Subj. 2018 May;1862(5):1134-1147. [Abstract]

    Customer Validation
     The effects of CS1 on polymerized microtubules are also investigated using a cellular tubulin polymer assay. Nocodazole (1 μM) and Paclitaxel (1.5 μM) are used as depolymerization and polymerization controls, respectively.

  • 1/16

    Paclitaxel purchased from MedChemExpress. Usage Cited in: Am J Cancer Res. 2017 Apr 1;7(4):903-912. [Abstract]

    Customer Validation
     Synergistic inhibition of colony formation of ATC cells by E7080 and Paclitaxel. Representative images of colony formation in C643 cells treated with vehicle control (DMSO) or E7080 and Paclitaxel at the indicated concentrations, individually or in combination, are shown in left panel. Quantitative analysis of colony numbers is shown in right panel.

  • Paclitaxel