Ep300 - E1A binding protein p300 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 170915

About Ep300

Primary_assembly 7: 113,106,247-113,178,529 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 285 orthologues, 2 paralogues and is associated with 72 phenotypes. Biased expression in Spleen (RPKM 141.5), Thymus (RPKM 139.8) and 9 other tissues.

Summary

Enables several functions, including DNA binding activity; DNA-binding transcription factor binding activity; and p53 binding activity. Involved in several processes, including cellular response to organic cyclic compound; positive regulation of cell differentiation; and regulation of protein metabolic process. Located in chromatin; cytoplasm; and nucleus. Part of protein-DNA complex. Used to study diabetic retinopathy and membranoproliferative glomerulonephritis. Biomarker of congenital diaphragmatic hernia; heart disease; hepatocellular carcinoma; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Apr 2022]

Ep300 Products (1)

mRNA	Protein	Name
XM_039080287.1	XP_038936215.1	LOW QUALITY PROTEIN: histone acetyltransferase p300

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15117818	RGD
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	17252537	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20702579	RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10362258	RGD
enables SMAD binding	IPI IPI: Inferred from physical interaction	18486259	RGD
enables antigen binding	IDA IDA: Inferred from direct assay	9252373	RGD
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	11466227	RGD
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	20702579	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	23652932	RGD
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19057620	RGD
enables histone acetyltransferase activity	IDA IDA: Inferred from direct assay	21307242	RGD
enables mitogen-activated protein kinase binding	IPI IPI: Inferred from physical interaction	10363932	RGD
enables nuclear glucocorticoid receptor binding	IDA IDA: Inferred from direct assay	17884810	RGD
enables p53 binding	IPI IPI: Inferred from physical interaction	21792911	RGD
enables peroxisome proliferator activated receptor binding	IDA IDA: Inferred from direct assay	12095700	RGD
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	21307242	RGD
enables protein antigen binding	IPI IPI: Inferred from physical interaction	8985331	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12970734	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20081228	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11755530	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15084519	RGD
enables transcription coactivator activity	IGI IGI: Inferred from genetic interaction	10362258	RGD
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	15598887	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	22562121	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	20352046	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	22465009	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	23211718	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	17457521	RGD
involved in cellular response to interleukin-1	IMP IMP: Inferred from mutant phenotype	18315570	RGD
involved in cellular response to mineralocorticoid stimulus	IEP IEP: Inferred from expression pattern	22465009	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	20399742	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	23632743	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	20711222	RGD
involved in cellular response to trichostatin A	IEP IEP: Inferred from expression pattern	20094059	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20888352	RGD
involved in digestive tract development	IEP IEP: Inferred from expression pattern	17916272	RGD
involved in internal peptidyl-lysine acetylation	IMP IMP: Inferred from mutant phenotype	22292478	RGD
involved in memory	IEP IEP: Inferred from expression pattern	20811339	RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22562121	RGD
involved in negative regulation of miRNA metabolic process	IMP IMP: Inferred from mutant phenotype	22367739	RGD
involved in peptidyl-lysine acetylation	IMP IMP: Inferred from mutant phenotype	12724418	RGD
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19057620	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	19339625	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	15593114	RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	12724418	RGD
involved in positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	23211718	RGD
involved in positive regulation of cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	18586071	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18438857	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18315570	RGD
involved in positive regulation of glycoprotein biosynthetic process	IMP IMP: Inferred from mutant phenotype	17065349	RGD
involved in positive regulation of hydrogen peroxide-mediated programmed cell death	IMP IMP: Inferred from mutant phenotype	23585551	RGD
involved in positive regulation of muscle atrophy	IMP IMP: Inferred from mutant phenotype	22292478	RGD
involved in positive regulation of protein acetylation	IMP IMP: Inferred from mutant phenotype	22566696	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22566696	RGD
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	12477714	RGD
involved in positive regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	16973938	RGD
involved in positive regulation of sarcomere organization	IMP IMP: Inferred from mutant phenotype	12724418	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15598887	RGD
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	12477714	RGD
involved in protein modification process	IMP IMP: Inferred from mutant phenotype	22648458	RGD
involved in protein-DNA complex assembly	IDA IDA: Inferred from direct assay	9215639	RGD
involved in regulation of angiotensin metabolic process	IDA IDA: Inferred from direct assay	17495236	RGD
involved in response to calcium ion	IMP IMP: Inferred from mutant phenotype	16000154	RGD
involved in response to cobalt ion	IEP IEP: Inferred from expression pattern	18586071	RGD
involved in response to dexamethasone	IMP IMP: Inferred from mutant phenotype	16973938	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	15722556	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	17208223	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	17916272	RGD
involved in response to glucose	IMP IMP: Inferred from mutant phenotype	18413674	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	17457521	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	16000154	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18292809	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	17164434	RGD
involved in response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	18438857	RGD
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	15593114	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	20702579	RGD
part of protein-DNA complex	IDA IDA: Inferred from direct assay	19765194	RGD
part of protein-DNA complex	IPI IPI: Inferred from physical interaction	10362258	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	21252119	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ep300 Protein Structure

Med15

zf-TAZ

KIX

PABP-1234

PHA03247

Bromo_cbp_like

RING_CBP-p300

PHD_p300

HAT_KAT11

ZZ_CBP

zf-TAZ

Med15

Creb_binding

0
400
800
1200
1600
2000
2413 a.a.

Protein Preferred Names	Protein Names
histone acetyltransferase p300 LOW QUALITY PROTEIN: histone acetyltransferase p300

Protein Preferred Names

Protein Names

histone acetyltransferase p300

LOW QUALITY PROTEIN: histone acetyltransferase p300

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0005	Curcumin		98.84%	Phase 4
HY-134964	CTB		99.93%	Phase 4
HY-111784	Inobrodib	Inhibitor	99.95%	Phase 2
HY-111422	PLX51107	Inhibitor	99.98%	Phase 2
HY-112359	C-82	Inhibitor	99.91%	Phase 2
HY-136938	NEO2734	Inhibitor	99.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (154)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107455	A-485	Inhibitor	99.87%	Unkown
HY-13823	C646		99.88%	Unkown
HY-14428	ICG-001		99.86%	Unkown
HY-15826	SGC-CBP30	Inhibitor	99.83%	Unkown
HY-15887	MG 149		99.60%	Unkown
HY-N2020	Anacardic Acid	Inhibitor	98.49%	Unkown
HY-110127	NU9056		98.81%	Unkown
HY-134582	dCBP-1		99.37%	Unkown
HY-107569	Garcinol		98.85%	Unkown
HY-W105310A	Croconic acid disodium		99.98%	Unkown
HY-138536	PROTAC CBP/P300 Degrader-1		99.97%	Unkown
HY-W013274	CPTH2		99.82%	Unkown
HY-124696	PU139	Inhibitor	99.51%	Unkown
HY-116673	TTK21	Activator	99.39%	Unkown
HY-136285	CPI-1612	Inhibitor	99.75%	Unkown
HY-158113	CBPD-409	Degrader	99.38%	Unkown
HY-N0005R	Curcumin (Standard)		98.01%	Unkown
HY-138539	CBP/p300 ligand 2	Ligand	99.39%	Unkown
HY-145765	JQAD1		98.24%	Unkown
HY-124960	CTPB	Activator	≥99.0%	Unkown
HY-100482	CPI-637	Inhibitor	99.94%	Unkown
HY-100726	GNE-272	Inhibitor	99.60%	Unkown
HY-19541	I-CBP112		98.43%	Unkown
HY-154984	JET-209	Degrader	99.27%	Unkown
HY-N2345	Procyanidin B3	Inhibitor	99.92%	Unkown
HY-10593	IQ 1	Modulator	99.13%	Unkown
HY-161369	CBPD-268	Degrader	99.23%	Unkown
HY-P10238	MYBMIM	Inducer	99.96%	Unkown
HY-100671	L002	Inhibitor	99.44%	Unkown
HY-173552	TCIP3	Inhibitor	99.30%	Unkown
HY-100734	Histone Acetyltransferase Inhibitor II	Inhibitor	98.70%	Unkown
HY-152241	DS-9300	Inhibitor	99.83%	Unkown
HY-N0005S	Curcumin-d6		99.78%	Unkown
HY-131035	Lys-CoA TFA	Inhibitor	98.52%	Unkown
HY-101125	L-Moses	Inhibitor	99.97%	Unkown
HY-128876	CBP/p300-IN-3	Inhibitor	98.01%	Unkown
HY-141466A	Crotonyl-CoA tetrasodium	Substrate	97.85%	Unkown
HY-149878	BD-9136	Degrader	98.81%	Unkown
HY-115539	Windorphen	Inhibitor	99.75%	Unkown
HY-17663	KMR-206		98.86%	Unkown
HY-100697	TPOP146	Inhibitor	98.94%	Unkown
HY-111420	CBP/p300-IN-1	Inhibitor	99.71%	Unkown
HY-139108	DCH36_06		99.19%	Unkown
HY-RS04405	EP300 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-147008	XP-524	Inhibitor	98.02%	Unkown
HY-134591	Thalidomide-NH-PEG4-COOH	Inducer	96.65%	Unkown
HY-125847	Salvianolic acid F		99.50%	Unkown
HY-147290	NSC 694623	Inhibitor	99.53%	Unkown
HY-161483	CBP/p300 ligand 3	Inhibitor	98.82%	Unkown
HY-W877997	Pomalidomide 5'-pip-acid		98.06%	Unkown
HY-136920	CBP/p300-IN-8	Inhibitor	98.03%	Unkown
HY-132197	CBP/p300-IN-12	Inhibitor	99.72%	Unkown
HY-120290	PU141	Inhibitor	99.96%	Unkown
HY-139148	UMB298	Inhibitor	99.28%	Unkown
HY-141546	Pocenbrodib	Inhibitor	98.49%	Unkown
HY-134592	Piperidine-GNE-049-N-Boc		98.48%	Unkown
HY-146277A	CBP/p300-IN-19 hydrochloride	Inhibitor	99.00%	Unkown
HY-177840	Liposomal Curcumin		/	Unkown
HY-RS04406	Ep300 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-162259	QC-182		98.94%	Unkown
HY-128875	CBP/p300-IN-10	Inhibitor	99.74%	Unkown
HY-139707	PROTAC CBP/P300 Degrader-3	Degrader	98.55%	Unkown
HY-110263	EML 425	Inhibitor	98.04%	Unkown
HY-174866	BT-O2C	Inhibitor	99.31%	Unkown
HY-101125A	L-Moses dihydrochloride	Inhibitor	99.38%	Unkown
HY-184124	JZY3032	Inhibitor	/	Unkown
HY-100132	CBP/p300-IN-5	Inhibitor	≥97.0%	Unkown
HY-101125B	D-Moses	Control	/	Unkown
HY-136285A	(R,R)-CPI-1612	Control	99.68%	Unkown
HY-145386	(S,S)-CPI-1612	Control	99.88%	Unkown
HY-147261	B026	Inhibitor	/	Unkown
HY-151812	CBP/p300-IN-20	Inhibitor	98.03%	Unkown
HY-153768	KAT modulator-1	Modulator	98.0%	Unkown
HY-168201	MJP6412		95.90%	Unkown
HY-128761	CBP/p300-IN-2	Inhibitor	/	Unkown
HY-134621	P300-IN-1	Inhibitor	/	Unkown
HY-143443	DS17701585	Inhibitor	/	Unkown
HY-W013274A	CPTH2 hydrochloride		/	Unkown
HY-114510	PRMT/HKMT-IN-1		/	Unkown
HY-121009	CCT077791	Inhibitor	/	Unkown
HY-121089	P300-IN-5	Inhibitor	/	Unkown
HY-122081	CPI-644	Inhibitor	/	Unkown
HY-123009	KCN1		/	Unkown
HY-124722	OHM1	Inhibitor	/	Unkown
HY-128362	Ep300/CREBBP-IN-8	Inhibitor	/	Unkown
HY-128363	Ep300/CREBBP-IN-2	Inhibitor	/	Unkown
HY-128364	Ep300/CREBBP-IN-3	Inhibitor	/	Unkown
HY-128367	Ep300/CREBBP-IN-4	Inhibitor	/	Unkown
HY-139804	CTK7A	Inhibitor	/	Unkown
HY-139861	CBP/p300-IN-14	Inhibitor	/	Unkown
HY-143339	CBP/p300-IN-15	Inhibitor	/	Unkown
HY-143440	CBP/p300-IN-16	Inhibitor	/	Unkown
HY-143441	CBP/p300-IN-17	Inhibitor	/	Unkown
HY-143442	CBP/p300-IN-18	Inhibitor	/	Unkown
HY-146277	CBP/p300-IN-19	Inhibitor	/	Unkown
HY-146445	P300 bromodomain-IN-1	Inhibitor	/	Unkown
HY-155229	CBP/p300-IN-21	Inhibitor	/	Unkown
HY-159587	P300-IN-4	Inhibitor	/	Unkown
HY-160261S	EP300/CBP-IN-2	Inhibitor	/	Unkown
HY-161250	Pomalidomide-NH-PEG6-amide-C2-CPI-1612	Degrader	/	Unkown
HY-161494	XYD190		/	Unkown
HY-161495	CBP/p300 ligand 4		/	Unkown
HY-161498	XYD198		/	Unkown
HY-161710	XYD129	Degrader	/	Unkown
HY-161711	CBP/p300 ligand 5		/	Unkown
HY-161958	dCE-2		/	Unkown
HY-161959	EP300/CBP ligand 1		/	Unkown
HY-161960	EP300/CBP ligand 2		/	Unkown
HY-162128	Antitumor agent-130	Inhibitor	/	Unkown
HY-164005	CBP/EP300 bromodomain receptor-IN-1	Inhibitor	/	Unkown
HY-165413	KST012174 hydrochloride	Inhibitor	/	Unkown
HY-168148S	CZL-046	Inhibitor	/	Unkown
HY-168463	Y16524	Inhibitor	/	Unkown
HY-168464	Y16526	Inhibitor	/	Unkown
HY-173641	MNN-02-155		/	Unkown
HY-174868	iP300w	Inhibitor	/	Unkown
HY-175898	CBP/EP300 ligand-1		/	Unkown
HY-175907	CBP/p300 ligand 7	Ligand	/	Unkown
HY-176251	CBP/p300-IN-22	Inhibitor	/	Unkown
HY-179498	ROCK2-IN-13		/	Unkown
HY-179657	PROTAC p300 degrader-2	Inhibitor	/	Unkown
HY-180804	CZL-077	Inhibitor	/	Unkown
HY-181261	PROTAC CBP/P300 Degrader-2		/	Unkown
HY-181669	P300-IN-6	Inhibitor	/	Unkown
HY-181758	PROTAC CBP/p300/BRD4 Degrader-1		/	Unkown
HY-181759	CBP/p300/BRD4 ligand-1	Ligand	/	Unkown
HY-181852	CBP/p300 ligand 10	Degrader	/	Unkown
HY-181957	KB528		/	Unkown
HY-183251	PROTAC p300 degrader-1	Degrader	/	Unkown
HY-183802	PROTAC CBP/P300 Degrader-4	Degrader	/	Unkown
HY-183817	GNE-781-COOH	Ligand	/	Unkown
HY-183818	CRBN ligand-903		/	Unkown
HY-183819	CRBN ligand-903-trans-1,4-cyclohexanediamine-Boc		/	Unkown
HY-183992	CZL-149	Inhibitor	/	Unkown
HY-184453	PROTAC CBP/EP300 degrader-1		/	Unkown
HY-184454	EP300/CBP ligand 3	Ligand	/	Unkown
HY-184556	dCBP-30		/	Unkown
HY-185009	GSK702		/	Unkown
HY-185786	CBP/p300-IN-25		/	Unkown
HY-186064	CBP/p300 ligand-Linker Conjugate 3		/	Unkown
HY-187066	trans-CBP/p300 ligand 3-cyclohexane-CHO		/	Unkown
HY-CE00983A	4-Pentynoyl-Coenzyme A TFA	Substrate	/	Unkown
HY-P11829	ACTR-AD1 2L	Inhibitor	/	Unkown
HY-RS04407	Ep300 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W197205	SL010110		/	Unkown
HY-W585171	CRBN ligand-896		/	Unkown
HY-123758	XDM-CBP	Inhibitor	/	Unkown
HY-141466	Crotonyl-CoA	Substrate	/	Unkown
HY-160260	EP300/CBP-IN-1	Inhibitor	/	Unkown
HY-161961	Thalidomide-NH-C10-Boc		/	Unkown
HY-166309	Crotonyl-CoA tetralithium	Substrate	/	Unkown
HY-19541A	I-CBP112 hydrochloride	Inhibitor	/	Unkown
HY-N0005S1	Curcumin-d3		/	Unkown
HY-W173361	CBP/p300-IN-24	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ep300	NCBI	NCBI:2033