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Val

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GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16562

Irinotecan 70+ Cited Publications (+)-Irinotecan; CPT-11; Val-413free base	Topoisomerase Autophagy	Neurological Disease Cancer
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-N6693

Valinomycin 5+ Cited Publications NSC 122023	Apoptosis Antibiotic Autophagy Fungal	Infection Others Cancer
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

HY-100374

Val-Cit-PAB-MMAE 1 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

HY-13233A

Talabostat mesylate 40+ Cited Publications Val-boroPro mesylate; PT100 mesylate	Dipeptidyl Peptidase	Inflammation/Immunology Cancer
Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC₅₀ < 4 nM; K_i = 0.18 nM) and the inhibitor of fibroblast activation protein (FAP) (IC₅₀ = 560 nM), inhibits DPP8/9 (IC₅₀ = 4/11 nM; K_i = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC₅₀ = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities .

HY-16562A

Irinotecan hydrochloride 70+ Cited Publications (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; Val-413	Topoisomerase Autophagy	Cancer
Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-145929

*MC-Val-Cit-PAB-Exatecan* 1 Publications Verification MC-Val-Cit-PAB-DX8951	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) is a agent-linker conjugate for ADC. MC-Val-Cit-PAB-Exatecan is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker.

HY-12362

Val-cit-PAB-OH 1 Publications Verification	ADC Linker	Cancer
Val-cit-PAB-OH is a degradable ADC linker.

HY-130989

*SuO-Glu-Val-Cit-PAB-MMAE* NHS-Glutarate-Val-Cit-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
SuO-Glu-Val-Cit-PAB-MMAE (NHS-Glutarate-Val-Cit-PAB-MMAE) consists a cleavable ADC linker (SuO-Glu-Val-Cit-PAB) and a potent tubulin inhibitor (MMAE). SuO-Glu-Val-Cit-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-13233

Talabostat Val-boroPro; PT100	Dipeptidyl Peptidase	Inflammation/Immunology Cancer
Talabostat (Val-boroPro; PT100) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC₅₀ < 4 nM; K_i = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC₅₀ = 560 nM), inhibits DPP8/9 (IC₅₀ = 4/11 nM; K_i = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC₅₀ = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities .

HY-153031

Val-Cit-PAB-Exatecan Val-Cit-PAB-DX8951	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Val-Cit-PAB-Exatecan (Val-Cit-PAB-DX8951) is a agent-linker conjugate for ADC. Val-Cit-PAB-Exatecan is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker .

HY-140014

Val-Cit	ADC Linker	Cancer
Val-Cit is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W190927

*MC-Val-Cit-Doxorubicin* MC-Val-Cit-PAB-Doxorubicin	Drug-Linker Conjugates for ADC	Cancer
MC-Val-Cit-Doxorubicin (MC-Val-Cit-PAB-Doxorubicin) is drug-linker conjugate for ADC. The maleimide can conjugate with thiol containing molecules. Doxorubicin is an anthracycline antibiotic with antineoplastic activity

HY-147095

Val-Ala-PABC-Exatecan	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Val-Ala-PABC-Exatecan is a Drug-Linker Conjugates for ADC, consiting of a cleavable Tesirine linker (Val-Ala-PABC) and Exatecan (HY-13631) (topoisomerase I inhibitor). Val-Ala-PABC-Exatecan can be used for ADC molecues synthesis, such as Mal-PEGn-amide-va-Exatecan .

HY-125933

Val-Ala-PAB	ADC Linker	Cancer
Val-Ala-PAB is a cleavable ADC linker that can be used for ADCs synthesis .

HY-W007035

*H-Val-Ala-OH* 1 Publications Verification Valyl-alanine	Endogenous Metabolite Amino Acid Derivatives	Metabolic Disease
H-Val-Ala-OH (Valyl-alanine) is a dipeptide formed from L-Valine and L-Alanine residues. H-Val-Ala-OH has a role as a metabolite and also has a bitter taste .

HY-P1938

*Cyclo(L-Pro-L-Val)*	Bacterial	Infection Inflammation/Immunology
Cyclo(L-Pro-L-Val) is an antimicrobial and anti-inflammatory agent. Cyclo(L-Pro-L-Val) has toxic activity against plant pathogens such as R. fascians LMG 3605, and its potency may be comparable to that of Chloramphenicol (HY-B0239). Cyclo(L-Pro-L-Val) can inhibit the phosphorylation of IKKα, IKKβ, NF-κB, etc., and the activation of iNOS and COX-2, thereby exerting anti-inflammatory activity. Cyclo(L-Pro-L-Val) can be used in the research of biopesticides in the agricultural field, as well as in the research of inflammation-related diseases .

HY-16513

VAL-083 2 Publications Verification Dianhydrodulcitol; Dianhydrogalactitol	DNA Alkylator/Crosslinker	Cancer
VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.

HY-19811

*Fmoc-Val-Cit-PAB-MMAE*	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
Fmoc-Val-Cit-PAB-MMAE consists the ADCs linker (Fmoc-Val-Cit-PAB) and potent tubulin inhibitor (MMAE). Fmoc-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC.

HY-W106311

*Fmoc-Val-Ala-OH*	Drug Intermediate	Cancer
Fmoc-Val-Ala-OH is an intermediate for synthesizing the ADC linker. Fmoc-Val-Ala-OH can be used for the research of cancer .

HY-153032

Val-Ala-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
Val-Ala-PAB-MMAE is a Drug-Linker Conjugate for ADC, consisting of ADC linker (Val-Ala-PAB) and MMAE. MMAE is an effective inhibitor of tubulin.

HY-P4322

*H-Ile-Lys-Val-Ala-Val-OH* 1 Publications Verification	ERK Akt	Neurological Disease Cancer
H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways .

HY-118060

Dipeptide 2 N-Valyltryptophan; Val-Trp	Angiotensin-converting Enzyme (ACE) Calcium Channel NO Synthase	Cardiovascular Disease
Dipeptide 2 (N-Valyltryptophan) is an orally active, competitive angiotensin-converting enzyme (ACE) inhibitory peptide with an IC₅₀ of 10.50 μM. Dipeptide 2 reduces intracellular Calcium ions. Dipeptide 2 significantly increases the content of NO, inhibits the production of ET-1, and induces the phosphorylation of eNOS. Dipeptide 2 decreases the systolic and diastolic blood pressure of spontaneously hypertensive rats .

HY-W250408

*Fmoc-NMe-Val-Val-Dil-Dap-OH*	Drug-Linker Conjugates for ADC	Cancer
Fmoc-NMe-Val-Val-Dil-Dap-OH is an intermediate for preparing drug-linker conjugate MC-MMAF, which can be used for synthesis of ADC molecule .

HY-78736

Val-Cit-PAB-OSBT	ADC Linker	Cancer
Val-Cit-PAB-OSBT is a degradable ADC linker composed of the peptide Val-Cit-PAB and the OSBT group, which ensures stable performance during targeted drug delivery .

HY-158137

Val-Cit-PAB-DEA-Dxd	Drug-Linker Conjugates for ADC	Cancer
Val-Cit-PAB-DEA-Dxd (compound 81) is a Drug-Linker Conjugates for ADC, which is composed of a linker and a toxic molecule Dxd (DNA topoisomerase I inhibitor). Val-Cit-PAB-DEA-Dxd can be used for ADC synthesis .

HY-107378

L-Valyl-L-phenylalanine Valylphenylalanine; H-Val-PHE-OH	Endogenous Metabolite	Inflammation/Immunology
L-Valyl-L-phenylalanine (Valylphenylalanine; H-VAL-PHE-OH) has been reported as biocompatible polymer.

HY-P4666

Valylhistidine	Biochemical Assay Reagents	Others
Valylhistidine is a dipeptide composed of valine and histidine (Val-His). Valylhistidine can form a dipeptide complex with Cu (II) that mimics superoxide dismutase but lacks activity .

HY-126584

*H-Val-Val-OH* Val-Val	Drug Intermediate Oligopeptide Cotransporter	Others
H-Val-Val-OH (Val-Val) is a stereochemistry-dependent substrate and inhibitor of apical oligopeptide transporters. H-Val-Val-OH undergoes apical intracellular accumulation in human intestinal cells via carrier-mediated transport, and inhibits the uptake of Cephalexin (HY-B0200) through interaction with transporters. Substitution of L-valine with D-valine in H-Val-Val-OH abolishes its binding ability to apical oligopeptide transporters .

HY-P0108

Angiotensin II 5-valine Valine angiotensin II; 5-L-Valine angiotensin II	Angiotensin Receptor	Endocrinology Cancer
Angiotensin II 5-valine is an agonist of angiotensin receptor.

HY-160795

*Boc-NMe-Val-Val-Dil-Dap-OH*	ADC Linker	Cancer
Boc-NMe-Val-Val-Dil-Dap-OH is a linker, that can be used for ADC synthesis.

HY-P4566

*H-Pro-Val-OH* Pro-Val	Dipeptidyl Peptidase	Others
H-Pro-Val-OH is a deprotonation dipeptide containing proline, which can catalyze the Michael addition reaction of acetone to trans-β-nitrostyrene. H-Pro Val OH can also serve as a substrate for fibroblast enzymes and prolinase, and has potential applications in biochemical analysis .

HY-W008733

L-Phenylalanyl-L-valine L-Phe-L-Val; Phe-Val; H-Phe-Val-OH	Amino Acid Derivatives	Others
L-Phenylalanyl-L-valine (L-Phe-L-Val) is a valine derivative .

HY-44177

Val-Cit-PAB-MMAF sodium	Drug-Linker Conjugates for ADC	Cancer
Val-Cit-PAB-MMAF sodium is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAF sodium contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin polymerization inhibitor MMAF (HY-15579)

HY-137367

*Z-Val-Val-Arg-AMC*	Cathepsin	Infection
Z-Val-Val-Arg-AMC is a fluorescent peptide substrate that can be used to test the activity of cathepsins .

HY-W009338

*H-Val-Tyr-OH* 1 Publications Verification Val-Tyr	IKK NF-κB	Inflammation/Immunology Cancer
H-Val-Tyr-OH (Val-Tyr) is a dipeptide formed by the connection of valine and tyrosine via a peptide bond. H-Val-Tyr-OH is a potential IKKα inhibitor and can be used in the research of cancer and inflammatory diseases .

HY-P4518

*Z-Val-Gly-Arg-pNA*	Ser/Thr Protease	Others
Z-Val-Gly-Arg-pNA is a chromogenic substrate for urokinase. Z-Val-Gly-Arg-pNA can be used for determination of urokinase activity .

HY-153031A

Val-Cit-PAB-Exatecan TFA Val-Cit-PAB-DX8951 TFA	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Val-Cit-PAB-Exatecan (Val-Cit-PAB-DX8951) TFA is a agent-linker conjugate for ADC. Val-Cit-PAB-Exatecan TFA is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker .

HY-177307

*Mal-Val-Lys-PAB-MMAE*	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
Mal-Val-Lys-PAB-MMAE is a drug-linker conjugate for ADC. Mal-Val-Lys-PAB-MMAE consists of a Tubulin inhibitor (MMAE) (HY-15162) and a linker (Mal-Val-Lys-PAB). Mal-Val-Lys-PAB-MMAE can be used for synthesis of ADCs .

HY-P3726

Lys-Gln-Ala-Gly-Asp-Val	Integrin	Inflammation/Immunology Cancer
Lys-Gln-Ala-Gly-Asp-Val (KQAGDV) is the six most carboxyl-terminal amino acids in the fibrinogen γ-chain sequence. Lys-Gln-Ala-Gly-Asp-Val is a cell adhesion peptide which is mediated through the α_2bβ₃ integrin. Lys-Gln-Ala-Gly-Asp-Val is a potent adhesion ligand for smooth muscle cells (SMCs) .

HY-160774

Val-Cit-PABC-DOX	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Val-Cit-PABC-DOX (compound 10109), an epsilon-poly-L-lysine-based drug conjugate, is an agent-linker conjugate for ADC by using a DNA topoisomerase I and topoisomerase II inhibitor, Doxorubicin (HY-15142), linked via the linker, Val-Cit-PABC .

HY-173243A

Val-Ala-PAB-SN38 TFA	Drug-Linker Conjugates for ADC	Cancer
Val-Ala-PAB-SN38 TFA is a drug-linker conjugate for ADC, composed of ADC linker Val-Ala-PAB (HY-125933) and SN38 (HY-13704), which is the active metabolite of the Topoisomerase I inhibitor Irinotecan (HY-16562) .

HY-P5898

*Z-Val-Val-Nle-diazomethylketone* Z-Val-Val-Nle-CHN2	Cathepsin MHC	Inflammation/Immunology
Z-Val-Val-Nle-diazomethylketone is a cathepsin S (CATS) inhibitor. Z-Val-Val-Nle-diazomethylketone significantly inhibits the IFNg-induced upregulation of the MHCII molecules HLA-DR and Ii-p33/35 with an increase of Ii-p10 protein level. Z-Val-Val-Nle-diazomethylketone can be used for dermatological diseases like psoriasis, atopic dermatitis and actinic keratosis research .

HY-P4668

Valylleucine Val-Leu; H-Val-Leu-OH	Bacterial	Infection
Valylleucine (Val-Leu; H-Val-Leu-OH) is a branched-chain dipeptide that can enter cells independently via bacterial dipeptide transport systems, and is hydrolyzed by dipeptidases to release Val and Leu. Valylleucine, as a model peptide, has its α-amino pK determined to be 7.90 by combining FDNB reaction kinetics with potentiometric titration .

HY-P4668A

Valylleucine TFA Val-Leu TFA; H-Val-Leu-OH TFA	Bacterial	Infection
Valylleucine (Val-Leu; H-Val-Leu-OH) TFA is a branched-chain dipeptide that can enter cells independently via bacterial dipeptide transport systems, and is hydrolyzed by dipeptidases to release Val and Leu. Valylleucine TFA, as a model peptide, has its α-amino pK determined to be 7.90 by combining FDNB reaction kinetics with potentiometric titration .

HY-P2381

*Sar-Arg-Val-Tyr-Val-His-NH2* 2 Publications Verification	Angiotensin Receptor	Others
Sar-Arg-Val-Tyr-Val-His-NH2 is a G_q-biased agonists, exhibits 10-fold larger molecular efficacies at the AT₁R-Gq fusion protein compared with the AT₁R-βarr2 fusion protein .

HY-101909

Val-Cit-PAB-MMAF	Drug-Linker Conjugates for ADC	Cancer
Val-Cit-PAB-MMAF is a drug-Linker conjugates for ADC. Val-Cit-PAB-MMAF is composed of an ADC linker (peptide Val-Cit-PAB) and a potent microtubule polymerization inhibitor MMAF (HY-15579) .

HY-156897

Val-Cit-amide-Ph-Maytansine	Drug-Linker Conjugates for ADC	Cancer
Val-Cit-amide-Ph-Maytansine is an antibody and bispecific antigen-binding mol. that bind hepatocyte growth factor receptor c-Met (MET) or antibody-drug conjugates (ADCs) .

HY-P4658

*H-Val-Ala-pNA*	Dipeptidyl Peptidase	Others
H-Val-Ala-pNA is a substrate for the dipeptide aminopeptidase (DPAPase) of Streptococcus bovis. H-Val-Ala-pNA can be used to measure the activity of the protease .

HY-P3910

*[Val4] Angiotensin III*	Angiotensin Receptor	Cardiovascular Disease
[Val4] Angiotensin III is an angiotension III peptide. [Val4] Angiotensin III is a potent full agonist of Gα_q and βarr2 response, with pEC₅₀ values of 8.31 and 8.44, respectively .

HY-P4126

*Suc-Ala-Ala-Pro-Val-AMC*	Elastase	Others
Suc-Ala-Ala-Pro-Val-AMC, a tetrapeptide, is an elastasesubstrate. Suc-Ala-Ala-Pro-Val-AMC can be used for determining elastase activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13948

Angiotensin II human Maximum Cited Publications 222 Publications Verification Angiotensin II; Ang II; DRVYIHPF	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Source Classification Cancer	Angiotensin Receptor Apoptosis
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-P0018

Pepstatin 55+ Cited Publications Pepstatin A	Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification Cancer	HIV Protease Autophagy
Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease .

HY-P0017

Aprotinin 30+ Cited Publications	Cardiovascular Disease Natural Products Animals Disease Research Fields Source Classification	Influenza Virus Ser/Thr Protease
Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with K_is of 0.06 pM and 9 nM, respectively.

HY-N6693

Valinomycin 5+ Cited Publications NSC 122023	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Apoptosis Antibiotic Autophagy Fungal
Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

HY-16562A

Irinotecan hydrochloride 70+ Cited Publications (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; Val-413	Alkaloids Classification of Application Fields Quinoline Alkaloids Camptotheca acuminata Decne. Nyssaceae Plants Disease Research Fields Source Classification Cancer	Topoisomerase Autophagy
Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-P0239

HA Peptide 10+ Cited Publications	Natural Products Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Influenza Virus
HA Peptide (HA tag) is a nine amino acids peptide derived from the human influenza hemagglutinin (HA). HA Peptide is extensively used to isolate, purify, detect, and track the protein of interest in cell biology and biochemistry.

HY-N6708

Alamethicin 2 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Mammalian Cell Culture Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes .

HY-12403

Talfirastide 15+ Cited Publications TXA127; Angiotensin (1-7); Ang-(1-7)	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .

HY-105174

BPC 157	Alkaloids Pyrrole Alkaloids Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	JAK FAK
BPC 157 is the 15-amino acide fragment of gastric peptide BPC. BPC 157 exhibits wound healing promoting and neuroprotective activity. BPC 157 maintains the integrity of the gastrointestinal mucosa without significant toxicity. BPC 157 acetate counteracts NSAIDs/insulin overdose/copper-induced toxicity. BPC 157 ameliorates specific (over)stimulated/damaged neurotransmitter systems-induced behavioral disorders through serotonergic and dopaminergic systems .

HY-P0190

Iberiotoxin 2 Publications Verification	Cardiovascular Disease Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Potassium Channel
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca ²⁺-activated K ⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels .

HY-P0195

Bombesin 1 Publications Verification	Natural Products Animals Source Classification	Bombesin Receptor
Bombesin, a tetradecapeptide, plays an important role in the release of gastrin and the activation of G-protein receptors .

HY-W007035

*H-Val-Ala-OH* 1 Publications Verification Valyl-alanine	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Amino Acid Derivatives
H-Val-Ala-OH (Valyl-alanine) is a dipeptide formed from L-Valine and L-Alanine residues. H-Val-Ala-OH has a role as a metabolite and also has a bitter taste .

HY-N7122

Thymopentin	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Thymopentin is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs) .

HY-P2358

PSMα3	Structural Classification Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	NF-κB p38 MAPK
PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection .

HY-P1938

*Cyclo(L-Pro-L-Val)*	Natural Products Microorganisms Source Classification	Bacterial
Cyclo(L-Pro-L-Val) is an antimicrobial and anti-inflammatory agent. Cyclo(L-Pro-L-Val) has toxic activity against plant pathogens such as R. fascians LMG 3605, and its potency may be comparable to that of Chloramphenicol (HY-B0239). Cyclo(L-Pro-L-Val) can inhibit the phosphorylation of IKKα, IKKβ, NF-κB, etc., and the activation of iNOS and COX-2, thereby exerting anti-inflammatory activity. Cyclo(L-Pro-L-Val) can be used in the research of biopesticides in the agricultural field, as well as in the research of inflammation-related diseases .

HY-N2453

Convallatoxin 1 Publications Verification	Structural Classification Classification of Application Fields Cardiacglycosides Ranunculaceae Adonis amurensis Regel et Radde Plants Inflammation/Immunology Disease Research Fields Steroids	PPAR NF-κB P-glycoprotein
Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties .

HY-P0270

Magainin 2 Magainin II	Infection Structural Classification Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Bacterial Antibiotic Fungal
Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .

HY-W019721

Cyclosporin D	Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Nuclear Factor of activated T Cells (NFAT)
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .

HY-P2031

Phallacidin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Arp2/3 Complex
Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a K_d of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy .

HY-106302

Duramycin Moli1901; Lancovutide	Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Bacterial
Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF) .

HY-107378

L-Valyl-L-phenylalanine Valylphenylalanine; H-Val-PHE-OH	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
L-Valyl-L-phenylalanine (Valylphenylalanine; H-VAL-PHE-OH) has been reported as biocompatible polymer.

HY-107245

Segetalin B 2 Publications Verification	Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Cyclopeptides Metabolic Disease Plants Disease Research Fields Caryophyllaceae Source Classification	Estrogen Receptor/ERR Sirtuin RUNX
Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP) .

HY-12403A

Talfirastide acetate 15+ Cited Publications TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Angiotensin Receptor Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium .

HY-P0239A

HA Peptide TFA 10+ Cited Publications	Natural Products Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Influenza Virus
HA Peptide (TFA) is a nine amino acids peptide derived from the human influenza hemagglutinin (HA). HA Peptide (TFA) is extensively used to isolate, purify, detect, and track the protein of interest in cell biology and biochemistry .

HY-P0279

Systemin	Natural Products other families Classification of Application Fields Other Diseases Solanum lycopersicum L. Solanaceae Plants Disease Research Fields Source Classification	Endogenous Metabolite
Systemin, an 18-amino acid polypeptide, has been isolated from tomato leaves that is a powerful inducer of over 15 defensive genes.

HY-P0269

Magainin 1 Magainin I	Infection Structural Classification Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Bacterial Fungal Antibiotic
Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .

HY-P1280

Margatoxin 1 Publications Verification	Natural Products Animals Neurological Disease Disease Research Fields Source Classification	Potassium Channel
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (K_d=11.7 pM). Margatoxin inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research .

HY-W009338

*H-Val-Tyr-OH* 1 Publications Verification Val-Tyr	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	IKK NF-κB
H-Val-Tyr-OH (Val-Tyr) is a dipeptide formed by the connection of valine and tyrosine via a peptide bond. H-Val-Tyr-OH is a potential IKKα inhibitor and can be used in the research of cancer and inflammatory diseases .

HY-N13371

*Cyclo(Leu-Val)*	Alkaloids Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Plants Araliaceae Source Classification	Others
Cyclo(Leu-Val) is a natural product .

HY-P0018A

Pepstatin Trifluoroacetate 55+ Cited Publications Pepstatin A Trifluoroacetate	Infection Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	HIV Protease Autophagy
Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Trifluoroacetate also inhibits HIV protease .

HY-P5714

Abaecin	Animals Ketones, Aldehydes, Acids Source Classification	Bacterial
Abaecin is an antibacterial response peptide. Abaecin shows specific activity against an Apidaecin-resistant Xanthomonas strain .

HY-P5957

Omphalotin A	Microorganisms Cyclopeptides Source Classification	Parasite
Omphalotin A is a cyclic peptide, and shows nematicidal activity .

HY-P0259

Xenin	Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite
Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.

HY-N11615

*Cyclo(Pro-Val)* 1 Publications Verification	Alkaloids Microorganisms Other Alkaloids Source Classification	Others
Cyclo(Pro-Val) can be isolated from Pseudomonas fluorescens GcM5-1A and has cytotoxicity .

HY-P1508A

Bactenecin TFA Bactenecin, bovine TFA	Infection Natural Products Classification of Application Fields Animals Disease Research Fields Source Classification	Bacterial Fungal
Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-P1508

Bactenecin Bactenecin, bovine	Infection Animals Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Fungal Antibiotic
Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-N7122A

Thymopentin acetate	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Thymopentin acetate is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin acetate is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin acetate enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs) .

HY-P1866A

β-Endorphin, equine TFA 1 Publications Verification	Natural Products Endogenous metabolite Source Classification	Opioid Receptor
β-Endorphin, equine TFA is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. β-Endorphin, equine TFA has analgesic properties .

HY-P5751

*Cyclo(Ile-Val)*	Alkaloids Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Other Alkaloids Plants Araliaceae Source Classification	Others
Cyclo(Ile-Val) is a Alkaloids product that can be isolated from the roots of Panax notoginseng (Burk.)F.H.Chen .

HY-W007035R

*H-Val-Ala-OH (Standard)* Valyl-alanine (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Amino Acid Derivatives
H-Val-Ala-OH (Valyl-alanine) is a dipeptide formed from L-Valine and L-Alanine residues. H-Val-Ala-OH has a role as a metabolite and also has a bitter taste .

HY-P10809

VAMP	Structural Classification Cannabis sativa L Ketones, Aldehydes, Acids Plants Moraceae Source Classification	Dipeptidyl Peptidase
VAMP, a tetrapeptide, is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 1.00 μM and a K_d of 6.89 μM. VAMP effectively targets the DPP-IV-GLP-1 axis and can be used for the study of type 2 diabetes .

HY-P0302

HEX3 1 Publications Verification	Infection Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Others
HEX3 is a fragment of the adenoviral hexon. Hexon is the major capsid protein of adenovirion and is comprised of three identical polypeptide chains.

HY-P0324

Parasin I	Infection Natural Products Classification of Application Fields Animals Disease Research Fields Source Classification	Bacterial
Parasin I is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.

HY-P5708

Adenoregulin Dermaseptin b2	Animals Ketones, Aldehydes, Acids Source Classification	Antibiotic Fungal Bacterial
Adenoregulin (Dermaseptin b2) is an antimicrobial peptide antibiotic. Adenoregulin is active against Gram-negative and Gram-positive bacteria, yeast and fungi. Adenoregulin also enhances the binding of agonists to the A1 adenosine receptor .

HY-P5719

Andropin	Animals Ketones, Aldehydes, Acids Source Classification	Bacterial
Andropin is a male-specific antibacterial peptide that can be found in Drosophila melanogaster .

HY-P5702

EP3	Animals Ketones, Aldehydes, Acids Source Classification	Bacterial Apoptosis Fungal
EP3 is an antimicrobial peptide. EP3 has antibacterial and antifungal activities. EP3 inhibits E. gallinarum, P. pyocyanea, A. baumanii, K. terrigena with a MIC value of 12.85 μg/mL. EP3 also shows antitumor activity against cancer cells, and induces cell apoptosis .

HY-P6293

Heterophyllin A	Natural Products Pseudostellaria heterophylla (Miq.) Pax Plants Caryophyllaceae Source Classification	Cathepsin
Heterophyllin A can be isolated from the aboveground parts of Elaeagnus angustifolia.

HY-P2005

Malformin C	Natural Products Microorganisms Source Classification	Reactive Oxygen Species (ROS) SOD
Malformin C is an algicidal peptide can be isolated from Aspergillus and exhibits dose-dependent algicidal activity. Malformin C induces a significant increase in ROS levels in algal cells, resulting in impaired SOD activity and high production of MDA content .

HY-105088A

Pexiganan acetate MSI 78	Structural Classification Natural Products Animals Source Classification	Bacterial
Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection .

HY-P1866

β-Endorphin, equine	Natural Products Endogenous metabolite Source Classification	Opioid Receptor
β-Endorphin, equine is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors . Analgesic properties .

Cat. No.	Product Name	Chemical Structure

HY-114118S3

Semaglutide-13C6,15N TFA

Semaglutide- ¹³C₆, ¹⁵N TFA is the ¹³C- and ¹⁵N-labeled Semaglutide TFA (HY-114118A). Semaglutide TFA is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide TFA promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide TFA also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide TFA has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide TFA can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

HY-15575S

VcMMAE-d8
VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .

HY-114118S1

Semaglutide-d8 tetraTFA

Semaglutide-d₈ tetraTFA is the deuterium labeled Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

HY-114118S

Semaglutide-d8

Semaglutide-d₈ is the deuterium labeled Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

HY-P0014S1

Liraglutide-13C5,15N tetraTFA
Liraglutide- ¹³C₆, ¹⁵ tetraTFA is the ¹³C and ¹⁵N labeled Liraglutide (HY-P0014) . Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .

HY-I1111S

*Fmoc-L-Val-OH-d8*
Fmoc-L-Val-OH-d₈ is a deuterium labeled Fmoc-L-Val-OH (HY-I1111). Fmoc-L-Val-OH is a kind of protect amino acids .

HY-I1111S2

*Fmoc-L-Val-OH-13C5,15N*
Fmoc-L-Val-OH- ¹³C₅, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled Fmoc-L-Val-OH (HY-I1111). Fmoc-L-Val-OH is a valine derivative .

HY-P1363S

β-Amyloid-15N (1-42), human TFA
β-Amyloid- ¹⁵N (1-42), human (TFA) is the ¹⁵N-labledβ-Amyloid (1-42) (TFA). β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease .

HY-P0014AS

Liraglutide-d8 tetraTFA
Liraglutide-d₈ tetraTFA is deuterium labeled Liraglutide (HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .

HY-P0265AS

β-Amyloid-15N (1-40) TFA
β-Amyloid- ¹⁵N (1-40) (TFA) is the ¹⁵N-labledβ-Amyloid (1-40) (TFA). β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease .

HY-P1363S1

β-Amyloid (1-42), human, Ala(13C3,15N) TFA

β-Amyloid (1-42), human, Ala( ¹³C₃, ¹⁵N) TFA is the ¹³C and ¹⁵N-labeled β-Amyloid (1-42), human (HY-P1363A). β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P0014S2

Liraglutide-13C6,15N TFA
Liraglutide- ¹³C₆, ¹⁵ TFA is the ¹³C and ¹⁵N labeledLiraglutide(HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .

HY-P5168S

GPSVFPLAPSSK-13C6,15N2
GPSVFPLAPSSK- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .

HY-13443S

Exendin-4 (Leu-13C6,15N) TFA
Exendin-4 (Leu- ¹³C₆, ¹⁵N) (Exenatide (Leu- ¹³C₆, ¹⁵N)) TFA is the ¹³C- and ¹⁵N-labeled Exendin-4 TFA (HY-13443). Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC₅₀ of 3.22 nM .

HY-126584S

*H-Val-Val-OH-13C10,15N2 TFA*
H-Val-Val-OH- ¹³C₁₀, ¹⁵N₂ TFA (Val-val- ¹³C₁₀, ¹⁵N₂) is the ¹³C- and ¹⁵N-labeled H-Val-Val-OH (HY-126584). H-VAL-VAL-OH (Val-val) is a dipeptide in which two valine (Val) residues are linked by an amide bond. H-VAL-VAL-OH can be used for the synthesis of some important compounds such as Poststatin (HY-125432) .

HY-159064S

*DSPSAPVNVT(Val-13C5,15N)R TFA*
DSPSAPVNVT(Val- ¹³C₅, ¹⁵N)R TFA is the ¹³C and ¹⁵N-labeled DSPSAPVNVT(Val)R.

HY-159065S

*FIQE(Val-13C5,15N)NTTTR TFA*
FIQE(Val- ¹³C₅, ¹⁵N)NTTTR TFA is the ¹³C and ¹⁵N-labeled FIQE(Val)NTTTR.

HY-I1111S4

*Fmoc-L-Val-OH-15N*
Fmoc-L-Val-OH- ¹⁵N is a ¹⁵N-labeled Fmoc-L-Val-OH (HY-I1111). Fmoc-L-Val-OH is a valine derivative .

HY-P4229

*C-Peptide (human)-[Val7.10-d16]*
([D8]Val7,10)-C-Peptide (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-158992S

*SP-(Val-13C5,15N)-EKNQ-(Leu-13C6,15N)-TIDFINIVKDPVPHNEYKT TFA*
SP-(Val- ¹³C₅, ¹⁵)-EKNQ-(Leu- ¹³C₆, ¹⁵)-TIDFINIVKDPVPHNEYKT TFA is a ¹³C- and ¹⁵N-labeled peptide containing ¹³C₅, ¹⁵N-labeled valine (Val) and ¹³C₆, ¹⁵N-labeled leucine (Leu).

HY-I1111S1

*Fmoc-L-Val-OH-1-13C*
Fmoc-L-Val-OH-1- ¹³C is a ¹³C-labeled Fmoc-L-Val-OH (HY-I1111). Fmoc-L-Val-OH is a valine derivative .

HY-W007035S

*H-Val-Ala-OH-13C5,15N TFA*
H-Val-Ala-OH- ¹³C₅, ¹⁵N (Valyl-alanine- ¹³C₅, ¹⁵N) TFA is the ¹³C- and ¹⁵N-labeled H-Val-Ala-OH (HY-W007035). H-Val-Ala-OH (Valyl-alanine) is a dipeptide formed from L-Valine and L-Alanine residues. H-Val-Ala-OH has a role as a metabolite and also has a bitter taste .

HY-I1111S3

*Fmoc-L-Val-OH-13C5*
Fmoc-L-Val-OH- ¹³C₅ is a ¹³C-labeled Fmoc-L-Val-OH (HY-I1111). Fmoc-L-Val-OH is a valine derivative .

HY-16562AS

Irinotecan-d5 hydrochloride
Irinotecan-d₅ hydrochloride is deuterated labeled Irinotecan hydrochloride (HY-16562A). Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer .

HY-16562S

Irinotecan-d10
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-176176S

MDEKMLVLWVVALS(Gly-13C2,15N)IST
MDEKMLVLWVVALS(Gly- ¹³C₂, ¹⁵N)IST is the ¹³C- and ¹⁵N-labeled MDEKMLVLWVVALSIST.

HY-159193S

DHATS(Leu-13C6,15N)PVTIPSAVST(Gly-13C2,15N)HTTPLPVTDT TFA
DHATS(Leu- ¹³C₆, ¹⁵N)PVTIPSAVST(Gly- ¹³C₂, ¹⁵N)HTTPLPVTDT (TFA) is the ¹³C and ¹⁵N labeled isotope of DHATS-PVTIPSAVST-HTTPLPVTDT (TFA) .

HY-163424S

SSVFVADPK-(Lys-13C6,15N2)
SSVFVADPK-(Lys- ¹³C₆, ¹⁵N₂) is ¹³C and ¹⁵N labeled SSVFVADPK-(Lys).

HY-159191S

VQPGQN(Phe-13C9,15N)HMFTKEKLEEVIKDI TFA
VQPGQN(Phe- ¹³C9, ¹⁵N)HMFTKEKLEEVIKDI (TFA) is the ¹³C and ¹⁵N labeled isotope of VQPGQN-HMFTKEKLEEVIKDI (TFA) .

HY-P10324

TAT-p16
TAT-p16 (p16INK4a peptide) is a peptide mimic of p16INK4a that can induce an early G phase cell cycle arrest in the absence of active cyclin E:Cdk2 complex .

HY-P0058S

Pramlintide-(Ala-13C3,15N)
Pramlintide-(Ala- ¹³C₃, ¹⁵N) is the ¹³C- and ¹⁵N-labeled Pramlintide. Pramlintide is a polypeptide analogue of human amylin. Pramlintide, an antidiabetic agent, is antineoplastic in colorectal cancer .

HY-163425S

AILNYVANK-(Lys-13C6,15N2)
AILNYVANK-(Lys- ¹³C₆, ¹⁵N₂) is ¹³C and ¹⁵N labeled AILNYVANK-(Lys) .

HY-P6423S

CLAVYQAGA-Arg(13C6,15N4) TFA
CLAVYQAGA-Arg( ¹³C₆, ¹⁵N₄) TFA is a peptide containing ¹³C₆ and ¹⁵N₄ labeled Arg .

HY-P5168AS

GPSVFPLAPSSK-13C6,15N2 TFA
GPSVFPLAPSSK- ¹³C₆, ¹⁵N₂ TFA is the ¹³C- and ¹⁵N-labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .

HY-156344S1

GLEWVAEIR-(Arg-13C6,15N4) TFA
GLEWVAEIR-(Arg- ¹³C₆, ¹⁵N₄) (TFA) is the peptide containing ¹³C- and ¹⁵N-labeled Arg.

HY-163426S

AFFGHYLYEVAR-(Arg-13C6,15N4)
AFFGHYLYEVAR-(Arg- ¹³C₆, ¹⁵N₄) is ¹³C and ¹⁵N labeled AFFGHYLYEVAR-(Arg) .

HY-P5201S1

VTSEGAGLQLQK-13C6,15N2 TFA
VTSEGAGLQLQK-13C6,15N2 (TFA) is the 13C- and 15N-labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA), which can be used to bind anti-drug antibodies in plasma and quantitatively analyze the therapeutic effect .

HY-163427S

FNLEALVTHTLPFEK-(Lys-13C6,15N2)
FNLEALVTHTLPFEK-(Lys- ¹³C₆, ¹⁵N₂) is ¹³C and ¹⁵N labeled FNLEALVTHTLPFEK-(Lys) .

HY-156343S1

SNNYATHYAESVK-(Lys-13C6,15N2) TFA
SNNYATHYAESVK-(Lys- ¹³C₆, ¹⁵N₂) (TFA) is the peptide containing ¹³C- and ¹⁵N-labeled Lys.

HY-156341S1

LLIYYTSSLHSGVPSR-(Arg-13C6,15N4) TFA
LLIYYTSSLHSGVPSR-(Arg- ¹³C₆, ¹⁵N₄) (TFA) is the peptide containing ¹³C- and ¹⁵N-labeled Arg.

HY-P0090S

Calcitonin-13C6,15N4 (salmon) TFA
Calcitonin- ¹³C₆, ¹⁵N₄ (salmon) (Salmon calcitonin- ¹³C₆, ¹⁵N₄) TFA is ¹³C and ¹⁵N-labeled Calcitonin (salmon) (HY-P0090). Calcitonin (salmon) , a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption .

HY-P0119S

Lixisenatide (Leu-13C6,15N) TFA

Lixisenatide (Leu- ¹³C₆, ¹⁵N) TFA is the ¹³C- and ¹⁵N-labeled Lixisenatide (HY-P0119). Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of pro-inflammatory cytokines, and suppresses of the Akt-MEK1/2 signaling pathway. Lixisenatide can inhibit oxidative stress, mitochondrial dysfunction and apoptosis. Lixisenatide can be used for the researches of inflammation, metabolic disease, neurological disease and cardiovascular disease, such as rheumatoid arthritis, diabetes, Alzheimer's disease and atherosclerosis .

HY-P1938S1

*Cyclo(Pro-Val)-d4*
Cyclo(Pro-Val)-d₄ is the deuterium labeled Cyclo(Pro-Val) (HY-N11615). Cyclo(Pro-Val) can be isolated from Pseudomonas fluorescens GcM5-1A and has cytotoxicity .

HY-176179S

*LFFAADHLV(Val-13C5,15N)CE*
LFFAADHLV(Val- ¹³C₅, ¹⁵N)CE is the ¹³C- and ¹⁵N-labeled LFFAADHLVCE.

HY-159046S

*ASGITFSNSGMHW(Val-13C5,15N)R TFA*
ASGITFSNSGMHW(Val-13C5,15N)R TFA is an isotope of ASGITFSNSGMHWVR TFA labeled with ¹³C and ¹⁵N .

HY-P60515S1

*NQVSLWC-(Leu-13C6,15N)-(Val-13C5,15N)-K TFA*
NQVSLWC-(Leu- ¹³C₆, ¹⁵N)-(Val- ¹³C₅, ¹⁵N)-K TFA is the ¹³C- and ¹⁵N-labeled NQVSLWCK TFA.

HY-P60514S1

*NQVS-(Leu-13C6,15N)-SCA-(Val-13C5,15N)-K TFA*
NQVS-(Leu- ¹³C₆, ¹⁵N)-SCA-(Val- ¹³C₅, ¹⁵N)-K TFA is the ¹³C- and ¹⁵N-labeled NQVSSCAK TFA.

HY-P60516S

*ASQDISSA-(Leu-13C6,15N)-(Val-13C5,15N)-WYQQKPGK TFA*
ASQDISSA-(Leu- ¹³C₆, ¹⁵N)-(Val- ¹³C₅, ¹⁵N)-WYQQKPGK TFA is the ¹³C- and ¹⁵N-labeled ASQDISSAWYQQKPGK TFA.

HY-176277S

*Fibrinopeptide B, human-(Val-13C5,15N, Arg-13C6,15N4) TFA*
Fibrinopeptide B, human-(Val- ¹³C₅, ¹⁵N, Arg- ¹³C₆, ¹⁵₄) TFA is the ¹³C- and ¹⁵N-labeled Fibrinopeptide B, human (HY-P1493). Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin .

HY-173090S

VAVVR(pT)PPK(pS)PSSAK-(Lys-13C6,15N2) TFA
VAVVR(pT)PPK(pS)PSSAK-(Lys- ¹³C₆, ¹⁵N₂) TFA is the ¹³C- and ¹⁵N-labeled VAVVR(pT)PPK(pS)PSSAK-(Lys) TFA.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-78736G

Val-Cit-PAB-OSBT	ADC Linker	Cancer
Val-Cit-PAB-OSBT GMP is a GMP grade Val-Cit-PAB-OSBT (HY-78736). Val-Cit-PAB-OSBT is a degradable ADC linker, which is composed of the polypeptide Val-Cit-PAB and OSBT groups coupled together .

HY-100374G

Val-Cit-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
Val-Cit-PAB-MMAE GMP is a GMP grade Val-Cit-PAB-MMAE (HY-100374). Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

HY-12362G

Val-cit-PAB-OH	ADC Linker	Cancer
Val-cit-PAB-OH GMP is a GMP grade Val-cit-PAB-OH (HY-12362). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Val-cit-PAB-OH is a degradable ADC linker.

HY-19318G

Fmoc-Val-Cit-PAB	ADC Linker	Cancer
Fmoc-Val-Cit-PAB GMP is a GMP grade Fmoc-Val-Cit-PAB (HY-19318). Fmoc-Val-Cit-PAB is a cleavable antibody-conjugated active molecule (ADC) commonly used linker.

HY-20336G

Mc-Val-Cit-PABC-PNP	ADC Linker	Cancer
Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-78738G

MC-Val-Cit-PAB	ADC Linker	Cancer
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

HY-15575G

VcMMAE MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
VcMMAE (MC-Val-Cit-PAB-MMAE) (GMP) is VcMMAE (HY-15575) produced by using GMP guidelines. VcMMAE is a drug-linker conjugate for ADC .

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