CDK2 - cyclin dependent kinase 2 Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 100855704

About CDK2

Primary_assembly 10: 307,694-312,540 forward strand.ROS_Cfam_1.0:CM025109.1

This gene has 4 transcripts (splice variants), 203 orthologues and 25 paralogues.

CDK2 Products (4)

mRNA Protein Name
XM_038678951.1 XP_038534879.1 cyclin-dependent kinase 2 isoform X2
XM_038678952.1 XP_038534880.1 cyclin-dependent kinase 2 isoform X3
XM_038678950.1 XP_038534878.1 cyclin-dependent kinase 2 isoform X1
XM_038678953.1 XP_038534881.1 cyclin-dependent kinase 2 isoform X4

CDK2 Protein Structure

STKc_CDK2_3

STKc_CDK2_3: cd07860 (2 - 333)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16297A Abemaciclib Inhibitor 99.97% Yes
HY-10492 Dinaciclib Inhibitor 99.80% Yes
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-B0402 Amantadine Inhibitor 99.90% Unkown
HY-B0402A Amantadine hydrochloride Inhibitor 98.0% Yes
HY-B0263 Thiabendazole 99.94% Unkown
HY-B1165 Cyproheptadine (hydrochloride sesquihydrate) 99.74% Unkown
HY-B0402B Amantadine sulfate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name Effect
Purity Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.73% Phase 4
HY-112272 Lerociclib Inhibitor 96.42% Phase 3
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-10005 Flavopiridol Inhibitor 99.72% Phase 2
HY-30237 (R)-Roscovitine Inhibitor 99.53% Phase 2
HY-137894A Tagtociclib hydrate Inhibitor 99.73% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-101212 Fadraciclib Inhibitor 99.77% Phase 2
HY-10006 Flavopiridol Hydrochloride Inhibitor 99.73% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Phase 2
HY-10424 Milciclib Inhibitor 99.89% Phase 2
HY-103712 Samuraciclib Inhibitor 99.55% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.16% Phase 2
HY-15163 Zotiraciclib Inhibitor 99.88% Phase 2
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Phase 2
HY-50940A AT7519 TFA Inhibitor 99.75% Phase 2
HY-X0009A Tambiciclib dimaleate Inhibitor 99.53% Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10008 SNS-032 Inhibitor 99.91% Phase 1
HY-138293 SY-5609 Inhibitor 99.93% Phase 1
HY-141680 CPS2 Inhibitor 99.33% Phase 1
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-12871B Atuveciclib Inhibitor 99.75% Phase 1
HY-15504 RGB-286638 Inhibitor 99.67% Phase 1
HY-111361 FN-1501 Inhibitor 98.72% Phase 1
HY-137443 Ipivivint Inhibitor 99.95% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.09% Phase 1

Pre-clinical Phase

Bioactive Molecules (242)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12529 Ro-3306 Inhibitor 99.83% Unkown
HY-124719 hSMG-1 inhibitor 11j Inhibitor 99.82% Unkown
HY-12302 Kenpaullone Inhibitor 98.20% Unkown
HY-103248 Toyocamycin Inhibitor 99.27% Unkown
HY-101257 YKL-5-124 Inhibitor 99.53% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.39% Unkown
HY-15339 CVT-313 Inhibitor 99.90% Unkown
HY-114177 Ebvaciclib Inhibitor 99.98% Unkown
HY-124760 hSMG-1 inhibitor 11e Inhibitor 99.94% Unkown
HY-18340 (R)​-​CR8 Inhibitor 99.52% Unkown
HY-122609 XO44 99.38% Unkown
HY-15004 AUZ 454 Inhibitor 99.15% Unkown
HY-18930 NU6300 Inhibitor 98.44% Unkown
HY-18299A Purvalanol A Inhibitor 98.61% Unkown
HY-15275 BMS-265246 Inhibitor 99.59% Unkown
HY-130665 TL12-186 Inhibitor 99.23% Unkown
HY-130709 PROTAC CDK2/9 Degrader-1 Degrader 99.85% Unkown
HY-127104 FMF-04-159-2 Inhibitor 99.64% Unkown
HY-13914 Roniciclib Inhibitor 98.00% Unkown
HY-163814 CDK2 degrader 1 Degrader 99.74% Unkown
HY-108359 Alsterpaullone Inhibitor 99.85% Unkown
HY-15166 (E/Z)-Zotiraciclib Inhibitor 99.96% Unkown
HY-18629 SU9516 Inhibitor 99.85% Unkown
HY-15878 LDC000067 Inhibitor 99.00% Unkown
HY-144117 GFB-12811 Inhibitor 98.04% Unkown
HY-11009 CGP60474 Inhibitor 98.90% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-13461A PHA-767491 hydrochloride Inhibitor 99.49% Unkown
HY-117535 CDK2-IN-4 Inhibitor 99.85% Unkown
HY-W019806 Lacto-N-fucopentaose I Activator 99.92% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-18340A (R)-CR8 trihydrochloride Inhibitor 99.37% Unkown
HY-13461 PHA-767491 Inhibitor 99.97% Unkown
HY-X0150 JSH-150 Inhibitor 98.36% Unkown
HY-176444 CDK2 degrader 6 Degrader 99.81% Unkown
HY-N0260 Epmedin C Inhibitor 99.47% Unkown
HY-18299 Purvalanol B Inhibitor 97.0% Unkown
HY-123772 CDK5 inhibitor 20-223 Inhibitor 99.62% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-16559 Riviciclib hydrochloride 99.08% Unkown
HY-112626 CDK12-IN-2 Inhibitor 99.36% Unkown
HY-112358 GW8510 Inhibitor 99.04% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.93% Unkown
HY-119940 MC180295 Inhibitor 98.07% Unkown
HY-108136A Bisindolylmaleimide X hydrochloride Antagonist 98.90% Unkown
HY-145694 CDK5-IN-3 Inhibitor 99.49% Unkown
HY-103647 K00546 Inhibitor 99.48% Unkown
HY-164664 CDK2-IN-30 Inhibitor 98.40% Unkown
HY-175842 CDK2 degrader 7 Degrader 99.51% Unkown
HY-162919 YK-2168 Inhibitor 98.05% Unkown
HY-164827 CDK2 degrader 3 Degrader 99.91% Unkown
HY-170442 ECI830 Inhibitor 98.01% Unkown
HY-120497 PKCζ-IN-1 Inhibitor 99.1% Unkown
HY-50914 AZD5597 Inhibitor 98.09% Unkown
HY-151071 TMX-3013 Inhibitor 98.02% Unkown
HY-101257B YKL-5-124 TFA Inhibitor 99.74% Unkown
HY-15889 AMG 925 Inhibitor 99.02% Unkown
HY-W011428 Olomoucine Inhibitor 99.88% Unkown
HY-15166A (E/Z)-Zotiraciclib hydrochloride Inhibitor 99.90% Unkown
HY-N5072 Desmethylglycitein Inhibitor 99.99% Unkown
HY-112403 (S)-Roscovitine Inhibitor 99.15% Unkown
HY-169912 CDK2 degrader 5 Degrader 99.17% Unkown
HY-155218 TMX-2172 Degrader 99.38% Unkown
HY-148214 CDK2/4/6-IN-2 Inhibitor 98.20% Unkown
HY-N0699 Daphnoretin Inhibitor 99.83% Unkown
HY-139329 CDK12-IN-6 Inhibitor 99.15% Unkown
HY-151069 TMX-2039 Inhibitor 99.42% Unkown
HY-142076 CDK4/6-IN-15 Inhibitor 99.32% Unkown
HY-13816 NU6027 Inhibitor 98.01% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.94% Unkown
HY-N7045 Isosilybin B Inhibitor 99.32% Unkown
HY-N1465 Aristolochic acid D Inhibitor 99.74% Unkown
HY-159805 CDK2-IN-31 Inhibitor 98.22% Unkown
HY-107419 NU6140 Inhibitor 99.53% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-15166B (E/Z)-Zotiraciclib citrate Inhibitor 99.83% Unkown
HY-154851 GSK-3 inhibitor 3 Inhibitor 99.10% Unkown
HY-14372 BS-194 Inhibitor 99.13% Unkown
HY-169910 CDK2 degrader 4 Inhibitor 99.71% Unkown
HY-112462 Cdk1/2 Inhibitor III Inhibitor 99.69% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.71% Unkown
HY-112460 CDK2-IN-3 Inhibitor 95.12% Unkown
HY-100600 BGG463 Inhibitor 98.0% Unkown
HY-123045 PNU-292137 Inhibitor 99.95% Unkown
HY-41076 Ca2+ channel agonist 1 Inhibitor 98.87% Unkown
HY-100429 CAN508 Inhibitor 99.71% Unkown
HY-157516 CDK2-IN-22 Inhibitor 98.64% Unkown
HY-136726 CGP-82996 Inhibitor 98.12% Unkown
HY-155787 SHR5428 Inhibitor 99.80% Unkown
HY-19316 NU2058 Inhibitor 99.66% Unkown
HY-45661 Inixaciclib Inhibitor 99.93% Unkown
HY-119715 AG-012986 Inhibitor 99.78% Unkown
HY-176444A (R)-CDK2 degrader 6 Degrader 99.55% Unkown
HY-139328 CDK12-IN-5 Inhibitor 98.03% Unkown
HY-103646 CK7 Inhibitor 99.72% Unkown
HY-117393 Bisindolylmaleimide III Inhibitor 98.95% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.88% Unkown
HY-179688 PROTAC CDK2/4 Degrader-1 Degrader / Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-201330 GDC-4198 Inhibitor / Unkown
HY-168440 Aurora-A ligand 1 Ligand 98.75% Unkown
HY-170897 CDK2-IN-40 Inhibitor 99.80% Unkown
HY-119979 Cardanol monoene 98.02% Unkown
HY-114903 (E/Z)-BIO-acetoxime Inhibitor 99.9% Unkown
HY-154852 GSK-3 inhibitor 4 Inhibitor 99.02% Unkown
HY-139011 IV-361 Inhibitor 99.60% Unkown
HY-112468 PNU112455A hydrochloride Inhibitor 99.56% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-12843 Bohemine Inhibitor 98.93% Unkown
HY-15889A AMG 925 (HCl) Inhibitor / Unkown
HY-112346 RGB-286147 Inhibitor 98.60% Unkown
HY-100035 PT-262 Inhibitor 99.21% Unkown
HY-148868A Akt1&PKA-IN-2 Inhibitor / Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-164906 TMX-2138 Degrader / Unkown
HY-161708 PROTAC FLT3/CDKs degrader-1 Degrader / Unkown
HY-185121 PROTAC CDK2/4/6 Degrader-2 Degrader / Unkown
HY-158170 CDK7-IN-28 Inhibitor / Unkown
HY-170820 XYD049 Inhibitor 99.46% Unkown
HY-148868 Akt1&PKA-IN-1 Inhibitor / Unkown
HY-149636 Multi-target kinase inhibitor 2 Inhibitor 99.82% Unkown
HY-112450 Olomoucine II Inhibitor 98.0% Unkown
HY-111207 CA224 Inhibitor 99.94% Unkown
HY-151409 CDK1-IN-5 Inhibitor / Unkown
HY-151407 CDK1-IN-3 Inhibitor / Unkown
HY-143497 HDAC1/2 and CDK2-IN-1 Inhibitor / Unkown
HY-151436 ZLMT-12 Inhibitor / Unkown
HY-110368 BS-181 dihydrochloride Inhibitor / Unkown
HY-130981 FN-1501-propionic acid / Unkown
HY-130001 CDK9-IN-9 Inhibitor / Unkown
HY-173348 BLINK15 Inhibitor / Unkown
HY-146253 CDK1/2/4-IN-1 Inhibitor / Unkown
HY-173310 CDK2-IN-44 Inhibitor / Unkown
HY-161595 CDK5-IN-4 Inhibitor / Unkown
HY-161463 CDK2-IN-28 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-139651 CDK2-IN-7 Inhibitor / Unkown
HY-112471 TrkA Inhibitor Inhibitor / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-128491 UNC10112785 Inhibitor / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-160556 RLY-2139 Inhibitor / Unkown
HY-144811 CDK2-IN-9 Inhibitor / Unkown
HY-150573 CDK2-IN-12 Inhibitor / Unkown
HY-180242 EGFR/CDK2-IN-5 Inhibitor / Unkown
HY-15570 NU6301 Inhibitor / Unkown
HY-171826 PROTAC CDK2/4/6 Degrader-1 Inhibitor / Unkown
HY-180355 SY-5102 Inhibitor / Unkown
HY-173347 BLINK11 Inhibitor / Unkown
HY-180546 CDK2-IN-53 Inhibitor / Unkown
HY-178168 ARUK2010694 Inhibitor / Unkown
HY-162416 CDK7-IN-27 Inhibitor / Unkown
HY-183273 BRD4/AKT-IN-1 Inhibitor / Unkown
HY-162619 CDK9-IN-33 Inhibitor / Unkown
HY-155602 CDK2-IN-18 Inhibitor / Unkown
HY-178157 Multi-target kinase-IN-7 Inhibitor / Unkown
HY-139327 CDK12-IN-4 Inhibitor / Unkown
HY-145867 EGFR-IN-45 Inhibitor / Unkown
HY-177957 CDK2-IN-52 Inhibitor / Unkown
HY-10793 CDK2-IN-56 Inhibitor / Unkown
HY-182986 LS-Q2 Inhibitor / Unkown
HY-149407 Multi-kinase-IN-4 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-170441 CDK2-IN-36 Inhibitor / Unkown
HY-162528 CDK12-IN-7 Inhibitor / Unkown
HY-168067 CDK-IN-14 Inhibitor / Unkown
HY-180157 CDK2-IN-51 Inhibitor / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-147771 ZLWT-37 Inhibitor / Unkown
HY-186126 CDK2 modulator 1 Modulator / Unkown
HY-160941 CDK2-IN-29 Inhibitor / Unkown
HY-183789 CDK2-IN-59 Inhibitor / Unkown
HY-W1047040 CDK2/4 ligand 1 Inhibitor / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-161776 P-gp/CDK2-IN-1 Inhibitor / Unkown
HY-182789 VEGFR2-IN-86 Inhibitor / Unkown
HY-119831 Rohitukine Inhibitor / Unkown
HY-147698 ZLHQ-5f Inhibitor / Unkown
HY-180630 CDK2-IN-54 Inhibitor / Unkown
HY-181838 CIRc-014 Inhibitor / Unkown
HY-182734 BMS-357075 Inhibitor / Unkown
HY-181620 CDK2 degrader 9 Degrader / Unkown
HY-178084 CDK2 ligand-3 / Unkown
HY-172128 NUAK1-IN-2 Inhibitor / Unkown
HY-178142 Multi-kinase-IN-7 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-173224 CDK2/PIM1-IN-1 Inhibitor / Unkown
HY-186132 PROTAC CDK2-pRb degrader-1 Degrader / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-181645 CDK12-IN-9 Inhibitor / Unkown
HY-182752 CDK1-IN-9 Inhibitor / Unkown
HY-148651 CDK2-IN-15 Inhibitor / Unkown
HY-181116 Anticancer agent 298 / Unkown
HY-181501 CDK2/4/6-IN-3 Inhibitor / Unkown
HY-172153 CDK2-IN-41 Inhibitor / Unkown
HY-111356 IIIM-290 Inhibitor / Unkown
HY-178112 CDK2-IN-47 Inhibitor / Unkown
HY-176718 VEGFR-2-IN-69 Inhibitor / Unkown
HY-183710 CDK9-IN-50 Inhibitor / Unkown
HY-176124 CDK2 ligand-2 Ligand / Unkown
HY-148213 CDK2/4/6-IN-1 Inhibitor / Unkown
HY-111932 Indirubin-5-sulfonate Inhibitor / Unkown
HY-179022 CAIX/CDK-2-IN-1 Inhibitor / Unkown
HY-112363 Aloisine A Inhibitor / Unkown
HY-183854 AG-12286 Inhibitor / Unkown
HY-145693 CDK5-IN-2 Inhibitor / Unkown
HY-168845 CDK2/9-IN-1 Inhibitor / Unkown
HY-170965 Anticancer agent 264 Inhibitor / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-123034 CDKI-83 Inhibitor / Unkown
HY-179231 CDK2-IN-50 Inhibitor / Unkown
HY-151580S CDK2-IN-14-d3 Inhibitor / Unkown
HY-183146 CDK2-IN-57 Inhibitor / Unkown
HY-141685 3-Methylthienyl-carbonyl-JNJ-7706621 Inhibitor / Unkown
HY-172872 CDK2-IN-45 Inhibitor / Unkown
HY-151408 CDK1-IN-4 Inhibitor / Unkown
HY-178756 CDK2-IN-48 Inhibitor / Unkown
HY-178171 ARUK2010489 Inhibitor 96.64% Unkown
HY-168513 ALK-IN-29 Inhibitor / Unkown
HY-176282 CDK8-IN-19 Inhibitor / Unkown
HY-144810 CDK2-IN-8 Inhibitor / Unkown
HY-181906 ZnPc-PEG2-VH032 Inhibitor / Unkown
HY-182605 NU6310 Inhibitor / Unkown
HY-176281 PI3Kα-IN-26 Inhibitor / Unkown
HY-156470 Multi-kinase-IN-6 Inhibitor / Unkown
HY-115943 Anticancer agent 30 Inhibitor / Unkown
HY-173203 CDK2-IN-43 Inhibitor / Unkown
HY-182470 AG-012986 dihydrochloride Inhibitor / Unkown
HY-155441 CDK2-IN-20 Inhibitor / Unkown
HY-180817 CDK2-IN-55 Inhibitor 98.91% Unkown
HY-159155 CDK2/4-IN-1 Inhibitor / Unkown
HY-150570 Carbonic anhydrase inhibitor 14 Inhibitor / Unkown
HY-161690 EF-4-177 Inhibitor / Unkown
HY-151984 CDK9-IN-22 Inhibitor / Unkown
HY-179633 ZLMT-72 Inhibitor / Unkown
HY-19926A GDC-0425 hydrochloride Inhibitor / Unkown
HY-183529 Antitrypanosomal agent 31 Inhibitor / Unkown
HY-183534 CDK2-IN-58 Inhibitor / Unkown
HY-160643 CDK2-IN-27 Inhibitor / Unkown
HY-123826 CCT68127 Inhibitor / Unkown
HY-160185 CDK2-IN-21 Inhibitor / Unkown
HY-11001A PHA-793887 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CDK2 NCBI NCBI:1017
Mus musculus CDK2 NCBI NCBI:12566