Topics

Characteristic Interleukin Family Cytokines In Various Inflammatory Models

Chronic Inflammation Inflammation Initiation Complex Intercellular Communication & Diseases Tumor Microenvironment

Interleukin family cytokines define inflammatory models because they translate tissue injury, infection, barrier stress, and immune-cell activation into recognizable cytokine signatures. IL-1 family cytokines mark innate inflammation; IL-6 connects acute-phase responses, immune activation, and chronic inflammatory disease; IL-23 and IL-17 characterize Th17-driven inflammation; IL-10 provides counter-regulatory anti-inflammatory control. This framework explains why interleukin profiling remains central to inflammatory disease biology, biomarker discovery, and cytokine-targeted therapeutics[1][2][3][4].

In inflammasome-rich and innate immune models, IL-1β and IL-18 dominate early inflammatory amplification, while IL-33 acts through ST2 to induce type 2-associated cytokines. IL-1 family signaling uses receptor complexes, MyD88-dependent pathways, and downstream inflammatory transcriptional programs, linking sterile injury, infection, autoinflammation, rheumatic disease, and mucosal inflammation. IL-6 is produced after infection or tissue injury and drives acute-phase proteins, hematopoiesis, immune reactions, chronic inflammation, and autoimmunity when synthesis becomes persistent[1][2][5][6].

In autoimmune and barrier-tissue inflammatory models, the IL-23-IL-17 axis identifies chronic neutrophilic and tissue-destructive inflammation. IL-23 promotes IL-17-producing T-cell responses, and IL-17 family cytokines induce chemokines that recruit myeloid cells, especially neutrophils. These mechanisms support research models of psoriasis, spondyloarthritis, inflammatory bowel disease, inflammatory arthritis, and host defense at epithelial barriers. IL-10-producing immune cells restrain excessive inflammation by limiting overactive responses to pathogens and microbiota, making IL-10 essential for interpreting resolution, tolerance, and chronic inflammatory relapse[3][4][7].

Drug discovery now treats characteristic interleukins as model-specific targets rather than interchangeable inflammatory markers. IL-1 blockade supports autoinflammatory disease research; IL-6 pathway inhibitors are effective in rheumatoid arthritis and are being extended to other acute and chronic inflammatory settings; IL-17 and IL-23 inhibitors validate cytokine-axis targeting in selected immune-mediated inflammatory diseases. Remaining gaps include separating protective cytokine activity from pathological inflammation, defining tissue-specific cytokine hierarchies, and predicting when blockade of one interleukin will redirect disease through another inflammatory pathway[6][8][9].

Articles

All
  • All
  • Scientific Reviews
  • EDM
  • Blog
Most Recent
  • Most Recent
  • Oldest

Products

All
  • All
  • Inhibitors & Agonists
  • Isotope-Labeled Compounds
  • Peptides
  • Recombinant Proteins
  • Antibodies
  • Screening Libraries
  • Kits
  • Inhibitory Antibodies
  • Reference Standards
  • Induced Disease Models Products
  • Biochemical Assay Reagents
  • Natural Products
Cat. No. Product Name Information Application Publication
HY-11109 Resatorvid
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases.
Toll-like Receptor (TLR)   TNF Receptor   Interleukin Related   Autophagy  
Prostate Cancer   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
536
HY-B2176 ATP
ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice.

Source: widespread

Endogenous Metabolite   NOD-like Receptor (NLR)   Interleukin Related   Bacterial  
Infection   Inflammation or Immune System Disease   Metabolic or Endocrine Disease  
178
HY-B0240 Disulfiram
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu2+ increases intracellular ROS levels and induces cuproptosis.
Aldehyde Dehydrogenase (ALDH)   Interleukin Related   Pyroptosis   Apoptosis   Cuproptosis  
Metabolic or Endocrine Disease   Breast Cancer   Prostate Cancer   Pancreatic Cancer   Ovarian Cancer   Viral Infection   Depression   Pain   Autoimmune Disease   Digestive System Inflammation   SARS-CoV-2 Infection  
161
HY-100573 Necrosulfonamide
Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.
Mixed Lineage Kinase   Necroptosis   Pyroptosis   Caspase   NOD-like Receptor (NLR)   Keap1-Nrf2   TNF Receptor   Interleukin Related   NO Synthase   Heme Oxygenase (HO)  
Digestive System Disease   Prostate Cancer   Leukemia/Lymphoma/Myeloma   Depression   Digestive System Inflammation   Cardiovascular Disease   Parkinson's Disease   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
147
HY-L007 Immunology/Inflammation Compound Library
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation. MCE designs a unique collection of 8,643 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

Signaling Pathway Targeting Libraries

89
HY-14519 Methotrexate
Methotrexate (Amethopterin; CL14377; WR19039) is an orally active antifolate (Antifolate). Methotrexate inhibits dihydrofolate reductase (DHFR), blocks tetrahydrofolate production, suppresses purine/pyrimidine synthesis and transmethylation, and causes intracellular accumulation of AICAR. Methotrexate promotes extracellular adenosine release, regulates the cytokine network, and inhibits the alarmin function of HMGB1. Methotrexate induces apoptosis and cytotoxicity, upregulates the expression of iNOS and COX-2, suppresses hippocampal neurogenesis, and induces pulmonary fibrosis. Methotrexate is used in the research of various immune and inflammation-related diseases such as arthritis, psoriasis, systemic lupus erythematosus, as well as pulmonary fibrosis and breast cancer.
Antifolate   Dihydrofolate reductase (DHFR)   NO Synthase   COX   Interleukin Related  
Breast Cancer   Arthritis   Systemic Lupus Erythematosus   Psoriasis   Lung Fibrosis  
87
HY-L008 JAK/STAT Compound Library
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 738 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Signaling Pathway Targeting Libraries

86
HY-L014 NF-κB Signaling Compound Library
Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. MCE owns a unique collection of 1,801 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Signaling Pathway Targeting Libraries

85
HY-L046 Anti-Cardiovascular Disease Compound Library
Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels which include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, etc. CVDs are the number 1 cause of death globally. Smoking, unhealthy nutrition, aging population, lack of physical activity, arterial hypertension, or diabetes can promote cardiovascular disease like myocardial infarction or stroke. It is multifactorial and encompasses a multitude of mechanisms, such as eNOS uncoupling, reactive oxygen species formation, chronic inflammatory disorders and abnormal calcium homeostasis. Antioxidant, anti-inflammatory and anti-diabetes agents may reduce the cardiovascular disease risk. MCE supplies a unique collection of 2,468 compounds with confirmed anti-cardiovascular activity. These compounds mainly target metabolic enzyme, membrane transporter, ion channel, inflammation related signaling pathways. MCE Anti-Cardiovascular Disease Compound Library can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.

Disease Focused Libraries

84
HY-L114 Anti-inflammatory Traditional Chinese Medicine Active Compound Library
Inflammation promotes physiological and pathological processes by the activation of the immune system, local vascular system, and various cells within the damaged tissue. Accumulating epidemiological and clinical evidence shows that chronic inflammation is causally linked to various human diseases, including cerebrovascular, cardiovascular, joint, cutaneous, pulmonary, blood, liver, and intestinal diseases as well as diabetes. Various natural products from Traditional Chinese Medicine (TCM) have been shown to safely suppress proinflammatory pathways and control inflammation-associated disease. MCE designs a unique collection of 1,665 Traditional Chinese Medicine active compounds with anti-inflammatory activity, which are derived from Coptis chinensis, Radix isatidis, Flos Lonicerae, Forsythia suspensa, etc. MCE Anti-inflammatory Traditional Chinese Medicine Active Compound Library is a useful tool for discovery anti-inflammatory drugs from TCM.

Disease Focused Libraries Traditional Chinese Medicine Libraries

84
HY-L097 Animal Disease Model Inducer Library
Animal disease models are used in a variety of settings in basic research, such as studies on mechanisms of disease progression and evaluation new drugs. Animal models can be broadly classified into five categories: 1) experimental, 2) spontaneous, 3) negative, 4) orphan, 5) genetically engineered. Experimental models, which are induced artificially in the laboratory, are most common. Some small molecular compounds are usually used as inducers for animal models, such as Ceruletide for inflammatory model, Azoxymethane for tumor model. These inducers are useful tool in building animal models. MCE offers a unique collection of 52 animal model inducers, involving inflammatory model, tumor model, nervous disease model, etc. MCE Animal Disease Model library is a powerful tool for the establishment of animal disease models.

Compound Characteristic Classified Libraries

83
HY-L156 Autoimmune Disease Compound Library
Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A). MCE designs a unique collection of 1,040 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

Disease Focused Libraries

83
HY-L161 Cytokine Inhibitors Library
Cytokines are a kind of low molecular soluble proteins synthesized and secreted by immunogen, mitogen or other factors. They have functions of regulating innate and adaptive immune responses, promoting hematopoiesis, stimulating cell activation, proliferation and differentiation. The process of releasing a large number of cytokines is also called “Cytokine storm”, which can cause damage to many tissues and organs in the body. Cytokine is involved in the pathogenesis of many human diseases, including cancer, diabetes, chronic inflammatory diseases and so on. Cytokine inhibitors are a class of essential compounds that act by directly inhibiting the synthesis and release of cytokine or blocking the binding of cytokine to their receptors. Cytokine inhibitors are important compounds for the study of tumor and autoimmune diseases. MCE designs a unique collection of 1,416 cytokine inhibitors, mainly targeting the receptor interleukin (IL), colony-stimulating factor (CSF), interferon (IFN), tumor necrosis factor (TNF), growth factor (GF) and chemokine, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases and anti-autoimmune diseases compounds.

Signaling Pathway Targeting Libraries

83
HY-L164 Serine/Threonine Kinase Inhibitor Library
Protein serine/threonine kinases (PSKs) are protein kinases that use ATP as a high-energy donor molecule to transfer phosphate groups to serine/threonine residues of target protein. As an important signal transduction regulator, serine/threonine kinases can affect the function of target proteins by disrupting enzyme activity or binding of target proteins to other proteins. Serine/threonine kinases are involved in the regulation of immune response, cell proliferation, differentiation, apoptosis and other physiological processes. Serine/threonine kinase inhibitors are an important class of compounds that have been widely studied in cancer, chronic inflammation, autoimmune diseases, aging and other diseases. MCE designs a unique collection of 2,276 serine/threonine kinase inhibitors, mainly targeting the receptor PKA, Akt, PKC, MAPK/ERK, etc, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases, anti-autoimmune diseases and anti-aging compounds.

Signaling Pathway Targeting Libraries

83
HY-L175 Inflammasomes related Compound Library
Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response. MCE designs a unique collection of 178 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.

Compound Characteristic Classified Libraries

83
HY-107202 Polyinosinic-polycytidylic acid
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis.
RIG-I-like receptor (RLR)   Toll-like Receptor (TLR)   PKD   HSP   Bcl-2 Family   Interleukin Related   Apoptosis  
Infection   Digestive System Disease   Prostate Cancer   Pain   Digestive System Inflammation   Lung Fibrosis   Rheumatoid Arthritis  
73
HY-108841 Raleukin
Raleukin (Kineret) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin significantly reduces neutrophil accumulation in blood vessels and brain infarct volume as well as improves motor coordination performance in ischemic stroke mice model. Anakinra can be used to study chronic inflammatory disorders like rheumatoid arthritis and cardiovascular recurrence post-myocardial infarction.

Species: Human

Interleukin Related  
Metastatic Breast Cancer   SARS-CoV-2 Infection   Rheumatoid Arthritis  
57
HY-B1081A Oxidopamine hydrobromide
Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. Oxidopamine hydrobromide is a widely used neurotoxin and selectively destroys dopaminergic neurons. Oxidopamine hydrobromide promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion. Oxidopamine hydrobromide can be used for the research of Parkinson’s disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.
Dopamine Receptor   Autophagy   Mitophagy   COX   PGE synthase   Interleukin Related   p38 MAPK   Apoptosis   Caspase  
Breast Cancer   Parkinson's Disease  
50
HY-P9926 Dupilumab
Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease   Breast Cancer   Non-Small Cell Lung Cancer   Staphylococcus Aureus Infection  
9
HY-W250978 Ovalbumins
Ovalbumins are the major proteins in egg white. Ovalbumins act as an allergen and inducer, and can be applied to mouse models of allergic diseases. Ovalbumins can induce allergic rhinitis in mice via sensitization and nasal challenge. Ovalbumins can be used to establish asthma models.
Ovalbumin, low endotoxin (HY-W250978A) is recommended for model establishment.
Interleukin Related   IFNAR  
Allergic Asthma   Allergic Rhinitis  
6
HY-N3029 Noreugenin
Noreugenin is a phenolic compound found in Calea uniflora Less. Noreugenin inhibits myeloperoxidase activity and reduces levels of proinflammatory cytokines IL-1β and IL-17A levels in LPS (HY-D1056)-induced murine pleurisy model. Noreugenin reduces apoptosis and necrosis. Noreugenin reduces lipid peroxidation, and antioxidant enzyme (CAT, SOD, GST) activity. Noreugenin exhibits anti-inflammatory and antioxidant effects. Noreugenin can be used for the research of inflammatory conditions, such as pleurisy.
Interleukin Related   Apoptosis   Glutathione Peroxidase   SOD   Glutathione S-transferase   Necroptosis  
Experimental Autoimmune Encephalomyelitis   Experimental Autoimmune Encephalomyelitis  
2
HY-P99550 Tozorakimab
Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
2
HY-P10935 Amilo-5MER
Amilo-5MER (5-MP) is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). Amilo-5MER is promising for research of autoimmune diseases and chronic inflammatory diseases.
Amyloid-β   Interleukin Related  
Inflammation or Immune System Disease  
1
HY-P10935A Amilo-5MER TFA
Amilo-5MER (5-MP) TFA is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER TFA specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER TFA reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). Amilo-5MER TFA is promising for research of autoimmune diseases and chronic inflammatory diseases.
Amyloid-β   Interleukin Related  
Inflammation or Immune System Disease  
1
HY-N2908 Atraric acid
Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases.

Source: Stereocaulon japonicum

Environmental Pollutants   p38 MAPK   Androgen Receptor   NF-κB   NO Synthase  
Lung Cancer   Breast Cancer   Prostate Cancer   Gastric Cancer   Liver Cancer   Leukemia/Lymphoma/Myeloma   Pancreatic Cancer   Ovarian Cancer   Neurodegenerative Disease   Depression   Pain   Digestive System Inflammation   Obesity   Lung Fibrosis   Rheumatoid Arthritis  
1
HY-P78315 IL-17B Protein, Mouse (His)
IL-17B is a proinflammatory cytokine and stimulates the release of tumour necrosis factor alpha (TNFα) and IL-1β. IL-17B plays an important role in cancer progression, angiogenesis, and inflammatory arthritis. IL-17B Protein, Mouse (His) is a recombinant mouse IL-17B protein with His tag at the N-terminus and is expressed in E. coli. It consists of 160 amino acids (H21-F180).

Species: Mouse; Source: E. coli

Cytokines and Growth Factors Interleukin & Receptors IL-17 IL-17B

1
HY-P7214 IL-20 Protein, Human
IL-20 Protein, Human is a member of the IL-10 family of cytokines. Interleukin-20 binds to the IL-20 heterodimeric receptor with a Kd of 1.5 nM.

Species: Human; Source: E. coli

Cytokines and Growth Factors Interleukin & Receptors IL-20

1
HY-N2908R Atraric acid (Standard)
Atraric acid (Standard) is the analytical standard of Atraric acid. This product is intended for research and analytical applications. Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases[1][2].
Reference Standards   Androgen Receptor   NO Synthase   p38 MAPK   NF-κB  
Cancer   Inflammation or Immune System Disease  
/
HY-B0966S Dioxybenzone-d3
Dioxybenzone-d3 is deuterium labeled Dioxybenzone. Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study.
Isotope-Labeled Compounds   Biochemical Assay Reagents  
Cancer   Inflammation or Immune System Disease  
/
HY-P991633 TQC2938
TQC2938 is a humanized IgG2 monoclonal antibody inhibitor targeting Stimulation-2 (ST2). TQC2938 inhibits the ST2/IL-33 signaling pathway, reduces the level of downstream Th2 cytokines (such as IL-4, IL-5, and IL-13) and eosinophils as well as other inflammatory cells. TQC2938 can be used for inflammatory diseases like asthma research.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P991274 BMS-986010
BMS-986010 is a monoclonal antibody inhibitor targeting the p19 subunit of interleukin-23 (IL-23). BMS-986010 reduces IL-23-induced STAT3 phosphorylation and inhibits Th17 cell differentiation and the release of proinflammatory cytokines (such as IL-17 and TNF-α). BMS-986010 is promising for research of autoimmune diseases such as psoriasis and Crohn's disease.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P3728 Interleukin II (60-70)
Interleukin II (60-70) is a 60-70 fragment of the cytokine Interleukin II polypeptide.
Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P10796 YARA peptide
YARA peptide, a cell-penetrating peptide, is a MK2 inhibitor. YARA-loaded nanoparticles decreases the levels of inflammatory cytokines (IL-1β, IL-6, and TNF-α) in an ex vivo skin culture model. YARA peptide is promising for research of atopic dermatitis (AD).
MAPKAPK2 (MK2)  
Inflammation or Immune System Disease  
/
HY-P10631 gp96-II
Gp96-II is a gp96-blocking peptide that antagonizes gp96-mediated LPS(HY-D1056)-induced cytokine production. Gp96-II can be utilized in research on inflammatory disease.
HSP  
Inflammation or Immune System Disease  
/
HY-P3831 β-Interleukin II (44-56)
β-Interleukin II (44-56) is a 44-56 fragment of beta-interleukin II polypeptide. Interleukin family are a group of cytokines associated with immune system, mainly expressed by leukocytes.
Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P991467 RG-7258
RG-7258 is a human monoclonal antibody (mAb) targeting CRLF2. RG-7258 blocks dendritic cell activation and mast cell cytokine release. RG-7258 reduces Th2 inflammation in a non-human primate model of allergic lung inflammation. RG-7258 can be used in asthma research.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P991263 SCH-900117
SCH-900117 is a humanized monoclonal antibody inhibitor targeting interleukin-17A (IL-17A). SCH-900117 is promising for research of autoimmune diseases such as psoriasis and rheumatoid arthritis.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P11208 mNLS-CPP-WSTF
mNLS-CPP-WSTF is a nuclear localization signal (NLS)-cell-penetrating peptide based on the mouse WSTF sequence. mNLS-CPP-WSTF significantly inhibits the GABARAP-WSTF interaction, WSTF degradation and inflammatory gene expression. mNLS-CPP-WSTF effectively attenuates chronic inflammation, liver fibrosis and cartilage damage in metabolic-dysfunction-associated steatohepatitis (MASH) and osteoarthritis (OA) mice model. mNLS-CPP-WSTF is promising for research of chronic inflammatory diseases such as MASH and OA.
GABA Receptor  
Inflammation or Immune System Disease  
/
HY-P4720 Interleukin-6 fragment (human)
Interleukin-6 fragment (human) is a pleiotropic cytokine produced by lymphocytes and non-lymphocytes. The Interleukin-6 fragment (human) coding gene is located on human chromosome 7, with a length of approximately 5 kilobases. Interleukin-6 fragment (human) has potential applications in immune response, acute response, inflammation, tumors, and hematopoiesis.
Interleukin Related  
Cancer   Inflammation or Immune System Disease  
/
HY-177130S Socrodeucitinib
Socrodeucitinib (Compound Example 58) is an orally active and selective tyrosine kinase 2 (TYK2) inhibitor with an IC50 value of 1.41 nM. Socrodeucitinib exerts anti-inflammatory activity by inhibiting TYK2-mediated cytokine signaling pathways and reducing the secretion of inflammatory factors. Socrodeucitinib is promising for research of autoimmune diseases such as psoriasis and inflammatory diseases.
JAK  
Inflammation or Immune System Disease  
/
HY-P991275 CNTO4088
CNTO4088 is a monoclonal antibody inhibitor targeting interleukin-23 (IL-23). CNTO4088 is promising for research of autoimmune diseases such as psoriasis and rheumatoid arthritis.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-N15322 Polyandric acid A
Polyandric acid A is a clerodane diterpenoid that can be isolated from the Australian medicinal plant D. polyandra. Polyandric acid A attenuates pro-inflammatory cytokine secretion.
Interleukin Related  
Inflammation or Immune System Disease  
/
HY-P991129 Crusekitug
Crusekitug is a humanized monoclonal antibody targeting human interleukin 17A (IL-17A). Crusekitug specifically binds to IL-17A, blocking its signal transduction, thus exerting immunosuppressive and anti-inflammatory activities. Crusekitug is promising for research of autoimmune and inflammatory diseases, such as psoriasis and rheumatoid arthritis.

Species: Human

Interleukin Related  
Inflammation or Immune System Disease  
/
HY-W145695 Chitoheptaose
Chitoheptaose is an orally active chitooligosaccharide (degree of polymerization = 7). Chitoheptaose can be extracted from the exoskeletons of crustaceans, such as the shells of crabs, shrimps and lobsters. Chitoheptaose reduces pro-inflammatory cytokines while increasing the levels of anti-inflammatory cytokines (decreasing the levels of pro-inflammatory cytokines IL-1β, IL-17A and IFN-γ, and increasing the level of the anti-inflammatory cytokine IL-10). Chitoheptaose possesses antioxidant, anti-inflammatory and anti-Apoptotic activities. Chitoheptaose improves cardiac parameters, alleviates myocarditis injury, and exerts cardioprotective effects in a rat model of myocarditis. Chitoheptaose can be used in studies related to myocarditis.
Biochemical Assay Reagents   Apoptosis   Interleukin Related   IFNAR  
Inflammation or Immune System Disease   Cardiomyopathy  
/
HY-136512 Streptazolin
Streptazolin is an antibiotic. Streptazolin increases bacterial killing and elaboration of immunostimulatory cytokines by macrophages in vitro. Streptazolin stimulates the macrophage NF-κB pathway via PI3K signaling.

Source: Streptomyces viridochromogenes

Antibiotic  
Infection   Inflammation or Immune System Disease  
/
HY-P11208C mNLS-CPP-WSTF TFA
mNLS-CPP-WSTF TFA is the trifluoroacetate salt of mNLS-CPP-WSTF (HY-P11208). mNLS-CPP-WSTF is a nuclear localization signal (NLS)-cell-penetrating peptide based on the mouse WSTF sequence. mNLS-CPP-WSTF significantly inhibits the GABARAP-WSTF interaction, WSTF degradation and inflammatory gene expression. mNLS-CPP-WSTF effectively attenuates chronic inflammation, liver fibrosis and cartilage damage in metabolic-dysfunction-associated steatohepatitis (MASH) and osteoarthritis (OA) mice model. mNLS-CPP-WSTF is promising for research of chronic inflammatory diseases such as MASH and OA.
GABA Receptor  
Inflammation or Immune System Disease  
/
HY-P991146 Lecankitug
Lecankitug (LZM-012) is a humanized IgG1κ monoclonal antibody targeting IL-17A/F. Lecankitug exerts immunosuppressive and anti-inflammatory activities. Lecankitug can be used in the research of autoimmune and inflammatory diseases, such as psoriasis, ankylosing spondylitis, and rheumatoid arthritis.

Species: Human

Interleukin Related  
Psoriasis   Rheumatoid Arthritis   Ankylosing Spondylitis  
/
HY-P99704 Licaminlimab
Licaminlimab (OCS-02) is a single-chain anti-TNF alpha antibody fragment. TNF alpha is an inflammatory cytokine produced by macrophages and monocytes during inflammation.

Species: Human

TNF Receptor  
Inflammation or Immune System Disease  
/
HY-153701S Envudeucitinibum
Envudeucitinibum (Envudeucitinib) is a highly selective, allosteric and orally active TYK2 inhibitor binding to the JH2 domain of TYK2. Envudeucitinibum has no off-target effects on other kinases (JAK1-3). Envudeucitinibum reduces signaling and production of proinflammatory cytokines including IL-12, IL-23, IL-17, and type I interferons (IFNs). Envudeucitinibum can be used for the research of plaque psoriasis, systemic lupus erythematosus (SLE), and other immune-mediated diseases.
JAK   Interleukin Related   IFNAR   Isotope-Labeled Compounds  
Systemic Lupus Erythematosus   Psoriasis  
/
HY-P99335 Vunakizumab
Vunakizumab (Anti-Human IL17A Recombinant Antibody) is a recombinant human IgGκ monoclonal antibody and an Interleukin-17A (IL-17A) inhibitor. Vunakizumab binds to IL-17A to inhibit downstream cytokines and block inflammatory signaling. Vunakizumab can be used for the research of chronic plaque psoriasis and ankylosing spondylitis.

Species: Human

Interleukin Related  
Psoriasis   Ankylosing Spondylitis  
/
HY-P10939A Ac-DMLD-CMK TFA
Ac-DMLD-CMK TFA is a caspase 3 inhibitor and a GSDME inhibitor. Ac-DMLD-CMK TFA binds directly to the catalytic domain of caspase-3, blocks caspase-3-mediated cleavage of GSDME, inhibits the activation of caspase 3 and Gsdme in the caspase 3-Gsdme signaling pathway, and reduces the levels of pyroptosis and apoptosis as well as the expression of LDH, IL-6, IL-1β and IL-18. Ac-DMLD-CMK TFA alleviates renal function deterioration, renal tubular epithelial cell injury, inflammatory cytokine secretion, pulmonary structural damage, and chemotherapy-induced nephrotoxicity.
Caspase   Pyroptosis  
Cancer   Inflammation or Immune System Disease  
/
HY-N7696 Physalin F
Physalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection.
Apoptosis  
Digestive System Disease   Digestive System Inflammation  
/
HY-P700111AF Animal-Free IL-20 Protein, Human (His)
IL-20 protein is a proinflammatory cytokine secreted by monocytes and keratinocytes that is critical for immune responses, inflammation, hematopoiesis, and epidermal cell differentiation. It plays a key role in tissue remodeling, wound healing, and maintenance of epithelial homeostasis during infection. Animal-Free IL-20 Protein, Human (His) is the recombinant human-derived animal-FreeIL-20 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

Species: Human; Source: E. coli

Cytokines and Growth Factors Animal-free Recombinant Proteins Interleukin & Receptors IL-20

/
HY-P77964 IL-20 Protein, Mouse (HEK293, His)
IL-20 protein is secreted by monocytes and skin keratinocytes and is a proinflammatory cytokine critical for immune responses, inflammatory regulation, hematopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. IL-20 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-20 protein, expressed by HEK293 , with N-His labeled tag.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Interleukin & Receptors IL-20

/
HY-P71856 IL-17B Protein, Human
IL-17B Proteinas, crucial in cellular signaling, induces the release of pro-inflammatory cytokines, TNF-α, and IL-1β from THP-1 monocytic cells. Its role in regulating immune responses and inflammatory processes underscores its potential significance in mediating crosstalk between immune cells, contributing to overall immune homeostasis. IL-17B Protein, Human is the recombinant human-derived IL-17B protein, expressed by E. coli , with tag free.

Species: Human; Source: E. coli

Cytokines and Growth Factors Interleukin & Receptors IL-17 IL-17B

/
HY-P700198AF Animal-Free IL-20 Protein, Mouse (His)
IL-20 protein is secreted by monocytes and skin keratinocytes and is a proinflammatory cytokine critical for immune responses, inflammatory regulation, hematopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. Animal-Free IL-20 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-20 protein, expressed by E. coli , with C-His labeled tag.This product is for cell culture use only.

Species: Mouse; Source: E. coli

Cytokines and Growth Factors Animal-free Recombinant Proteins Interleukin & Receptors IL-20

/
HY-P73892 IL-20 Protein, Rat
IL-20 Protein, a pivotal immune regulatory cytokine, critically modulates immune responses. IL-20 Protein, Rat is the recombinant rat-derived IL-20 protein, expressed by E. coli , with tag free.

Species: Rat; Source: E. coli

Cytokines and Growth Factors Interleukin & Receptors IL-20

/
HY-P77963 IL-20 Protein, Mouse (HEK293, Fc)
IL-20 protein is secreted by monocytes and skin keratinocytes and is a proinflammatory cytokine critical for immune responses, inflammatory regulation, hematopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. IL-20 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-20 protein, expressed by HEK293 , with N-hFc labeled tag.

Species: Mouse; Source: HEK293

Cytokines and Growth Factors Interleukin & Receptors IL-20

/
HY-P78315Y IL-17B Protein, Mouse (His, solution)
IL-17B is a proinflammatory cytokine and stimulates the release of tumour necrosis factor alpha (TNFα) and IL-1β. IL-17B plays an important role in cancer progression, angiogenesis, and inflammatory arthritis. IL-17B Protein, Mouse (His, solution) is a recombinant mouse IL-17B protein with His tag at the N-terminus and is expressed in E. coli. It consists of 160 amino acids (H21-F180).

Species: Mouse; Source: E. coli

Cytokines and Growth Factors Interleukin & Receptors IL-17 IL-17B

/
HY-P704387 IL-20 Protein, Human (HEK293, His)
IL-20 protein is a proinflammatory cytokine secreted by monocytes and keratinocytes that is critical for immune responses, inflammation, hematopoiesis, and epidermal cell differentiation. It plays a key role in tissue remodeling, wound healing, and maintenance of epithelial homeostasis during infection. IL-20 Protein, Human (HEK293, His) is the recombinant human-derived IL-20 protein, expressed by HEK293, with N-His labeled tag.

Species: Human; Source: HEK293

Cytokines and Growth Factors Interleukin & Receptors IL-20

/
HY-P81113 IL-10 Antibody (YA3521)
IL-10 Antibody (YA3521) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-10.

Host: Rabbit; Reactivity: Human

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

/
HY-P84952 IL-10 Antibody (YA4644)
IL-10 Antibody (YA4644) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-10.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P80897 SOCS-1 Antibody
SOCS-1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to SOCS-1.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Polyclonal Antibodies Primary Antibodies

/
HY-P80328 SOCS2 Antibody (YA072)
SOCS2 Antibody (YA072) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SOCS2.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P86311 IL-10 Antibody (YA6003)
IL-10 Antibody (YA6003) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-10.

Host: Rabbit; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-P85219 IL-10 Antibody (YA4911)
IL-10 Antibody (YA4911) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to IL-10.

Host: Rabbit; Reactivity: Human, Mouse

Monoclonal Antibodies Recombinant Antibodies Flow Cytometry Antibodies Primary Antibodies

/
HY-P85715 SOCS-1 Antibody (YA5407)
SOCS-1 Antibody (YA5407) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SOCS-1.

Host: Mouse; Reactivity: Human, Mouse, Rat

Monoclonal Antibodies Primary Antibodies

/
HY-P811603 Autoimmune regulator (AIRE) Antibody
Autoimmune regulator (AIRE) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Autoimmune regulator (AIRE).

Host: Rabbit; Reactivity: Human

Polyclonal Antibodies Primary Antibodies

/
HY-P85469 SOCS-3 Antibody (YA5161)
SOCS-3 Antibody (YA5161) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SOCS-3.

Host: Mouse; Reactivity: Human, Pig

Monoclonal Antibodies Primary Antibodies

/
HY-P87554 SOCS7 Antibody (YA7238)
SOCS7 Antibody (YA7238) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SOCS7.

Host: Rabbit

Monoclonal Antibodies Recombinant Antibodies Primary Antibodies

/
HY-K2101 HOLO Human Interleukin-2 (IL-2) Detection Kit

MCE HOLO Human Interleukin-2 (IL-2) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IL-2 concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

/
HY-K2102 HOLO Human Interleukin-5 (IL-5) Detection Kit

MCE HOLO Human Interleukin-5 (IL-5) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IL-5 concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

/
HY-K2103 HOLO Human Interleukin-6 (IL-6) Detection Kit

MCE HOLO Human Interleukin-6 (IL-6) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IL-6 concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

/
HY-K2104 HOLO Human Interleukin-8 (IL-8) Detection Kit

MCE HOLO Human Interleukin-8 (IL-8) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IL-8 concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

/
HY-K2105 HOLO Human Interleukin-10 (IL-10) Detection Kit

MCE HOLO Human Interleukin-10 (IL-10) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IL-10 concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

/
HY-K2107 HOLO Human Interleukin-17A (IL-17A) Detection Kit

MCE HOLO Human Interleukin-17A (IL-17A) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IL-17A concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

/
HY-K2109 HOLO Human Interleukin-22 (IL-22) Detection Kit

MCE HOLO Human Interleukin-22 (IL-22) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IL-22 concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

/
HY-K2117 HOLO Mouse Interleukin-6 (IL-6) Detection Kit

MCE HOLO Mouse Interleukin-6 (IL-6) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of Mouse IL-6 concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

/
HY-K2118 HOLO Mouse Interleukin-2 (IL-2) Detection Kit

MCE HOLO Mouse Interleukin-2 (IL-2) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of Mouse IL-2 concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Protein Biology Immunoassay

/
HY-K6303 Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit

MCE Human iPSC/ESC Cardiomyocyte Induction Differentiation Kit is based on the classical GiWi system. By precisely modulating the Wnt/β-catenin signaling pathway in a temporally controlled manner (sequential activation and inhibition), the kit enables highly efficient directed differentiation of human pluripotent stem cells into cardiomyocytes. It is suitable for cardiac disease modeling, drug cardiotoxicity assessment, and mechanistic studies.

Cell Biology 3D Cell Culture PSC Induction Product Series

/

Keywords

interleukin cytokines, inflammatory models, IL-1, IL-6, IL-17, IL-23, IL-10, cytokine signaling, chronic inflammation, autoimmune disease