GRB2 - growth factor receptor bound protein 2 Gene

Also Known as ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2885

About GRB2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,318,076-75,405,678 (from NCBI)

This gene has 12 transcripts (splice variants), 233 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 63.6), appendix (RPKM 60.2) and 25 other tissues.

Summary

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of Other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GRB2 Products (4)

mRNA	Protein	Name
NM_002086.5	NP_002077.1	growth factor receptor-bound protein 2 isoform 1
NM_203506.3	NP_987102.1	growth factor receptor-bound protein 2 isoform 2
NM_002086.5	NP_002077.1	growth factor receptor-bound protein 2 isoform 1
NM_203506.3	NP_987102.1	growth factor receptor-bound protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IDA IDA: Inferred from direct assay	19509291	GOA
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	12925710	GOA
enables epidermal growth factor receptor binding	IPI IPI: Inferred from physical interaction	12577067	GOA
enables guanyl-nucleotide exchange factor adaptor activity	IDA IDA: Inferred from direct assay	8386805	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	12577067	GOA
enables insulin receptor substrate binding	IPI IPI: Inferred from physical interaction	8388384	GOA
enables neurotrophin TRKA receptor binding	IPI IPI: Inferred from physical interaction	15488758	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7504175	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20086093	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	7539782	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell activation	IDA IDA: Inferred from direct assay	7568038	GOA
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	8253073	GOA
involved in cellular response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	20160708	GOA
involved in epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8253073	GOA
involved in insulin receptor signaling pathway	IPI IPI: Inferred from physical interaction	8388384	GOA
involved in natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	16582911	GOA
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	20160708	GOA
involved in receptor internalization	IMP IMP: Inferred from mutant phenotype	14985334	GOA
involved in signal transduction in response to DNA damage	IMP IMP: Inferred from mutant phenotype	20160708	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	22561606	GOA
part of Grb2-EGFR complex	IDA IDA: Inferred from direct assay	20086093	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21179510	GOA
located in endosome	IDA IDA: Inferred from direct assay	21179510	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21179510	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRB2 Protein Structure

SH3_1

SH2

SH3_1

0
100
200
217 a.a.

Protein Preferred Names	Protein Names
growth factor receptor-bound protein 2	HT027

GRB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GRB2	P62993	PNMA5	Homo sapiens	Q96PV4	Validated Y2H	25416956
Intra	GRB2	P62993	HOMEZ	Homo sapiens	Q8IX15-3	Y2H Array	25416956
Intra	GRB2	P62993	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32814053
Intra	GRB2	P62993	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Pooling	32814053
Intra	GRB2	P62993	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32814053
Intra	GRB2	P62993	TP53BP2	Homo sapiens	Q13625-3	Y2H Array	25416956
Intra	GRB2	P62993	TP53BP2	Homo sapiens	Q13625-3	Y2H Prey Pooling	25416956
Intra	GRB2	P62993	FAM22F	Homo sapiens	B7ZLH0	Y2H Array	32296183
Intra	GRB2	P62993	FAM22F	Homo sapiens	B7ZLH0	Y2H Prey Pooling	25416956
Intra	GRB2	P62993	GGN	Homo sapiens	Q86UU5	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	GGN	Homo sapiens	Q86UU5	Validated Y2H	32296183
Intra	GRB2	P62993	GGN	Homo sapiens	Q86UU5	Y2H Array	32296183
Intra	GRB2	P62993	FGFR2	Homo sapiens	P21802	ITC	22726438
Intra	GRB2	P62993	FGFR2	Homo sapiens	P21802	NMR	22726438
Intra	GRB2	P62993	FGFR2	Homo sapiens	P21802	Protein Kinase Assay	22726438
Intra	GRB2	P62993	JADE2	Homo sapiens	Q9NQC1-2	Validated Y2H	32814053
Intra	GRB2	P62993	JADE2	Homo sapiens	Q9NQC1-2	Y2H Array	32814053
Intra	GRB2	P62993	JADE2	Homo sapiens	Q9NQC1-2	Y2H Pooling	32814053
Intra	GRB2	P62993	PAK2	Homo sapiens	Q13177	Filter Binding	16374509
Intra	GRB2	P62993	PAK2	Homo sapiens	Q13177	Phage Display	16374509
Intra	GRB2	P62993	PLD2	Homo sapiens	O14939	IF	17276458
Intra	GRB2	P62993	PLD2	Homo sapiens	O14939	Anti Tag CoIP	17276458
Intra	GRB2	P62993	DOCK4	Homo sapiens	Q8N1I0	Anti Tag CoIP	33961781
Intra	GRB2	P62993	DOCK4	Homo sapiens	Q8N1I0	Anti Tag CoIP	31980649
Intra	GRB2	P62993	DOCK4	Homo sapiens	Q8N1I0	Anti Tag CoIP	21706016
Intra	GRB2	P62993	SH2B1	Homo sapiens	Q9NRF2-2	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	SH2B1	Homo sapiens	Q9NRF2-2	Validated Y2H	32296183
Intra	GRB2	P62993	SH2B1	Homo sapiens	Q9NRF2-2	Y2H Array	32296183
Intra	GRB2	P62993	LMX1A	Homo sapiens	Q8TE12	Y2H Array	25814554
Intra	GRB2	P62993	LMX1A	Homo sapiens	Q8TE12	Lumier	25814554
Intra	GRB2	P62993	PARD6A	Homo sapiens	Q9NPB6-2	Y2H Array	25814554
Intra	GRB2	P62993	PARD6A	Homo sapiens	Q9NPB6-2	Validated Y2H	25814554
Intra	GRB2	P62993	PARD6A	Homo sapiens	Q9NPB6-2	Lumier	25814554
Intra	GRB2	P62993	CPSF7	Homo sapiens	Q8N684-3	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	CPSF7	Homo sapiens	Q8N684-3	Validated Y2H	32296183
Intra	GRB2	P62993	CPSF7	Homo sapiens	Q8N684-3	Y2H Array	32296183
Intra	GRB2	P62993	PLEKHA7	Homo sapiens	Q6IQ23-2	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	PLEKHA7	Homo sapiens	Q6IQ23-2	Validated Y2H	32296183
Intra	GRB2	P62993	PLEKHA7	Homo sapiens	Q6IQ23-2	Y2H Array	32296183
Intra	GRB2	P62993	LAT	Homo sapiens	O43561	CoIP	9489702
Intra	GRB2	P62993	LAT	Homo sapiens	O43561	Anti Bait CoIP	16938345
Intra	GRB2	P62993	LAT	Homo sapiens	O43561	Pull Down	10811803
Intra	GRB2	P62993	GRB10	Homo sapiens	Q13322-4	Validated Y2H	32814053
Intra	GRB2	P62993	GRB10	Homo sapiens	Q13322-4	Y2H Array	32814053
Intra	GRB2	P62993	GRB10	Homo sapiens	Q13322-4	Y2H Pooling	32814053
Intra	GRB2	P62993	ZBTB12	Homo sapiens	Q9Y330	Validated Y2H	32296183
Intra	GRB2	P62993	ZBTB12	Homo sapiens	Q9Y330	Y2H Array	32296183
Intra	GRB2	P62993	ZBTB12	Homo sapiens	Q9Y330	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	MAP4K5	Homo sapiens	Q9Y4K4	Anti Tag CoIP	21706016
Intra	GRB2	P62993	MAP4K5	Homo sapiens	Q9Y4K4	Anti Tag CoIP	33961781
Intra	GRB2	P62993	MAP4K5	Homo sapiens	Q9Y4K4	Anti Tag CoIP	28514442
Intra	GRB2	P62993	CCDC28B	Homo sapiens	Q9BUN5-3	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	CCDC28B	Homo sapiens	Q9BUN5-3	Validated Y2H	32296183
Intra	GRB2	P62993	CCDC28B	Homo sapiens	Q9BUN5-3	Y2H Array	32296183
Intra	GRB2	P62993	TBC1D3G	Homo sapiens	Q6DHY5	Y2H Array	32296183
Intra	GRB2	P62993	TBC1D3G	Homo sapiens	Q6DHY5	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	TBC1D3G	Homo sapiens	Q6DHY5	Validated Y2H	32296183
Intra	GRB2	P62993	MED19	Homo sapiens	A0JLT2-2	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	MED19	Homo sapiens	A0JLT2-2	Y2H Array	32296183
Intra	GRB2	P62993	KHDRBS1	Homo sapiens	Q07666	CoIP	9045636
Intra	GRB2	P62993	KHDRBS1	Homo sapiens	Q07666	Y2H Pooling	20936779
Intra	GRB2	P62993	KHDRBS1	Homo sapiens	Q07666	Anti Tag CoIP	21706016
Intra	GRB2	P62993	KHDRBS1	Homo sapiens	Q07666	Pull Down	11278465
Intra	GRB2	P62993	KHDRBS1	Homo sapiens	Q07666	Y2H	21988832
Intra	GRB2	P62993	KHDRBS1	Homo sapiens	Q07666	Pull Down	7537265
Intra	GRB2	P62993	KIT	Homo sapiens	P10721	FPS	24728074
Intra	GRB2	P62993	KIT	Homo sapiens	P10721	Far-WB	7523381
Intra	GRB2	P62993	KIT	Homo sapiens	P10721	Pull Down	10377264
Cross	GRB2	P62993	Dab2	Mus musculus	P98078	Pull Down	9569023
Cross	GRB2	P62993	Dab2	Mus musculus	P98078	Anti Bait CoIP	9569023
Intra	GRB2	P62993	PHETA1	Homo sapiens	Q8N4B1-4	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	PHETA1	Homo sapiens	Q8N4B1-4	Validated Y2H	32296183
Intra	GRB2	P62993	PHETA1	Homo sapiens	Q8N4B1-4	Y2H Array	32296183
Intra	GRB2	P62993	THEMIS	Homo sapiens	Q8N1K5-1	Pull Down	23460737
Intra	GRB2	P62993	SOCS7	Homo sapiens	O14512	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	SOCS7	Homo sapiens	O14512	Y2H Array	32296183
Intra	GRB2	P62993	WASF1	Homo sapiens	Q92558	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	WASF1	Homo sapiens	Q92558	Validated Y2H	32296183
Intra	GRB2	P62993	WASF1	Homo sapiens	Q92558	Y2H Array	32296183
Intra	GRB2	P62993	SHANK2	Homo sapiens	Q9UPX8	Peptide Array	17474147
Intra	GRB2	P62993	AGER	Homo sapiens	Q15109	Anti Tag CoIP	21706016
Intra	GRB2	P62993	AGER	Homo sapiens	Q15109	Peptide Array	17474147
Cross	GRB2	P62993	Sos1	Mus musculus	Q62245	Solution Sedimentation	8940013
Cross	GRB2	P62993	Sos1	Mus musculus	Q62245	SPR	8940013
Cross	GRB2	P62993	Sos1	Mus musculus	Q62245	Pull Down	9569023
Intra	GRB2	P62993	ZNF474	Homo sapiens	Q6S9Z5	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	ZNF474	Homo sapiens	Q6S9Z5	Validated Y2H	32296183
Intra	GRB2	P62993	ZNF474	Homo sapiens	Q6S9Z5	Y2H Array	32296183
Intra	GRB2	P62993	PRR5-ARHGAP8	Homo sapiens	B1AHC3	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	PRR5-ARHGAP8	Homo sapiens	B1AHC3	Y2H Array	32296183
Intra	GRB2	P62993	DLGAP1	Homo sapiens	O14490	Peptide Array	17474147
Intra	GRB2	P62993	DLGAP1	Homo sapiens	O14490	Y2H Pooling	20936779
Intra	GRB2	P62993	MAP4K3	Homo sapiens	Q8IVH8	Peptide Array	17474147
Intra	GRB2	P62993	MAP4K3	Homo sapiens	Q8IVH8	Y2H Pooling	20936779
Intra	GRB2	P62993	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
Intra	GRB2	P62993	PIK3CA	Homo sapiens	P42336	Anti Tag CoIP	28514442
Intra	GRB2	P62993	PIK3CA	Homo sapiens	P42336	Validated Y2H	32814053
Intra	GRB2	P62993	PIK3CA	Homo sapiens	P42336	Y2H Pooling	32814053
Intra	GRB2	P62993	PIK3CA	Homo sapiens	P42336	Y2H Array	32814053
Intra	GRB2	P62993	PIK3CA	Homo sapiens	P42336	Anti Tag CoIP	21706016
Intra	GRB2	P62993	PIK3CA	Homo sapiens	P42336	Anti Tag CoIP	33961781
Intra	GRB2	P62993	TMEM185A	Homo sapiens	Q8NFB2	Y2H Array	32814053
Intra	GRB2	P62993	TMEM185A	Homo sapiens	Q8NFB2	Validated Y2H	32814053
Intra	GRB2	P62993	TMEM185A	Homo sapiens	Q8NFB2	Y2H Pooling	32814053
Cross	GRB2	P62993	Zdhhc19	Mus musculus	Q810M5	Anti Tag CoIP	31462771
Intra	GRB2	P62993	DTX3	Homo sapiens	Q8N9I9	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	DTX3	Homo sapiens	Q8N9I9	Validated Y2H	32296183
Intra	GRB2	P62993	DTX3	Homo sapiens	Q8N9I9	Y2H Array	32296183
Intra	GRB2	P62993	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
Intra	GRB2	P62993	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	GRB2	P62993	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	SF3A2	Homo sapiens	Q15428	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	SF3A2	Homo sapiens	Q15428	Validated Y2H	32296183
Intra	GRB2	P62993	SF3A2	Homo sapiens	Q15428	Y2H Array	32296183
Intra	GRB2	P62993	SPATA2L	Homo sapiens	Q8IUW3	Y2H Array	32296183
Intra	GRB2	P62993	SPATA2L	Homo sapiens	Q8IUW3	Anti Tag CoIP	33961781
Intra	GRB2	P62993	SPATA2L	Homo sapiens	Q8IUW3	Anti Tag CoIP	28514442
Intra	GRB2	P62993	SPATA2L	Homo sapiens	Q8IUW3	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	SPATA2L	Homo sapiens	Q8IUW3	Validated Y2H	32296183
Intra	GRB2	P62993	VPS37C	Homo sapiens	A5D8V6	Y2H Array	32296183
Intra	GRB2	P62993	VPS37C	Homo sapiens	A5D8V6	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	PTPRA	Homo sapiens	P18433	Pull Down	11923305
Intra	GRB2	P62993	PTPRA	Homo sapiens	P18433	TAP	24189400
Intra	GRB2	P62993	PTPRA	Homo sapiens	P18433	Pull Down	7518772
Intra	GRB2	P62993	PTPRA	Homo sapiens	P18433	Anti Tag CoIP	31980649
Intra	GRB2	P62993	PTPRA	Homo sapiens	P18433	Anti Tag CoIP	35271311
Intra	GRB2	P62993	PTPRA	Homo sapiens	P18433	TAP	19380743
Intra	GRB2	P62993	PTPRA	Homo sapiens	P18433	Anti Bait CoIP	11923305
Intra	GRB2	P62993	BLNK	Homo sapiens	Q8WV28	ITC	16912232
Intra	GRB2	P62993	PLEKHS1	Homo sapiens	Q5SXH7-1	Y2H Array	25814554
Intra	GRB2	P62993	PIK3AP1	Homo sapiens	Q6ZUJ8	Anti Tag CoIP	21706016
Intra	GRB2	P62993	PIK3AP1	Homo sapiens	Q6ZUJ8	Anti Tag CoIP	33961781
Intra	GRB2	P62993	PIK3AP1	Homo sapiens	Q6ZUJ8	Anti Tag CoIP	31980649
Intra	GRB2	P62993	PIK3AP1	Homo sapiens	Q6ZUJ8	Anti Tag CoIP	28514442
Intra	GRB2	P62993	KLF15	Homo sapiens	Q9UIH9	Validated Y2H	32814053
Intra	GRB2	P62993	KLF15	Homo sapiens	Q9UIH9	Y2H Array	32814053
Intra	GRB2	P62993	KLF15	Homo sapiens	Q9UIH9	Y2H Pooling	32814053
Intra	GRB2	P62993	ARHGDIB	Homo sapiens	P52566	Y2H Array	32814053
Intra	GRB2	P62993	ARHGDIB	Homo sapiens	P52566	Y2H Pooling	32814053
Intra	GRB2	P62993	ARHGDIB	Homo sapiens	P52566	Validated Y2H	32814053
Intra	GRB2	P62993	WIPF2	Homo sapiens	Q8TF74	Anti Tag CoIP	33961781
Intra	GRB2	P62993	WIPF2	Homo sapiens	Q8TF74	Anti Tag CoIP	31980649
Intra	GRB2	P62993	WIPF2	Homo sapiens	Q8TF74	Anti Tag CoIP	28514442
Intra	GRB2	P62993	WIPF2	Homo sapiens	Q8TF74	Anti Tag CoIP	21706016
Intra	GRB2	P62993	AXL	Homo sapiens	P30530	Far-WB	9178760
Intra	GRB2	P62993	TNPO1	Homo sapiens	Q92973	Peptide Array	17474147
Intra	GRB2	P62993	ERRFI1	Homo sapiens	Q9UJM3	Anti Tag CoIP	21706016
Intra	GRB2	P62993	ERRFI1	Homo sapiens	Q9UJM3	TAP	24189400
Intra	GRB2	P62993	ERRFI1	Homo sapiens	Q9UJM3	Anti Tag CoIP	33961781
Intra	GRB2	P62993	ERRFI1	Homo sapiens	Q9UJM3	Anti Tag CoIP	21988832
Intra	GRB2	P62993	ERRFI1	Homo sapiens	Q9UJM3	Anti Tag CoIP	28514442
Intra	GRB2	P62993	ERRFI1	Homo sapiens	Q9UJM3	Anti Tag CoIP	31980649
Intra	GRB2	P62993	ERRFI1	Homo sapiens	Q9UJM3	Validated Y2H	32296183
Intra	GRB2	P62993	ERRFI1	Homo sapiens	Q9UJM3	Y2H	21988832
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	Anti Tag CoIP	28514442
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	Anti Bait CoIP	9569023
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	ITC	19323566
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	Y2H	7629138
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	SPR	7527391
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	Anti Bait CoIP	16520382
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	NMR	7773779
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	Pull Down	12577067
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	Anti Tag CoIP	31980649
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	Anti Bait CoIP	20473329
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	Peptide Array	17474147
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	Anti Tag CoIP	21706016
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	Pull Down	14679214
Intra	GRB2	P62993	SOS1	Homo sapiens	Q07889	Anti Tag CoIP	33961781
Intra	GRB2	P62993	VAV3	Homo sapiens	Q9UKW4	Validated Y2H	32296183
Intra	GRB2	P62993	VAV3	Homo sapiens	Q9UKW4	Pull Down	12577067
Intra	GRB2	P62993	VAV3	Homo sapiens	Q9UKW4	Anti Tag CoIP	21706016
Intra	GRB2	P62993	PTPN11	Homo sapiens	Q06124	Anti Tag CoIP	31980649
Intra	GRB2	P62993	PTPN11	Homo sapiens	Q06124	TAP	19380743
Intra	GRB2	P62993	PTPN11	Homo sapiens	Q06124	Pull Down	12577067
Intra	GRB2	P62993	PTPN11	Homo sapiens	Q06124	Anti Bait CoIP	20473329
Intra	GRB2	P62993	PTPN11	Homo sapiens	Q06124	Anti Bait CoIP	31585087
Intra	GRB2	P62993	PTPN11	Homo sapiens	Q06124	Anti Tag CoIP	21706016
Intra	GRB2	P62993	PTPN11	Homo sapiens	Q06124	Anti Bait CoIP	7523381
Intra	GRB2	P62993	PTPN11	Homo sapiens	Q06124	Anti Tag CoIP	33961781
Intra	GRB2	P62993	KRT8	Homo sapiens	P05787	Pull Down	12577067
Intra	GRB2	P62993	CD2AP	Homo sapiens	Q9Y5K6	TAP	19380743
Intra	GRB2	P62993	CD2AP	Homo sapiens	Q9Y5K6	Y2H Array	21988832
Intra	GRB2	P62993	CD2AP	Homo sapiens	Q9Y5K6	Anti Tag CoIP	21706016
Intra	GRB2	P62993	SOS2	Homo sapiens	Q07890	Anti Tag CoIP	28514442
Intra	GRB2	P62993	SOS2	Homo sapiens	Q07890	Anti Tag CoIP	31980649
Intra	GRB2	P62993	SOS2	Homo sapiens	Q07890	Pull Down	14679214
Intra	GRB2	P62993	SOS2	Homo sapiens	Q07890	Y2H	7629138
Intra	GRB2	P62993	SOS2	Homo sapiens	Q07890	Y2H	21988832
Intra	GRB2	P62993	SOS2	Homo sapiens	Q07890	Anti Tag CoIP	33961781
Intra	GRB2	P62993	SOS2	Homo sapiens	Q07890	Peptide Array	17474147
Intra	GRB2	P62993	SOS2	Homo sapiens	Q07890	Y2H Pooling	20936779
Intra	GRB2	P62993	SOS2	Homo sapiens	Q07890	Anti Tag CoIP	21706016
Intra	GRB2	P62993	HNRNPK	Homo sapiens	P61978	Y2H Array	25416956
Intra	GRB2	P62993	HNRNPK	Homo sapiens	P61978	Pull Down	12577067
Intra	GRB2	P62993	HNRNPK	Homo sapiens	P61978	Anti Tag CoIP	31980649
Intra	GRB2	P62993	HNRNPK	Homo sapiens	P61978	Y2H	21988832
Intra	GRB2	P62993	HNRNPK	Homo sapiens	P61978	Validated Y2H	25416956
Intra	GRB2	P62993	SYNJ2	Homo sapiens	O15056	Peptide Array	17474147
Intra	GRB2	P62993	SYNJ2	Homo sapiens	O15056	Y2H Pooling	20936779
Intra	GRB2	P62993	ASAP2	Homo sapiens	O43150	Peptide Array	17474147
Intra	GRB2	P62993	ASAP2	Homo sapiens	O43150	Anti Tag CoIP	21706016
Intra	GRB2	P62993	ASAP2	Homo sapiens	O43150	Anti Tag CoIP	33961781
Intra	GRB2	P62993	GAREM1	Homo sapiens	Q9H706	Y2H Pooling	20936779
Intra	GRB2	P62993	GAREM1	Homo sapiens	Q9H706	Anti Tag CoIP	21706016
Intra	GRB2	P62993	GAREM1	Homo sapiens	Q9H706	Anti Tag CoIP	31980649
Intra	GRB2	P62993	GAREM1	Homo sapiens	Q9H706	Validated Y2H	32296183
Intra	GRB2	P62993	GAREM1	Homo sapiens	Q9H706	Y2H Array	25416956
Intra	GRB2	P62993	WIPF1	Homo sapiens	O43516	Y2H Pooling	20936779
Intra	GRB2	P62993	WIPF1	Homo sapiens	O43516	Anti Tag CoIP	21706016
Intra	GRB2	P62993	WIPF1	Homo sapiens	O43516	Anti Tag CoIP	33961781
Intra	GRB2	P62993	WIPF1	Homo sapiens	O43516	Anti Tag CoIP	28514442
Intra	GRB2	P62993	DNM2	Homo sapiens	P50570	BFG-2H	27107012
Intra	GRB2	P62993	DNM2	Homo sapiens	P50570	Anti Tag CoIP	31980649
Intra	GRB2	P62993	DNM2	Homo sapiens	P50570	TAP	19380743
Intra	GRB2	P62993	DNM2	Homo sapiens	P50570	Anti Tag CoIP	21706016
Intra	GRB2	P62993	DNM2	Homo sapiens	P50570	Anti Tag CoIP	33961781
Intra	GRB2	P62993	ASAP1	Homo sapiens	Q9ULH1	Y2H Pooling	20936779
Intra	GRB2	P62993	ASAP1	Homo sapiens	Q9ULH1	Anti Tag CoIP	21706016
Intra	GRB2	P62993	ASAP1	Homo sapiens	Q9ULH1	Peptide Array	17474147
Intra	GRB2	P62993	ASAP1	Homo sapiens	Q9ULH1	Anti Tag CoIP	33961781
Intra	GRB2	P62993	ASAP1	Homo sapiens	Q9ULH1	Anti Tag CoIP	31980649
Intra	GRB2	P62993	ASAP1	Homo sapiens	Q9ULH1	Anti Tag CoIP	28514442
Intra	GRB2	P62993	ASAP1	Homo sapiens	Q9ULH1	TAP	19380743
Intra	GRB2	P62993	ASAP1	Homo sapiens	Q9ULH1	Y2H	21988832
Intra	GRB2	P62993	PIK3R2	Homo sapiens	O00459	Anti Tag CoIP	21706016
Intra	GRB2	P62993	PIK3R2	Homo sapiens	O00459	TAP	19380743
Intra	GRB2	P62993	LCP2	Homo sapiens	Q13094	Anti Tag CoIP	15929943
Intra	GRB2	P62993	LCP2	Homo sapiens	Q13094	Validated Y2H	25416956
Intra	GRB2	P62993	LCP2	Homo sapiens	Q13094	Y2H Prey Pooling	25416956
Intra	GRB2	P62993	LCP2	Homo sapiens	Q13094	TAP	19380743
Intra	GRB2	P62993	LCP2	Homo sapiens	Q13094	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	LCP2	Homo sapiens	Q13094	Y2H Array	32296183
Intra	GRB2	P62993	LCP2	Homo sapiens	Q13094	Y2H Pooling	20936779
Intra	GRB2	P62993	LCP2	Homo sapiens	Q13094	Pull Down	15929943
Intra	GRB2	P62993	LCP2	Homo sapiens	Q13094	Peptide Array	17235283
Intra	GRB2	P62993	LCP2	Homo sapiens	Q13094	Validated Y2H	32296183
Intra	GRB2	P62993	NELFB	Homo sapiens	Q8WX92	Peptide Array	17474147
Intra	GRB2	P62993	SF3B4	Homo sapiens	Q15427	Peptide Array	17474147
Intra	GRB2	P62993	MYH9	Homo sapiens	P35579	Pull Down	12577067
Intra	GRB2	P62993	MYH9	Homo sapiens	P35579	TAP	24189400
Intra	GRB2	P62993	FLNA	Homo sapiens	P21333	Pull Down	12577067
Intra	GRB2	P62993	PRMT5	Homo sapiens	O14744	Pull Down	12577067
Intra	GRB2	P62993	PRMT5	Homo sapiens	O14744	Validated Y2H	32814053
Intra	GRB2	P62993	PRMT5	Homo sapiens	O14744	Y2H Array	32814053
Intra	GRB2	P62993	PRMT5	Homo sapiens	O14744	Y2H Pooling	32814053
Intra	GRB2	P62993	DBN1	Homo sapiens	Q16643	Validated Y2H	25814554
Intra	GRB2	P62993	DBN1	Homo sapiens	Q16643	Pull Down	12577067
Intra	GRB2	P62993	FLNB	Homo sapiens	O75369	Pull Down	12577067
Intra	GRB2	P62993	PPP3CA	Homo sapiens	Q08209	Pull Down	12577067
Intra	GRB2	P62993	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	31980649
Intra	GRB2	P62993	HSPA5	Homo sapiens	P11021	Y2H Pooling	20936779
Intra	GRB2	P62993	HSPA5	Homo sapiens	P11021	Pull Down	12577067
Intra	GRB2	P62993	VCP	Homo sapiens	P55072	Validated Y2H	25814554
Intra	GRB2	P62993	DARS1	Homo sapiens	P14868	Peptide Array	17474147
Intra	GRB2	P62993	DARS1	Homo sapiens	P14868	TAP	19380743
Intra	GRB2	P62993	EPS8	Homo sapiens	Q12929	Y2H Array	25416956
Intra	GRB2	P62993	EPS8	Homo sapiens	Q12929	Y2H Prey Pooling	25416956
Intra	GRB2	P62993	TSPAN2	Homo sapiens	O60636	Pull Down	25814554
Intra	GRB2	P62993	TSPAN2	Homo sapiens	O60636	Validated Y2H	25814554
Intra	GRB2	P62993	TSPAN2	Homo sapiens	O60636	Y2H Array	25814554
Intra	GRB2	P62993	TSPAN2	Homo sapiens	O60636	Lumier	25814554
Intra	GRB2	P62993	SOCS4	Homo sapiens	Q8WXH5	Y2H Array	25814554
Intra	GRB2	P62993	TYRO3	Homo sapiens	Q06418	Validated Y2H	32296183
Intra	GRB2	P62993	TYRO3	Homo sapiens	Q06418	Y2H Array	32296183
Intra	GRB2	P62993	TYRO3	Homo sapiens	Q06418	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	STAMBP	Homo sapiens	O95630	Y2H Array	31515488
Intra	GRB2	P62993	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	21706016
Intra	GRB2	P62993	STAMBP	Homo sapiens	O95630	Y2H	16730941
Intra	GRB2	P62993	STAMBP	Homo sapiens	O95630	Validated Y2H	25416956
Intra	GRB2	P62993	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	33961781
Intra	GRB2	P62993	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	28514442
Intra	GRB2	P62993	STAMBP	Homo sapiens	O95630	Y2H Pooling	20936779
Cross	GRB2	P62993	Ptpn11	Mus musculus	P35235	Far-WB	7523381
Cross	GRB2	P62993	Ptpn11	Mus musculus	P35235	CoIP	7522233
Cross	GRB2	P62993	Ptpn11	Mus musculus	P35235	CoIP	8959326
Intra	GRB2	P62993	ZNF620	Homo sapiens	Q6ZNG0	Validated Y2H	32296183
Intra	GRB2	P62993	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	GRB2	P62993	DOCK1	Homo sapiens	Q14185	Peptide Array	17474147
Intra	GRB2	P62993	DOCK1	Homo sapiens	Q14185	Anti Tag CoIP	31980649
Intra	GRB2	P62993	DOCK1	Homo sapiens	Q14185	Anti Tag CoIP	33961781
Intra	GRB2	P62993	DOCK1	Homo sapiens	Q14185	Anti Tag CoIP	28514442
Intra	GRB2	P62993	GIT1	Homo sapiens	Q9Y2X7	Anti Tag CoIP	31980649
Intra	GRB2	P62993	GIT1	Homo sapiens	Q9Y2X7	Anti Tag CoIP	21706016
Intra	GRB2	P62993	FLNC	Homo sapiens	Q14315	Peptide Array	17474147
Intra	GRB2	P62993	RB1	Homo sapiens	P06400	Lumier	25814554
Intra	GRB2	P62993	RB1	Homo sapiens	P06400	BiFC	25814554
Intra	GRB2	P62993	RB1	Homo sapiens	P06400	Validated Y2H	25814554
Intra	GRB2	P62993	TRIB3	Homo sapiens	Q96RU7	Validated Y2H	32296183
Intra	GRB2	P62993	TRIB3	Homo sapiens	Q96RU7	Y2H Array	32296183
Intra	GRB2	P62993	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	MED28	Homo sapiens	Q9H204	Far-WB	15467741
Intra	GRB2	P62993	MED28	Homo sapiens	Q9H204	Anti Bait CoIP	15467741
Intra	GRB2	P62993	GAB1	Homo sapiens	Q13480	Far-WB	10913131
Intra	GRB2	P62993	GAB1	Homo sapiens	Q13480	Pull Down	10913131
Intra	GRB2	P62993	GAB1	Homo sapiens	Q13480	ITC	22536782
Intra	GRB2	P62993	GAB1	Homo sapiens	Q13480	Anti Bait CoIP	20473329
Intra	GRB2	P62993	GAB1	Homo sapiens	Q13480	TAP	19380743
Intra	GRB2	P62993	GAB1	Homo sapiens	Q13480	Anti Tag CoIP	10913131
Intra	GRB2	P62993	GAB1	Homo sapiens	Q13480	Anti Tag CoIP	33961781
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	Anti Bait CoIP	18273061
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	Anti Tag CoIP	28514442
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	Y2H Pooling	20936779
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	Pull Down	7642581
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	Competition Binding	17094785
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	Anti Bait CoIP	7642581
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	Anti Tag CoIP	7642581
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	Anti Tag CoIP	31980649
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	Anti Tag CoIP	15677445
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	TAP	19380743
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	Anti Tag CoIP	21706016
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	Lumier	25814554
Intra	GRB2	P62993	CBL	Homo sapiens	P22681	Anti Tag CoIP	33961781
Intra	GRB2	P62993	LPIN1	Homo sapiens	Q14693	Validated Y2H	32814053
Intra	GRB2	P62993	LPIN1	Homo sapiens	Q14693	Y2H Pooling	32814053
Intra	GRB2	P62993	LPIN1	Homo sapiens	Q14693	Y2H Array	32814053
Intra	GRB2	P62993	ARL6IP4	Homo sapiens	Q66PJ3-4	Lumier	25814554
Intra	GRB2	P62993	ANKRD23	Homo sapiens	Q86SG2	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	ANKRD23	Homo sapiens	Q86SG2	Validated Y2H	32296183
Intra	GRB2	P62993	ANKRD23	Homo sapiens	Q86SG2	Y2H Array	32296183
Intra	GRB2	P62993	ARHGEF5	Homo sapiens	Q12774	Anti Tag CoIP	31980649
Intra	GRB2	P62993	ARHGEF5	Homo sapiens	Q12774	TAP	24189400
Intra	GRB2	P62993	ARHGEF5	Homo sapiens	Q12774	Anti Tag CoIP	33961781
Intra	GRB2	P62993	ARHGEF5	Homo sapiens	Q12774	Y2H	21988832
Intra	GRB2	P62993	VAV1	Homo sapiens	P15498	BRET	29997244
Intra	GRB2	P62993	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	GRB2	P62993	PIK3C2B	Homo sapiens	O00750	Anti Tag CoIP	28514442
Intra	GRB2	P62993	PIK3C2B	Homo sapiens	O00750	Anti Tag CoIP	31980649
Intra	GRB2	P62993	PIK3C2B	Homo sapiens	O00750	Anti Tag CoIP	21706016
Intra	GRB2	P62993	PIK3C2B	Homo sapiens	O00750	Anti Tag CoIP	33961781
Intra	GRB2	P62993	INCA1	Homo sapiens	Q0VD86	Y2H Array	25416956
Intra	GRB2	P62993	INCA1	Homo sapiens	Q0VD86	Y2H Array	31515488
Intra	GRB2	P62993	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	25416956
Intra	GRB2	P62993	LY6G6F	Homo sapiens	Q5SQ64	Anti Bait CoIP	12852788
Intra	GRB2	P62993	LY6G6F	Homo sapiens	Q5SQ64	Anti Tag CoIP	12852788
Intra	GRB2	P62993	PTK2	Homo sapiens	Q05397	Pull Down	7597091
Intra	GRB2	P62993	REPS2	Homo sapiens	Q8NFH8	Anti Tag CoIP	18647389
Intra	GRB2	P62993	REPS2	Homo sapiens	Q8NFH8	Pull Down	18647389
Intra	GRB2	P62993	REPS2	Homo sapiens	Q8NFH8	Peptide Array	18647389
Intra	GRB2	P62993	MYG1	Homo sapiens	Q9HB07	Validated Y2H	32296183
Intra	GRB2	P62993	MYG1	Homo sapiens	Q9HB07	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	MYG1	Homo sapiens	Q9HB07	Y2H Array	32296183
Intra	GRB2	P62993	DPPA4	Homo sapiens	Q7L190	Validated Y2H	25416956
Intra	GRB2	P62993	DPPA4	Homo sapiens	Q7L190	Y2H Array	25416956
Intra	GRB2	P62993	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	GRB2	P62993	BCR	Homo sapiens	P11274	Anti Tag CoIP	33961781
Intra	GRB2	P62993	BCR	Homo sapiens	P11274	CoIP	11726515
Intra	GRB2	P62993	BCR	Homo sapiens	P11274	Pull Down	8112292
Intra	GRB2	P62993	BCR	Homo sapiens	P11274	CoIP	8112292
Intra	GRB2	P62993	BCR	Homo sapiens	P11274	Pull Down	9174058
Intra	GRB2	P62993	BCR	Homo sapiens	P11274	Anti Tag CoIP	21706016
Intra	GRB2	P62993	BCR	Homo sapiens	P11274	Anti Bait CoIP	11726515
Intra	GRB2	P62993	BCR	Homo sapiens	P11274	Pull Down	9178913
Intra	GRB2	P62993	BCR	Homo sapiens	P11274	Anti Tag CoIP	28514442
Intra	GRB2	P62993	DNM1	Homo sapiens	Q05193	Anti Tag CoIP	21706016
Intra	GRB2	P62993	DNM1	Homo sapiens	Q05193	SPR	15834155
Intra	GRB2	P62993	DNM1	Homo sapiens	Q05193	Anti Tag CoIP	31980649
Intra	GRB2	P62993	DNM1	Homo sapiens	Q05193	Anti Tag CoIP	33961781
Intra	GRB2	P62993	DNM1	Homo sapiens	Q05193	Peptide Array	17474147
Intra	GRB2	P62993	WBP11	Homo sapiens	Q9Y2W2	Y2H Prey Pooling	25416956
Intra	GRB2	P62993	WBP11	Homo sapiens	Q9Y2W2	Y2H	21988832
Intra	GRB2	P62993	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	GRB2	P62993	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	GRB2	P62993	DLGAP4	Homo sapiens	Q9Y2H0	Peptide Array	17474147
Intra	GRB2	P62993	RAB11B	Homo sapiens	Q15907	Validated Y2H	32814053
Intra	GRB2	P62993	RAB11B	Homo sapiens	Q15907	Y2H Array	32814053
Intra	GRB2	P62993	RAB11B	Homo sapiens	Q15907	Y2H Pooling	32814053
Intra	GRB2	P62993	PTPN23	Homo sapiens	Q9H3S7	Anti Tag CoIP	28514442
Intra	GRB2	P62993	PTPN23	Homo sapiens	Q9H3S7	Far-WB	21179510
Intra	GRB2	P62993	PTPN23	Homo sapiens	Q9H3S7	Pull Down	21179510
Intra	GRB2	P62993	PTPN23	Homo sapiens	Q9H3S7	IF	21179510
Intra	GRB2	P62993	PTPN23	Homo sapiens	Q9H3S7	Y2H	21179510
Intra	GRB2	P62993	PTPN23	Homo sapiens	Q9H3S7	Y2H Pooling	20936779
Intra	GRB2	P62993	PTPN23	Homo sapiens	Q9H3S7	Anti Tag CoIP	33961781
Intra	GRB2	P62993	PTPN23	Homo sapiens	Q9H3S7	Anti Bait CoIP	21179510
Intra	GRB2	P62993	PTPRT	Homo sapiens	O14522	Anti Bait CoIP	21725282
Intra	GRB2	P62993	KIAA0408	Homo sapiens	Q6ZU52	Y2H Array	32296183
Intra	GRB2	P62993	KIAA0408	Homo sapiens	Q6ZU52	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	KIAA0408	Homo sapiens	Q6ZU52	Validated Y2H	32296183
Intra	GRB2	P62993	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	GRB2	P62993	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	GRB2	P62993	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	GRB2	P62993	ZBTB7B	Homo sapiens	O15156	Y2H Prey Pooling	25416956
Intra	GRB2	P62993	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	25416956
Intra	GRB2	P62993	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	25416956
Intra	GRB2	P62993	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	25416956
Intra	GRB2	P62993	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	GRB2	P62993	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	GRB2	P62993	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	GRB2	P62993	BTG1	Homo sapiens	P62324	Y2H Array	32296183
Intra	GRB2	P62993	BTG1	Homo sapiens	P62324	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	SPRY2	Homo sapiens	O43597	Anti Tag CoIP	16893902
Intra	GRB2	P62993	CBLB	Homo sapiens	Q13191	Validated Y2H	27107012
Intra	GRB2	P62993	CBLB	Homo sapiens	Q13191	Anti Tag CoIP	21706016
Intra	GRB2	P62993	CBLB	Homo sapiens	Q13191	Anti Tag CoIP	28514442
Intra	GRB2	P62993	CBLB	Homo sapiens	Q13191	BFG-2H	27107012
Intra	GRB2	P62993	CBLB	Homo sapiens	Q13191	Pull Down	12577067
Intra	GRB2	P62993	CBLB	Homo sapiens	Q13191	Validated Y2H	25416956
Intra	GRB2	P62993	CBLB	Homo sapiens	Q13191	Y2H Array	25416956
Intra	GRB2	P62993	CBLB	Homo sapiens	Q13191	Y2H Pooling	20936779
Intra	GRB2	P62993	DDX17	Homo sapiens	Q92841	Validated Y2H	25416956
Intra	GRB2	P62993	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	32296183
Intra	GRB2	P62993	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	GRB2	P62993	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	25416956
Intra	GRB2	P62993	IKZF3	Homo sapiens	Q9UKT9	BFG-2H	27107012
Intra	GRB2	P62993	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	GRB2	P62993	ARHGAP9	Homo sapiens	Q9BRR9	Y2H Prey Pooling	25416956
Intra	GRB2	P62993	ARHGAP9	Homo sapiens	Q9BRR9	Validated Y2H	25416956
Intra	GRB2	P62993	RNF208	Homo sapiens	Q9H0X6	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	RNF208	Homo sapiens	Q9H0X6	Validated Y2H	32296183
Intra	GRB2	P62993	RNF208	Homo sapiens	Q9H0X6	Y2H Array	32296183
Intra	GRB2	P62993	ACAP1	Homo sapiens	Q15027	Y2H Array	25814554
Intra	GRB2	P62993	ACAP1	Homo sapiens	Q15027	Validated Y2H	25814554
Intra	GRB2	P62993	ADAM15	Homo sapiens	Q13444	Filter Binding	16374509
Intra	GRB2	P62993	ADAM15	Homo sapiens	Q13444	Pull Down	11741929
Intra	GRB2	P62993	PTPN6	Homo sapiens	P29350	Far-WB	25535246
Intra	GRB2	P62993	PTPN6	Homo sapiens	P29350	Anti Tag CoIP	25535246
Intra	GRB2	P62993	PTPN6	Homo sapiens	P29350	Y2H	10660620
Intra	GRB2	P62993	PPARA	Homo sapiens	Q07869	Lumier	25814554
Intra	GRB2	P62993	PPARA	Homo sapiens	Q07869	Y2H Array	25814554
Intra	GRB2	P62993	TXK	Homo sapiens	P42681	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	TXK	Homo sapiens	P42681	Y2H Array	32296183
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	Pull Down	9175774
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	Anti Tag CoIP	21706016
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	CoIP	12485888
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	NMR	10356320
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	Anti Tag CoIP	15688026
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	Anti Tag CoIP	33961781
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	TAP	24189400
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	SPR	8663178
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	Anti Bait CoIP	19380743
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	Anti Tag CoIP	31980649
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	TAP	19380743
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	Anti Bait CoIP	21725358
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	ITC	9254595
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	Anti Tag CoIP	35271311
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	Pull Down	15688026
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	BiFC	25416956
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	Pull Down	12577067
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353	Pull Down	8939605
Intra	GRB2	P62993	PLCG1	Homo sapiens	P19174	Anti Tag CoIP	21706016
Intra	GRB2	P62993	PIK3R1	Homo sapiens	P27986	Anti Tag CoIP	21706016
Intra	GRB2	P62993	PIK3R1	Homo sapiens	P27986	Pull Down	16219545
Intra	GRB2	P62993	PIK3R1	Homo sapiens	P27986	MAPPIT	25416956
Intra	GRB2	P62993	PIK3R1	Homo sapiens	P27986	TAP	19380743
Intra	GRB2	P62993	PIK3R3	Homo sapiens	Q92569	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	PIK3R3	Homo sapiens	Q92569	Validated Y2H	32296183
Intra	GRB2	P62993	PIK3R3	Homo sapiens	Q92569	Anti Tag CoIP	21706016
Intra	GRB2	P62993	PIK3R3	Homo sapiens	Q92569	Y2H Array	32296183
Intra	GRB2	P62993	EPHB1	Homo sapiens	P54762	Pull Down	8798570
Intra	GRB2	P62993	FANCA	Homo sapiens	O15360	Peptide Array	17474147
Intra	GRB2	P62993	SHC1	Homo sapiens	P29353-1	Anti Bait CoIP	16520382
Intra	GRB2	P62993	MAP4K1	Homo sapiens	Q92918	Peptide Array	17474147
Intra	GRB2	P62993	MAP4K1	Homo sapiens	Q92918	Y2H	9346925
Intra	GRB2	P62993	q7z783_human	Homo sapiens	Q7Z783	Validated Y2H	32296183
Intra	GRB2	P62993	q7z783_human	Homo sapiens	Q7Z783	Y2H Array	32296183
Intra	GRB2	P62993	q7z783_human	Homo sapiens	Q7Z783	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	ZNF341	Homo sapiens	Q9BYN7	Validated Y2H	32296183
Intra	GRB2	P62993	ZNF341	Homo sapiens	Q9BYN7	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	ZNF341	Homo sapiens	Q9BYN7	Y2H Array	32296183
Intra	GRB2	P62993	ANK2	Homo sapiens	Q01484	Peptide Array	17474147
Intra	GRB2	P62993	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	GRB2	P62993	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	GRB2	P62993	ARID5A	Homo sapiens	Q03989	Validated Y2H	32296183
Intra	GRB2	P62993	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	GRB2	P62993	BECN1	Homo sapiens	Q14457	Anti Bait CoIP	38182563
Intra	GRB2	P62993	BECN1	Homo sapiens	Q14457	Y2H Pooling	32814053
Intra	GRB2	P62993	BECN1	Homo sapiens	Q14457	Validated Y2H	32814053
Intra	GRB2	P62993	BECN1	Homo sapiens	Q14457	Y2H Array	32814053
Intra	GRB2	P62993	WASL	Homo sapiens	O00401	Anti Tag CoIP	21706016
Intra	GRB2	P62993	WASL	Homo sapiens	O00401	Validated Y2H	27107012
Intra	GRB2	P62993	WASL	Homo sapiens	O00401	BFG-2H	27107012
Intra	GRB2	P62993	WASL	Homo sapiens	O00401	Anti Tag CoIP	33961781
Intra	GRB2	P62993	WASL	Homo sapiens	O00401	Validated Y2H	25416956
Intra	GRB2	P62993	WASL	Homo sapiens	O00401	Anti Tag CoIP	28514442
Intra	GRB2	P62993	WASL	Homo sapiens	O00401	Y2H Array	25416956
Intra	GRB2	P62993	WASL	Homo sapiens	O00401	Peptide Array	17474147
Intra	GRB2	P62993	WASL	Homo sapiens	O00401	Anti Tag CoIP	31980649
Intra	GRB2	P62993	PTPN1	Homo sapiens	P18031	Anti Tag CoIP	31980649
Intra	GRB2	P62993	GAB2	Homo sapiens	Q9UQC2	Y2H Array	31515488
Intra	GRB2	P62993	GAB2	Homo sapiens	Q9UQC2	TAP	19380743
Intra	GRB2	P62993	GAB2	Homo sapiens	Q9UQC2	Anti Tag CoIP	33961781
Intra	GRB2	P62993	GAB2	Homo sapiens	Q9UQC2	Anti Tag CoIP	21706016
Intra	GRB2	P62993	GAB2	Homo sapiens	Q9UQC2	Validated Y2H	32296183
Cross	GRB2	P62993	lspA1	Haemophilus ducreyi	Q7VLE8	Pull Down	24902122
Cross	GRB2	P62993	Irs1	Rattus norvegicus	P35570	Far-WB	10660596
Cross	GRB2	P62993	Irs1	Rattus norvegicus	P35570	Pull Down	8491186
Cross	GRB2	P62993	polg_hcv77	Hepatitis C virus	P27958	Pull Down	14993658
Cross	GRB2	P62993	polg_hcvj4	Hepatitis C virus	O92972	ELISA	15784897
Cross	GRB2	P62993	polg_hcvj4	Hepatitis C virus	O92972	Pull Down	14993658
Cross	GRB2	P62993	P26662-PRO_0000037647	Hepatitis C virus	P26662-PRO_0000037647	Anti Bait CoIP	10318918

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GRB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70396	Grb2 Protein, Human (His)	P62993-1 (M1-V217)	≥ 95%, as determined by reducing SDS-PAGE.

GRB2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80147	GRB2 Antibody (YA747)	WB, IHC-P, ICC/IF	Human, Rat
HY-P80695	GRB2 Antibody (YA748)	WB	Human, Mouse, Rat
HY-P80695A	GRB2 Antibody (YA748)(PBS only)	WB	Human, Mouse, Rat
HY-P85536	GRB2 Antibody (YA5228)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Hepatitis E
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Immunodeficiency 45	IMD45
Pancreatic Adenocarcinoma	Adenocarcinoma Of The Pancreas Adenocarcinoma Of Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma
Speech Disorder	Speech Disorders
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Congenital Generalized Lipodystrophy	Berardinelli-Seip Congenital Lipodystrophy Berardinelli-Seip Syndrome Brunzell Syndrome Bscl Generalized Lipodystrophy Lipodystrophy, Congenital Generalized Seip Syndrome Total Lipodystrophy Cgl Lipoatrophic Diabetes Lipodystrophy, Generalized, Congenital Familial Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 2 Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Hydrocele	Testicular Hydrocele
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Skin Granular Cell Tumor	Granular Cell Neoplasm Of The Skin Granular Cell Tumor Of Skin Granular Cell Tumour Of Skin Skin Granular Cell Tumour
Autosomal Dominant Intellectual Developmental Disorder 8	Autosomal Dominant Non-Syndromic Intellectual Disability 8 Mental Retardation, Autosomal Dominant 8 Autosomal Dominant Mental Retardation 8 Mrd8
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Cowden Syndrome 6	CWS6 Cowden Syndrome, Type 6
Noonan Syndrome With Multiple Lentigines	Leopard Syndrome Multiple Lentigines Syndrome Moynahan Syndrome Cardiomyopathic Lentiginosis Progressive Cardiomyopathic Lentiginosis Cardio-Cutaneous Syndrome Lentiginosis Profusa Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome Generalized Lentiginosis Gorlin Syndrome Ii Lentiginosis Profusa Syndrome Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes Diffuse Lentiginosis Nsml Familial Multiple Lentigines Syndrome Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type Progressive Cardiomyopathic Lentiginosis Syndrome Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Mitochondrial Complex Iii Deficiency, Nuclear Type 2	Mitochondrial Complex Iii Deficiency Nuclear Type 2 MC3DN2 Mitochondrial Complex Ii Deficiency, Nuclear Type 3 MC2DN3 Mitochondrial Complex 2 Deficiency, Nuclear Type 3 Mitochondrial Complex Iii Deficiency, Nuclear 2
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N14349	Asterriquinone	Inhibitor	/	Phase 3
HY-153495	Prexigebersen		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153495A	Prexigebersen sodium	Inhibitor	98.95%	Unkown
HY-129800	CGP78850	Inhibitor	99.47%	Unkown
HY-146127A	Grb2 SH2 domain inhibitor 1 TFA	Inhibitor	99.62%	Unkown
HY-146127	Grb2 SH2 domain inhibitor 1	Inhibitor	98.24%	Unkown
HY-RS05780	GRB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17407	Grb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23861	Grb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GRB2	VGNC	VGNC:67457
Bos taurus	GRB2	VGNC	VGNC:29631
Canis familiaris	GRB2	VGNC	VGNC:41472
Macaca mulatta	GRB2	VGNC	VGNC:99157
Mus musculus	GRB2	MGD	MGI:95805
Rattus norvegicus	GRB2	RGD	RGD:619758
Others	GRB2	NCBI