2. Gene
  3. Gcgr - glucagon receptor Gene

Gcgr - glucagon receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as GR

Gene ID: 14527 | Gene type: protein coding

About Gcgr

Chromosome 11: 120,421,525-120,429,812 forward strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 184 orthologues, 41 paralogues and is associated with 63 phenotypes. Biased expression in liver adult (RPKM 145.3), liver E18 (RPKM 21.1) and 4 other tissues.

Summary

Enables Glucagon Receptor activity. Involved in several processes, including cellular response to glucagon stimulus; glucose homeostasis; and regulation of glycogen metabolic process. Acts upstream of or within cellular response to starvation and positive regulation of gene expression. Predicted to be located in endosome. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; foot mesenchyme; gut; liver; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (Glucagon Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Gcgr Products(1)

mRNA Protein Name
NM_008101.2 NP_032127.2 glucagon receptor precursor

Gcgr Protein Structure

HRM

HRM: pfam02793 (55 - 124)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (136 - 416)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (140 - 165)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (174 - 196)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (225 - 252)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (264 - 284)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (300 - 329)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (345 - 370)

7tmB1_GCGR

7tmB1_GCGR: cd15267 (379 - 404)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
Protein Preferred Names Protein Names

glucagon receptor

GL-R

Recombinant Gcgr Proteins

Cat. No. Product Name Accession Purity
HY-P78702 GCGR/Glucagon receptor Protein, Mouse (HEK293, Fc) Q61606 (A27-K137) ≥95%

Related Agents

Approval
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114118 Semaglutide Agonist 99.84% Unkown
HY-13443 Exendin-4 Agonist 99.94% Yes
HY-P0014 Liraglutide Agonist 99.82% Unkown
HY-P0082 Glucagon (1-29), bovine, human 99.84% Unkown
HY-114118A Semaglutide TFA Agonist 99.92% Unkown
HY-P0119 Lixisenatide Agonist 99.93% Unkown
HY-P0119A Lixisenatide acetate Agonist 99.65% Unkown
Clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Phase
HY-P3463 Beinaglutide 99.74% Phase 4
HY-13443A Exendin-4 acetate Agonist 99.67% Phase 4
HY-P3506 Retatrutide Agonist 99.89% Phase 3
HY-112185 Orforglipron Agonist 99.57% Phase 3
HY-P3506A Retatrutide TFA Agonist 99.31% Phase 3
HY-P3375 Mazdutide Agonist 99.74% Phase 3
HY-P2221B Glepaglutide acetate Agonist 98.47% Phase 3
HY-P0165 Taspoglutide Agonist 99.51% Phase 3
HY-P3366 Ecnoglutide Agonist 98.61% Phase 3
HY-P2221 Glepaglutide Agonist / Phase 3
HY-P3506B Retatrutide acetate Agonist / Phase 3
HY-P3375A Mazdutide TFA Agonist / Phase 3
HY-P0264 Exendin(9-39) amide Antagonist 99.81% Phase 2
HY-50663 MK 0893 Antagonist 99.86% Phase 2
HY-19904 Adomeglivant Antagonist 98.18% Phase 2
HY-P2231A Cotadutide acetate Agonist 98.88% Phase 2
HY-P4146 Survodutide Agonist 99.98% Phase 2
HY-19947 PF-06291874 Antagonist 99.18% Phase 2
HY-12525 LGD-6972 Antagonist ≥98.0% Phase 2
HY-P4146A Survodutide TFA Agonist 99.62% Phase 2
HY-P10018 Bamadutide Agonist / Phase 2
HY-P3498 Elsiglutide Agonist / Phase 2
HY-P2231 Cotadutide Agonist / Phase 2
HY-P10031 SAR441255 Agonist / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99383 Volagidemab Antagonist 98.43% Phase 2
HY-P99357 Crotedumab Inhibitor 96.61% Phase 1
Pre-clinical Phase
Bioactive Molecules (95)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0055 GLP-1(7-37) 99.82% Unkown
HY-P0054 GLP-1(7-36), amide acetate 96.58% Unkown
HY-P0055A GLP-1(7-37) acetate 99.63% Unkown
HY-103546 BETP Agonist 99.28% Unkown
HY-10930 UNC0321 Inhibitor 99.80% Unkown
HY-101116 GLP-1R Antagonist 1 Antagonist 99.84% Unkown
HY-125824 Danuglipron Agonist 98.63% Unkown
HY-P1141 GLP-1(9-36)amide Antagonist 99.78% Unkown
HY-P1024 GLP-2(1-33)(human) Agonist 98.73% Unkown
HY-P1144 Oxyntomodulin (bovine, porcine) Agonist 99.91% Unkown
HY-153865 Lotiglipron Agonist 99.68% Unkown
HY-124622 NNC-0640 Modulator 98.10% Unkown
HY-121835 GLP-1R agonist 2 Agonist 99.94% Unkown
HY-P0054B GLP-1(7-36), amide TFA 98.04% Unkown
HY-P2625 GLP-2(3-33) Agonist 99.88% Unkown
HY-103547 L-168049 Antagonist 99.93% Unkown
HY-50159 Glucagon receptor antagonists-3 Antagonist 98.52% Unkown
HY-P1348 GLP-1 moiety from Dulaglutide 95.02% Unkown
HY-142162 LSN3318839 Modulator 99.81% Unkown
HY-N0630 Shanzhiside methyl ester Agonist 99.32% Unkown
HY-P3291 Dapiglutide Agonist 96.01% Unkown
HY-50158 Glucagon receptor antagonists-2 Antagonist 98.93% Unkown
HY-116819A VU0453379 hydrochloride Modulator ≥99.0% Unkown
HY-141839 GLP-1R modulator C16 Modulator 99.60% Unkown
HY-112679 GLP-1 receptor agonist 2 Agonist 98.70% Unkown
HY-141842 GLP-1R modulator L7-028 Modulator 98.77% Unkown
HY-P1145A Glucagon-like peptide 1 (1-37), human TFA Agonist 95.21% Unkown
HY-129658A TT-OAD2 Agonist 99.59% Unkown
HY-P3102 GLP-1(32-36)amide 98.42% Unkown
HY-141840 GLP-1R modulator C5 Modulator 99.60% Unkown
HY-P0150 Glucagon (19-29), human Inhibitor 98.15% Unkown
HY-50675 GRA Ex-25 Inhibitor 98.59% Unkown
HY-P1143A [Des-His1,Glu9]-Glucagon amide TFA Antagonist 99.62% Unkown
HY-P3101 GLP-1(28-36)amide 98.79% Unkown
HY-144035 GLP-1R agonist 4 Agonist 98.26% Unkown
HY-112185A Orforglipron hemicalcium hydrate Agonist / Unkown
HY-P1160 Bay 55-9837 Agonist 99.08% Unkown
HY-148844 GCGR antagonist 2 Antagonist 99.76% Unkown
HY-P10032A NN1177 TFA Agonist / Unkown
HY-116819 VU0453379 Modulator ≥98.0% Unkown
HY-P2497 Exendin (5-39) Antagonist 99.81% Unkown
HY-P1231 GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 99.03% Unkown
HY-P1226 HAEGTFTSD Agonist 98.48% Unkown
HY-P1224 HAEGTFTSDVS 98.31% Unkown
HY-144034 GLP-1R agonist 3 Agonist 99.15% Unkown
HY-119739 Skyrin Antagonist / Unkown
HY-147622 GLP-1R agonist 9 Agonist / Unkown
HY-10036 Glucagon receptor antagonists-1 Antagonist 98.65% Unkown
HY-P3622 (Ser8)-GLP-1 (7-36) amide, human Agonist / Unkown
HY-P0054A GLP-1(7-36), amide Agonist / Unkown
HY-145412 GLP-1 receptor agonist 7 98.41% Unkown
HY-P1228 HAEGTFT 99.63% Unkown
HY-P5815A GLP-1 (1-36) amide (human, rat) (TFA) 98.81% Unkown
HY-P1229 FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 98.01% Unkown
HY-P1223 Exendin-3/4 (59-86) 98.19% Unkown
HY-P1225 {Val1}-Exendin-3/4 99.45% Unkown
HY-N2452 Cochinchinenin C Agonist / Unkown
HY-145458 GLP-1 receptor agonist 9 Agonist / Unkown
HY-138996 GLP-1 receptor agonist 8 Agonist / Unkown
HY-128781 Glucagon receptor antagonists-5 Antagonist / Unkown
HY-P1145 Glucagon-like peptide 1 (1-37), human Agonist / Unkown
HY-P5578 A8SGLP-1 Agonist / Unkown
HY-P10019 Pegsebrenatide Agonist / Unkown
HY-P1141A GLP-1(9-36)amide TFA Antagonist / Unkown
HY-P0212A Neuropeptide Y, porcine TFA / Unkown
HY-144135 GLP-1R agonist 7 Agonist / Unkown
HY-P3542 Des His1, Glu8 Exendin-4 Antagonist / Unkown
HY-P5161A FC382K10W15 TFA Agonist / Unkown
HY-P1143 [Des-His1,Glu9]-Glucagon amide Antagonist / Unkown
HY-P3539 Exendin-4 (3-39) / Unkown
HY-P5074 GRPP (human) Agonist / Unkown
HY-P10341 ZP3022 Agonist / Unkown
HY-124803 GPCR modulator-1 Modulator / Unkown
HY-144134 GLP-1R agonist 6 Agonist / Unkown
HY-P3616 Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide / Unkown
HY-129656 GLP-1 receptor agonist 3 Agonist / Unkown
HY-P10032 NN1177 Agonist / Unkown
HY-144136 GLP-1R agonist 8 Agonist / Unkown
HY-P4672 (Met(O)27)-Glucagon (1-29) (human, rat, porcine) / Unkown
HY-P5815 GLP-1 (1-36) amide (human, rat) / Unkown
HY-P1144A Oxyntomodulin (bovine, porcine) (TFA) Agonist / Unkown
HY-153476 GIP/GLP-1 dual receptor agonist-1 Agonist / Unkown
HY-144033 GLP-1R agonist 1 Agonist / Unkown
HY-129658 TT-OAD2 free base Agonist / Unkown
HY-P3102A GLP-1(32-36)amide TFA / Unkown
HY-148212 GLP-1R agonist 17 Agonist / Unkown
HY-P1160A Bay 55-9837 TFA / Unkown
HY-P0082A Glucagon (1-29), bovine, human hydrochloride / Unkown
HY-144133 GLP-1R agonist 5 Agonist / Unkown
HY-P3621 Biotinyl-Glucagon (1-29), human, bovine, porcine / Unkown
HY-129657 GLP-1 receptor agonist 4 Agonist / Unkown
HY-P3101A GLP-1(28-36)amide TFA / Unkown
HY-P3388 Utreglutide Agonist 98.42% Unkown
HY-P3608 [Des-His1,Glu9] Glucagon Antagonist / Unkown
HY-P5578A A8SGLP-1 TFA Agonist / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990013 Gulgafafusp alfa Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gcgr NCBI NCBI:2642