Maoa - monoamine oxidase A Gene

Also Known as 1110061B18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17161

About Maoa

Chromosome X: 16,485,937-16,554,057 forward strand.GRCm39:CM001013.3

This gene has 1 transcript (splice variant), 147 orthologues, 9 paralogues and is associated with 28 phenotypes. Broad expression in large intestine adult (RPKM 27.2), colon adult (RPKM 1.2) and 19 other tissues.

Summary

Enables primary amine oxidase activity. Acts upstream of or within dopamine catabolic process and positive regulation of signal transduction. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Used to study Brunner Syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease; Brunner Syndrome; alcohol use disorder; autism spectrum disorder; and panic disorder. Orthologous to human MAOA (Monoamine Oxidase A). [provided by Alliance of Genome Resources, Apr 2022]

Maoa Products (1)

mRNA Protein Name
NM_173740.3 NP_776101.3 amine oxidase [flavin-containing] A

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables primary methylamine oxidase activity IDA
IDA: Inferred from direct assay
23926250 MGI
enables primary methylamine oxidase activity IMP
IMP: Inferred from mutant phenotype
7792602 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23926250 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within dopamine catabolic process IDA
IDA: Inferred from direct assay
9520487 MGI
acts upstream of or within positive regulation of signal transduction IMP
IMP: Inferred from mutant phenotype
17561096 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Maoa Protein Structure

YobN

YobN: COG1231 (14 - 462)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 526 a.a.
Protein Preferred Names Protein Names

amine oxidase [flavin-containing] A

  • MAO-A

  • monoamine oxidase type A

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (27)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14536 Methylene Blue Inhibitor 95.05% Unkown
HY-14199 Selegiline hydrochloride Inhibitor 99.96% Unkown
HY-14280 Entacapone Inhibitor 99.97% Yes
HY-14197A Clorgyline hydrochloride Inhibitor 99.92% Unkown
HY-N0159 Paeonol 99.98% Unkown
HY-B1018A Phenelzine sulfate Inhibitor 99.96% Unkown
HY-A0091A Pargyline Inhibitor 99.92% Unkown
HY-70057 Safinamide Inhibitor 99.86% Yes
HY-A0091 Pargyline hydrochloride Inhibitor 99.91% Unkown
HY-B1359 Methylene blue trihydrate Inhibitor 98.0% Yes
HY-14197 Clorgyline Inhibitor 99.76% Unkown
HY-B0534 Moclobemide Inhibitor 99.12% Yes
HY-70057A Safinamide mesylate Inhibitor 99.07% Yes
HY-14855B Tedizolid phosphate Inhibitor 99.61% Yes
HY-D0958 Methylene blue hydrate Inhibitor / Unkown
HY-B0678 Metaxalone 99.77% Unkown
HY-N0159R Paeonol (Standard) 99.98% Unkown
HY-14196 Toloxatone Inhibitor 98.11% Unkown
HY-B1558A Bifemelane hydrochloride Inhibitor 99.86% Unkown
HY-100679 Pirlindole Inhibitor 98.90% Unkown
HY-14895 Fabomotizole 99.96% Unkown
HY-14198 Selegiline Inhibitor / Unkown
HY-14280R Entacapone (Standard) Inhibitor 99.24% Unkown
HY-100679A Pirlindole mesylate Inhibitor / Unkown
HY-B0678R Metaxalone (Standard) / Unkown
HY-W018475 Rizatriptan Agonist / Unkown
HY-14280A Entacapone sodium salt Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-N0529 Rosmarinic acid 99.73% Phase 4
HY-120017 Befloxatone Inhibitor / Phase 3
HY-154977 ETAP Inhibitor / Phase 3
HY-13339 Brofaromine Inhibitor 99.37% Phase 2
HY-14260 RS 8359 Inhibitor 97.35% Phase 2
HY-129388 Pulrodemstat Methylbenzenesulfonate Inhibitor / Phase 2
HY-100178 CX-157 Inhibitor / Phase 2
HY-108048 Desoxypeganine Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (135)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W008566 Norharmane Inhibitor 99.93% Unkown
HY-129388B Pulrodemstat benzenesulfonate Inhibitor 99.64% Unkown
HY-B1311 Proadifen hydrochloride 99.95% Unkown
HY-Y1322 Triphenyl phosphate 99.67% Unkown
HY-N2554 Osthenol 99.15% Unkown
HY-N0126 Xanthone Inhibitor 99.97% Unkown
HY-W015490 1,4-Naphthoquinone Inhibitor 99.97% Unkown
HY-14536A Methylene blue (purity≥70%) Inhibitor 95.0% Unkown
HY-110130 RN-1 dihydrochloride Inhibitor 99.21% Unkown
HY-E70074 Monoamine oxidase, plasma / Unkown
HY-N4177 Rubrofusarin gentiobioside Inhibitor 99.07% Unkown
HY-164099 LSD1/HDAC6-IN-2 Inhibitor 99.66% Unkown
HY-19333 OG-L002 Inhibitor 99.55% Unkown
HY-124591 TC-2153 Inhibitor 98.19% Unkown
HY-N12485 MAO-A inhibitor 1 Inhibitor 98.55% Unkown
HY-129388A Pulrodemstat Inhibitor 98.86% Unkown
HY-16677A Mofegiline hydrochloride Inhibitor 99.57% Unkown
HY-131036 MAO-IN-M30 dihydrochloride Inhibitor 98.48% Unkown
HY-14201 Lazabemide Inhibitor 99.95% Unkown
HY-D0004 Azure B Inhibitor 99.87% Unkown
HY-N4246 Bacopaside I 99.20% Unkown
HY-100588 VU0364770 Agonist 99.94% Unkown
HY-137570 Ethyl homovanillate Inhibitor 98.41% Unkown
HY-149213 LSD1/TLK1-IN-1 99.20% Unkown
HY-W004882 6-Hydroxy-1-tetralone 99.56% Unkown
HY-W655727 (-)-2-Phenylpropylamine Inhibitor 98.44% Unkown
HY-125515 Tetrahydroharmine Inhibitor 99.61% Unkown
HY-100027A Ro 41-1049 hydrochloride Inhibitor 99.57% Unkown
HY-121072 ASS234 Inhibitor 99.6% Unkown
HY-145259 HDAC6-IN-3 Inhibitor 98.0% Unkown
HY-149408 MAOA-IN-1 Inhibitor 98.24% Unkown
HY-151466 HIF-1α-IN-5 Inhibitor 99.95% Unkown
HY-N0126R Xanthone (Standard) Inhibitor 99.99% Unkown
HY-W015490S 1,4-Naphthoquinone-d6 Inhibitor 99.20% Unkown
HY-W049881 9-Methyl-β-carboline 99.86% Unkown
HY-100588A VU0364770 hydrochloride Agonist 99.63% Unkown
HY-101578 2614W94 Inhibitor 99.76% Unkown
HY-114620 MAO-B-IN-55 Inhibitor 98.10% Unkown
HY-14280S Entacapone-d10 Inhibitor 98.6% Unkown
HY-151596 MAO-A/5-HT2AR-IN-1 Inhibitor 99.71% Unkown
HY-156255 MAO-B-IN-25 Inhibitor 99.11% Unkown
HY-70057S1 Safinamide-d4-1 Inhibitor 98.90% Unkown
HY-B1018AS Phenelzine-d5 sulfate Inhibitor 99.97% Unkown
HY-W010130 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone Inhibitor 99.96% Unkown
HY-W275048 MAO-A inhibitor 3 Inhibitor 99.85% Unkown
HY-Y1322S Triphenyl phosphate-d15 99.74% Unkown
HY-100027 Ro 41-1049 Inhibitor / Unkown
HY-100679B (R)-Pirlindole mesylate Inhibitor / Unkown
HY-106041A Sercloremine hydrochloride Inhibitor / Unkown
HY-106972 SL-251131 Inhibitor / Unkown
HY-108048A Desoxypeganine hydrochloride Inhibitor / Unkown
HY-114915 PSB-1434 Inhibitor 98.05% Unkown
HY-116097 PSB-1491 Inhibitor / Unkown
HY-119885A (±)-Amiflamine Inhibitor 99.23% Unkown
HY-129388C Pulrodemstat hydrochloride Inhibitor / Unkown
HY-129449 AnnH31 Inhibitor 99.91% Unkown
HY-131660 MAO-B-IN-54 Inhibitor / Unkown
HY-134664 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Inhibitor / Unkown
HY-135265 Moclobemide N-Oxide Inhibitor 99.35% Unkown
HY-136878 LSD1-IN-10 Inhibitor / Unkown
HY-14198B (±)-Selegiline hydrochloride Inhibitor / Unkown
HY-14202 Lazabemide hydrochloride Inhibitor 95.0% Unkown
HY-143438 2-PAT Inhibitor / Unkown
HY-144673 LSD1-IN-12 Inhibitor / Unkown
HY-144756 LSD1-IN-15 Inhibitor / Unkown
HY-144757 LSD1-IN-16 Inhibitor / Unkown
HY-144758 LSD1-IN-17 Inhibitor / Unkown
HY-149528 MAO-B-IN-24 Inhibitor / Unkown
HY-149978 LSD1-IN-26 / Unkown
HY-151094 FTEAA Inhibitor / Unkown
HY-151800 MAO-A/B-IN-2 Inhibitor / Unkown
HY-152109 AChE/MAO-IN-1 Inhibitor / Unkown
HY-152110 AChE/MAO-IN-2 Inhibitor / Unkown
HY-15386 Cimoxatone Inhibitor 98.03% Unkown
HY-157934 MAO-IN-4 Inhibitor / Unkown
HY-157981 AChE-IN-60 Inhibitor / Unkown
HY-157982 BChE-IN-28 Inhibitor / Unkown
HY-158092 ChEs/MAOs-IN-2 Inhibitor / Unkown
HY-158732 MAO-B-IN-33 Inhibitor / Unkown
HY-159106 MeSeI / Unkown
HY-161240 MAO-B-IN-30 Inhibitor 98.53% Unkown
HY-162606 MAO-A/B-IN-3 Inhibitor / Unkown
HY-162760 COMT-IN-1 Inhibitor / Unkown
HY-163322 MAO-A inhibitor 2 Inhibitor / Unkown
HY-163618 DHMQ / Unkown
HY-170487 MAO-B-IN-38 Inhibitor / Unkown
HY-174833 MAO-A-IN-2 Inhibitor / Unkown
HY-174834 MAO-B-IN-44 Inhibitor / Unkown
HY-176254 LSD1-IN-43 Inhibitor / Unkown
HY-176271 MAO-B-IN-45 / Unkown
HY-178149 MAO-A/B-IN-5 Inhibitor / Unkown
HY-178352 MAO-B-IN-49 / Unkown
HY-179126 BChE/MAO-A-IN-1 Inhibitor / Unkown
HY-180552 AChE-IN-104 Inhibitor / Unkown
HY-180783 AChE/BChE/MAO-A-IN-1 Inhibitor / Unkown
HY-180843 Aβ/tau aggregation-IN-4 Inhibitor / Unkown
HY-181110 MAO-A-IN-4 Inhibitor / Unkown
HY-182727 MDL 72392 Inhibitor / Unkown
HY-184159 AChE/BChE/MAO-A-IN-2 Inhibitor / Unkown
HY-184381 MAO-B-IN-61 Inhibitor / Unkown
HY-186195 Methyl-cudratricusxanthone B / Unkown
HY-186306 MAO-A-IN-5 Inhibitor / Unkown
HY-B0534S Moclobemide-d8 Inhibitor / Unkown
HY-B0534S1 Moclobemide-d4 Inhibitor 99.0% Unkown
HY-B0678S Metaxalone-d3 98.0% Unkown
HY-B0678S1 Metaxalone-d6 / Unkown
HY-D3221 MAO Probe 1 / Unkown
HY-N0377B (R)-Liquiritigenin Inhibitor / Unkown
HY-N1638 1-Methyl-2-undecyl-4(1H)-quinolone Inhibitor / Unkown
HY-N18471 5,7-Dihydroxytryptamine Ligand / Unkown
HY-N18471A 5,7-Dihydroxytryptamine hydrobromide Ligand / Unkown
HY-N18471B 5,7-Dihydroxytryptamine creatinine sulfate Ligand / Unkown
HY-RS08019 MAOA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08020 Maoa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08021 Maoa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W008566S Norharmane-13C / Unkown
HY-W1058437 (trans)-m-CI-PCA hydrochloride Inhibitor / Unkown
HY-100679S Pirlindole-d4 Inhibitor / Unkown
HY-105041 Tedizolid phosphate sodium Inhibitor / Unkown
HY-105127 Brofaromine hydrochloride Inhibitor / Unkown
HY-124331 H77-77 Inhibitor / Unkown
HY-124885 MD 220661 Inhibitor / Unkown
HY-14198S Selegiline-d5 Inhibitor / Unkown
HY-14199S Selegiline-d5 hydrochloride Inhibitor / Unkown
HY-160936 5-Hydroxyindoleacetaldehyde / Unkown
HY-167152 Pirlindole lactate Inhibitor / Unkown
HY-19333A OG-L002 hydrochloride Inhibitor / Unkown
HY-70057S4 Safinamide-d5 Inhibitor / Unkown
HY-N12134 Methyl piperate Inhibitor / Unkown
HY-N13041 Acacetin 7-O-(6-O-malonylglucoside) Inhibitor / Unkown
HY-W029600 6,7-Dimethylisatin Inhibitor / Unkown
HY-W067583 Norharmine Inhibitor / Unkown
HY-W279140 Pirlindole hydrochloride Inhibitor / Unkown
HY-W700241 Norharman-d7 Inhibitor / Unkown
HY-W792513 WAY-620147 Inhibitor 98.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Maoa NCBI NCBI:4128