2. Gene
  3. Ep300 - E1A binding protein p300 Gene

Ep300 - E1A binding protein p300 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p300; KAT3B; p300 HAT; A430090G16; A730011L11

Gene ID: 328572 | Gene type: protein coding

About Ep300

Chromosome 15: 81,469,552-81,536,278 forward strand.GRCm39:CM001008.3

This gene has 10 transcripts (splice variants), 286 orthologues, 1 paralogue and is associated with 62 phenotypes. Ubiquitous expression in thymus adult (RPKM 18.7), spleen adult (RPKM 16.4) and 28 other tissues.

Summary

Enables several functions, including N-acyltransferase activity; nucleic acid binding activity; and p53 binding activity. Involved in several processes, including face morphogenesis; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; and protein acylation. Acts upstream of or within several processes, including animal organ development; histone H3-K56 acetylation; and regulation of gene expression. Part of Histone Acetyltransferase complex and transcription regulator complex. Is expressed in several structures, including alimentary system; heart; lung; nervous system; and skin. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Apr 2022]

Ep300 Products(1)

mRNA Protein Name
NM_177821.6 NP_808489.4 histone acetyltransferase p300

Ep300 Protein Structure

Med15

Med15: cl26621 (97 - 327)

zf-TAZ

zf-TAZ: pfam02135 (347 - 414)

KIX

KIX: pfam02172 (566 - 646)

Atrophin-1

Atrophin-1: cl38111 (641 - 995)

Bromo_cbp_like

Bromo_cbp_like: cd05495 (1049 - 1156)

RING_CBP-p300

RING_CBP-p300: cd15802 (1168 - 1240)

PHD_p300

PHD_p300: cd15646 (1241 - 1275)

HAT_KAT11

HAT_KAT11: pfam08214 (1304 - 1610)

ZZ_CBP

ZZ_CBP: cd02337 (1666 - 1706)

zf-TAZ

zf-TAZ: pfam02135 (1733 - 1801)

Med15

Med15: cl26621 (1957 - 2364)

Creb_binding

Creb_binding: pfam09030 (1992 - 2098)

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  • 2412 a.a.
Protein Preferred Names Protein Names

histone acetyltransferase p300

E1A-associated protein p300

histone butyryltransferase p300

histone crotonyltransferase p300

protein 2-hydroxyisobutyryltransferase p300

protein lactyltransferas p300

protein propionyltransferase p300

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-N0005 Curcumin 98.84% Phase 4
HY-134964 CTB 99.76% Phase 4
HY-111784 Inobrodib Inhibitor 99.53% Phase 2
HY-111422 PLX51107 Inhibitor 99.74% Phase 2
HY-136938 NEO2734 Inhibitor 99.79% Phase 1
Pre-clinical Phase
Bioactive Molecules (88)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107455 A-485 Inhibitor 99.83% Unkown
HY-13823 C646 99.78% Unkown
HY-14428 ICG-001 99.86% Unkown
HY-15826 SGC-CBP30 Inhibitor 99.83% Unkown
HY-134582 dCBP-1 Inhibitor 99.44% Unkown
HY-N2020 Anacardic Acid Inhibitor 98.86% Unkown
HY-15887 MG 149 99.86% Unkown
HY-124696 PU139 Inhibitor 99.14% Unkown
HY-110127 NU9056 98.81% Unkown
HY-107569 Garcinol ≥99.0% Unkown
HY-100482 CPI-637 Inhibitor 99.94% Unkown
HY-136285 CPI-1612 Inhibitor 99.85% Unkown
HY-W013274 CPTH2 99.79% Unkown
HY-145765 JQAD1 98.70% Unkown
HY-116673 TTK21 Activator 99.43% Unkown
HY-100671 L002 Inhibitor 99.02% Unkown
HY-19541 I-CBP112 98.46% Unkown
HY-19999A PF-CBP1 hydrochloride Inhibitor 99.99% Unkown
HY-100726 GNE-272 99.76% Unkown
HY-124960 CTPB Activator ≥99.0% Unkown
HY-101125 L-Moses Inhibitor 99.97% Unkown
HY-138539 CBP/p300 ligand 2 98.17% Unkown
HY-100734 Histone Acetyltransferase Inhibitor II Inhibitor 99.01% Unkown
HY-10593 IQ 1 Modulator 99.69% Unkown
HY-132197 CBP/p300-IN-12 Inhibitor 99.70% Unkown
HY-128876 CBP/p300-IN-3 Inhibitor 98.95% Unkown
HY-138536 PROTAC CBP/P300 Degrader-1 Inhibitor 99.18% Unkown
HY-N2345 Procyanidin B3 Inhibitor 99.63% Unkown
HY-131035 Lys-CoA TFA Inhibitor 99.42% Unkown
HY-136920 CBP/p300-IN-8 Inhibitor 99.94% Unkown
HY-154984 JET-209 Degrader 98.07% Unkown
HY-111420 CBP/p300-IN-1 Inhibitor 99.45% Unkown
HY-100697 TPOP146 Inhibitor 98.98% Unkown
HY-128875 CBP/p300-IN-10 Inhibitor 98.69% Unkown
HY-147008 XP-524 Inhibitor 99.66% Unkown
HY-110263 EML 425 Inhibitor 98.16% Unkown
HY-101125A L-Moses dihydrochloride Inhibitor 99.38% Unkown
HY-134591 Thalidomide-NH-PEG4-COOH Inducer 98.55% Unkown
HY-139108 DCH36_06 99.22% Unkown
HY-139707 Thalidomide-NH-CBP/p300 ligand 2 Degrader 99.85% Unkown
HY-120290 PU141 Inhibitor 99.30% Unkown
HY-139148 UMB298 Inhibitor 99.11% Unkown
HY-145386 (S,S)-CPI-1612 / Unkown
HY-153768 KAT modulator-1 Modulator ≥98.0% Unkown
HY-152241 DS-9300 Inhibitor 99.83% Unkown
HY-100132 CBP/p300-IN-5 Inhibitor ≥97.0% Unkown
HY-115539 Windorphen Inhibitor ≥96.0% Unkown
HY-136285A (R,R)-CPI-1612 99.49% Unkown
HY-147290 NSC 694623 Inhibitor 99.36% Unkown
HY-151812 CBP/p300-IN-20 Inhibitor / Unkown
HY-134621 P300-IN-1 Inhibitor / Unkown
HY-143443 DS17701585 Inhibitor / Unkown
HY-W013274A CPTH2 hydrochloride / Unkown
HY-134592 Piperidine-GNE-049-N-Boc 98.82% Unkown
HY-141546 Pocenbrodib Inhibitor / Unkown
HY-124722 OHM1 Inhibitor / Unkown
HY-128362 Ep300/CREBBP-IN-8 Inhibitor / Unkown
HY-128363 Ep300/CREBBP-IN-2 Inhibitor / Unkown
HY-128364 Ep300/CREBBP-IN-3 Inhibitor / Unkown
HY-128367 Ep300/CREBBP-IN-4 Inhibitor / Unkown
HY-128761 CBP/p300-IN-2 Inhibitor / Unkown
HY-139861 CBP/p300-IN-14 Inhibitor / Unkown
HY-143339 CBP/p300-IN-15 Inhibitor / Unkown
HY-143440 CBP/p300-IN-16 Inhibitor / Unkown
HY-143441 CBP/p300-IN-17 Inhibitor / Unkown
HY-143442 CBP/p300-IN-18 Inhibitor / Unkown
HY-146277 CBP/p300-IN-19 Inhibitor / Unkown
HY-146277A CBP/p300-IN-19 hydrochloride Inhibitor / Unkown
HY-146445 P300 bromodomain-IN-1 Inhibitor / Unkown
HY-147261 B026 Inhibitor / Unkown
HY-149306 MS78 / Unkown
HY-155229 CBP/p300-IN-21 Inhibitor / Unkown
HY-158113 CBPD-409 Degrader / Unkown
HY-161250 Pomalidomide-NH-PEG6-amide-C2-CPI-1612 / Unkown
HY-161369 CBPD-268 Degrader / Unkown
HY-161494 XYD190 Inhibitor / Unkown
HY-161495 CBP/p300 ligand 4 Inhibitor / Unkown
HY-161498 XYD198 Inhibitor / Unkown
HY-162128 Antitumor agent-130 Inhibitor / Unkown
HY-162259 QC-182 Degrader / Unkown
HY-N0005S Curcumin-d6 / Unkown
HY-P10238 MYBMIM Inducer / Unkown
HY-RS04405 EP300 Human Pre-designed siRNA Set A / Unkown
HY-RS04406 Ep300 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04407 Ep300 Rat Pre-designed siRNA Set A / Unkown
HY-160260 EP300/CBP-IN-1 Inhibitor / Unkown
HY-160261S EP300/CBP-IN-2 Inhibitor / Unkown
HY-19541A I-CBP112 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ep300 NCBI NCBI:2033