PARP1 - poly(ADP-ribose) polymerase 1 Gene

Also Known as PARP; PARS; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; Poly-PARP

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 142

About PARP1

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:226,360,691-226,408,093 (from NCBI)

This gene has 26 transcripts (splice variants), 210 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 71.4), appendix (RPKM 40.9) and 25 other tissues.

Summary

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

PARP1 Products (1)

mRNA	Protein	Name
NM_001618.4	NP_001609.2	poly [ADP-ribose] polymerase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables DNA binding	IDA IDA: Inferred from direct assay	21233213	GOA
enables NAD DNA ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	27471034	GOA
enables NAD+-histone H2BS6 serine ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	34874266	GOA
enables NAD+-histone H3S10 serine ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	34874266	GOA
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	7852410	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	7852410	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP IMP: Inferred from mutant phenotype	22504299	GOA
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	19764761	GOA
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	19764761	GOA
enables NAD+-protein-histidine ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	35393539	GOA
enables NAD+-protein-serine ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	28190768	GOA
enables NAD+-protein-tyrosine ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	29954836	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19303849	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	30675909	GOA
enables damaged DNA binding	IDA IDA: Inferred from direct assay	22683995	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23382074	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	14734561	GOA
enables nucleosome binding	IDA IDA: Inferred from direct assay	15607977	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7596430	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	22683995	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17177976	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	18055453	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in ATP generation from poly-ADP-D-ribose	IDA IDA: Inferred from direct assay	27257257	GOA
involved in DNA ADP-ribosylation	IDA IDA: Inferred from direct assay	27471034	GOA
involved in DNA damage response	IDA IDA: Inferred from direct assay	22683995	GOA
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	24550317	GOA
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	24289924	GOA
involved in DNA repair	IDA IDA: Inferred from direct assay	30104678	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	15565177	GOA
involved in cellular response to UV	IMP IMP: Inferred from mutant phenotype	24289924	GOA
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	19303849	GOA
acts upstream of or within cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	25378300	GOA
involved in double-strand break repair	IDA IDA: Inferred from direct assay	24906880	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	23230272	GOA
acts upstream of or within mitochondrial DNA metabolic process	IMP IMP: Inferred from mutant phenotype	25378300	GOA
acts upstream of or within mitochondrial DNA repair	IMP IMP: Inferred from mutant phenotype	25378300	GOA
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	25378300	GOA
involved in negative regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	24289924	GOA
involved in negative regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	35460603	GOA
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	35460603	GOA
involved in negative regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	32844745	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15607977	GOA
involved in negative regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	35393539	GOA
involved in positive regulation of DNA-templated transcription, elongation	IDA IDA: Inferred from direct assay	27256882	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	22464733	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	26344098	GOA
involved in positive regulation of single strand break repair	IGI IGI: Inferred from genetic interaction	28002403	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11112786	GOA
involved in protein auto-ADP-ribosylation	IDA IDA: Inferred from direct assay	15607977	GOA
involved in protein localization to chromatin	IDA IDA: Inferred from direct assay	34874266	GOA
acts upstream of or within protein modification process	IMP IMP: Inferred from mutant phenotype	25378300	GOA
involved in protein poly-ADP-ribosylation	IDA IDA: Inferred from direct assay	15674325	GOA
involved in regulation of base-excision repair	IDA IDA: Inferred from direct assay	34102106	GOA
involved in regulation of catalytic activity	IDA IDA: Inferred from direct assay	25749521	GOA
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	24550317	GOA
involved in replication fork reversal	IDA IDA: Inferred from direct assay	33412112	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in chromatin	IDA IDA: Inferred from direct assay	30675909	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	35460603	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25378300	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	9518481	GOA
is active in nuclear replication fork	IDA IDA: Inferred from direct assay	33412112	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	9518481	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	22464733	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17177976	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	22504299	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22504299	GOA
is active in site of DNA damage	IDA IDA: Inferred from direct assay	22683995	GOA
located in site of DNA damage	IMP IMP: Inferred from mutant phenotype	27248496	GOA
is active in site of double-strand break	IDA IDA: Inferred from direct assay	29234005	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	26344098	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	19303849	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP1 Protein Structure

zf-PARP

PADR1

BRCT

WGR

PARP_reg

PARP

0
200
400
600
800
1014 a.a.

Protein Preferred Names	Protein Names
poly [ADP-ribose] polymerase 1	ADP-ribosyltransferase (NAD+ poly (ADP-ribose) polymerase) ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase diphtheria toxin-like 1 DNA ADP-ribosyltransferase PARP1 NAD(+) ADP-ribosyltransferase 1 poly (ADP-ribose) polymerase family, member 1 poly(ADP-ribose) synthetase poly(ADP-ribosyl)transferase poly[ADP-ribose] synthase 1 protein poly-ADP-ribosyltransferase PARP1

PARP1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	PARP1	P09874	SNAI1	Homo sapiens	O95863	Anti Bait CoIP	21577210
Intra	PARP1	P09874	SNAI1	Homo sapiens	O95863	Confocal	21577210
Intra	PARP1	P09874	RECQL	Homo sapiens	P46063	Anti Tag CoIP	35271311
Intra	PARP1	P09874	XRCC5	Homo sapiens	P13010	Anti Bait CoIP	17283121
Intra	PARP1	P09874	XRCC5	Homo sapiens	P13010	Anti Tag CoIP	14734561
Intra	PARP1	P09874	XRCC5	Homo sapiens	P13010	Enzymatic Study	14734561
Intra	PARP1	P09874	XRCC6	Homo sapiens	P12956	Anti Bait CoIP	17283121
Intra	PARP1	P09874	XRCC5	Homo sapiens	P13010	Anti Bait CoIP	20085707
Intra	PARP1	P09874	XRCC6	Homo sapiens	P12956	Anti Tag CoIP	35271311
Intra	PARP1	P09874	XRCC6	Homo sapiens	P12956	Enzymatic Study	14734561
Intra	PARP1	P09874	XRCC6	Homo sapiens	P12956	Anti Tag CoIP	14734561
Intra	PARP1	P09874	XRCC6	Homo sapiens	P12956	GMS	14734561
Intra	PARP1	P09874	XRCC5	Homo sapiens	P13010	Anti Bait CoIP	21575865
Intra	PARP1	P09874	XRCC5	Homo sapiens	P13010	Anti Tag CoIP	35271311
Intra	PARP1	P09874	TP53	Homo sapiens	P04637	Anti Bait CoIP	15044383
Intra	PARP1	P09874	TP53	Homo sapiens	P04637	Anti Bait CoIP	14627987
Intra	PARP1	P09874	WRN	Homo sapiens	Q14191	Anti Bait CoIP	14596914
Intra	PARP1	P09874	WRN	Homo sapiens	Q14191	Anti Tag CoIP	14734561
Intra	PARP1	P09874	WRN	Homo sapiens	Q14191	GMS	14734561
Intra	PARP1	P09874	EP400	Homo sapiens	Q96L91	Anti Tag CoIP	35271311
Intra	PARP1	P09874	E2F1	Homo sapiens	Q01094	Anti Bait CoIP	14627987
Intra	PARP1	P09874	E2F1	Homo sapiens	Q01094	Anti Bait CoIP	20133863
Intra	PARP1	P09874	PIAS4	Homo sapiens	Q8N2W9	Pull Down	19779455
Intra	PARP1	P09874	PIAS4	Homo sapiens	Q8N2W9	Anti Tag CoIP	19779455
Intra	PARP1	P09874	CASP3	Homo sapiens	P42574	Protease Assay	17167422
Intra	PARP1	P09874	RRP1B	Homo sapiens	Q14684-1	Anti Tag CoIP	19710015
Intra	PARP1	P09874	RRP1B	Homo sapiens	Q14684-1	Confocal	19710015
Cross	PARP1	P09874	Snai1	Mus musculus	Q02085	ADP Ribosylase	21577210
Intra	PARP1	P09874	RNF146	Homo sapiens	Q9NTX7	Anti Tag CoIP	35271311
Intra	PARP1	P09874	RNF146	Homo sapiens	Q9NTX7	Anti Tag CoIP	21799911
Intra	PARP1	P09874	NFIC	Homo sapiens	P08651	Anti Tag CoIP	35271311
Intra	PARP1	P09874	ERG	Homo sapiens	P11308	CH-IP	21575865
Intra	PARP1	P09874	ERG	Homo sapiens	P11308	Anti Bait CoIP	21575865
Intra	PARP1	P09874	SUMO1	Homo sapiens	P63165	Anti Bait CoIP	19779455
Intra	PARP1	P09874	APTX	Homo sapiens	Q7Z2E3	Anti Tag CoIP	35271311
Intra	PARP1	P09874	APTX	Homo sapiens	Q7Z2E3	Anti Bait CoIP	15044383
Intra	PARP1	P09874	APTX	Homo sapiens	Q7Z2E3	Anti Tag CoIP	15555565
Intra	PARP1	P09874	APTX	Homo sapiens	Q7Z2E3	Y2H	15555565
Intra	PARP1	P09874	OARD1	Homo sapiens	Q9Y530	Crosslink	23481255
Intra	PARP1	P09874	OARD1	Homo sapiens	Q9Y530	Enzymatic Study	23481255
Intra	PARP1	P09874	XRCC1	Homo sapiens	P18887	Anti Bait CoIP	15044383
Intra	PARP1	P09874	XRCC1	Homo sapiens	P18887	Anti Tag CoIP	18971944
Intra	PARP1	P09874	XRCC1	Homo sapiens	P18887	Anti Tag CoIP	35271311
Intra	PARP1	P09874	XRCC1	Homo sapiens	P18887	Anti Bait CoIP	24778456
Intra	PARP1	P09874	ZNF423	Homo sapiens	Q2M1K9	Anti Tag CoIP	22863007

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PARP1 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P74652	PARP1 Protein, Human (sf9, His)	P09874 (M1-W1014)	≥ 90%, as determined by reducing SDS-PAGE.

PARP1 抗体

製品番号	製品名	アプリケーション	反応性
HY-P80263	PARP1 Antibody (YA246)	WB, ICC/IF, IHC-P, FC	Human, Mouse
HY-P80448	Cleaved-PARP1 Antibody (YA500)	WB, ICC/IF, IP, FC	Human
HY-P80625	Cleaved-PARP1 Antibody (YA498)	WB	Human
HY-P80625A	Cleaved-PARP1 Antibody (YA498)(PBS only)	WB	Human
HY-P80780	PARP1 Antibody (YA245)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P80780A	PARP1 Antibody (YA245)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P84036	PARP1 Antibody (YA3733)	WB, FC, ELISA	Human
HY-P84036A	PARP1 Antibody (YA3733)(PBS only)	WB, FC, ELISA	Human

関連疾患

Diseases	Alias
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma Primitive Neuroectodermal Tumor ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Ewing Family Of Tumors Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Cervical Adenocarcinoma	Adenocarcinoma Cervix Uteri Adenocarcinoma Of Cervix Adenocarcinoma Of The Uterine Cervix Adenocarcinoma Of The Cervix Uteri
Oligospermia
Pellagra	Niacin Deficiency Niacin-Tryptophan Deficiency Pellagroid Syndrome
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Lymphangioleiomyomatosis	Lymphangiomyomatosis LAM Lung Lymphangioleiomyomatosis Pulmonary Lymphangioleiomyomatosis Lymphangioleiomyomatosis, Somatic Lymphangio-Myomatosis
Diphtheria	Corynebacterium Infections Corynebacterium Infection Diphtherial Infection Infection Due To Corynebacterium Diphtheriae
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Osebold-Remondini Syndrome	Brachydactyly Type A6 Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities Bda6 Brachydactyly, Type A6
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Rhabdomyosarcoma
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Osteonecrosis Of The Jaw
Aging
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Glioblastoma Classical Subtype
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Reticulosarcoma	Histiocytic Lymphoma Large-Cell Lymphomas Lymphoma, Large-Cell Lymphoma Large Cell Diffuse Large B-Cell Lymphoma Histiocytic Sarcoma
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis De Sanctis-Cacchione Syndrome Xp Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Xeroderma Pigmentosum, Complementation Group A	Xeroderma Pigmentosum Group A Xp1 Xeroderma Pigmentosum, Group A XPA Xeroderma Pigmentosum I Xeroderma Pigmentosum Complementation Group A Xp Group A Xp, Group A Xeroderma Pigmentosum 1 Xeroderma Pigmentosum, Type 1 XP-A
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Diabetes Mellitus	Diabetes
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Werner Syndrome	Werner'S Syndrome WRN Adult Progeria Ws Adult Premature Ageing Syndrome Adult Premature Aging Syndrome Werners Syndrome
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Fallopian Tube Carcinoma	Fallopian Tube Cancer Cancer Of The Fallopian Tube Carcinoma Of Fallopian Tube Neoplasm Of Fallopian Tube Fallopian Tube Neoplasms Fallopian Tube Ca Fallopian Tube Neoplasm Malignant Neoplasm Of Uterine Tube Malignant Tumor Of Fallopian Tube Malignant Tumour Of Fallopian Tube Tumor Of The Fallopian Tube Tumor, Fallopian Tube, Malignant Malignant Tumor Of Fallopian Tubes Cancer Of Fallopian Tubes Malignant Tubal Tumor Tubal Cancer Malignant Neoplasm Of Fallopian Tube Primary Malignant Neoplasm Of Fallopian Tube Cancer Of The Oviduct
Neuroma
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Sporadic Breast Cancer	Sporadic Breast Carcinoma
Dyslexia
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (17)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-10162	Olaparib	Inhibitor	99.98%	Yes
HY-16106	Talazoparib	Inhibitor	99.89%	Unkown
HY-10619	Niraparib	Inhibitor	99.96%	Yes
HY-10617A	Rucaparib	Inhibitor	99.96%	Yes
HY-114778	Fluzoparib	Inhibitor	99.96%	Unkown
HY-10619A	Niraparib hydrochloride	Inhibitor	99.41%	Yes
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	Yes
HY-10619B	Niraparib tosylate	Inhibitor	99.99%	Yes
HY-102003	Rucaparib monocamsylate	Inhibitor	99.91%	Yes
HY-113041	Prostaglandin A2	Activator	99.9%	Unkown
HY-B0960	Sulfabenzamide		99.68%	Unkown
HY-10619E	Niraparib tosylate hydrate	Inhibitor	99.97%	Yes
HY-136489	KU-0058948	Inhibitor	99.79%	Unkown
HY-10617C	Rucaparib tartrate	Inhibitor	/	Unkown
HY-102003A	Rucaparib camsylate	Inhibitor	/	Unkown
HY-10617D	Rucaparib acetate	Inhibitor	/	Unkown
HY-10617B	Rucaparib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (13)

製品番号	製品名	製品効果	純度	Phase
HY-132167	Saruparib	Inhibitor	99.76%	Phase 3
HY-10129	Veliparib	Inhibitor	99.77%	Phase 3
HY-12032	AG14361	Inhibitor	99.42%	Phase 3
HY-12015	Iniparib	Inhibitor	99.74%	Phase 3
HY-12418	Stenoparib	Inhibitor	98.0%	Phase 2
HY-137457	Venadaparib	Inhibitor	98.52%	Phase 2
HY-122661	Mefuparib hydrochloride	Inhibitor	98.62%	Phase 2
HY-105303	CEP-9722	Inhibitor	/	Phase 2
HY-150207	RBN-3143	Inhibitor	99.29%	Phase 1
HY-13536	AZD-2461	Inhibitor	99.79%	Phase 1
HY-13326	ASP3026		99.88%	Phase 1
HY-115552	Simmiparib	Inhibitor	99.01%	Phase 1
HY-170432	PARP1-IN-34	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (174)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-15147	XAV-939	Inhibitor	99.91%	Unkown
HY-13688A	PJ34	Inhibitor	99.66%	Unkown
HY-171006	IRF1-IN-1	Inhibitor	99.72%	Unkown
HY-145471	KSQ-4279	Inhibitor	99.96%	Unkown
HY-139156	SK-575	Inhibitor	99.86%	Unkown
HY-N0213	Peiminine		99.89%	Unkown
HY-171007	IRF1-IN-2	Inhibitor	99.83%	Unkown
HY-N3584	Paris saponin VII	Inhibitor	99.84%	Unkown
HY-148566	OUL232	Inhibitor	99.86%	Unkown
HY-14478	UPF 1069	Inhibitor	99.02%	Unkown
HY-13688	PJ34 hydrochloride	Inhibitor	99.81%	Unkown
HY-114869	DPQ	Inhibitor	99.68%	Unkown
HY-N6866	Gomisin N	Activator	99.94%	Unkown
HY-130644	iRucaparib-AP6	Degrader	99.03%	Unkown
HY-123851	MSC2504877	Inhibitor	99.25%	Unkown
HY-75706	N-Descyclopropanecarbaldehyde Olaparib	Inhibitor	99.46%	Unkown
HY-100225	ME0328	Inhibitor	99.64%	Unkown
HY-10130	Veliparib dihydrochloride	Inhibitor	99.98%	Yes
HY-12975	AZ6102	Inhibitor	99.53%	Unkown
HY-113352	7-Methylguanine	Inhibitor	99.97%	Unkown
HY-19351	MN-64	Inhibitor	99.61%	Unkown
HY-16106A	(8R,9S)-Talazoparib	Inhibitor	98.28%	Unkown
HY-117889	PARP14 inhibitor H10	Inhibitor	99.46%	Unkown
HY-170620	PARP1 PROTAC 180055	Degrader	98.90%	Unkown
HY-158045	PROTAC PARP1 degrader-1	Degrader	99.86%	Unkown
HY-108632	BYK204165	Inhibitor	99.89%	Unkown
HY-18954	NMS-P118	Inhibitor	99.54%	Unkown
HY-10619D	Niraparib (R-enantiomer)	Inhibitor	99.29%	Unkown
HY-114324	PROTAC PARP1 degrader	Degrader	99.74%	Unkown
HY-156419	PARP7-IN-16	Inhibitor	99.91%	Unkown
HY-148754	PARP10-IN-3	Inhibitor	98.72%	Unkown
HY-156419A	PARP7-IN-16 free base	Inhibitor	99.40%	Unkown
HY-132297A	PARP1-IN-5 dihydrochloride	Inhibitor	97.56%	Unkown
HY-10615	A-620223	Inhibitor	98.84%	Unkown
HY-130353	Desethylamiodarone hydrochloride	Activator	98.26%	Unkown
HY-149800	PARP-1-IN-3	Inhibitor	99.80%	Unkown
HY-10614	A-966492	Inhibitor	99.00%	Unkown
HY-145749	PARPYnD	Inhibitor	98.86%	Unkown
HY-147886	PARP1-IN-11	Inhibitor	99.42%	Unkown
HY-114324A	rel-PROTAC PARP1 degrader	Degrader	98.32%	Unkown
HY-164926	PARP1-IN-33	Inhibitor	99.02%	Unkown
HY-155993	YCH1899	Inhibitor	99.39%	Unkown
HY-148753	PARP10-IN-2	Inhibitor	98.07%	Unkown
HY-145471A	KSQ-4279 gentisate	Inhibitor	99.75%	Unkown
HY-147027	PARP-1-IN-2	Inhibitor	99.48%	Unkown
HY-15046	EB-47	Inhibitor	99.89%	Unkown
HY-133124	PARP/PI3K-IN-1	Inhibitor	99.40%	Unkown
HY-128599	NMS-P515	Inhibitor	98.18%	Unkown
HY-164475	PARP1-IN-29	Inhibitor	/	Unkown
HY-182499	PARP1-IN-56	Inhibitor	99.03%	Unkown
HY-105692	DR2313	Inhibitor	99.66%	Unkown
HY-168979	Itareparib	Inhibitor	99.24%	Unkown
HY-146548	Anticancer agent 43	Inducer	98.58%	Unkown
HY-146336	PARP1/2/TNKS1/2-IN-1	Inhibitor	98.66%	Unkown
HY-176713	KWZY-11	Inhibitor	/	Unkown
HY-178496	DDO3602	Degrader	/	Unkown
HY-130646	iVeliparib-AP6	Degrader	/	Unkown
HY-160937	AZD-9574-acid	Ligand	99.44%	Unkown
HY-175885	PROTAC FTO degrader 1	Inducer	/	Unkown
HY-123232	KU-0058684	Inhibitor	98.54%	Unkown
HY-137457A	Venadaparib hydrochloride	Inhibitor	/	Unkown
HY-132297	PARP1-IN-5	Inhibitor	/	Unkown
HY-163658	PARP-1-IN-23	Inhibitor	/	Unkown
HY-W424851	DPQ hydrochloride	Inhibitor	98.97%	Unkown
HY-149001	PARP1-IN-9	Inhibitor	/	Unkown
HY-161606	PARP-1/2/7-IN-1	Inhibitor	/	Unkown
HY-181999	PC8	Inhibitor	/	Unkown
HY-172224	PARP1/CDK12-IN-1	Inhibitor	/	Unkown
HY-130647	Vrucaparib-TP4	Degrader	/	Unkown
HY-178032	PARP1-IN-44	Inhibitor	/	Unkown
HY-180276	PARP1 degrader 1	Degrader	/	Unkown
HY-181265	PARP1-IN-53	Inhibitor	/	Unkown
HY-132885	PARP/EZH2-IN-1	Inhibitor	/	Unkown
HY-W973851	2H-Indazole-7-carboxamide	Degrader	/	Unkown
HY-181140	UNPD139734	Inhibitor	/	Unkown
HY-187513	MAHS-3	Inhibitor	/	Unkown
HY-181664	YCH3971	Inhibitor	/	Unkown
HY-158334	NDs-IN-1	Inhibitor	/	Unkown
HY-161868	DLC-50	Inhibitor	/	Unkown
HY-184895	CM002	Activator	/	Unkown
HY-163817	PARP1/2-IN-3	Inhibitor	/	Unkown
HY-175482	PARP1-IN-43	Inhibitor	/	Unkown
HY-144338	PARP1/BRD4-IN-1	Inhibitor	/	Unkown
HY-129599	L-2286	Inhibitor	/	Unkown
HY-169299	TOPOI/PARP-1-IN-2	Inhibitor	/	Unkown
HY-148710	ARTD10/PARP10-IN-2	Inhibitor	/	Unkown
HY-171543	PARP1-IN-37	Inhibitor	/	Unkown
HY-178100	PARP1-IN-45	Inhibitor	/	Unkown
HY-187473	PARP1-IN-58	Inhibitor	/	Unkown
HY-179386	PARP1/EZH2-IN-1	Inhibitor	/	Unkown
HY-168094	PARP1-IN-30	Inhibitor	/	Unkown
HY-183373	EGFR/PARP-1-IN-1	Inhibitor	/	Unkown
HY-170942	CDK9/PARP-IN-1	Inhibitor	/	Unkown
HY-161372	PARP1/c-Met-IN-1	Inhibitor	/	Unkown
HY-184557	DZ-1-DHA	Activator	/	Unkown
HY-187514	MAHS-4	Inhibitor	/	Unkown
HY-W294889	OUL245	Inhibitor	/	Unkown
HY-114943	TNKS-IN-1	Inhibitor	99.55%	Unkown
HY-130353R	Desethylamiodarone hydrochloride (Standard)	Activator	/	Unkown
HY-181967	PROTAC PARP1 degrader-5	Degrader	/	Unkown
HY-178468	PARP1-IN-47	Inhibitor	/	Unkown
HY-181459	PARP1-IN-55	Inhibitor	/	Unkown
HY-147030	PARP1-IN-8	Inhibitor	99.29%	Unkown
HY-169170	PARP1/BRD4-IN-3	Inhibitor	/	Unkown
HY-183317	IDO1-IN-34	Activator	/	Unkown
HY-175471	PARP1-IN-42	Inhibitor	/	Unkown
HY-178972	PARP1-IN-48	Inhibitor	/	Unkown
HY-183143	Lss-11	Activator	/	Unkown
HY-168722	PROTAC PARP1 degrader-3	Degrader	/	Unkown
HY-149003	PARP1-IN-10	Inhibitor	/	Unkown
HY-158680	PARP1-IN-21	Inhibitor	/	Unkown
HY-179614	PARP1-IN-50	Inhibitor	/	Unkown
HY-162114	PARP1-IN-18	Inhibitor	/	Unkown
HY-161769	HL435	Activator	/	Unkown
HY-178348	PARP1/c-Met-IN-2	Inhibitor	/	Unkown
HY-105253	PARP-2/1-IN-2	Inhibitor	/	Unkown
HY-180809	YCH3292	Inhibitor	/	Unkown
HY-158681	PARP1-IN-22	Inhibitor	/	Unkown
HY-178178	PARP1-IN-46	Inhibitor	/	Unkown
HY-148709	ARTD10/PARP10-IN-1	Inhibitor	/	Unkown
HY-161517	PARP1-IN-20	Inhibitor	/	Unkown
HY-136489A	KU-0058948 hydrochloride	Inhibitor	/	Unkown
HY-181460	PARP1 degrader-2	Degrader	/	Unkown
HY-161083	PARP/EZH2-IN-2	Inhibitor	/	Unkown
HY-157137	PARP1-IN-17		/	Unkown
HY-181158	PARP1-IN-52	Inhibitor	/	Unkown
HY-181746	Bcl-2/Mcl-1-IN-5	Activator	/	Unkown
HY-168851	PARP1-IN-35	Inhibitor	/	Unkown
HY-155766	PARP1-IN-14	Inhibitor	/	Unkown
HY-181928	PARP1/c-Met-IN-3	Inhibitor	/	Unkown
HY-184597	PARP1-IN-57	Inhibitor	/	Unkown
HY-122423	Desethylamiodarone	Activator	/	Unkown
HY-100847	AZ0108	Inhibitor	/	Unkown
HY-179020	PARP/VEGFR3-IN-1	Inhibitor	/	Unkown
HY-N17653	13'-Carboxy-δ-tocopherol		/	Unkown
HY-184277	Tubulin/PARP1-IN-1	Inhibitor	/	Unkown
HY-130645	iRucaparib-TP3	Degrader	/	Unkown
HY-174836	ZINC000081009201	Inhibitor	/	Unkown
HY-182269	Cathepsin-IN-5		/	Unkown
HY-176128	BWA-6047		/	Unkown
HY-146160	PARP-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-130353S	Desethylamiodarone-d4 hydrochloride	Activator	/	Unkown
HY-181842	PARP1/ERK IN-1	Inhibitor	/	Unkown
HY-181720	Antitumor agent-214	Degrader	/	Unkown
HY-179685	PARP1-IN-51	Inhibitor	/	Unkown
HY-182246	MC2050	Inhibitor	/	Unkown
HY-170978	PROTAC CDK9 degrader-11	Activator	/	Unkown
HY-172747	TNKS-2-IN-3	Inhibitor	/	Unkown
HY-N20707	Castalagin	Inhibitor	/	Unkown
HY-150613	PARP1/BRD4-IN-2	Inhibitor	/	Unkown
HY-174828	ATR/PARP1-IN-1	Inhibitor	/	Unkown
HY-175175	MAPK-IN-5	Inhibitor	/	Unkown
HY-179349	PARP-1/2-IN-5	Inhibitor	/	Unkown
HY-184967	XZ8078	Degrader	/	Unkown
HY-184273	TH-407a	Inhibitor	/	Unkown
HY-167762	TNKS-2-IN-4	Inhibitor	/	Unkown
HY-183765	PARP1/PKM2-IN-1	Inhibitor	/	Unkown
HY-147101	SK-575-NEG	Inhibitor	/	Unkown
HY-173597	ZINC43120769	Inhibitor	/	Unkown
HY-150765	PARP1-IN-12	Inhibitor	/	Unkown
HY-14687	(rac)-Talazoparib	Inhibitor	/	Unkown
HY-181254	PARP1/NAMPT-IN-1	Inhibitor	98.45%	Unkown
HY-184737	TPP-C8-CO-DSG bromide	Activator	/	Unkown
HY-179406	PARP1-IN-49	Inhibitor	/	Unkown
HY-187176	CPP-13	Degrader	/	Unkown
HY-175466	BER-IN-1	Inhibitor	/	Unkown
HY-173441	PARP1 ligand-1	Ligand	/	Unkown
HY-181068	2'-Nitroflavone	Inhibitor	/	Unkown
HY-108238	BSI-401	Inhibitor	/	Unkown
HY-117423	ST7710AA1	Inhibitor	/	Unkown
HY-115862	Benzo[c][1,8]naphthyridin-6(5H)-one	Inhibitor	/	Unkown
HY-14477	UPF-1035	Inhibitor	/	Unkown
HY-132157	8-Chloroquinazolin-4-ol	Inhibitor	98.44%	Unkown
HY-U00223	WD2000-012547	Inhibitor	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	PARP1	VGNC	VGNC:100025
Rattus norvegicus	PARP1	RGD	RGD:2053
Canis familiaris	PARP1	VGNC	VGNC:53874
Mus musculus	PARP1	MGD	MGI:1340806
Felis catus	PARP1	VGNC	VGNC:107909
Others	PARP1	NCBI