Braf - B-Raf proto-oncogene, serine/threonine kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114486

About Braf

Primary_assembly 4: 68,384,649-68,510,463 reverse strand.mRatBN7.2:CM026977.1

This gene has 4 transcripts (splice variants), 220 orthologues, 23 paralogues and is associated with 97 phenotypes. Biased expression in Brain (RPKM 22.7), Lung (RPKM 19.6) and 9 other tissues.

Summary

Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of ERK1 and ERK2 cascade; and response to cAMP. Located in neuron projection; nucleus; and plasma membrane. Used to study bile duct adenoma; cholangiocarcinoma; intrahepatic cholangiocarcinoma; and thyroid gland papillary carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Braf Products (13)

mRNA Protein Name
XM_006236359.4 XP_006236421.3 serine/threonine-protein kinase B-raf isoform X13
XM_039108633.1 XP_038964561.1 serine/threonine-protein kinase B-raf isoform X4
XM_039108631.1 XP_038964559.1 serine/threonine-protein kinase B-raf isoform X2
XM_039108634.1 XP_038964562.1 serine/threonine-protein kinase B-raf isoform X5
XM_039108635.1 XP_038964563.1 serine/threonine-protein kinase B-raf isoform X7
XM_006236357.4 XP_006236419.3 serine/threonine-protein kinase B-raf isoform X6
XM_039108630.1 XP_038964558.1 serine/threonine-protein kinase B-raf isoform X1
XM_039108636.1 XP_038964564.1 serine/threonine-protein kinase B-raf isoform X8
XM_039108632.1 XP_038964560.1 serine/threonine-protein kinase B-raf isoform X3
XM_039108637.1 XP_038964565.1 serine/threonine-protein kinase B-raf isoform X10
XM_039108639.1 XP_038964567.1 serine/threonine-protein kinase B-raf isoform X12
XM_231692.10 XP_231692.4 serine/threonine-protein kinase B-raf isoform X9
XM_039108638.1 XP_038964566.1 serine/threonine-protein kinase B-raf isoform X11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MAP kinase kinase kinase activity IDA
IDA: Inferred from direct assay
10648842 RGD
enables MAP kinase kinase kinase activity IMP
IMP: Inferred from mutant phenotype
16508002 RGD
enables mitogen-activated protein kinase kinase binding IMP
IMP: Inferred from mutant phenotype
16508002 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15150271 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15150271 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15917294 RGD
enables small GTPase binding IDA
IDA: Inferred from direct assay
12138204 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
12138204 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18194435 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
19720729 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10648842 RGD
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16508002 RGD
involved in response to cAMP IMP
IMP: Inferred from mutant phenotype
19720729 RGD
involved in response to peptide hormone IMP
IMP: Inferred from mutant phenotype
19720729 RGD
Cellular Component GO Annotation Evidence References Source
is active in postsynapse IDA
IDA: Inferred from direct assay
1884206 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Braf Protein Structure

RBD_BRAF

RBD_BRAF: cd17134 (169 - 250)

C1_B-Raf

C1_B-Raf: cd20871 (248 - 307)

STKc_Raf

STKc_Raf: cd14062 (535 - 787)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 847 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase B-raf

  • v-raf murine sarcoma viral oncogene homolog B

  • v-raf murine sarcoma viral oncogene homolog B1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10201 Sorafenib 99.85% Yes
HY-14660 Dabrafenib 99.94% Yes
HY-12057 Vemurafenib 99.90% Yes
HY-15605 Encorafenib Inhibitor 99.94% Yes
HY-18652 Avutometinib Inhibitor 99.43% Unkown
HY-10201A Sorafenib tosylate 99.98% Yes
HY-10201S Sorafenib-d3 99.57% Unkown
HY-10201R Sorafenib (Standard) 99.71% Unkown
HY-10201AR Sorafenib tosylate (Standard) / Unkown

Clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Phase
HY-148439 Daraxonrasib Inhibitor 99.96% Phase 3
HY-112089 Naporafenib Inhibitor 99.92% Phase 3
HY-132844 Tunlametinib Inhibitor 99.53% Phase 3
HY-10320 Doramapimod Inhibitor 99.98% Phase 2
HY-18972 Plixorafenib Inhibitor 99.80% Phase 2
HY-109080 Belvarafenib Inhibitor 98.97% Phase 2
HY-114491 Rineterkib Inhibitor 98.79% Phase 2
HY-111940 LUT014 97.09% Phase 2
HY-114491A Rineterkib hydrochloride Inhibitor 99.81% Phase 2
HY-109080A Belvarafenib TFA Inhibitor ≥99.0% Phase 2
HY-158115 NST-628 Inhibitor 98.35% Phase 1
HY-51424 PLX-4720 Inhibitor 99.90% Phase 1
HY-12558 LY3009120 98.66% Phase 1
HY-15200 Agerafenib Inhibitor 99.78% Phase 1
HY-153341 Tagarafdeg Degrader 99.41% Phase 1
HY-15610 GDC-0623 98.74% Phase 1
HY-18957 Lifirafenib Inhibitor 98.01% Phase 1
HY-159795 Claturafenib Inhibitor 99.95% Phase 1
HY-147405 Tinlorafenib Inhibitor 98.21% Phase 1
HY-15199 Agerafenib hydrochloride Inhibitor / Phase 1
HY-18957B Lifirafenib maleate Inhibitor / Phase 1
HY-19343 XL-281 Inhibitor / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991507 SCT200 Inhibitor 99.09% Phase 2

Pre-clinical Phase

Bioactive Molecules (143)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50846 SCH772984 Inhibitor 99.83% Unkown
HY-10966 SB-590885 Inhibitor 99.77% Unkown
HY-101494 Temuterkib Inhibitor 99.93% Unkown
HY-12661A AMG PERK 44 99.67% Unkown
HY-50864 GDC-0879 Inhibitor 99.49% Unkown
HY-147268 Exarafenib Inhibitor 99.68% Unkown
HY-11004 AZ 628 99.44% Unkown
HY-18832 AWL-II-38.3 Inhibitor 99.68% Unkown
HY-136420 SJF-0628 99.90% Unkown
HY-15767 TAK-632 Inhibitor 98.93% Unkown
HY-W074340 tert-Butyl 5-aminopentanoate / Unkown
HY-Y1322 Triphenyl phosphate 99.67% Unkown
HY-137487 PROTAC BRAF-V600E degrader-1 Degrader 98.04% Unkown
HY-14177 Raf inhibitor 1 Inhibitor 98.03% Unkown
HY-202699 SHOC2-RAS PPI-IN-1 Inhibitor 99.50% Unkown
HY-17598 Rafoxanide 98.60% Unkown
HY-155736 MAPK-IN-2 Inhibitor 99.66% Unkown
HY-181067 IK-595 Inhibitor 98.55% Unkown
HY-145120 Mosperafenib Inhibitor 98.29% Unkown
HY-111758 PROTAC B-Raf degrader 1 Inhibitor 99.78% Unkown
HY-N9330 Broussoflavonol F 98.11% Unkown
HY-12846 CCT196969 Inhibitor 99.67% Unkown
HY-100510 RAF709 Inhibitor 99.92% Unkown
HY-18997 PLX7904 Inhibitor 98.72% Unkown
HY-10247 BRAF inhibitor Inhibitor 98.07% Unkown
HY-136567 TBAP-001 Inhibitor 98.97% Unkown
HY-12787 L-779450 98.75% Unkown
HY-107779 BI-882370 Inhibitor 98.55% Unkown
HY-77113 B-Raf IN 11 Inhibitor 99.46% Unkown
HY-12291 HG6-64-1 99.32% Unkown
HY-149464 ARN22089 Inhibitor 98.18% Unkown
HY-P10438 TAT-Braftide Inhibitor 99.52% Unkown
HY-107415 PLX7922 Inhibitor 98.68% Unkown
HY-P10436 Braftide Inhibitor 99.51% Unkown
HY-148059 Uplarafenib Inhibitor 99.63% Unkown
HY-18227 B-Raf IN 1 Inhibitor 99.94% Unkown
HY-18507 AD57 Inhibitor 98.27% Unkown
HY-10201S2 Sorafenib-13C,d3 98.35% Unkown
HY-117658 GSK-114 Inhibitor 99.52% Unkown
HY-153603 B-Raf IN 15 Inhibitor 98.0% Unkown
HY-142160 GNE-9815 Inhibitor 98.94% Unkown
HY-12847 CCT241161 99.77% Unkown
HY-144269 SHR902275 Inhibitor 99.80% Unkown
HY-149380 Vem-L-Cy5 Inhibitor 98.31% Unkown
HY-P11706 MS1 peptide / Unkown
HY-15605S Encorafenib-13C,d3 Inhibitor 98.14% Unkown
HY-RS01588 BRAF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117273 AZ304 Inhibitor 99.77% Unkown
HY-130617 Pomalidomide-amido-C1-Br / Unkown
HY-150639 Everafenib Inhibitor / Unkown
HY-15198 KG5 Inhibitor 99.79% Unkown
HY-164474 DS03090629 Inhibitor / Unkown
HY-179505 OPN-9652 Inhibitor 98.84% Unkown
HY-10966R SB-590885 (Standard) Inhibitor 99.55% Unkown
HY-164524 SBI-0640726 Inhibitor / Unkown
HY-10201S1 Sorafenib-d4 99.9% Unkown
HY-108887 Anticancer agent 124 Inhibitor / Unkown
HY-11043 PF-0419789 Inhibitor / Unkown
HY-126298 RAF mutant-IN-1 Inhibitor / Unkown
HY-44237 Pomalidomide-CO-C-NH2 / Unkown
HY-10201S4 Sorafenib-d3 tosylate Inhibitor / Unkown
HY-103086 INU-152 Inhibitor / Unkown
HY-10966G SB-590885 (GMP) Inhibitor / Unkown
HY-115933 EGFR/BRAF-IN-1 Inhibitor / Unkown
HY-117707 EBI-907 Inhibitor / Unkown
HY-12057S Vemurafenib-d5 / Unkown
HY-12057S1 Vemurafenib-d7 / Unkown
HY-123799 SB-699393 Inhibitor / Unkown
HY-126180 BAY-866 Inhibitor / Unkown
HY-135216 Antiproliferative agent-54 Inhibitor / Unkown
HY-137488 PROTAC BRAF-V600E degrader-2 Inhibitor / Unkown
HY-13810 PF-04880594 Inhibitor / Unkown
HY-142820 B-Raf IN 5 Inhibitor / Unkown
HY-142830 B-Raf IN 6 Inhibitor / Unkown
HY-144271 RAF-IN-1 Inhibitor / Unkown
HY-146442 BRAF V600E/CRAF-IN-1 Inhibitor / Unkown
HY-146443 BRAF V600E/CRAF-IN-2 Inhibitor / Unkown
HY-146491 VEGFR-2/BRAF-IN-1 / Unkown
HY-146492 VEGFR-2/BRAF-IN-2 / Unkown
HY-147825 EGFR/BRAFV600E-IN-1 / Unkown
HY-147852 B-Raf IN 7 Inhibitor / Unkown
HY-147853 B-Raf IN 8 Inhibitor / Unkown
HY-147854 B-Raf IN 9 / Unkown
HY-149415 Multi-kinase-IN-5 Inhibitor / Unkown
HY-149517 EGFR/BRAFV600E-IN-2 / Unkown
HY-14979 ML786 Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-150250 B-Raf IN 13 Inhibitor / Unkown
HY-153914 B-Raf IN 14 Inhibitor / Unkown
HY-155942 B-Raf IN 19 Inhibitor / Unkown
HY-156554 Raf inhibitor 3 Inhibitor / Unkown
HY-156590 B-Raf IN 16 Inhibitor / Unkown
HY-158027 B-Raf IN 17 Inhibitor / Unkown
HY-16063 ARQ-736 Inhibitor / Unkown
HY-162460 ERK1/2 inhibitor 10 Inhibitor / Unkown
HY-162873 MEK/RAF-IN-1 Inhibitor / Unkown
HY-164400 SIJ1777 / Unkown
HY-164428 AE 51310 Inhibitor / Unkown
HY-164492 LSN3074753 Inhibitor / Unkown
HY-168013 KRASG12C IN-14 Inhibitor / Unkown
HY-168125 JNK-IN-18 Inhibitor / Unkown
HY-168442 KRAS inhibitor-40 Inhibitor / Unkown
HY-168512 BRAFV600E-IN-1 Inhibitor / Unkown
HY-169869 pan-Raf/RTK inhibitor 1 Inhibitor / Unkown
HY-173164 EGFR/BRAFV600E-IN-4 / Unkown
HY-174274 ERK2-IN-6 Inhibitor / Unkown
HY-175435 CST905 Degrader / Unkown
HY-175726 BRAF ligand-Linker Conjugate 1 / Unkown
HY-175831 BRAFV600E-IN-2 Inhibitor / Unkown
HY-17598R Rafoxanide (Standard) / Unkown
HY-178995 BRAFV600E-IN-3 Inhibitor / Unkown
HY-179012 CDC20/HSP90-IN-1 / Unkown
HY-179098 Multi-target kinase-IN-8 / Unkown
HY-179559 OPN-9643 Inhibitor / Unkown
HY-180154 EGFR/BRAFV600E-IN-6 / Unkown
HY-180161 B-Raf-IN-20 Inhibitor / Unkown
HY-180419 SF-3-030 / Unkown
HY-181061 COX/5-LO-IN-2 / Unkown
HY-181130 Anticancer agent 299 / Unkown
HY-181131 Anticancer agent 300 / Unkown
HY-181913 KRAS G12C-IN-76 Inhibitor / Unkown
HY-181978 GIT1-IN-1 / Unkown
HY-182763 EGFR/BRAFV600E-IN-7 / Unkown
HY-18318 Takeda-6D Inhibitor 99.41% Unkown
HY-183674 MEK-IN-10 / Unkown
HY-184546 BRAFV600E ligand-1 Ligand / Unkown
HY-184581 Pomalidomide-5-C4-acid / Unkown
HY-18507A AD57 hydrochloride Inhibitor / Unkown
HY-18652A Avutometinib potassium Inhibitor / Unkown
HY-E70649 BRAF V600E Recombinant Human Active Protein Kinase / Unkown
HY-N13841 2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose / Unkown
HY-RS01589 Braf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01590 Braf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120676 B-Raf IN 18 Inhibitor / Unkown
HY-14177A Raf inhibitor 1 dihydrochloride Inhibitor 99.29% Unkown
HY-164529 SJ-C1044 Inhibitor 98.63% Unkown
HY-164530 SKLB646 Inhibitor / Unkown
HY-177946 RAF-IN-4 Inhibitor / Unkown
HY-180329 CG 858-Neg / Unkown
HY-186223 Enzyme modulator-1 Modulator / Unkown
HY-18817 AFG210 Inhibitor / Unkown
HY-41747 BRAF ligand-1 Ligand / Unkown
HY-51424S PLX-4720-d7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Braf NCBI NCBI:673