Cdk6 - cyclin-dependent kinase 6 Gene

Also Known as Crk2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12571

About Cdk6

Chromosome 5: 3,391,485-3,581,008 forward strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 199 orthologues, 25 paralogues and is associated with 48 phenotypes. Ubiquitous expression in thymus adult (RPKM 7.), lung adult (RPKM 3.6) and 26 other tissues.

Summary

This gene encodes a member of the cyclin dependent kinase family of proteins that play important roles in the progression and regulation of the cell cycle. The encoded protein binds to a D-type cyclin to form an active kinase complex to regulate progression through the G1 phase of the cell cycle. Mice lacking the encoded protein exhibit thymic and splenic hypoplasia, and hematopoietic defects such as reduced number of megakaryocytes and erythrocytes. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2015]

Cdk6 Products (2)

mRNA Protein Name
NM_009873.3 NP_034003.1 cyclin-dependent kinase 6
NM_009873.3 NP_034003.1 cyclin-dependent kinase 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinase activity IDA
IDA: Inferred from direct assay
21508411 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7651726 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
21508411 MGI
acts upstream of or within Notch signaling pathway IGI
IGI: Inferred from genetic interaction
21508411 MGI
acts upstream of or within T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
21508411 MGI
acts upstream of or within cell quiescence IMP
IMP: Inferred from mutant phenotype
25342715 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
21508411 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
21508411 MGI
involved in hemopoiesis IMP
IMP: Inferred from mutant phenotype
15315761 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
25342715 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
21508411 MGI
acts upstream of or within regulation of hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
25342715 MGI
acts upstream of or within response to 5-fluorouracil IMP
IMP: Inferred from mutant phenotype
25342715 MGI
Cellular Component GO Annotation Evidence References Source
part of cyclin D2-CDK6 complex IDA
IDA: Inferred from direct assay
7739547 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk6 Protein Structure

STKc_CDK6

STKc_CDK6: cd07862 (10 - 299)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 6

  • CR2 protein kinase

  • cell division protein kinase 6

  • serine/threonine-protein kinase PLSTIRE

Cdk6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cdk6 Q64261 Jun Mus musculus P05627
Anti Bait CoIP
23948297
Intra
Cdk6 Q64261 Ccnd3 Mus musculus P30282
Anti Bait CoIP
23948297
Intra
Cdk6 Q64261 Ccnd3 Mus musculus P30282
Anti Bait CoIP
23079656
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50767 Palbociclib Inhibitor 99.94% Unkown
HY-16297A Abemaciclib Inhibitor 99.97% Yes
HY-15777 Ribociclib Inhibitor 99.94% Unkown
HY-50767C Palbociclib hydrochloride Inhibitor 99.96% Unkown
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% Unkown
HY-A0065 Palbociclib isethionate Inhibitor 99.98% Unkown
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-15777B Ribociclib succinate Inhibitor 99.93% Unkown
HY-15777A Ribociclib hydrochloride Inhibitor 99.95% Unkown
HY-114338 Dalpiciclib Inhibitor 99.70% Unkown
HY-101467A Trilaciclib hydrochloride Inhibitor 99.69% Unkown
HY-B0877 Halcinonide Activator 98.29% Unkown
HY-15777C Ribociclib succinate hydrate Inhibitor 99.94% Unkown
HY-50767B Palbociclib dihydrochloride Inhibitor / Unkown
HY-50767D Palbociclib orotate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-125101A Rafutrombopag diolamine Agonist / Phase 4
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-101563 GSK3326595 99.83% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-114177 Ebvaciclib Inhibitor 99.98% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-12624 Narazaciclib Inhibitor 98.66% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-45661 Inixaciclib Inhibitor 99.93% Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-15504 RGB-286638 Inhibitor 99.67% Phase 1
HY-111361 FN-1501 Inhibitor 98.72% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.26% Phase 1
HY-172234 PF-06842874 Inhibitor / Phase 1
HY-153336 PRT3645 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (135)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Unkown
HY-103248 Toyocamycin Inhibitor 99.27% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.39% Unkown
HY-136250 BSJ-03-204 Inhibitor 99.76% Unkown
HY-116035 Nimbolide Inhibitor 99.79% Unkown
HY-138946 XY028-140 Inhibitor 98.52% Unkown
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Unkown
HY-N0404 Sinigrin Inhibitor 99.97% Unkown
HY-111556 BSJ-03-123 Inhibitor 99.19% Unkown
HY-114338A Dalpiciclib hydrochloride Inhibitor 99.41% Unkown
HY-136252 BSJ-04-132 Inhibitor 99.07% Unkown
HY-122620 Rafutrombopag (tautomerism) Agonist 98.33% Unkown
HY-144117 GFB-12811 Inhibitor 98.04% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-N0805 Alisol B 23-acetate Inhibitor 99.65% Unkown
HY-12422 Voruciclib Inhibitor 99.76% Unkown
HY-128669 Abemaciclib metabolite M2 Inhibitor 99.75% Unkown
HY-103712 Samuraciclib Inhibitor 99.55% Unkown
HY-126534A Abemaciclib metabolite M18 hydrochloride Inhibitor 98.18% Unkown
HY-16559 Riviciclib hydrochloride 99.08% Unkown
HY-148530 YX-2-107 Degrader 98.60% Unkown
HY-163786 PROTAC CDK4/6 degrader 1 Degrader 98.88% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.93% Unkown
HY-119940 MC180295 Inhibitor 98.07% Unkown
HY-112272 Lerociclib Inhibitor 96.42% Unkown
HY-125835 CP-10 Inhibitor 98.41% Unkown
HY-129336 Abemaciclib metabolite M20 Inhibitor 95.92% Unkown
HY-129180 XY028-133 Inhibitor 99.07% Unkown
HY-151071 TMX-3013 Inhibitor 98.02% Unkown
HY-15889 AMG 925 Inhibitor 99.02% Unkown
HY-126534 Abemaciclib metabolite M18 Inhibitor 98.01% Unkown
HY-50943 AT7519 Hydrochloride Inhibitor 99.16% Unkown
HY-50767S Palbociclib-d8 Inhibitor 99.84% Unkown
HY-144995 BSJ-02-162 Degrader 98.07% Unkown
HY-15504A RGB-286638 free base Inhibitor 98.09% Unkown
HY-148214 CDK2/4/6-IN-2 Inhibitor 98.20% Unkown
HY-151069 TMX-2039 Inhibitor 99.42% Unkown
HY-142076 CDK4/6-IN-15 Inhibitor 99.32% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-148070 FLT3-IN-17 99.11% Unkown
HY-164129 CDK4-IN-3 Inhibitor 98.07% Unkown
HY-152263 HEMTAC CDK4/6 degrader 1 Inhibitor 98.18% Unkown
HY-153894 SRX3177 Inhibitor 99.33% Unkown
HY-148062 RSS0680 99.85% Unkown
HY-114339 CDK4/6-IN-2 Inhibitor 99.67% Unkown
HY-16942 Damulin B Inhibitor 96.62% Unkown
HY-126251 CDK9-IN-7 Inhibitor 98.05% Unkown
HY-148063 DB0614 99.92% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.88% Unkown
HY-129336S Abemaciclib metabolite M20-d8 Inhibitor 99.26% Unkown
HY-155787 SHR5428 Inhibitor 99.80% Unkown
HY-136726 CGP-82996 Inhibitor 98.12% Unkown
HY-50940A AT7519 TFA Inhibitor 99.75% Unkown
HY-108420 INK4C-IN-2 Activator 98.35% Unkown
HY-115992 CDK4/6-IN-9 Inhibitor 99.46% Unkown
HY-146213 CDK4/6-IN-12 Inhibitor 99.76% Unkown
HY-168996 LA-CB1 Degrader 98.20% Unkown
HY-142696A CDK6/PIM1-IN-1 hydrochloride Inhibitor 99.38% Unkown
HY-145589 Rafutrombopag Agonist 95.29% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-185121 PROTAC CDK2/4/6 Degrader-2 Degrader 97.22% Unkown
HY-168440 Aurora-A ligand 1 Ligand 98.75% Unkown
HY-123535 P18IN003 Activator 99.49% Unkown
HY-112243A Cimpuciclib tosylate Inhibitor 99.65% Unkown
HY-181490 WWZ-11-098 Degrader / Unkown
HY-164906 TMX-2138 Degrader 98.99% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-180277 PROTAC CDK6 Degrader 1 Degrader 98.89% Unkown
HY-112418 CDK4/6-IN-18 Inhibitor 98.9% Unkown
HY-161708 PROTAC FLT3/CDKs degrader-1 Degrader / Unkown
HY-112346 RGB-286147 Inhibitor 98.60% Unkown
HY-176713 KWZY-11 Inhibitor / Unkown
HY-15889A AMG 925 (HCl) Inhibitor / Unkown
HY-N2423 Sinigrin hydrate Inhibitor 99.92% Unkown
HY-112243 Cimpuciclib Inhibitor / Unkown
HY-126244 CDK4/6-IN-3 Inhibitor / Unkown
HY-131063 CDK6/9-IN-1 Inhibitor / Unkown
HY-184911 CDK6 ligand-3 Degrader / Unkown
HY-153088 CDK4/6-IN-16 Inhibitor / Unkown
HY-178168 ARUK2010694 Inhibitor / Unkown
HY-184910 JHK-02-108-2 Degrader / Unkown
HY-182071 MG16 Inhibitor / Unkown
HY-179375 LCI133 Inhibitor / Unkown
HY-180279 CDK6 ligand-Linker Conjugate 1 Inhibitor / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-181501 CDK2/4/6-IN-3 Inhibitor / Unkown
HY-161709 FLT3/CDKs ligand-1 Degrader / Unkown
HY-143258 CDK4/6-IN-8 Inhibitor / Unkown
HY-182036 KWZL-7f15 Inhibitor / Unkown
HY-179452 KRAS G13D-IN-2 Inhibitor / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-185487 CDK4/6-IN-27 Inhibitor / Unkown
HY-172899 Carbonic anhydrase inhibitor 33 Inhibitor / Unkown
HY-162529 CDK4/6-IN-19 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-179151 CDK4/6-IN-26 Inhibitor / Unkown
HY-183771 CDK4/6-IN-28 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-171656 G721-0282 Inhibitor 99.96% Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-181999 PC8 Inhibitor / Unkown
HY-178171 ARUK2010489 Inhibitor 96.64% Unkown
HY-171826 PROTAC CDK2/4/6 Degrader-1 Inhibitor / Unkown
HY-162530 CDK4/6-IN-20 Inhibitor / Unkown
HY-114338B Dalpiciclib isethionate Inhibitor / Unkown
HY-182986 LS-Q2 Inhibitor / Unkown
HY-162619 CDK9-IN-33 Inhibitor / Unkown
HY-181729 PROTAC BET Degrader-15 Inhibitor / Unkown
HY-163787 YY173 Inhibitor / Unkown
HY-172128 NUAK1-IN-2 Inhibitor / Unkown
HY-175013 CDK6/9-IN-2 Inhibitor / Unkown
HY-181483 CDK6-IN-2 Inhibitor / Unkown
HY-176718 VEGFR-2-IN-69 Inhibitor / Unkown
HY-134303 CST651 Degrader / Unkown
HY-164376 CDK4/6-IN-21 Inhibitor / Unkown
HY-184707 CDK4/6-IN-29 Inhibitor / Unkown
HY-178112 CDK2-IN-47 Inhibitor / Unkown
HY-143257 CDK4/6-IN-7 Inhibitor / Unkown
HY-180262 PROTAC CDK6 Degrader 2 Degrader / Unkown
HY-148213 CDK2/4/6-IN-1 Inhibitor / Unkown
HY-178516 PROTAC CDK4/6/9 degrader 2 Degrader / Unkown
HY-173237 CDK4/6/BRD4-IN-1 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-180278 CDK6 ligand 1 Inhibitor / Unkown
HY-115993 CDK4/6-IN-10 Inhibitor / Unkown
HY-178452 PROTAC CDK4/6/9 degrader 1 Degrader / Unkown
HY-176365 Palbociclib-C4-Boc Inhibitor / Unkown
HY-170651 CDK4/6/HDAC-IN-1 Inhibitor / Unkown
HY-183571 JD128 Inhibitor / Unkown
HY-168444 CDK4/6-IN-23 Inhibitor / Unkown
HY-164376A CDK4/6-IN-21 maleate Inhibitor / Unkown
HY-102088 P18IN011 Inhibitor / Unkown
HY-N11852 Momilactone B Inhibitor 99.47% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk6 NCBI NCBI:1021