Nav1 - neuron navigator 1 Gene

Also Known as Gm38399; Pomfil3; Unc53h1; mKIAA1151; steerin-1; 9530089B19; 9930003A20Rik; C230080M11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 215690

Summary

Acts upstream of or within microtubule bundle formation and neuron migration. Located in axon initial segment and microtubule Cytoskeleton. Is expressed in several structures, including central nervous system; embryo mesenchyme; molar; peripheral nervous system ganglion; and sensory organ. Orthologous to human NAV1 (neuron navigator 1). [provided by Alliance of Genome Resources, Apr 2022]

Nav1 Products (1)

mRNA Protein Name
NM_173437.2 NP_775613.2 neuron navigator 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within microtubule bundle formation IDA
IDA: Inferred from direct assay
15797708 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
15797708 MGI
Cellular Component GO Annotation Evidence References Source
located in axon initial segment IDA
IDA: Inferred from direct assay
26671463 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
15797708 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuron navigator 1

  • Steerin1

  • pore membrane and/or filament-interacting-like protein 3

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148800 Suzetrigine Inhibitor 99.98% Unkown
HY-17429 Flecainide acetate Inhibitor 99.35% Unkown
HY-17355A Dexpramipexole dihydrochloride 99.94% Yes
HY-B0262 Methocarbamol Inhibitor 99.68% Unkown
HY-17355B Dexpramipexole 99.56% Yes
HY-17355AR Dexpramipexole dihydrochloride (Standard) / Unkown

Clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Phase
HY-148410A Zorevunersen sodium Activator 99.27% Phase 3
HY-105285 Piromelatine 99.70% Phase 3
HY-148410 Zorevunersen Activator 98.50% Phase 3
HY-12883 PF 05089771 Inhibitor 99.87% Phase 2
HY-147423 Zandatrigine Inhibitor 99.28% Phase 2
HY-12796A Raxatrigine hydrochloride Inhibitor 99.10% Phase 2
HY-12796 Raxatrigine Inhibitor 99.85% Phase 2
HY-16723 Funapide Inhibitor 99.83% Phase 2
HY-131182 DS-1971a Inhibitor 99.30% Phase 2
HY-105283 PF 04531083 Antagonist 99.62% Phase 2
HY-125079 DSP-2230 Inhibitor 98.33% Phase 1
HY-114237 GDC-0276 Inhibitor 99.69% Phase 1
HY-139081 GDC-0310 Inhibitor 98.84% Phase 1
HY-103623 PF-05241328 Inhibitor 98.08% Phase 1
HY-114301 PF-06305591 Inhibitor 99.74% Phase 1
HY-101383 PF-01247324 Inhibitor 99.77% Phase 1
HY-122001 PF-05186462 Inhibitor 99.69% Phase 1
HY-114301A PF-06305591 dihydrate Inhibitor 99.84% Phase 1
HY-128794 PF-05150122 / Phase 1
HY-W040555 Norquetiapine dihydrochloride 99.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (172)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N6691 Veratridine Inhibitor 99.42% Unkown
HY-100001 SKF-96365 (hydrochloride) 99.93% Unkown
HY-11079 A-803467 Inhibitor 99.69% Unkown
HY-100345 AMTB hydrochloride Inhibitor 99.08% Unkown
HY-16787 ICA-121431 Inhibitor 99.35% Unkown
HY-12811 PF-04856264 Inhibitor 99.29% Unkown
HY-118952A PF-06456384 trihydrochloride Inhibitor 99.38% Unkown
HY-P1221A ProTx II TFA Inhibitor 99.86% Unkown
HY-107405 TC-N 1752 Inhibitor 99.67% Unkown
HY-157802 LTGO-33 Inhibitor 98.83% Unkown
HY-126429 Nav1.1 activator 1 Activator 98.98% Unkown
HY-B0824 Bifenthrin Activator 99.76% Yes
HY-148792 Relutrigine Inhibitor 99.33% Unkown
HY-157786 XPC-5462 Inhibitor 99.65% Unkown
HY-164795A SBI-810 hydrochloride 99.55% Unkown
HY-100727 AM-2099 Inhibitor 98.37% Unkown
HY-W052508 Norquetiapine 99.95% Unkown
HY-157784 XPC-7724 Inhibitor 99.46% Unkown
HY-133012 GFB-8438 Inhibitor 99.74% Unkown
HY-171244 Sodium Channel inhibitor 6 Inhibitor 99.93% Unkown
HY-110325 PF-04885614 Inhibitor 97.00% Unkown
HY-B1837 Cyfluthrin Inhibitor 99.52% Unkown
HY-P10234A Poneratoxin acetate Modulator 98.35% Unkown
HY-19958 XEN907 Inhibitor 98.74% Unkown
HY-139346 VX-150 Inhibitor 98.36% Unkown
HY-133910 Lu AE98134 Activator 98.07% Unkown
HY-13985 Nav1.7 inhibitor Inhibitor 99.63% Unkown
HY-112279 GNE-131 Inhibitor 98.15% Unkown
HY-131870 GX-201 Inhibitor 98.46% Unkown
HY-145169 AZ194 Inhibitor 99.45% Unkown
HY-152166 NaV1.2/1.6 channel blocker-1 Inhibitor / Unkown
HY-125928 AA43279 Inhibitor 99.80% Unkown
HY-101789 Nav1.7-IN-3 Inhibitor 98.21% Unkown
HY-123824 GNE-0439 Inhibitor 99.80% Unkown
HY-155635 Nav1.8-IN-4 Inhibitor 99.78% Unkown
HY-20362 4-Azaindole 99.57% Unkown
HY-N0478 Neoline 98.0% Unkown
HY-N1847 3'-Methoxydaidzein Inhibitor 99.67% Unkown
HY-128772 XPC-6444 Inhibitor 98.93 Unkown
HY-157802A (S)-LTGO-33 Inhibitor 99.41% Unkown
HY-P1220A Huwentoxin-IV TFA Inhibitor 99.18% Unkown
HY-119934 NaV1.7 inhibitor-1 Inhibitor 99.17% Unkown
HY-123825 GX-674 Antagonist 98.45% Unkown
HY-143481 Nav1.8-IN-2 Inhibitor 99.83% Unkown
HY-P1218B Phrixotoxin 3-NH2 TFA Inhibitor 98.96% Unkown
HY-148410C Zorevunensen negative control Activator 99.28% Unkown
HY-12883A PF-05198007 Inhibitor 99.27% Unkown
HY-146069 ABBV-318 Inhibitor 98.72% Unkown
HY-125942 SKF-96365 99.97% Unkown
HY-156596 Aneratrigine Inhibitor 99.60% Unkown
HY-164795 SBI-810 98.25% Unkown
HY-178281 E0199 99.89% Unkown
HY-P5807A Cn2 toxin TFA Agonist 96.59% Unkown
HY-155058 Nav1.3 channel inhibitor 1 Inhibitor 99.11% Unkown
HY-178494 Nav1.7-IN-19 Inhibitor 98.87% Unkown
HY-P1073 ProTx-I Inhibitor 95.15% Unkown
HY-P1441A Mambalgin 1 TFA Inhibitor 95.72% Unkown
HY-P1443 OD1 Modulator 99.40% Unkown
HY-P1681A GpTx-1 TFA Antagonist 99.56% Unkown
HY-18689 SYM2206 Antagonist 99.83% Unkown
HY-108425B (Rac)-AMG8379 Antagonist 99.25% Unkown
HY-16723A (R)-Funapide Inhibitor 99.22% Unkown
HY-123414 GX-936 Inhibitor 97.06% Unkown
HY-15736 Sodium Channel inhibitor 1 Inhibitor 99.38% Unkown
HY-158979 Nav1.8-IN-14 Inhibitor 99.83% Unkown
HY-160591 Nav1.8-IN-10 Inhibitor / Unkown
HY-160593 Nav1.8-IN-12 Inhibitor / Unkown
HY-163855 KGP-25 Inhibitor 95.0% Unkown
HY-172903 Nav1.8-IN-16 Inhibitor / Unkown
HY-172933 Nav1.8 modulator 1 Modulator / Unkown
HY-17429S Flecainide-d4 acetate Inhibitor 99.0% Unkown
HY-176911 Nav1.8-IN-21 Inhibitor / Unkown
HY-19366 Nav1.7-IN-2 Inhibitor 98.28% Unkown
HY-P1221 ProTx II Inhibitor 98.34% Unkown
HY-P5160A Phlotoxin-1 TFA Inhibitor 92.73% Unkown
HY-P5786 Heteropodatoxin-1 / Unkown
HY-RS09046 NAV1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123833 PF-05661014 Modulator 99.56% Unkown
HY-102998 Nav1.7-IN-6 Inhibitor / Unkown
HY-108425 AMG8379 Antagonist / Unkown
HY-126291 GNE-616 Inhibitor / Unkown
HY-183566 MK-5661 Inhibitor / Unkown
HY-W052508S Norquetiapine-d8 / Unkown
HY-108425A AMG8380 Inhibitor / Unkown
HY-116137 Nav1.7-IN-17 / Unkown
HY-117714 AZD-3161 Inhibitor / Unkown
HY-118952 PF-06456384 Inhibitor / Unkown
HY-120774 GS-462808 Inhibitor / Unkown
HY-126005 VGSC blocker-1 Inhibitor / Unkown
HY-12883B PF 05089771 tosylate Inhibitor / Unkown
HY-132133 Nav1.8-IN-1 Inhibitor / Unkown
HY-135495 AM-0466 Inhibitor / Unkown
HY-138816 Nav1.7-IN-15 Antagonist / Unkown
HY-141547 Nav1.7-IN-8 Inhibitor / Unkown
HY-149944 Analgesic agent-2 Inhibitor / Unkown
HY-149994 DS43260857 Inhibitor / Unkown
HY-155236 Ancistrotecine B Inhibitor / Unkown
HY-159094 Nav1.8-IN-15 Inhibitor / Unkown
HY-160588 Nav1.8-IN-7 Inhibitor / Unkown
HY-160589 Nav1.8-IN-8 Inhibitor / Unkown
HY-160592 Nav1.8-IN-11 Inhibitor / Unkown
HY-160663 Nav1.7 blocker 1 / Unkown
HY-161272 Nav1.8-IN-6 Inhibitor / Unkown
HY-161572 Nav1.8-IN-13 Inhibitor / Unkown
HY-162246 Nav1.8-IN-5 Inhibitor / Unkown
HY-162347 Nav1.7-IN-13 Inhibitor / Unkown
HY-162757 Anticonvulsant agent 5 Modulator / Unkown
HY-167852 GX-585 Inhibitor / Unkown
HY-169421 Nav1.7-IN-18 Inhibitor / Unkown
HY-170930 Anticonvulsant agent 9 / Unkown
HY-171778 QLS-81 Inhibitor / Unkown
HY-172998 Nav1.8-IN-18 Inhibitor / Unkown
HY-172999 Nav1.8-IN-19 Inhibitor / Unkown
HY-174845 Nav1.8-IN-20 Inhibitor / Unkown
HY-175289 hERG-IN-3 Inhibitor / Unkown
HY-176065 Nav1.2-IN-1 Inhibitor / Unkown
HY-178344 Multi-target kinase-IN-6 Activator / Unkown
HY-178963 Nav1.2-IN-2 Inhibitor 99.82% Unkown
HY-179445 Nav1.7-IN-20 Inhibitor / Unkown
HY-181063 Nav1.5-IN-1 Inhibitor / Unkown
HY-181615 Nav1.8-IN-22 Inhibitor / Unkown
HY-182334 azo-Q2a Inhibitor / Unkown
HY-182710 DA-0218 Inhibitor / Unkown
HY-182831 Nav1.7-IN-22 Inhibitor / Unkown
HY-183646 Nav1.8-IN-23 Inhibitor / Unkown
HY-183709 Nav1.8-IN-24 Inhibitor / Unkown
HY-184190 ERG-IN-7 Inhibitor / Unkown
HY-185333 Sodium Channel-IN-7 Inhibitor / Unkown
HY-B0262S Methocarbamol-d5 Inhibitor / Unkown
HY-B0262S2 Methocarbamol-13C,d3 Inhibitor / Unkown
HY-B1837S Cyfluthrin-d6 Inhibitor / Unkown
HY-P10234 Poneratoxin Modulator / Unkown
HY-P11045 JNJ63955918 Inhibitor / Unkown
HY-P1218 Phrixotoxin 3 Inhibitor / Unkown
HY-P1218A Phrixotoxin 3 TFA Inhibitor / Unkown
HY-P1219 Jingzhaotoxin-III Inhibitor / Unkown
HY-P1220 Huwentoxin-IV Inhibitor / Unkown
HY-P1681 GpTx-1 Antagonist / Unkown
HY-P5152 Scorpion toxin Tf2 Activator / Unkown
HY-P5153 ProTx-III Inhibitor / Unkown
HY-P5160 Phlotoxin-1 Inhibitor / Unkown
HY-P5164 GrTx1 Inhibitor / Unkown
HY-P5177 GsAF-II Inhibitor / Unkown
HY-P5781 δ-Theraphotoxin-Hm1b Inhibitor / Unkown
HY-P5782 δ-Theraphotoxin-Hm1a toxin Activator / Unkown
HY-P5783 δ-Buthitoxin-Hj2a Agonist / Unkown
HY-P5784 δ-Buthitoxin-Hj1a Agonist / Unkown
HY-P5790 μ-TRTX-Hd1a Inhibitor / Unkown
HY-P5793 GTx1-15 Inhibitor / Unkown
HY-P5795 GsAF-I Inhibitor / Unkown
HY-P5800 Phlo1b Inhibitor / Unkown
HY-P5801 Phlo1a Inhibitor / Unkown
HY-P5807 Cn2 toxin Activator / Unkown
HY-P5809 Pe1b Inhibitor / Unkown
HY-P5810 Ceratotoxin-2 Inhibitor / Unkown
HY-P5811 Ceratotoxin-1 Inhibitor / Unkown
HY-P5813 Cd1a Inhibitor / Unkown
HY-P5865 Tap1a Inhibitor / Unkown
HY-P5872 Jingzhaotoxin XI Inhibitor / Unkown
HY-P5900 m3-Huwentoxin IV Inhibitor / Unkown
HY-P5916 VSTx-3 Antagonist / Unkown
HY-W031620 VGSCs-IN-1 Inhibitor 99.92% Unkown
HY-W040171 Tefluthrin Activator / Unkown
HY-W699451 MTSET chloride Inhibitor / Unkown
HY-116194 NaV1.7 blocker-801 Inhibitor / Unkown
HY-118048 NAV 26 Inhibitor 99.79% Unkown
HY-17355BS Dexpramipexole-d3 dihydrochloride / Unkown
HY-175226 DPP8/9-IN-2 Inhibitor / Unkown
HY-182195 Suzetrigine N-oxide Inhibitor / Unkown
HY-185334 GNE-3565 Inhibitor / Unkown
HY-185335 Sodium Channel-IN-8 Inhibitor / Unkown
HY-B0262S1 Methocarbamol-d3 Inhibitor 98.15% Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990503 Anti-SCN9a/Nav1.7 Antibody Inhibitor 98.57% Unkown
HY-P990502 Anti-SCN11a/Nav1.9 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nav1 NCBI NCBI:89796