Bcr - BCR activator of RhoGEF and GTPase Gene

Also Known as mKIAA3017; 5133400C09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110279

Summary

Enables GTPase activator activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; and regulation of vascular permeability. Acts upstream of or within several processes, including animal organ development; cellular response to lipopolysaccharide; and regulation of vesicle-mediated transport. Located in cytosol; plasma membrane; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including cardiovascular system; central nervous system; forelimb bud; genitourinary system; and spleen. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Bcr Products (1)

mRNA Protein Name
NM_001081412.2 NP_001074881.1 breakpoint cluster region protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
17116687 MGI
enables GTPase activator activity IGI
IGI: Inferred from genetic interaction
19703997 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17000758 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
17116687 MGI
acts upstream of or within brain development IGI
IGI: Inferred from genetic interaction
11684658 MGI
acts upstream of cell migration IGI
IGI: Inferred from genetic interaction
17116687 MGI
acts upstream of or within cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
7889565 MGI
acts upstream of or within definitive hemopoiesis IMP
IMP: Inferred from mutant phenotype
7889565 MGI
acts upstream of establishment of localization in cell IGI
IGI: Inferred from genetic interaction
17116687 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
7889565 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
11921339 MGI
acts upstream of or within intracellular protein transmembrane transport IMP
IMP: Inferred from mutant phenotype
7889565 MGI
acts upstream of macrophage migration IGI
IGI: Inferred from genetic interaction
17116687 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
20962234 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
20962234 MGI
involved in negative regulation of blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
23152932 MGI
involved in negative regulation of cellular extravasation IMP
IMP: Inferred from mutant phenotype
23152932 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
19703997 MGI
acts upstream of or within negative regulation of macrophage migration IGI
IGI: Inferred from genetic interaction
17116687 MGI
acts upstream of or within negative regulation of neutrophil degranulation IGI
IGI: Inferred from genetic interaction
19703997 MGI
acts upstream of or within negative regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
7889565 MGI
acts upstream of or within negative regulation of respiratory burst IMP
IMP: Inferred from mutant phenotype
7889565 MGI
acts upstream of or within neuromuscular process controlling balance IGI
IGI: Inferred from genetic interaction
11921339 MGI
acts upstream of neutrophil degranulation IGI
IGI: Inferred from genetic interaction
19703997 MGI
acts upstream of phagocytosis IGI
IGI: Inferred from genetic interaction
17116687 MGI
acts upstream of or within positive regulation of phagocytosis IGI
IGI: Inferred from genetic interaction
17116687 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
11809706 MGI
involved in regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
23152932 MGI
acts upstream of or within renal system process IMP
IMP: Inferred from mutant phenotype
7889565 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
19703997 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
20962234 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
20962234 MGI
located in cytosol IDA
IDA: Inferred from direct assay
17116687 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20962234 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20962234 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17116687 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
25331951 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

breakpoint cluster region protein

  • breakpoint cluster region homolog

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10181 Dasatinib 99.85% Yes
HY-15463 Imatinib 99.95% Yes
HY-10159 Nilotinib 99.94% Yes
HY-50946 Imatinib Mesylate 99.97% Yes
HY-104010 Asciminib Inhibitor 99.61% Yes
HY-15666 Olverembatinib Inhibitor 99.47% Yes
HY-10181A Dasatinib hydrochloride 99.67% Yes
HY-129390 Orelabrutinib Inhibitor 99.97% Yes
HY-10159A Nilotinib monohydrochloride monohydrate 99.91% Yes
HY-13904 Flumatinib Inhibitor 99.94% Unkown
HY-10181B Dasatinib monohydrate 99.58% Yes
HY-104010A Asciminib hydrochloride Inhibitor 99.79% Yes
HY-15728 Radotinib 99.19% Yes
HY-15666A Olverembatinib dimesylate Inhibitor 99.80% Yes
HY-13905 Flumatinib mesylate Inhibitor 99.80% Unkown
HY-50946R Imatinib Mesylate (Standard) 99.98% Unkown
HY-10159B Nilotinib hydrochloride 99.86% Yes

Clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Phase
HY-160167 Birelentinib Inhibitor / Phase 3
HY-13024 Rebastinib 99.84% Phase 2
HY-50868 Bafetinib 99.18% Phase 2
HY-137460 Vodobatinib Inhibitor 98.09% Phase 2
HY-109010 Poseltinib Inhibitor 98.11% Phase 2
HY-109082 Cevidoplenib Inhibitor 99.58% Phase 2
HY-147414 Vamotinib Inhibitor 99.89% Phase 2
HY-120508 Pivanex 95.0% Phase 2
HY-10212A BIIB021 mesylate / Phase 2
HY-13468A KW-2478 hydrochloride / Phase 2
HY-15493 AN-019 Inhibitor / Phase 2
HY-147308 Zelenirstat Inhibitor 99.76% Phase 1
HY-15749 XL228 Inhibitor 99.64% Phase 1
HY-103275 Adaphostin 99.02% Phase 1
HY-118084 LS-104 / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99761 Obexelimab 99.99% Phase 3
HY-P991900 LY3541860 Inhibitor ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (160)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13520 Nocodazole 99.59% Unkown
HY-13264 Degrasyn 99.70% Unkown
HY-125845 (S,R,S)-AHPC 99.13% Unkown
HY-160141 Catadegbrutinib 99.18% Unkown
HY-158145 DS55980254 Inhibitor 99.25% Unkown
HY-157562 DS68591889 99.18% Unkown
HY-13468 KW-2478 99.53% Unkown
HY-118144 PD166326 Inhibitor 99.99% Unkown
HY-11007 GNF-2 Inhibitor 99.82% Unkown
HY-152036A SIAIS100 TFA Degrader 99.75% Unkown
HY-125834 GMB-475 98.69% Unkown
HY-15738 GNF-5 Inhibitor 99.95% Unkown
HY-128756 SIAIS178 Inhibitor 98.64% Unkown
HY-10181S Dasatinib-d8 99.15% Unkown
HY-10943 GNF-7 Inhibitor 99.70% Unkown
HY-107447 N-Deshydroxyethyl Dasatinib 97.19% Unkown
HY-153357 NRX-0492 98.30% Unkown
HY-10159S Nilotinib-d6 99.95% Unkown
HY-103274 PD180970 99.27% Unkown
HY-156640 Rocbrutinib Inhibitor 99.76% Unkown
HY-15814 HG-7-85-01 98.14% Unkown
HY-163962 L18I 99.89% Unkown
HY-100338 CNX-500 Inhibitor 99.86% Unkown
HY-153415 PROTAC BCR-ABL Degrader-1 Degrader 98.73% Unkown
HY-13943 CNX-774 Inhibitor 99.54% Unkown
HY-15463S1 Imatinib-d4 99.82% Unkown
HY-18010 PCI 29732 Inhibitor 99.59% Unkown
HY-103032 Multi-kinase inhibitor 1 Inhibitor 99.05% Unkown
HY-15463S Imatinib-d8 99.88% Unkown
HY-136268 AQX-435 Activator 99.15% Unkown
HY-153996 CT1113 99.61% Unkown
HY-10159C Nilotinib hydrochloride dihydrate 99.89% Unkown
HY-13520R Nocodazole (Standard) 98.40% Unkown
HY-101489A GZD856 formic 95.36% Unkown
HY-117718 AG957 Inhibitor 99.30% Unkown
HY-123450 S116836 99.78% Unkown
HY-13904S Flumatinib-d3 Inhibitor 99.9% Unkown
HY-145887 BCR-ABL1-IN-1 99.82% Unkown
HY-157327 AKE-72 Inhibitor 98.29% Unkown
HY-164393 ON044580 99.11% Unkown
HY-123159 AKI603 Inhibitor 98.03% Unkown
HY-133794 Dasatinib N-oxide 99.24% Unkown
HY-111872 SNIPER(ABL)-020 Inhibitor 99.79% Unkown
HY-10181G Dasatinib (GMP) / Unkown
HY-108486 Herbimycin A Inhibitor 99% Unkown
HY-123390 DB07107 Inhibitor / Unkown
HY-130297 PROTAC BCR-ABL1 ligand 1 Inhibitor 99.17% Unkown
HY-153008 BCR-ABL-IN-7 Inhibitor 99.66% Unkown
HY-15463S2 Imatinib-d3 hydrochloride 95.19% Unkown
HY-154860 PTD10 97.38% Unkown
HY-156148 BCR-ABL-IN-8 Inhibitor / Unkown
HY-180982 Asciminib-NH2 Degrader / Unkown
HY-10181S1 Dasatinib-d4 97.54% Unkown
HY-41940 Dasatinib intermediate-1 Control ≥98.0% Unkown
HY-101489 GZD856 / Unkown
HY-108704 CT-721 Inhibitor / Unkown
HY-110402 (S,R,S)-AHPC TFA / Unkown
HY-111871 SNIPER(ABL)-033 Inhibitor / Unkown
HY-128607 Mcl1-IN-9 Inhibitor / Unkown
HY-136526 BCR-ABL-IN-3 Inhibitor / Unkown
HY-111851 SNIPER(ABL)-049 Inhibitor / Unkown
HY-111854 SNIPER(ABL)-015 Inhibitor / Unkown
HY-111858 SNIPER(ABL)-050 Inhibitor / Unkown
HY-111859 SNIPER(ABL)-058 Inhibitor / Unkown
HY-111860 SNIPER(ABL)-013 Inhibitor / Unkown
HY-111861 SNIPER(ABL)-024 Inhibitor / Unkown
HY-111862 SNIPER(ABL)-044 Inhibitor / Unkown
HY-111873 SNIPER(ABL)-019 Inhibitor / Unkown
HY-13024A Rebastinib tosylate / Unkown
HY-165532 SGX393 Inhibitor / Unkown
HY-133794S Dasatinib N-oxide-d8 / Unkown
HY-100314 BCR-ABL-IN-1 Inhibitor / Unkown
HY-101268 CHMFL-ABL-053 Inhibitor / Unkown
HY-10159S1 Nilotinib-13C,d3 / Unkown
HY-101763B (S,R,S)-AHPC dihydrochloride / Unkown
HY-10181GL Dasatinib (GMP Like) / Unkown
HY-10364 AP24163 Inhibitor / Unkown
HY-104010S Asciminib-d4 Inhibitor / Unkown
HY-111863 SNIPER(ABL)-047 Inhibitor / Unkown
HY-111874 SNIPER(ABL)-039 Inhibitor / Unkown
HY-112404 BCR-ABL-IN-13 Inhibitor 99.86% Unkown
HY-119177 PD173956 Inhibitor / Unkown
HY-120036 Tyrphostin AG1112 Inhibitor / Unkown
HY-12292G IM-12 (GMP) / Unkown
HY-124605 IQS-019 / Unkown
HY-124792 MRLB-223 / Unkown
HY-125090 PHA-680626 / Unkown
HY-126143 CHMFL-ABL-039 Inhibitor / Unkown
HY-131275 Imatinib Impurity E 96.05% Unkown
HY-142922 BCR-ABL-IN-4 Inhibitor / Unkown
HY-147581 BTK-IN-11 Inhibitor / Unkown
HY-147584 BTK-IN-14 Inhibitor / Unkown
HY-150566 BCR-ABL-IN-5 Inhibitor / Unkown
HY-150569 BCR-ABL-IN-6 Inhibitor / Unkown
HY-150908 Brigatinib A Ligand / Unkown
HY-152036 SIAIS100 Degrader / Unkown
HY-153085 CD19 CAR circRNA / Unkown
HY-153582 ML 2-23 Degrader / Unkown
HY-15728S Radotinib-d6 / Unkown
HY-157389 AK-HW-90 Inhibitor / Unkown
HY-160478 GNF-6 Inhibitor / Unkown
HY-161323 FLT3-ITD/D835Y-IN-1 / Unkown
HY-161445 (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH / Unkown
HY-162257 BTK-IN-34 Inhibitor / Unkown
HY-162489 Tyrosine kinase-IN-8 Inhibitor / Unkown
HY-162698 JMF4073 Inhibitor / Unkown
HY-162952 cSRC/BCR-ABL1-IN-1 Inhibitor / Unkown
HY-169230 BCR-ABL-IN-9 Inhibitor / Unkown
HY-169231 BCR-ABL-IN-10 Inhibitor / Unkown
HY-171184 EAPB0503 / Unkown
HY-172096 cSRC/BCR-ABL-IN-1 Inhibitor / Unkown
HY-176269 VS1150 / Unkown
HY-177273 Kinase modulator-1 Inhibitor / Unkown
HY-179247 BCR-ABL1-IN-2 Inhibitor / Unkown
HY-179460 Radotinib dihydrochloride / Unkown
HY-180218 DS-PPE-GW Degrader / Unkown
HY-180798 BCR-ABL degrader 1 Degrader / Unkown
HY-180925 Leu-PEG1-Dasa Degrader / Unkown
HY-180962 Phe-PEG1-Dasa Degrader / Unkown
HY-180963 Lys-PEG1-Dasa Degrader / Unkown
HY-180967 PROTAC BCR-ABL Degrader-2 / Unkown
HY-180968 GMB-805 Degrader / Unkown
HY-180969 SIAIS056 Degrader / Unkown
HY-180977 P19P Degrader / Unkown
HY-180979 P22D Degrader / Unkown
HY-180981 P19As Degrader / Unkown
HY-180983 Azo-PROTAC-4C-trans Degrader / Unkown
HY-180984 trans-Lenalidomide-CO-Ph-N2-Ph-O-C4-Cl / Unkown
HY-180985 Azo-PROTAC-4C-cis Degrader / Unkown
HY-181546 Ibt-DOX / Unkown
HY-182792 Embibatinib Inhibitor / Unkown
HY-184728 Antifungal agent-169 Inhibitor / Unkown
HY-185658 3'-BPANeuGc Inhibitor / Unkown
HY-185659 6'-BPANeuGc / Unkown
HY-186016 Arg-PEG1-Dasa Degrader / Unkown
HY-186166 (S)-Embibatinib Inhibitor / Unkown
HY-18819 BCR-ABL-IN-2 Inhibitor / Unkown
HY-E70634 ABL1 E255K Recombinant Human Active Protein Kinase / Unkown
HY-E70635 ABL1 F317I Recombinant Human Active Protein Kinase / Unkown
HY-E70636 ABL1 G250E Recombinant Human Active Protein Kinase / Unkown
HY-E70637 ABL1 H396P Recombinant Human Active Protein Kinase / Unkown
HY-E70638 ABL1 M351T Recombinant Human Active Protein Kinase / Unkown
HY-E70639 ABL1 Q252H Recombinant Human Active Protein Kinase / Unkown
HY-E70640 ABL1 T315I Recombinant Human Active Protein Kinase / Unkown
HY-E70641 ABL1 Y253F Recombinant Human Active Protein Kinase / Unkown
HY-E70789 BCR-RET Recombinant Human Active Protein Kinase / Unkown
HY-E70808 BTK C481R Recombinant Human Active Protein Kinase / Unkown
HY-E70809 BTK V416L Recombinant Human Active Protein Kinase / Unkown
HY-RS01450 BCR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123486 HS-438 / Unkown
HY-132549S Nilotinib-d3 / Unkown
HY-15463S3 Imatinib-13C,d3 / Unkown
HY-160174 BCR-ABL kinase-IN-3 Inhibitor / Unkown
HY-160174A BCR-ABL kinase-IN-3 (dihydrocholide) Inhibitor / Unkown
HY-164469 CHMFL-48 Inhibitor / Unkown
HY-169608 BCR-ABL-IN-11 Inhibitor / Unkown
HY-185595 N,3-BisBoc-L-Histidine / Unkown
HY-186223 Enzyme modulator-1 Modulator / Unkown
HY-RS16598 Bcr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23032 Bcr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991086 MGD010 Inhibitor 99.06% Unkown
HY-P991804 Anti-Mouse CD79b Antibody (HM79b) Inhibitor / Unkown
HY-P991820 Anti-Mouse CD45 Antibody (I3/2.3) Inhibitor / Unkown
HY-P991996 SM201 Inhibitor / Unkown
HY-P991816 Mouse IgM, Isotype Control / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcr NCBI NCBI:613