Mcl1 - MCL1 apoptosis regulator, BCL2 family member Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60430

About Mcl1

Primary_assembly 2: 183,219,220-183,222,303 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 235 orthologues, 13 paralogues and is associated with 21 phenotypes. Biased expression in Spleen (RPKM 131.3), Lung (RPKM 852.7) and 9 other tissues.

Summary

Enables BH domain binding activity and protein dimerization activity. Involved in negative regulation of apoptotic process. Predicted to be located in several cellular components, including cytosol; mitochondrial matrix; and nucleus. Predicted to be part of Bcl-2 Family protein complex. Predicted to be active in mitochondrial outer membrane. Orthologous to human MCL1 (MCL1 Apoptosis regulator, BCL2 family member). [provided by Alliance of Genome Resources, Apr 2022]

Mcl1 Products (1)

mRNA Protein Name
NM_021846.2 NP_068618.2 induced myeloid leukemia cell differentiation protein Mcl-1 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables BH domain binding IPI
IPI: Inferred from physical interaction
9356461 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9356461 RGD
enables protein dimerization activity IPI
IPI: Inferred from physical interaction
9356461 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9356461 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
9356461 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mcl1 Protein Structure

Bcl-2_like

Bcl-2_like: cd06845 (154 - 297)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
Protein Preferred Names Protein Names

induced myeloid leukemia cell differentiation protein Mcl-1 homolog

  • BCL2 family apoptosis regulator

  • MCL1, BCL2 family apoptosis regulator

  • myeloid cell leukemia 1

  • myeloid cell leukemia sequence 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name Effect
Purity Phase
HY-112041 Unesbulin 99.17% Phase 3
HY-101533 AZD-5991 Inhibitor 99.79% Phase 2
HY-112218 MIK665 Inhibitor 99.11% Phase 2
HY-X0009 Tambiciclib 99.68% Phase 2
HY-15464 (R)-(-)-Gossypol 99.37% Phase 2
HY-15464A (R)-(-)-Gossypol acetic acid 98.93% Phase 2
HY-138697 S65487 99.91% Phase 2
HY-X0009A Tambiciclib dimaleate 99.53% Phase 2
HY-138697A S65487 sulfate 99.35% Phase 2
HY-138697B S65487 hydrochloride 98.54% Phase 2
HY-15163A Zotiraciclib hydrochloride Inhibitor / Phase 2
HY-10358 MK-2206 dihydrochloride 99.99% Phase 1
HY-149672 ABBV-467 Inhibitor 99.78% Phase 1
HY-12422 Voruciclib Inhibitor 99.76% Phase 1
HY-101565 Tapotoclax Inhibitor 99.53% Phase 1
HY-103019B (-)-Enitociclib 99.85% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.26% Phase 1
HY-109184 Murizatoclax Inhibitor 98.84% Phase 1
HY-101533B AZD-5991 (S-enantiomer) Inhibitor 99.83% Phase 1
HY-139453A LP-284 / Phase 1
HY-19471 (rac)-ZK-304709 / Phase 1
HY-103019BR (-)-Enitociclib (Standard) / Phase 1
HY-10358R MK-2206 dihydrochloride (Standard) / Phase 1
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991225 BI-1206 Antagonist 96.82% Phase 2

Pre-clinical Phase

Bioactive Molecules (161)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100741 S63845 Inhibitor 99.94% Unkown
HY-114855 BT2 Inhibitor 99.81% Unkown
HY-N0662 Amentoflavone 99.66% Unkown
HY-108232 MK-2206 99.72% Unkown
HY-N0087 Gambogic Acid 98.34% Unkown
HY-103019 Enitociclib 99.89% Unkown
HY-18628 UMI-77 Inhibitor 99.66% Unkown
HY-123954 BTX-A51 98.58% Unkown
HY-101972 AZ-PFKFB3-67 Inhibitor 97.03% Unkown
HY-N0763 Angelicin 99.98% Unkown
HY-12468 A-1210477 99.86% Unkown
HY-14985 BAY 61-3606 dihydrochloride 99.45% Unkown
HY-118341 Clitocine 95.88% Unkown
HY-W040129 Chromomycin A3 99.66% Unkown
HY-N0831 Jaceosidin 99.51% Unkown
HY-W008296 NH2-C6-NH-Boc 99.77% Unkown
HY-125876 PROTAC Bcl2 degrader-1 Inhibitor 99.80% Unkown
HY-103019A (±)-Enitociclib 99.23% Unkown
HY-125877 PROTAC Mcl1 degrader-1 Inhibitor 98.13% Unkown
HY-164515 ONC213 99.89% Unkown
HY-12020 TW-37 Inhibitor 99.50% Unkown
HY-129478 TC11 99.55% Unkown
HY-76474A BAY 61-3606 hydrochloride 98.08% Unkown
HY-162919 YK-2168 98.05% Unkown
HY-153803 GBD-9 Degrader 99.91% Unkown
HY-15191 Sabutoclax Inhibitor 99.80% Unkown
HY-112859 VU0661013 Inhibitor 98.45% Unkown
HY-N8146 Bruceantinol Inhibitor 98.89% Unkown
HY-122627 CLZ-8 99.14% Unkown
HY-100741A (S,R)-S63845 Control 98.09% Unkown
HY-129700 MCL-1/BCL-2-IN-2 Inhibitor 99.05% Unkown
HY-149007 STAT3-IN-11 98.29% Unkown
HY-119271 CMLD010509 99.11% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.71% Unkown
HY-129681 MCL-1/BCL-2-IN-1 Inhibitor 98.65% Unkown
HY-162858 BRD-810 98.00% Unkown
HY-101778 ML311 Inhibitor 98.98% Unkown
HY-112591 NSC260594 97.50% Unkown
HY-100741C (R,R)-S63845 Control 99.32% Unkown
HY-120113 SC-2001 99.37% Unkown
HY-P2343 BH3 hydrochloride Activator 98.03% Unkown
HY-128360 dMCL1-2 99.29% Unkown
HY-132307 Mcl-1 inhibitor 6 98.77% Unkown
HY-123955 Casein Kinase inhibitor A86 99.26% Unkown
HY-155472 Mcl-1 inhibitor 17 Inhibitor 99.41% Unkown
HY-15613 Maritoclax Inhibitor 99.97% Unkown
HY-16695 MIM1 Inhibitor 98.0% Unkown
HY-178226 PBX-7016 Inhibitor / Unkown
HY-158783 SACLAC 99.70% Unkown
HY-167881 MLS-0053105 Inhibitor 98.89% Unkown
HY-129702 MCL-1/BCL-2-IN-4 Inhibitor 99.95% Unkown
HY-160438B PBX-7011 TFA Inhibitor 98.60% Unkown
HY-176142 YX0798 98.90% Unkown
HY-164460 AZD1897 Inhibitor 99.69% Unkown
HY-19551 Apogossypolone 98.58% Unkown
HY-101533A AZD-5991 Racemate Inhibitor / Unkown
HY-12826 IMB-XH1 Inhibitor 98.0% Unkown
HY-129701 MCL-1/BCL-2-IN-3 Inhibitor 98.93% Unkown
HY-13408 (+)-Apogossypol Inhibitor / Unkown
HY-182312 CTX-439 / Unkown
HY-RS08230 MCL1 Human Pre-designed siRNA Set A / Unkown
HY-12527 Pyridoclax Inhibitor 99.95% Unkown
HY-15191B (S)-Sabutoclax Inhibitor 98.03% Unkown
HY-16669 Mcl1-IN-1 Inhibitor 98.02% Unkown
HY-76474 BAY 61-3606 98.21% Unkown
HY-112218A (R)-MIK665 Inhibitor / Unkown
HY-125908 A-1210477-piperazinyl Ligand / Unkown
HY-128607 Mcl1-IN-9 Inhibitor / Unkown
HY-100762 Mcl1-IN-11 Inhibitor / Unkown
HY-100763 Mcl1-IN-12 Inhibitor / Unkown
HY-10357 MK-2206 free base / Unkown
HY-111537 rel-AZ5576 Inhibitor / Unkown
HY-130261 Mcl-1 antagonist 1 Antagonist / Unkown
HY-133015 Mcl-1 inhibitor 3 Inhibitor / Unkown
HY-145825 Mcl-1 inhibitor 7 Inhibitor / Unkown
HY-145825A (E)-Mcl-1 inhibitor 7 Inhibitor / Unkown
HY-146097 RMS5 / Unkown
HY-111467 Mcl1-IN-4 Inhibitor / Unkown
HY-111468 Mcl1-IN-3 Inhibitor / Unkown
HY-115928 M24 Inhibitor / Unkown
HY-116220 Mcl1-IN-14 / Unkown
HY-122721 Mcl1-IN-5 Inhibitor / Unkown
HY-122759 CPA-7 / Unkown
HY-123034 CDKI-83 / Unkown
HY-123564 Mcl1-IN-7 Inhibitor / Unkown
HY-124846 MI-223 Modulator / Unkown
HY-125718 MLS-2384 free base / Unkown
HY-144428 Bcl-2/Mcl-1-IN-2 Inhibitor / Unkown
HY-144430 Bcl-2/Mcl-1-IN-1 Inhibitor / Unkown
HY-144431 Bcl-2/Mcl-1-IN-3 Inhibitor / Unkown
HY-145826 Mcl-1 inhibitor 8 Inhibitor / Unkown
HY-148203 Mcl-1 inhibitor 9 Inhibitor / Unkown
HY-148899 Mcl-1 inhibitor 10 Inhibitor / Unkown
HY-149495 CP-07 Degrader / Unkown
HY-150507 JNJ-4355 Inhibitor / Unkown
HY-153423 Mcl-1 inhibitor 12 Inhibitor / Unkown
HY-153423A Mcl-1 inhibitor 13 Inhibitor / Unkown
HY-154961 Mcl-1 inhibitor 14 / Unkown
HY-154962 Mcl-1 inhibitor 15 Inhibitor / Unkown
HY-155012 Mcl-1 inhibitor 16 Inhibitor / Unkown
HY-155153 CDK9-IN-24 / Unkown
HY-155245 A09-003 Inhibitor / Unkown
HY-15867 Meayamycin B / Unkown
HY-159513 Bcl-2/Mcl-1-IN-4 Inhibitor / Unkown
HY-159588 Mcl-1 inhibitor 20 Inhibitor / Unkown
HY-161274 Bfl-1-IN-1 Inhibitor / Unkown
HY-161732 GQN-B37-E Inhibitor / Unkown
HY-161733 GQN-B37-Me Inhibitor / Unkown
HY-162619 CDK9-IN-33 / Unkown
HY-162780 Mcl-1-IN-19 Inhibitor / Unkown
HY-163293 Mcl-1 inhibitor 18 Inhibitor / Unkown
HY-163681 Zamzetoclax Inhibitor / Unkown
HY-164452 A-1155905 / Unkown
HY-164453 A-1248767 / Unkown
HY-169797 STAT3-IN-38 / Unkown
HY-170762 Mcl-1 inhibitor 21 Inducer / Unkown
HY-170762A (+)-Mcl-1 inhibitor 21 Inducer / Unkown
HY-170762B (-)-Mcl-1 inhibitor 21 Inducer / Unkown
HY-170763 Mcl-1 inhibitor 22 Inducer / Unkown
HY-170763A (+)-Mcl-1 inhibitor 22 Inducer / Unkown
HY-170763B (-)-Mcl-1 inhibitor 22 / Unkown
HY-171334A P1D-34 / Unkown
HY-173065 CDK9-IN-36 / Unkown
HY-178008 Mcl-1-IN-16 / Unkown
HY-178010 Mcl-1-IN-17 Inhibitor / Unkown
HY-178499 CDK9-IN-44 Inhibitor / Unkown
HY-178910 Mcl-1-IN-20 / Unkown
HY-179023 CDK9-IN-45 / Unkown
HY-179633 ZLMT-72 / Unkown
HY-180190 Tubulin polymerization-IN-85 / Unkown
HY-181054 Mcl-1-IN-21 / Unkown
HY-181078 Cephalotaxine-ester-(R)-1-ethoxy-3-mercaptopropan-2-ol-Ph(3,4OMe) / Unkown
HY-181587 PDGFRA/CAIX/XII-IN-1 98.10% Unkown
HY-181746 Bcl-2/Mcl-1-IN-5 / Unkown
HY-181767 PROTAC HDAC3 degrader-1 / Unkown
HY-182671 SRX3305 / Unkown
HY-183328 MNK1/2-IN-11 Inhibitor / Unkown
HY-183601 Mcl-1-IN-22 / Unkown
HY-183601A Mcl-1-IN-22 hydrochloride / Unkown
HY-184160 Mcl1 Degrader-1 / Unkown
HY-184310 Mcl-1-IN-23 / Unkown
HY-18628S UMI-77-d4 Inhibitor / Unkown
HY-N0831R Jaceosidin (Standard) / Unkown
HY-N16746 Nordentatin Inhibitor / Unkown
HY-N17676 3-Tridecylphenol / Unkown
HY-N3913 Furowanin A Inhibitor / Unkown
HY-P4095 NoxaBH3 / Unkown
HY-RS08231 Mcl1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08232 Mcl1 Rat Pre-designed siRNA Set A / Unkown
HY-W043574 6-Ethyl-7-hydroxy-4-methyl-2H-chromen-2-one Inhibitor / Unkown
HY-W689801 A-1208746 / Unkown
HY-103019AR (±)-Enitociclib (Standard) / Unkown
HY-115529 (-)BI97D6 Inducer / Unkown
HY-116532 YCW-E11 Inhibitor / Unkown
HY-119009 TM-233 Inhibitor / Unkown
HY-119271A (-)-CMLD010509 / Unkown
HY-121638B (E/Z)-CU-3 / Unkown
HY-13551C Amsacrine isethionate / Unkown
HY-13551D Amsacrine lactate / Unkown
HY-164468 Ch282-5 Inhibitor / Unkown
HY-W286906 Mcl1-IN-15 / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991899 IKS03 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mcl1 NCBI NCBI:4170