2. Gene
  3. Mcl1 - MCL1 apoptosis regulator, BCL2 family member Gene

Mcl1 - MCL1 apoptosis regulator, BCL2 family member Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 60430 | Gene type: protein coding

About Mcl1

Primary_assembly 2: 183,219,220-183,222,303 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 235 orthologues, 13 paralogues and is associated with 21 phenotypes. Biased expression in Spleen (RPKM 131.3), Lung (RPKM 852.7) and 9 other tissues.

Summary

Enables BH domain binding activity and protein dimerization activity. Involved in negative regulation of apoptotic process. Predicted to be located in several cellular components, including cytosol; mitochondrial matrix; and nucleus. Predicted to be part of Bcl-2 Family protein complex. Predicted to be active in mitochondrial outer membrane. Orthologous to human MCL1 (MCL1 Apoptosis regulator, BCL2 family member). [provided by Alliance of Genome Resources, Apr 2022]

Mcl1 Products(1)

mRNA Protein Name
NM_021846.2 NP_068618.2 induced myeloid leukemia cell differentiation protein Mcl-1 homolog

Mcl1 Protein Structure

Bcl-2_like

Bcl-2_like: cd06845 (154 - 297)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
Protein Preferred Names Protein Names

induced myeloid leukemia cell differentiation protein Mcl-1 homolog

BCL2 family apoptosis regulator

MCL1, BCL2 family apoptosis regulator

myeloid cell leukemia 1

myeloid cell leukemia sequence 1

Related Agents

Clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-101533 AZD-5991 Inhibitor 99.50% Phase 2
HY-112218 MIK665 Inhibitor 99.72% Phase 2
HY-15464A (R)-(-)-Gossypol acetic acid 98.93% Phase 2
HY-138697 S65487 99.10% Phase 2
HY-15464 (R)-(-)-Gossypol 98.82% Phase 2
HY-138697B S65487 hydrochloride 99.67% Phase 2
HY-138697A S65487 sulfate 98.08% Phase 2
HY-101565 Tapotoclax Inhibitor 99.80% Phase 1
HY-112041 Unesbulin Activator 99.45% Phase 1
HY-12422 Voruciclib Inhibitor 99.77% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.23% Phase 1
Pre-clinical Phase
Bioactive Molecules (87)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100741 S63845 Inhibitor 99.94% Unkown
HY-114855 BT2 Inhibitor 98.93% Unkown
HY-N0662 Amentoflavone 99.81% Unkown
HY-N0087 Gambogic Acid 98.79% Unkown
HY-12468 A-1210477 99.40% Unkown
HY-18628 UMI-77 Inhibitor 99.66% Unkown
HY-123954 Casein Kinase inhibitor A51 98.58% Unkown
HY-125877 PROTAC Mcl1 degrader-1 Inhibitor 98.13% Unkown
HY-14985 BAY 61-3606 dihydrochloride 99.91% Unkown
HY-125876 PROTAC Bcl2 degrader-1 Inhibitor 98.78% Unkown
HY-118341 Clitocine 95.88% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.97% Unkown
HY-15191 Sabutoclax Inhibitor 99.80% Unkown
HY-12020 TW-37 Inhibitor 99.27% Unkown
HY-129478 TC11 98.04% Unkown
HY-N0831 Jaceosidin 99.51% Unkown
HY-122627 CLZ-8 99.85% Unkown
HY-15613 Maritoclax Inhibitor 99.97% Unkown
HY-129700 MCL-1/BCL-2-IN-2 Inhibitor 99.12% Unkown
HY-149007 STAT3-IN-11 98.30% Unkown
HY-W008296 NH2-C6-NH-Boc 99.61% Unkown
HY-123955 Casein Kinase inhibitor A86 98.47% Unkown
HY-12527 Pyridoclax Inhibitor 99.74% Unkown
HY-101778 ML311 Inhibitor 98.26% Unkown
HY-129681 MCL-1/BCL-2-IN-1 Inhibitor 99.86% Unkown
HY-112859 VU0661013 Inhibitor 98.45% Unkown
HY-N8146 Bruceantinol Inhibitor 98.89% Unkown
HY-16695 MIM1 Inhibitor ≥98.0% Unkown
HY-109184 Murizatoclax Inhibitor 98.85% Unkown
HY-132307 Mcl-1 inhibitor 6 98.40% Unkown
HY-100741A (S,R)-S63845 98.54% Unkown
HY-119271 CMLD010509 / Unkown
HY-101533B AZD-5991 (S-enantiomer) Inhibitor 99.83% Unkown
HY-112591 NSC260594 96.00% Unkown
HY-12826 IMB-XH1 Inhibitor ≥98.0% Unkown
HY-13408 (+)-Apogossypol Inhibitor / Unkown
HY-160438B PBX-7011 TFA Degrader / Unkown
HY-P2343 BH3 hydrochloride Activator 98.02% Unkown
HY-16669 Mcl1-IN-1 Inhibitor 98.40% Unkown
HY-76474 BAY 61-3606 98.21% Unkown
HY-112218A (R)-MIK665 Inhibitor / Unkown
HY-125908 A-1210477-piperazinyl / Unkown
HY-128360 dMCL1-2 Inhibitor / Unkown
HY-128607 Mcl1-IN-9 Inhibitor / Unkown
HY-100762 Mcl1-IN-11 Inhibitor / Unkown
HY-100763 Mcl1-IN-12 Inhibitor / Unkown
HY-101533A AZD-5991 Racemate Inhibitor / Unkown
HY-130261 Mcl-1 antagonist 1 Antagonist / Unkown
HY-133015 Mcl-1 inhibitor 3 Inhibitor / Unkown
HY-139453A LP-284 / Unkown
HY-145825 Mcl-1 inhibitor 7 Inhibitor / Unkown
HY-145825A (E)-Mcl-1 inhibitor 7 Inhibitor / Unkown
HY-146097 RMS5 / Unkown
HY-100741C (R,R)-S63845 98.03% Unkown
HY-111467 Mcl1-IN-4 Inhibitor / Unkown
HY-111468 Mcl1-IN-3 Inhibitor / Unkown
HY-115928 M24 Inhibitor / Unkown
HY-122721 Mcl1-IN-5 Inhibitor / Unkown
HY-129701 MCL-1/BCL-2-IN-3 Inhibitor 99.22% Unkown
HY-129702 MCL-1/BCL-2-IN-4 Inhibitor / Unkown
HY-144428 Bcl-2/Mcl-1-IN-2 Inhibitor / Unkown
HY-144430 Bcl-2/Mcl-1-IN-1 Inhibitor / Unkown
HY-144431 Bcl-2/Mcl-1-IN-3 Inhibitor / Unkown
HY-145826 Mcl-1 inhibitor 8 Inhibitor / Unkown
HY-148203 Mcl-1 inhibitor 9 Inhibitor / Unkown
HY-149495 CP-07 Degrader / Unkown
HY-149672 ABBV-467 Inhibitor / Unkown
HY-150507 JNJ-4355 Inhibitor / Unkown
HY-153423 Mcl-1 inhibitor 12 Inhibitor / Unkown
HY-153423A Mcl-1 inhibitor 13 Inhibitor / Unkown
HY-154961 Mcl-1 inhibitor 14 / Unkown
HY-154962 Mcl-1 inhibitor 15 Inhibitor / Unkown
HY-155012 Mcl-1 inhibitor 16 Inhibitor / Unkown
HY-155153 CDK9-IN-24 / Unkown
HY-155245 A09-003 Inhibitor / Unkown
HY-155472 Mcl-1 inhibitor 17 Inhibitor ≥98.0% Unkown
HY-161274 Bfl-1-IN-1 Inhibitor / Unkown
HY-163293 Mcl-1 inhibitor 18 Inhibitor / Unkown
HY-18628S UMI-77-d4 Inhibitor / Unkown
HY-N0831R Jaceosidin (Standard) / Unkown
HY-N3913 Furowanin A Inhibitor / Unkown
HY-P4095 NoxaBH3 / Unkown
HY-RS08230 MCL1 Human Pre-designed siRNA Set A / Unkown
HY-RS08231 Mcl1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08232 Mcl1 Rat Pre-designed siRNA Set A / Unkown
HY-15191B (S)-Sabutoclax Inhibitor 95.66% Unkown
HY-19551 Apogossypolone / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mcl1 NCBI NCBI:4170