製品番号: HY-118020A

Loliolid

Name: Loliolid
Brand: MedChemExpress
SKU: HY-118020A
Price: 320.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(別名: ロリオリド)

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Based on 1 Customer Validation

Loliolide (Loliolid) is a β-carotene metabolite. Loliolide reduces caspase 3, 8, 9 expression, enhances PI3K, AKT, SIRT1, inhibits ROS, apoptosis, and blocks NF-κB p65 nuclear translocation. Loliolide protects mitochondria, reduces oxidative stress, and increases cell viability in neuroblastoma cells. Loliolide can be used for the research of UV-induced skin damage and Parkinson’s disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 99.92%
CAS 番号: 5989-02-6
分子式: C₁₁H₁₆O₃
分子量:196.24

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Loliolide 構造式

CAS 番号: 5989-02-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

SIRT1

MMP-9

Caspase 3

Caspase 8

Caspase 9

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

Caspase アイソフォーム固有の製品をすべて表示 :

PI3K アイソフォーム固有の製品をすべて表示 :

Akt アイソフォーム固有の製品をすべて表示 :

Sirtuin アイソフォーム固有の製品をすべて表示 :

NF-κB アイソフォーム固有の製品をすべて表示 :

MMP アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>10 μM Compound: 19	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
HepG2	IC₅₀	>20 μg/mL Compound: loliolide	Growth inhibition of HepG2 cells Growth inhibition of HepG2 cells	[PMID: 17547458]
HT-29	IC₅₀	>10 μM Compound: S11	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 30057155]
HT-29	IC₅₀	>10 μM Compound: S11	Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay	[PMID: 30057155]
KB	IC₅₀	>10 μM Compound: 19	Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human KB cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
MCF7	IC₅₀	>10 μM Compound: 19	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
MDA-MB-231	IC₅₀	>10 μM Compound: 19	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 32946697]
MDA-MB-231	IC₅₀	>10 μM Compound: S11	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 30057155]
MDA-MB-435	IC₅₀	>10 μM Compound: S11	Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 30057155]
OVCAR-3	IC₅₀	>10 μM Compound: S11	Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 30057155]
RAW264.7	CC₅₀	>100 μM Compound: 11	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 33667099]
RAW264.7	IC₅₀	>0.4 μM Compound: loliolide	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide release after 24 hrs	[PMID: 20192236]
RAW264.7	IC₅₀	>50 μM Compound: 11	Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA	[PMID: 24963714]
RAW264.7	IC₅₀	>50 μM Compound: 11	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay	[PMID: 24963714]
RAW264.7	IC₅₀	56.7 μM Compound: 11	Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay	[PMID: 33667099]
WI-38	IC₅₀	>20 μg/mL Compound: loliolide	Growth inhibition of WI38 cells Growth inhibition of WI38 cells	[PMID: 17547458]
WI-38 VA13	IC₅₀	>20 μg/mL Compound: loliolide	Growth inhibition of VA13 cells Growth inhibition of VA13 cells	[PMID: 17547458]

体外実験

Loliolide (25-100 μM; 24 h) is non-toxic to HaCaT human keratinocytes at concentrations up to 100 μM and dose-dependently recovers UVB-reduced HaCaT cell viability^[1].
Loliolide (25-100 μM; 24 h) dose-dependently inhibits UVB-induced reactive oxygen species generation and DNA damage in HaCaT cells^[1].
Loliolide (50-100 μM; 24 h) reduces UVB-induced apoptosis in HaCaT cells^[1].
Loliolide (25-100 μM; 24 h) dose-dependently inhibits UVB-induced activation of caspase 3, 8, and 9 to reduce apoptosis in HaCaT cells^[1].
Loliolide (25-200 μM; 24 h) dose-dependently inhibits UVB-induced MMP-1, MMP-2, MMP-3, and MMP-9 expression and restores UVB-reduced SIRT1 expression in HaCaT cells^[1].
Loliolide (100 μM; 8-24 h) significantly accelerates scratch wound closure via increased cell migration in HaCaT cells^[1].
Loliolide (25-100 μM; 24-72 h) dose-dependently increases proliferation in HaCaT cells^[1].
Loliolide (25-100 μM; 24 h) dose-dependently upregulates migration factors, growth factor KGF, and wound-healing cytokines, while downregulating inflammation-related genes in scratched HaCaT cells^[1].
Loliolide (25-100 μM; 24 h) dose-dependently activates the PI3K/AKT EGFR signaling pathway in scratched HaCaT human keratinocytes, with maximum activity at 100 μM^[1].
Loliolide (1-100 μM; 24 h) exhibits no cytotoxicity and inhibits 6-hydroxydopamin (6-OHDA)-induced cytotoxicity in SH-SY5Y cells^[2].
Loliolide (50-100 μM; 6 h) reduces 6-OHDA-induced ROS production and Caspase-3 activity, stimulates catalase activity, prevents 6-OHDA-induced mitochondrial membrane depolarization in SH-SY5Y cells^[2].
Loliolide (50-100 μM; 24 h) prevents 6-OHDA-induced nuclear fragmentation and condensation in SH-SY5Y cells^[2].
Loliolide (50-100 μM; 6 h) inhibits 6-OHDA-induced NF-κB p65 translocation from the cytoplasm to the nucleus in SH-SY5Y cells^[2].
Loliolide (50-100 μM; 24 h) is non-cytotoxic to RAW 264.7 cells and does not induce NO production in RAW 264.7 cells^[2].
Loliolide (50-100 μM; 24 h) reduces LPS-induced NO production and reduces LPS (HY-D1056)-induced production of TNF-α and IL-6 in RAW 264.7 cells^[2].
Loliolide (300 μM; 24 h leaf treatment, 5 d mite incubation) reduces the survival rate of Tetranychus urticae and egg deposition in Solanum lycopersicum cv. Micro-Tom leaves ^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HaCaT cells
Concentration:

25; 50; 100 μM
Incubation Time:

24 h
Result:

Showed no effect on HaCaT cell viability at concentrations up to 100 μM under normal culture conditions.
Recovered UVB-reduced cell viability in a dose-dependent manner, with 100 μM producing the strongest statistically significant recovery.

Western Blot Analysis^[1]

Cell Line:

HaCaT cells
Concentration:

25; 50; 100 μM
Incubation Time:

24 h
Result:

Dose-dependently reduced UVB-induced expression of cleaved caspase 3, 8, and 9 in HaCaT cells.
Dose-dependently increased phosphorylation of PI3K and AKT in scratched HaCaT cells.
Showed the strongest activation at 100 μM, while total PI3K and AKT levels remained unchanged.

RT-PCR^[1]

Cell Line:

HaCaT cells
Concentration:

25; 50; 100; 200 μM
Incubation Time:

24 h
Result:

Dose-dependently reduced UVB-induced mRNA expression of MMP-1, MMP-2, MMP-3, and MMP-9 in HaCaT cells.
Restored UVB-reduced SIRT1 mRNA expression in HaCaT cells.
Dose-dependently increased mRNA expression of migration factors K6, K16, K17, growth factor KGF, and cytokines IL-1, IL-17, IL-22 in scratched HaCaT cells.
Dose-dependently reduced mRNA expression of inflammation-related genes TNF-α and MMP-1 in scratched HaCaT cells.

Cell Migration Assay ^[1]

Cell Line:

HaCaT cells
Concentration:

25; 50; 100 μM
Incubation Time:

8, 16, 24 h
Result:

Significantly increased HaCaT cell migration and scratch wound closure at 8, 16, and 24 h post-scratching.
Showed statistically significant differences (p<0.01 compared to untreated scratched control) at all time points.

Cell Proliferation Assay^[1]

Cell Line:

HaCaT cells
Concentration:

25-100 μM
Incubation Time:

24, 48, 72 h
Result:

Dose-dependently increased HaCaT cell proliferation over 72 h.
Produced statistically significant increases at 72 h for all concentrations, and at 48 h for 100 μM.

Cell Viability Assay^[2]

Cell Line:

SH-SY5Y cells
Concentration:

1; 5; 10; 50;100 μM
Incubation Time:

24 h
Result:

Did not induce cytotoxicity at any tested concentration.
Showed cell viability remained close to vehicle control levels.\nIncreased cell viability by 23.70% at 50 μM and 41.06% at 100 μM.

Western Blot Analysis^[2]

Cell Line:

SH-SY5Y cells
Concentration:

50; 100 μM
Incubation Time:

6 h
Result:

Downregulated nuclear NF-κB p65 and upregulated cytosolic levels, with significant inhibition of translocation observed at 100 μM compared to cells treated with 6-OHDA alone.

ELISA Assay^[2]

Cell Line:

RAW 264.7 murine macrophage cells
Concentration:

50; 100 μM
Incubation Time:

24 h
Result:

Reduced TNF-α production by 305% at 50 μM and 238% at 100 μM.
Reduced IL-6 production by 197% at 50 μM and 220% at 100 μM compared to cells stimulated with LPS alone.
Did not significantly affect IL-10 levels.

Apoptosis Analysis^[1]

Cell Line:

HaCaT cells
Concentration:

50; 100 μM
Incubation Time:

24 h
Result:

Reduced UVB-induced apoptosis in HaCaT cells.
Showed stronger activity at 100 μM than 50 μM.

Related Protocols :

化学情報

CAS 番号 5989-02-6
性状 Solid
分子量 196.24
分子式 C₁₁H₁₆O₃
Color White to off-white
SMILES

C[C@]12C(C(C)(C[C@@H](C1)O)C)=CC(O2)=O
別名

ロリオリド
Structure Classification
- Others
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

Methanol : 58.87 mg/mL (299.99 mM; Need ultrasonic and warming)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.0958 mL

25.4790 mL

50.9580 mL

5 mM

1.0192 mL

5.0958 mL

10.1916 mL

10 mM

0.5096 mL

2.5479 mL

5.0958 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (287 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Park SH, et al. Loliolide Presents Antiapoptosis and Antiscratching Effects in Human Keratinocytes. Int J Mol Sci. 2019;20(3):651. Published 2019 Feb 2. [Content Brief]

[2]. Silva J, et al. Loliolide, a New Therapeutic Option for Neurological Diseases? In Vitro Neuroprotective and Anti-Inflammatory Activities of a Monoterpenoid Lactone Isolated from Codium tomentosum. Int J Mol Sci. 2021;22(4):1888. Published 2021 Feb 14. [Content Brief]

[3]. Murata M, et al. Loliolide, a Carotenoid Metabolite, Is a Potential Endogenous Inducer of Herbivore Resistance. Plant Physiol. 2019;179(4):1822-1833. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Methanol	1 mM	5.0958 mL	25.4790 mL	50.9580 mL	127.3950 mL
	5 mM	1.0192 mL	5.0958 mL	10.1916 mL	25.4790 mL
	10 mM	0.5096 mL	2.5479 mL	5.0958 mL	12.7395 mL
	15 mM	0.3397 mL	1.6986 mL	3.3972 mL	8.4930 mL
	20 mM	0.2548 mL	1.2740 mL	2.5479 mL	6.3698 mL
	25 mM	0.2038 mL	1.0192 mL	2.0383 mL	5.0958 mL
	30 mM	0.1699 mL	0.8493 mL	1.6986 mL	4.2465 mL
	40 mM	0.1274 mL	0.6370 mL	1.2740 mL	3.1849 mL
	50 mM	0.1019 mL	0.5096 mL	1.0192 mL	2.5479 mL
	60 mM	0.0849 mL	0.4247 mL	0.8493 mL	2.1233 mL
	80 mM	0.0637 mL	0.3185 mL	0.6370 mL	1.5924 mL
	100 mM	0.0510 mL	0.2548 mL	0.5096 mL	1.2740 mL

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Loliolid

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

Caspase アイソフォーム固有の製品をすべて表示

PI3K アイソフォーム固有の製品をすべて表示

Akt アイソフォーム固有の製品をすべて表示

Sirtuin アイソフォーム固有の製品をすべて表示

NF-κB アイソフォーム固有の製品をすべて表示

MMP アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC₅₀ & Target

Cellular Effect

体外実験

化学情報

溶剤 & 溶解度

体外:

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

Keywords

最近チェックした製品

Loliolid

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

Caspase アイソフォーム固有の製品をすべて表示

PI3K アイソフォーム固有の製品をすべて表示

Akt アイソフォーム固有の製品をすべて表示

Sirtuin アイソフォーム固有の製品をすべて表示

NF-κB アイソフォーム固有の製品をすべて表示

MMP アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

Cellular Effect

体外実験

化学情報

溶剤 & 溶解度

体外:

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Loliolide 関連分類

HY-118020A 関連分類

Bioz

Keywords

最近チェックした製品

IC₅₀ & Target