2. Gene
  3. Braf - Braf transforming gene Gene

Braf - Braf transforming gene Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as B-raf; Braf2; Braf-2; C230098H17; D6Ertd631e; 9930012E13Rik

Gene ID: 109880 | Gene type: protein coding

About Braf

Chromosome 6: 39,580,171-39,702,397 reverse strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 220 orthologues, 23 paralogues and is associated with 76 phenotypes. Ubiquitous expression in frontal lobe adult (RPKM 6.7), bladder adult (RPKM 6.5) and 25 other tissues.

Summary

Enables protein kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; negative regulation of apoptotic process; and positive regulation of cellular component organization. Located in several cellular components, including cell body; mitochondrion; and neuron projection. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Langerhans-cell histiocytosis; cardiofaciocutaneous syndrome; melanoma; and thyroid gland papillary carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRaf (B-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Braf Products(1)

mRNA Protein Name
NM_139294.5 NP_647455.3 serine/threonine-protein kinase B-raf

Braf Protein Structure

RBD_BRAF

RBD_BRAF: cd17134 (137 - 215)

C1_B-Raf

C1_B-Raf: cd20871 (213 - 272)

STKc_Raf

STKc_Raf: cd14062 (499 - 751)

  • 0
  • 200
  • 400
  • 600
  • 804 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase B-raf

B-Raf proto-oncogene serine/threonine-protein kinase (p94)

proto-oncogene B-Raf

Related Agents

Approval
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10201 Sorafenib Inhibitor 99.92% Yes
HY-14660 Dabrafenib Inhibitor 99.91% Yes
HY-12057 Vemurafenib Inhibitor 99.83% Yes
HY-10331 Regorafenib Inhibitor 99.93% Yes
HY-10201A Sorafenib Tosylate Inhibitor 99.91% Yes
HY-14660A Dabrafenib Mesylate Inhibitor 99.95% Yes
HY-13308 Regorafenib Hydrochloride Inhibitor 99.58% Yes
HY-10331A Regorafenib monohydrate Inhibitor 99.96% Yes
HY-10331B Regorafenib mesylate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-10320 Doramapimod Inhibitor 99.98% Phase 2
HY-109080 Belvarafenib Inhibitor 99.71% Phase 2
HY-112089 Naporafenib Inhibitor 99.72% Phase 2
HY-153341 CFT1946 Degrader 99.84% Phase 2
HY-111940 LUT014 Inhibitor 97.23% Phase 2
HY-18652 Avutometinib Inhibitor 98.99% Phase 1
HY-12558 LY3009120 Inhibitor 98.97% Phase 1
HY-18957 Lifirafenib Inhibitor 98.73% Phase 1
HY-15200 Agerafenib Inhibitor 99.63% Phase 1
Pre-clinical Phase
Bioactive Molecules (41)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10966 SB-590885 Inhibitor 99.77% Unkown
HY-51424 PLX-4720 Inhibitor 99.91% Unkown
HY-50864 GDC-0879 Inhibitor 99.69% Unkown
HY-11004 AZ 628 Inhibitor 99.85% Unkown
HY-18997 PLX7904 Inhibitor 98.94% Unkown
HY-12846 CCT196969 Inhibitor 99.63% Unkown
HY-107779 BI-882370 Inhibitor 99.16% Unkown
HY-100510 RAF709 Inhibitor 99.45% Unkown
HY-12787 L-779450 Inhibitor 98.75% Unkown
HY-77113 B-Raf IN 11 Inhibitor 99.46% Unkown
HY-14177 Raf inhibitor 1 Inhibitor 98.11% Unkown
HY-12291 HG6-64-1 Inhibitor ≥98.0% Unkown
HY-147405 Tinlorafenib Inhibitor 98.20% Unkown
HY-10247 BRAF inhibitor Inhibitor 98.97% Unkown
HY-111758 PROTAC B-Raf degrader 1 Inhibitor 99.78% Unkown
HY-142160 GNE-9815 Inhibitor 98.28% Unkown
HY-137487 PROTAC BRAF-V600E degrader-1 Inhibitor 98.02% Unkown
HY-18227 B-Raf IN 1 Inhibitor 98.66% Unkown
HY-117273 AZ304 Inhibitor 99.96% Unkown
HY-145120 B-Raf IN 2 Inhibitor 99.27% Unkown
HY-148059 Uplarafenib Inhibitor 99.15% Unkown
HY-15198 KG5 Inhibitor 99.79% Unkown
HY-18507 AD57 Inhibitor 98.08% Unkown
HY-126298 RAF mutant-IN-1 Inhibitor / Unkown
HY-13810 PF-04880594 Inhibitor / Unkown
HY-147853 B-Raf IN 8 Inhibitor / Unkown
HY-115933 EGFR/BRAF-IN-1 Inhibitor / Unkown
HY-18318 Takeda-6D Inhibitor / Unkown
HY-147854 B-Raf IN 9 Inhibitor / Unkown
HY-16063 ARQ-736 Inhibitor / Unkown
HY-144269 SHR902275 Inhibitor / Unkown
HY-146492 VEGFR-2/BRAF-IN-2 Inhibitor / Unkown
HY-146491 VEGFR-2/BRAF-IN-1 Inhibitor / Unkown
HY-137488 PROTAC BRAF-V600E degrader-2 Inhibitor / Unkown
HY-149415 Multi-kinase-IN-5 Inhibitor / Unkown
HY-12847 CCT241161 Inhibitor / Unkown
HY-144271 RAF-IN-1 Inhibitor / Unkown
HY-147852 B-Raf IN 7 Inhibitor / Unkown
HY-150250 B-Raf IN 13 Inhibitor / Unkown
HY-14177A Raf inhibitor 1 dihydrochloride Inhibitor / Unkown
HY-15199 Agerafenib hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Braf NCBI NCBI:673