2. Gene
  3. Mmp2 - matrix metallopeptidase 2 Gene

Mmp2 - matrix metallopeptidase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81686 | Gene type: protein coding

About Mmp2

Primary_assembly 19: 14,154,657-14,182,870 reverse strand.mRatBN7.2:CM026992.1

This gene has 2 transcripts (splice variants), 210 orthologues, 23 paralogues and is associated with 166 phenotypes. Biased expression in Uterus (RPKM 651.), Lung (RPKM 536.) and 8 other tissues.

Summary

Enables fibronectin binding activity and peptidase activity. Involved in several processes, including cellular response to estradiol stimulus; circulatory system development; and reproductive structure development. Located in cytoplasm and extracellular space. Used to study artery disease (multiple); conjunctivitis; and transient cerebral ischemia. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); bile duct disease (multiple); brain ischemia (multiple); and liver cirrhosis (multiple). Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mmp2 Products(1)

mRNA Protein Name
NM_031054.2 NP_112316.2 72 kDa type IV collagenase precursor

Mmp2 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (69 - 96)

Peptidase_M10

Peptidase_M10: pfam00413 (117 - 445)

FN2

FN2: smart00059 (225 - 273)

FN2

FN2: smart00059 (283 - 331)

FN2

FN2: smart00059 (341 - 389)

HX

HX: cd00094 (467 - 661)

  • 0
  • 200
  • 400
  • 600
  • 662 a.a.
Protein Preferred Names Protein Names

72 kDa type IV collagenase

72 kDa gelatinase

MMP-2

gelatinase A

matrix metalloproteinase-2

Recombinant Mmp2 Proteins

Cat. No. Product Name Accession Purity
HY-P700573 MMP-2 Protein, Rat (P. pastoris, His) P33436 (Y110-C662) ≥95%

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0689A Indinavir sulfate 99.96% Yes
HY-B0493 Niflumic acid Inhibitor 99.88% Unkown
HY-B0689 Indinavir / Unkown
HY-B0689B Indinavir sulfate ethanolate / Unkown
Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-12169 Marimastat Inhibitor ≥98.0% Phase 3
HY-12170 Prinomastat ≥98.0% Phase 3
HY-12170A Prinomastat hydrochloride 98.18% Phase 3
HY-10398 CTS-1027 Inhibitor 99.19% Phase 2
HY-106992 S 3304 Inhibitor 99.11% Phase 2
HY-19485 XL-784 98.13% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (76)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15768 Ilomastat Inhibitor 98.33% Yes
HY-N0431 Astragaloside IV Inhibitor ≥98.0% Unkown
HY-122022 JR-AB2-011 Inhibitor 99.16% Unkown
HY-13564 Batimastat Inhibitor 98.92% Unkown
HY-12354 SB-3CT Inhibitor 99.59% Unkown
HY-122214 AC-73 Inducer 99.89% Unkown
HY-103444 ARP-100 Inhibitor ≥99.0% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-N0069 Solamargine 99.97% Unkown
HY-N2388 Auraptene Inhibitor 99.86% Unkown
HY-W068119A N-(2-Aminoethyl)maleimide hydrochloride 99.97% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-N0084 Betulinaldehyde Inhibitor 98.72% Unkown
HY-N0532 Morroniside Inhibitor 99.88% Unkown
HY-107428 PD-166793 Inhibitor 99.45% Unkown
HY-77813 Benzyl isothiocyanate 99.29% Unkown
HY-P3513 β-Neo-Endorphin Activator 98.22% Unkown
HY-120213 YH-306 98.01% Unkown
HY-112546 MMP-2 Inhibitor I Inhibitor 99.23% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-P0273A Histatin 5 TFA Inhibitor 99.89% Unkown
HY-131498 MOCAc-PLGL(Dpa)AR 99.86% Unkown
HY-146754 MMP2-IN-1 99.18% Unkown
HY-101535 ARP101 Inhibitor 99.39% Unkown
HY-122506 Salviolone Inhibitor 99.61% Unkown
HY-P1789A CTTHWGFTLC, CYCLIC TFA Inhibitor 98.60% Unkown
HY-P2213A GPLGIAGQ TFA Inducer 98.40% Unkown
HY-110116 SD-2590 hydrochloride Inhibitor ≥99.0% Unkown
HY-116399 MMP-2/MMP-9-IN-1 Inhibitor 99.25% Unkown
HY-117970 MMPI-1154 Inhibitor 99.87% Unkown
HY-12168 Tanomastat Inhibitor ≥99.0% Unkown
HY-124373 ND-336 Inhibitor ≥95.0% Unkown
HY-131417 cis-ACCP Inhibitor ≥97.0% Unkown
HY-147031 JAMM protein inhibitor 2 Inhibitor 98.20% Unkown
HY-147745 MMP2-IN-2 Inhibitor 98.80% Unkown
HY-147746 MMP2-IN-3 Inhibitor 99.64% Unkown
HY-148571 TP0597850 Inhibitor 99.09% Unkown
HY-111172 Inotilone Inhibitor / Unkown
HY-114396 BR351 Inhibitor / Unkown
HY-114785 BPHA Inhibitor / Unkown
HY-114911 Feprazone Inhibitor 99.88% Unkown
HY-120349 LL-Z1640-4 Inhibitor / Unkown
HY-12168B (Rac)-Tanomastat Inhibitor / Unkown
HY-124373A (R)-ND-336 Inhibitor / Unkown
HY-130076 MMP-2 Inhibitor II Inhibitor / Unkown
HY-136699 Excisanin A / Unkown
HY-14240 PG 116800 Inhibitor / Unkown
HY-143407 FAK-IN-3 Inhibitor / Unkown
HY-147867 MMP-2/9-IN-1 Inhibitor / Unkown
HY-147936 TP0556351 Inhibitor / Unkown
HY-149378 MMP13-IN-5 Inhibitor / Unkown
HY-152030 Tubulin/MMP-IN-2 / Unkown
HY-154698 Homouridine / Unkown
HY-155201 YJ182 Inhibitor / Unkown
HY-155721 22-(4′-py)-JA Inhibitor / Unkown
HY-156247 IVMT-Rx-3 Inhibitor / Unkown
HY-157382 AChE-IN-51 Inhibitor / Unkown
HY-162038 RXP03 Inhibitor / Unkown
HY-162344 Ir-CA Inducer / Unkown
HY-77813S Benzyl isothiocyanate-d7 / Unkown
HY-N10176 D-Isofloridoside Inhibitor / Unkown
HY-N5136 25(R,S)-Ruscogenin Inhibitor 99.84% Unkown
HY-N7385 Nudol / Unkown
HY-P1789 CTTHWGFTLC, CYCLIC Inhibitor / Unkown
HY-P2213 GPLGIAGQ Activator / Unkown
HY-P3477 Mca-PLA-Nva-Dap(Dnp)-AR-NH2 / Unkown
HY-P4574 VPLSLYSG / Unkown
HY-P5380 TNO211 / Unkown
HY-RS08537 MMP2 Human Pre-designed siRNA Set A / Unkown
HY-RS08538 Mmp2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08539 Mmp2 Rat Pre-designed siRNA Set A / Unkown
HY-W011085 CP-471474 Inhibitor / Unkown
HY-W277900 2-Methoxy-2,4-diphenylfuran-3-one / Unkown
HY-13564A Batimastat sodium salt Inhibitor / Unkown
HY-43586 BR351 precursor Inhibitor / Unkown
HY-P0273 Histatin 5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp2 NCBI NCBI:4313