Mmp2 - matrix metallopeptidase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 81686

About Mmp2

Primary_assembly 19: 14,154,657-14,182,870 reverse strand.mRatBN7.2:CM026992.1

This gene has 2 transcripts (splice variants), 210 orthologues, 23 paralogues and is associated with 166 phenotypes. Biased expression in Uterus (RPKM 651.), Lung (RPKM 536.) and 8 other tissues.

Summary

Enables fibronectin binding activity and peptidase activity. Involved in several processes, including cellular response to estradiol stimulus; circulatory system development; and reproductive structure development. Located in cytoplasm and extracellular space. Used to study artery disease (multiple); conjunctivitis; and transient cerebral ischemia. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); bile duct disease (multiple); brain ischemia (multiple); and liver cirrhosis (multiple). Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mmp2 Products (1)

mRNA	Protein	Name
NM_031054.2	NP_112316.2	72 kDa type IV collagenase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fibronectin binding	IPI IPI: Inferred from physical interaction	18039280	RGD
enables peptidase activity	IDA IDA: Inferred from direct assay	8531210	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	28659595	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in angiogenesis	IEP IEP: Inferred from expression pattern	12234794	RGD
involved in cell migration	IMP IMP: Inferred from mutant phenotype	20371087	RGD
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	19909738	RGD
involved in cellular response to estradiol stimulus	IMP IMP: Inferred from mutant phenotype	19861308	RGD
involved in cellular response to fluid shear stress	IEP IEP: Inferred from expression pattern	21637818	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	16046515	RGD
involved in collagen catabolic process	IDA IDA: Inferred from direct assay	22410640	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	15044600	RGD
involved in heart development	IDA IDA: Inferred from direct assay	12061388	RGD
involved in luteinization	IEP IEP: Inferred from expression pattern	10537164	RGD
involved in macrophage chemotaxis	IDA IDA: Inferred from direct assay	20110414	RGD
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	14645107	RGD
involved in negative regulation of vasoconstriction	IDA IDA: Inferred from direct assay	19482300	RGD
involved in ovarian follicle development	IDA IDA: Inferred from direct assay	15617683	RGD
involved in ovulation from ovarian follicle	IEP IEP: Inferred from expression pattern	14668206	RGD
involved in parturition	IEP IEP: Inferred from expression pattern	19923067	RGD
involved in peripheral nervous system axon regeneration	IDA IDA: Inferred from direct assay	15026117	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	16857167	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	21637818	RGD
involved in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	27614125	RGD
involved in prostate gland epithelium morphogenesis	IMP IMP: Inferred from mutant phenotype	20108352	RGD
involved in protein catabolic process	IDA IDA: Inferred from direct assay	16899336	RGD
involved in proteolysis	IDA IDA: Inferred from direct assay	20110414	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	19685505	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	17822627	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	19660200	RGD
involved in response to estrogen	IDA IDA: Inferred from direct assay	16765374	RGD
involved in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	16934674	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	19099751	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	16980344	RGD
involved in response to mechanical stimulus	IDA IDA: Inferred from direct assay	15350851	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	19879865	RGD
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	15642321	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	19099751	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16846501	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19874802	RGD
involved in tissue remodeling	IDA IDA: Inferred from direct assay	16740171	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	23911909	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp2 Protein Structure

PG_binding_1

Peptidase_M10

FN2

0
200
400
600
662 a.a.

Protein Preferred Names	Protein Names
72 kDa type IV collagenase	72 kDa gelatinase MMP-2 gelatinase A matrix metalloproteinase-2

Recombinant Mmp2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700573	MMP-2 Protein, Rat (P. pastoris, His)	P33436 (Y110-C662)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0493	Niflumic acid	Inhibitor	99.61%	Unkown
HY-B0689A	Indinavir sulfate		99.97%	Yes
HY-B0689	Indinavir		99.96%	Yes
HY-B0493R	Niflumic acid (Standard)	Inhibitor	99.93%	Unkown
HY-B0689B	Indinavir sulfate ethanolate		/	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12169	Marimastat	Inhibitor	99.90%	Phase 3
HY-12170	Prinomastat		98.41%	Phase 3
HY-12168	Tanomastat	Inhibitor	99.74%	Phase 3
HY-B0916	Propoxur		99.43%	Phase 3
HY-15768	Ilomastat	Inhibitor	99.14%	Phase 2
HY-10398	CTS-1027	Inhibitor	99.24%	Phase 2
HY-106992	S 3304	Inhibitor	99.75%	Phase 2
HY-112160	XL-784 free base	Inhibitor	/	Phase 2
HY-165386	TU-100	Inhibitor	/	Phase 2
HY-160822	AGG-523	Inhibitor	99.32%	Phase 1
HY-114214	CKD-712		/	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991419	MSB-0254	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (156)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0431	Astragaloside IV	Inhibitor	99.93%	Unkown
HY-13564	Batimastat	Inhibitor	98.92%	Unkown
HY-12354	SB-3CT	Inhibitor	99.84%	Unkown
HY-122022	JR-AB2-011	Inhibitor	98.15%	Unkown
HY-110397	KP-457	Inhibitor	98.88%	Unkown
HY-W068119A	N-(2-Aminoethyl)maleimide hydrochloride		99.97%	Unkown
HY-122214	AC-73	Inducer	99.91%	Unkown
HY-N0069	Solamargine		99.87%	Unkown
HY-103444	ARP-100	Inhibitor	≥99.0%	Unkown
HY-N0532	Morroniside	Inhibitor	99.94%	Unkown
HY-N2593	Isorhapontigenin		99.82%	Unkown
HY-W591424	m-PEG2000-NHS ester	Ligand	95.89%	Unkown
HY-N0805	Alisol B 23-acetate		99.65%	Unkown
HY-112546	MMP-2 Inhibitor I	Inhibitor	99.24%	Unkown
HY-N0853	Alisol A		99.59%	Unkown
HY-107394	UK 356618	Inhibitor	98.91%	Unkown
HY-124373	ND-336	Inhibitor	97.16%	Unkown
HY-164159	α-Glucosylrutin	Inhibitor	96.32%	Unkown
HY-120149	Inotodiol		98.29%	Unkown
HY-144707	AK-778-XXMU		99.96%	Unkown
HY-N0249	Saikosaponin C	Inducer	98.09%	Unkown
HY-N0419	Quercimeritrin		99.48%	Unkown
HY-146754	MMP2-IN-1		99.24%	Unkown
HY-113440	5-Methoxytryptophol		99.95%	Unkown
HY-128393	Trilinolein		98.0%	Unkown
HY-124813	PDZ1i	Inhibitor	99.29%	Unkown
HY-162038	RXP03	Inhibitor	98.82%	Unkown
HY-N0084	Betulinaldehyde	Inhibitor	98.72%	Unkown
HY-P3513	β-Neo-Endorphin	Activator	98.97%	Unkown
HY-N0566	23-Hydroxybetulinic acid		99.44%	Unkown
HY-107639	UK-370106	Inhibitor	≥99.0%	Unkown
HY-116474	Viridicatol		99.93%	Unkown
HY-N7627	Regaloside C		99.62%	Unkown
HY-P2213	GPLGIAGQ	Inducer	99.74%	Unkown
HY-116399	MMP-2/MMP-9-IN-1	Inhibitor	99.48%	Unkown
HY-P5982	PTPσ Inhibitor, ISP	Inhibitor	97.31%	Unkown
HY-107428	PD-166793	Inhibitor	99.21%	Unkown
HY-117970	MMPI-1154	Inhibitor	99.76%	Unkown
HY-12170A	Prinomastat hydrochloride		98.53%	Unkown
HY-122506	Salviolone	Inhibitor	99.32%	Unkown
HY-W001925	7-Methoxy-1-tetralone		99.93%	Unkown
HY-101535	ARP101	Inhibitor	≥99.0%	Unkown
HY-110397G	KP-457 (GMP)	Inhibitor	/	Unkown
HY-120213	YH-306		98.34%	Unkown
HY-19485	XL-784	Inhibitor	98.25%	Unkown
HY-W011085	CP-471474	Inhibitor	99.2%	Unkown
HY-143657	Myoferlin inhibitor 1	Inhibitor	99.88%	Unkown
HY-P2213A	GPLGIAGQ TFA	Inducer	99.89%	Unkown
HY-148571	TP0597850	Inhibitor	99.47%	Unkown
HY-114785	BPHA	Inhibitor	99.88%	Unkown
HY-126941	Hecogenin acetate		98.57%	Unkown
HY-176184	PROTAC DDR1 degrader-1		98.69%	Unkown
HY-N5136	25(R,S)-Ruscogenin	Inhibitor	99.83%	Unkown
HY-N6896	Isoviolanthin	Inhibitor	99.87%	Unkown
HY-P10143	MMP-2/MMP-9 Substrate	Substrate	98.48%	Unkown
HY-114911	Feprazone	Inhibitor	99.88%	Unkown
HY-Y1783	2-(Methylamino)ethanol	Inhibitor	99.51%	Unkown
HY-119979	Cardanol monoene	Inducer	99.51%	Unkown
HY-147745	MMP2-IN-2	Inhibitor	98.80%	Unkown
HY-181654	Snail IN-1	Inhibitor	98.27%	Unkown
HY-N7385	Nudol		99.60%	Unkown
HY-P0273A	Histatin 5 TFA	Inhibitor	99.98%	Unkown
HY-13564A	Batimastat sodium salt	Inhibitor	99.04%	Unkown
HY-N16129	Diplacone		98.38%	Unkown
HY-110116	SD-2590 hydrochloride	Inhibitor	99.4%	Unkown
HY-120349	LL-Z1640-4	Inhibitor	99.0%	Unkown
HY-130076	MMP-2 Inhibitor II	Inhibitor	98.0%	Unkown
HY-131417	cis-ACCP	Inhibitor	97.0%	Unkown
HY-147031	JAMM protein inhibitor 2	Inhibitor	98.20%	Unkown
HY-147746	MMP2-IN-3	Inhibitor	99.64%	Unkown
HY-P1789A	CTTHWGFTLC, CYCLIC TFA	Inhibitor	98.52%	Unkown
HY-160187A	(Rac)-AAA		99.02%	Unkown
HY-RS08537	MMP2 Human Pre-designed siRNA Set A		/	Unkown
HY-77813S	Benzyl isothiocyanate-d7		/	Unkown
HY-105854	Pipoxolan hydrochloride		/	Unkown
HY-109747	RO-28-2653	Inhibitor	/	Unkown
HY-111172	Inotilone	Inhibitor	95.26%	Unkown
HY-113621B	Ageladine A dihydrochloride	Inhibitor	/	Unkown
HY-114396	BR351	Inhibitor	/	Unkown
HY-116474R	Viridicatol (Standard)		/	Unkown
HY-119185	AZD-6605		/	Unkown
HY-120339	STK899704		/	Unkown
HY-12168B	(Rac)-Tanomastat	Inhibitor	/	Unkown
HY-124373A	(R)-ND-336	Inhibitor	/	Unkown
HY-128393S2	Trilinolein-d5		/	Unkown
HY-136699	Excisanin A	Inhibitor	/	Unkown
HY-137839	Anti-inflammatory agent 121	Inhibitor	/	Unkown
HY-138195	NEO212		/	Unkown
HY-14237	SC-77964	Inhibitor	/	Unkown
HY-143407	FAK-IN-3	Inhibitor	/	Unkown
HY-147867	MMP-2/9-IN-1	Inhibitor	/	Unkown
HY-147936	TP0556351	Inhibitor	/	Unkown
HY-149378	MMP13-IN-5	Inhibitor	/	Unkown
HY-152030	Tubulin/MMP-IN-2		/	Unkown
HY-154698	Homouridine		/	Unkown
HY-155201	YJ182	Inhibitor	/	Unkown
HY-155721	22-(4′-py)-JA	Inhibitor	/	Unkown
HY-156247	IVMT-Rx-3	Inhibitor	/	Unkown
HY-15668	ST09		/	Unkown
HY-157382	AChE-IN-51	Inhibitor	/	Unkown
HY-160720	ASPH-IN-1	Inhibitor	/	Unkown
HY-161707	MMP2-IN-4	Inhibitor	/	Unkown
HY-162344	Ir-CA	Inducer	/	Unkown
HY-168560	MMP Inhibitor 4	Inhibitor	/	Unkown
HY-168605	DH-18		/	Unkown
HY-170604	MMP-2 Inhibitor-4	Inhibitor	/	Unkown
HY-171776	OPB-3206	Inhibitor	/	Unkown
HY-172088	Tubulin/MMP-IN-3		/	Unkown
HY-172551	anti-TNBC agent-9		/	Unkown
HY-175291	Cystatin B agonist 1		/	Unkown
HY-175815	Apoptosis inducer 44		/	Unkown
HY-176149	Fluoxetine-Conjugated Platinum(IV) prodrug-1		/	Unkown
HY-180117	MMP-2/9-IN-2		/	Unkown
HY-180765	Colchicine-O-CO-Enyl(Me)-Enyl-Enyl(Me)-Enyl-1,3,3-trimethylcyclohex-1-ene	Activator	/	Unkown
HY-181272	MMP-9-IN-14		/	Unkown
HY-182795	Colchicine derivative-1		/	Unkown
HY-184501	UE01		/	Unkown
HY-184926	PEG9MA10-PAB10-GalMA10		/	Unkown
HY-18694	CGS 27023A	Inhibitor	/	Unkown
HY-18694A	CGS 27023A free base	Inhibitor	/	Unkown
HY-B0916R	Propoxur (Standard)		99.04%	Unkown
HY-B0916S	Propoxur-d3		/	Unkown
HY-N10176	D-Isofloridoside	Inhibitor	98.59%	Unkown
HY-N15588	Smyrindiol	Inhibitor	/	Unkown
HY-N17617	S-Petasin		/	Unkown
HY-N19029	Vernodalin		/	Unkown
HY-P11746	GPLGIAGQC		/	Unkown
HY-P1789	CTTHWGFTLC, CYCLIC	Inhibitor	/	Unkown
HY-P3477	Mca-PLA-Nva-Dap(Dnp)-AR-NH2		/	Unkown
HY-P3513A	β-Neo-Endorphin acetate	Activator	/	Unkown
HY-P3699	TNO003	Substrate	/	Unkown
HY-P4574	VPLSLYSG		/	Unkown
HY-P5764	TRAP-14 amide		/	Unkown
HY-RS08538	Mmp2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08539	Mmp2 Rat Pre-designed siRNA Set A		/	Unkown
HY-W012856	3-Ethyltoluene		/	Unkown
HY-W095774	(E)-N-(3-Methoxyphenyl)cinnamamide	Inhibitor	/	Unkown
HY-W277900	2-Methoxy-2,4-diphenylfuran-3-one		/	Unkown
HY-W750153	Propoxur-d7		/	Unkown
HY-105854A	Pipoxolan		/	Unkown
HY-113440R	5-Methoxytryptophol (Standard)		/	Unkown
HY-119110	LY52	Inhibitor	/	Unkown
HY-123130	ABT-770	Inhibitor	/	Unkown
HY-124341	ND-378	Inhibitor	/	Unkown
HY-128393S1	Trilinolein-13C54		/	Unkown
HY-133845	CIL-102		/	Unkown
HY-164525	SD-7300	Inhibitor	/	Unkown
HY-183408	MMI-166		/	Unkown
HY-35513	3-Aminobenzene-1,2-diol	Inhibitor	98.0%	Unkown
HY-43586	BR351 precursor	Inhibitor	/	Unkown
HY-B0689S1	Indinavir-13C4,15N		/	Unkown
HY-N13208	Stevia Powder		/	Unkown
HY-P3699A	TNO003 TFA	Substrate	/	Unkown
HY-W1057938	(E)-N-(4-Methoxyphenyl)cinnamamide	Inhibitor	/	Unkown
HY-W1058004	(E)-N-(2-Fluorophenyl)cinnamamide	Inhibitor	/	Unkown
HY-P0273	Histatin 5	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991609	ABX-MA1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mmp2	NCBI	NCBI:4313