MMP2 - matrix metallopeptidase 2 Gene

Also Known as CLG4; MONA; CLG4A; MMP-2; TBE-1; MMP-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4313

About MMP2

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:55,478,830-55,506,691 (from NCBI)

This gene has 8 transcripts (splice variants), 210 orthologues, 23 paralogues and is associated with 3 phenotypes. Broad expression in gall bladder (RPKM 482.6), urinary bladder (RPKM 341.0) and 15 other tissues.

Summary

This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent Enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V Collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

MMP2 Products (5)

mRNA	Protein	Name
NM_001127891.3	NP_001121363.1	72 kDa type IV collagenase isoform 2
NM_004530.6	NP_004521.1	72 kDa type IV collagenase isoform 1 preproprotein
NM_001302508.1	NP_001289437.1	72 kDa type IV collagenase isoform 3
NM_001302510.2	NP_001289439.1	72 kDa type IV collagenase isoform 3
NM_001302509.2	NP_001289438.1	72 kDa type IV collagenase isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	23845380	GOA
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	24236012	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12032297	GOA
enables serine-type endopeptidase activity	EXP EXP: Inferred from Experiment	17428795	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	31879982	GOA
involved in cellular response to UV-A	IDA IDA: Inferred from direct assay	31380578	GOA
involved in endodermal cell differentiation	IEP IEP: Inferred from expression pattern	23154389	GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	18667463	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	15863497	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18492766	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP2 Protein Structure

PG_binding_1

Peptidase_M10

fn2

Hemopexin

0
200
400
600
660 a.a.

Protein Preferred Names	Protein Names
72 kDa type IV collagenase	collagenase type IV-A matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) matrix metalloproteinase-2 matrix metalloproteinase-II neutrophil gelatinase

MMP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MMP2	P08253	TIMP2	Homo sapiens	P16035	Anti Tag CoIP	33961781
Intra	MMP2	P08253	TIMP2	Homo sapiens	P16035	Anti Tag CoIP	28514442
Intra	MMP2	P08253	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	MMP2	P08253	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	MMP2	P08253	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	MMP2	P08253	P05067-PRO_0000000093	Homo sapiens	P05067-PRO_0000000093	Protease Assay	25897080
Intra	MMP2	P08253	COL5A1	Homo sapiens	P20908	Anti Tag CoIP	33961781
Intra	MMP2	P08253	COL5A1	Homo sapiens	P20908	Anti Tag CoIP	28514442
Intra	MMP2	P08253	COL5A1	Homo sapiens	P20908	Y2H	20979576
Intra	MMP2	P08253	SCUBE3	Homo sapiens	Q8IX30	Protease Assay	21441952
Intra	MMP2	P08253	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	Protease Assay	25897080

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MMP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70268	MMP-2 Protein, Human (HEK293, His)	P08253 (A30-C660)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73296	MMP-2 Protein, Human (HEK293)	P08253-1/NP_004521.1 (A30-C660)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700139AF	Animal-Free MMP-2 Protein, Human (His)	P08253 (Y110-C660)	≥ 95%, as determined by reducing SDS-PAGE.

MMP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80509	MMP2 Antibody (YA287)	WB, IHC-P	Human, Mouse
HY-P84007	MMP2 Antibody (YA3704)	WB, FC, ELISA	Human, Mouse
HY-P84007A	MMP2 Antibody (YA3704)(PBS only)	WB, FC, ELISA	Human, Mouse
HY-P85767	MMP2 Antibody (YA5459)	WB, IHC-P, ICC/IF	Human, Rat, Mouse
HY-P86224	MMP2 Antibody (YA5916)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Larynx Cancer	Laryngeal Carcinoma Carcinoma Of Larynx Laryngeal Cancer Laryngeal Neoplasm Malignant Neoplasm Of Larynx Cancer Of Larynx Laryngeal Neoplasms Cancer, Laryngeal
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Infertility
Marfan Syndrome	MFS Mfs1 Marfan'S Syndrome Marfan Syndrome Type 1 Marfan Syndrome, Type I Mass Phenotype Contractural Arachnodactyly Mass Syndrome Octd Overlap Connective Tissue Disease Marfanoid Hypermobility Syndrome Marfan Disease
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Varicose Veins	Varices Varix Venous Ectasia Venous Varices Varicosity
Gingival Overgrowth	Gingival Enlargement Gingival Hyperplasia Gingival Bulge Gingival Enlargement Nos Gingival Hypertrophy Gum Hypertrophy Hyperplasia Gum Gingival Thickening Hyperplasia Of Gingiva Hypertrophy Of Gingiva Hypertrophy Of Mucous Membrane Of Gums
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Osteoarthritis	Osteoarthrosis Degenerative Joint Disease Hypertrophic Arthritis Arthropathy Degenerative Polyarthritis Degenerative Arthritis Osteoarthrosis And Allied Disorder Arthritis, Degenerative Oa Osteoarthritis Deformans Osteoarthrosis Deformans Kashin-Beck Disease
Pulmonary Emphysema
Pneumothorax	Pneumothorax Nos Air Leak Nos Pleural Air Leak Nos
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Spinal Cord Vascular Diseases Vascular Tissue Disease Vascular Anomaly
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Cataract 23, Multiple Types	Cataract 23 CTRCT23 Lamellar Cataract 23 Cataract 23, Multiple Types, With Or Without Microcornea Isolated Microphthalmia With Cataract 4 Mcopct4 Cataract, Type 23 Microphthalmia, Isolated, With Cataract 4
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Migraine With Aura	Classic Migraine Migraine With Typical Aura Migraine Accompagnée Complicated Migraine Classical Migraine Acute Migraine With Aura
Root Caries	Cementum Caries Dental Caries Of Root Surface
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Tongue Carcinoma	Tongue Cancer Malignant Neoplasm Of Tongue Tongue Neoplasms Tongue Neoplasm
Pelvic Inflammatory Disease	Pid
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Aggressive Periodontitis	Juvenile Periodontitis Periodontitis, Juvenile Prepubertal Periodontitis
Senile Ectropion	Involutional Ectropion
Choriocarcinoma	Chorioepithelioma
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Gastroenteritis	Cholera Morbus Infectious Colitis, Enteritis And Gastroenteritis Enteritis Due To Astrovirus Rotaviral Gastroenteritis Viral Gastroenteritis Due To Rotavirus
Aortic Dissection
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Pseudoxanthoma Elasticum	PXE Gronblad-Strandberg Syndrome Pseudoxanthoma Elasticum, Modifier Of Severity Of Gronblad-Strandberg-Touraine Syndrome Gronblad Strandberg Syndrome Groenblad-Strandberg Syndrome Nevus Elasticus Pxe - [Pseudoxanthoma Elasticum]
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Spastic Entropion
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Tongue Disease	Abnormality Of The Tongue Tongue Diseases Tongue Disorders Disorder Of Tongue Glossopathy Unspecified Condition Of The Tongue
Multicentric Osteolysis, Nodulosis, And Arthropathy	Torg-Winchester Syndrome Torg Syndrome Nao Syndrome MONA Nodulosis-Arthropathy-Osteolysis Syndrome Al-Aqeel Sewairi Syndrome Hereditary Multicentric Osteolysis Osteolysis, Hereditary Multicentric Torg-Winchester Syndrome, Formerly Multicentric Osteolysis Nodulosis And Arthropathy Multicentric Osteolysis, Nodulosis And Arthropathy Osteolysis, Multicentric, Nodulosis, And Arthropathy
Pulmonary Fibrosis	Fibrosis Of Lung
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Spinal Stenosis	Lumbar Spinal Stenosis Cervical Spinal Stenosis Spinal Stenosis Of Lumbar Region Spinal Stenosis In Cervical Region Spinal Canal Stenosis
Preterm Premature Rupture Of The Membranes	Preterm Premature Rupture Of Membranes PPROM Preterm Premature Rupture Of The Membranes, Susceptibility To Pprom - [Preterm Premature Rupture Of Membranes] Preterm Rupture Of Membranes
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Keratosis	Actinic Keratosis Hyperkeratosis
Corneal Ulcer	Cornea Ulcer Ulcerative Keratitis Corneal Ulcer Nos
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Arthropathy	Ankylosis Of Ankle And Foot Joint Ankylosis Of Forearm Joint Ankylosis Of Hand Joint Ankylosis Of Joint Of Ankle And/Or Foot Ankylosis Of Joint Of Forearm Ankylosis Of Joint Of Hand Ankylosis Of Joint Of Lower Leg Ankylosis Of Joint Of Multiple Sites Ankylosis Of Joint Of Pelvic Region And Thigh Ankylosis Of Joint Of Shoulder Region Ankylosis Of Joint Of Upper Arm Ankylosis Of Lower Leg Joint Ankylosis Of Multiple Joints Ankylosis Of Upper Arm Joint Infectious Arthropathy Joint Ankylosis Of The Ankle And Foot Joint Ankylosis Of The Ankle And/Or Foot Joint Ankylosis Of The Forearm Joint Ankylosis Of The Hand Joint Ankylosis Of The Lower Leg Joint Ankylosis Of The Pelvic Region And Thigh Joint Ankylosis Of The Shoulder Region Joint Ankylosis Of The Upper Arm Joint Diseases Joint Disease Arthropathy Associated With Infection
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Aortic Disease	Aortic Diseases Aortic Disorder Disorder Of The Aorta
Glioma
Lymphangioleiomyomatosis	Lymphangiomyomatosis LAM Lung Lymphangioleiomyomatosis Pulmonary Lymphangioleiomyomatosis Lymphangioleiomyomatosis, Somatic Lymphangio-Myomatosis
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Takayasu Arteritis	Aortic Arch Syndrome Pulseless Disease Idiopathic Aortitis Young Female Arteritis Takayasu'S Arteritis Aortic Arch Arteritis Aortic Arches Defect Aortic Arch Defects Takayasu Disease Aortic Arch Syndromes Takayasu'S Disease Ta Obliterative Aortitis Aortic Arch Giant-Cell Arteritis Subclavian-Carotid Obstruction Syndrome Idiopathic Medial Aortopathy And Arteriopathy Takayasu Syndrome Obliterative Brachiocephalic Arteritis Syndrome Raeder-Harbitz Syndrome Chronic Subclavian-Carotid Obstruction Syndrome Giant-Cell Aortitis Takayasu Aortitis Nonspecific Aortoarteritis Sclerosing Aortitis And Arteritis Martorell 2 Syndrome Young Female Aortic Arch Arteritis Syndrome
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Parotitis
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Multicentric Osteolysis-Nodulosis-Arthropathy Spectrum	Mona Spectrum Nao Syndrome Nodulosis-Arthropathy-Osteolysis Syndrome Torg-Winchester Syndrome Multicentric Osteolysis-Nodulosis-Arthropathy Spectrum Disorders
Oral Submucous Fibrosis	Oral Submucosal Fibrosis, Including Of Tongue Osmf Oral Cavity Submucous Fibrosis Oral Submucosal Fibrosis Submucosal Fibrosis
Conjunctivochalasis
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Smooth Muscle Tumor
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Anaplastic Astrocytoma	Grade Iii Astrocytoma Grade Iii Astrocytic Tumor Astrocytoma, Anaplastic
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Cutis Laxa	Generalized Elastolysis Loose Skin Dermatolysis Dermatomegaly Cutis Laxa Syndrome
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Myelitis	Spinal Cord Inflammation Nos Radiculomyelitis Nos Myeloradiculitis
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Hypertrichosis
Aortic Aneurysm	Aortic Rupture Thoracoabdominal Aortic Aneurysm, Ruptured Ruptured Aortic Aneurysm Aortic Aneurysms Aortic Aneurysm Without Mention Of Rupture Nos Ruptured Abdominal Aortic Aneurysm Aortic Aneurysm, Ruptured Ruptured Thoracic Aortic Aneurysm
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Pancreatic Adenocarcinoma	Adenocarcinoma Of Pancreas Adenocarcinoma Of The Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Winchester Syndrome	WNCHRS Winchester Disease Winchester-Grossman Syndrome
Adenomyosis	Endometriosis Of Uterus Endometriosis Interna Endometriosis Of Myometrium Endometriosis, Myometrium Uterine Adenomyosis Adenomyosis Uteri Internal Endometriosis
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Ameloblastoma	Adenoameloblastoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Hyperostosis	Hypertrophy Of Bone Bone Hypertrophy Bone Thickening Periosteum Thickening
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Diabetes Mellitus	Diabetes
Lip And Oral Cavity Cancer	Oral Cancer Lip And Oral Cavity Carcinoma Malignant Neoplasm Of Mouth
Dental Caries	Dental Caries Extending Into Pulp Dental Caries Of Smooth Surface Dental Caries Pit And Fissure Smooth Surface Dental Caries Dental Decay Carious Teeth Dental Cavity Saprodontia Teeth Decayed Tooth Caries Tooth Decay
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Degeneration Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Root Resorption
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Suppurative Periapical Periodontitis	Periapical Abscess Apical Abscess Suppurative Apical Periodontitis Dentoalveolar Abscess Dental Abscess With Sinus Dentoalveolar Abscess With Sinus Dental Sinus Periapical Abscess Fistula Apical Tooth Abscess Apex Abscess Dental Abscess Nos Infection Of Tooth Nos Abscess Of Tooth Dental Infection Nos
Rhabdomyosarcoma
Dentin Caries	Compound Dental Caries Dental Caries Extending Into Dentine Dental Caries Extending Into Dentin
Fibromatosis, Gingival, 1	GINGF1 Ggf1 Fibromatosis, Gingival, Hereditary Hgf Hereditary Gingival Fibromatosis Gingf Gingival Fibromatosis, 1 Fibromatosis Gingival, Hereditary, 1 Hgf1 Hereditary Gingival Fibromatosis, 1
Retinal Detachment	Retinal Detachments Rhegmatogenous Retinal Detachment Ruptured Retina With Detachment Retinal Hole With Detachment
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Sialadenitis	Sialoadenitis Adenitis, Salivary Gland Salivary Gland Inflammation Salivary Gland Adenitis Sialitis Inflammation Of Salivary Gland Inflammation Of Salivary Duct Or Gland Salivary Glandular Adenitis Sialoangiitis Sialoangitis Sialodochitis
Serous Cystadenocarcinoma	Serous Adenocarcinoma Cystadenocarcinoma, Serous Serous Carcinoma Cystadenocarcinoma Serous
Inguinal Hernia	Hernia Inguinal Hernia, Inguinal Inguinal Hernias Bubonocele Indirect Inguinal Hernia Direct Inguinal Hernia Oblique Inguinal Hernia Scrotal Hernia Ih - [Inguinal Hernia]
Aortic Aneurysm, Familial Abdominal, 1	Abdominal Aortic Aneurysm Aortic Aneurysm, Familial Abdominal 1 Aneurysm, Abdominal Aortic AAA Aortic Aneurysm, Abdominal AAA1 Aortic Aneurysm, Familial Abdominal Aortic Aneurysm Abdominal Abdominal Aortic Aneurysms Abdominal Aortic Aneurysm Without Mention Of Perforation Or Rupture Abdomen Aneurysm Abdominal Aorta Aneurysm Aneurysm Of Abdominal Aorta Aortic Abdomen Aneurysm Aaa - [Abdominal Aortic Aneurysm] Abdominal Aneurysm Abdominal Aorta Aneurysm Rupture Abdominal Aorta Aneurysm Ruptured Abdominal Aortic Aneurysm Which Has Ruptured Ruptured Aaa Abdomen Aorta Aneurysm Ruptured Abdomen Aorta Rupture Abdomen Aortic Aneurysm Rupture Abdomen Aneurysm Rupture Abdomen Aortic Aneurysm Ruptured Abdomen Aortic Rupture Abdominal Aorta Rupture Abdominal Aortic Rupture Rupture Abdomen Aorta Aneurysm Rupture Abdominal Aortic Aneurysm Ruptured Abdomen Aneurysm Ruptured Abdomen Aorta Ruptured Abdomen Aortic Ruptured Abdominal Aneurysm Ruptured Abdominal Aorta Ruptured Abdominal Aortic Ruptured Aorta Abdominalis Aneurysm False Abdomen Aorta Aneurysm Ruptured False Abdominal Aortic Aneurysm Ruptured False Abdominal Aorta Aneurysm Ruptured False Abdomen Aortic Aneurysm Ruptured
Periodontitis	Chronic Pericementitis Chronic Periodontitis
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0493	Niflumic acid	Inhibitor	99.61%	Unkown
HY-B0689A	Indinavir sulfate		99.97%	Yes
HY-B0689	Indinavir		99.96%	Yes
HY-B0493R	Niflumic acid (Standard)	Inhibitor	99.93%	Unkown
HY-B0689B	Indinavir sulfate ethanolate		/	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12169	Marimastat	Inhibitor	99.90%	Phase 3
HY-12170	Prinomastat		98.41%	Phase 3
HY-12168	Tanomastat	Inhibitor	99.74%	Phase 3
HY-B0916	Propoxur		99.43%	Phase 3
HY-15768	Ilomastat	Inhibitor	99.14%	Phase 2
HY-10398	CTS-1027	Inhibitor	99.24%	Phase 2
HY-106992	S 3304	Inhibitor	99.75%	Phase 2
HY-112160	XL-784 free base	Inhibitor	/	Phase 2
HY-165386	TU-100	Inhibitor	/	Phase 2
HY-160822	AGG-523	Inhibitor	99.32%	Phase 1
HY-114214	CKD-712		/	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991419	MSB-0254	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (152)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0431	Astragaloside IV	Inhibitor	99.93%	Unkown
HY-13564	Batimastat	Inhibitor	98.92%	Unkown
HY-12354	SB-3CT	Inhibitor	99.84%	Unkown
HY-122022	JR-AB2-011	Inhibitor	98.15%	Unkown
HY-110397	KP-457	Inhibitor	98.88%	Unkown
HY-W068119A	N-(2-Aminoethyl)maleimide hydrochloride		99.97%	Unkown
HY-122214	AC-73	Inducer	99.91%	Unkown
HY-N0069	Solamargine		99.87%	Unkown
HY-103444	ARP-100	Inhibitor	≥99.0%	Unkown
HY-N0532	Morroniside	Inhibitor	99.94%	Unkown
HY-N2593	Isorhapontigenin		99.82%	Unkown
HY-W591424	m-PEG2000-NHS ester	Ligand	95.89%	Unkown
HY-N0805	Alisol B 23-acetate		99.65%	Unkown
HY-112546	MMP-2 Inhibitor I	Inhibitor	99.24%	Unkown
HY-N0853	Alisol A		99.59%	Unkown
HY-107394	UK 356618	Inhibitor	98.91%	Unkown
HY-124373	ND-336	Inhibitor	97.16%	Unkown
HY-164159	α-Glucosylrutin	Inhibitor	96.32%	Unkown
HY-120149	Inotodiol		98.29%	Unkown
HY-144707	AK-778-XXMU		99.96%	Unkown
HY-N0249	Saikosaponin C	Inducer	98.09%	Unkown
HY-N0419	Quercimeritrin		99.48%	Unkown
HY-146754	MMP2-IN-1		99.24%	Unkown
HY-113440	5-Methoxytryptophol		99.95%	Unkown
HY-128393	Trilinolein		98.0%	Unkown
HY-124813	PDZ1i	Inhibitor	99.29%	Unkown
HY-162038	RXP03	Inhibitor	98.82%	Unkown
HY-N0084	Betulinaldehyde	Inhibitor	98.72%	Unkown
HY-P3513	β-Neo-Endorphin	Activator	98.97%	Unkown
HY-N0566	23-Hydroxybetulinic acid		99.44%	Unkown
HY-107639	UK-370106	Inhibitor	≥99.0%	Unkown
HY-116474	Viridicatol		99.93%	Unkown
HY-N7627	Regaloside C		99.62%	Unkown
HY-P2213	GPLGIAGQ	Inducer	99.74%	Unkown
HY-116399	MMP-2/MMP-9-IN-1	Inhibitor	99.48%	Unkown
HY-107428	PD-166793	Inhibitor	99.21%	Unkown
HY-117970	MMPI-1154	Inhibitor	99.76%	Unkown
HY-12170A	Prinomastat hydrochloride		98.53%	Unkown
HY-122506	Salviolone	Inhibitor	99.32%	Unkown
HY-W001925	7-Methoxy-1-tetralone		99.93%	Unkown
HY-101535	ARP101	Inhibitor	≥99.0%	Unkown
HY-110397G	KP-457 (GMP)	Inhibitor	/	Unkown
HY-120213	YH-306		98.34%	Unkown
HY-19485	XL-784	Inhibitor	98.25%	Unkown
HY-W011085	CP-471474	Inhibitor	99.2%	Unkown
HY-143657	Myoferlin inhibitor 1	Inhibitor	99.88%	Unkown
HY-P2213A	GPLGIAGQ TFA	Inducer	99.89%	Unkown
HY-148571	TP0597850	Inhibitor	99.47%	Unkown
HY-114785	BPHA	Inhibitor	99.88%	Unkown
HY-126941	Hecogenin acetate		98.57%	Unkown
HY-176184	PROTAC DDR1 degrader-1		98.69%	Unkown
HY-N5136	25(R,S)-Ruscogenin	Inhibitor	99.83%	Unkown
HY-N6896	Isoviolanthin	Inhibitor	99.87%	Unkown
HY-P10143	MMP-2/MMP-9 Substrate	Substrate	98.48%	Unkown
HY-114911	Feprazone	Inhibitor	99.88%	Unkown
HY-119979	Cardanol monoene	Inducer	99.51%	Unkown
HY-147745	MMP2-IN-2	Inhibitor	98.80%	Unkown
HY-181654	Snail IN-1	Inhibitor	98.27%	Unkown
HY-N7385	Nudol		99.60%	Unkown
HY-P0273A	Histatin 5 TFA	Inhibitor	99.98%	Unkown
HY-13564A	Batimastat sodium salt	Inhibitor	99.04%	Unkown
HY-N16129	Diplacone		98.38%	Unkown
HY-110116	SD-2590 hydrochloride	Inhibitor	99.4%	Unkown
HY-120349	LL-Z1640-4	Inhibitor	99.0%	Unkown
HY-130076	MMP-2 Inhibitor II	Inhibitor	98.0%	Unkown
HY-131417	cis-ACCP	Inhibitor	97.0%	Unkown
HY-147031	JAMM protein inhibitor 2	Inhibitor	98.20%	Unkown
HY-147746	MMP2-IN-3	Inhibitor	99.64%	Unkown
HY-P1789A	CTTHWGFTLC, CYCLIC TFA	Inhibitor	98.52%	Unkown
HY-160187A	(Rac)-AAA		99.02%	Unkown
HY-RS08537	MMP2 Human Pre-designed siRNA Set A		/	Unkown
HY-77813S	Benzyl isothiocyanate-d7		/	Unkown
HY-105854	Pipoxolan hydrochloride		/	Unkown
HY-109747	RO-28-2653	Inhibitor	/	Unkown
HY-111172	Inotilone	Inhibitor	95.26%	Unkown
HY-113621B	Ageladine A dihydrochloride	Inhibitor	/	Unkown
HY-114396	BR351	Inhibitor	/	Unkown
HY-116474R	Viridicatol (Standard)		/	Unkown
HY-119185	AZD-6605		/	Unkown
HY-120339	STK899704		/	Unkown
HY-12168B	(Rac)-Tanomastat	Inhibitor	/	Unkown
HY-124373A	(R)-ND-336	Inhibitor	/	Unkown
HY-128393S2	Trilinolein-d5		/	Unkown
HY-136699	Excisanin A	Inhibitor	/	Unkown
HY-138195	NEO212		/	Unkown
HY-14237	SC-77964	Inhibitor	/	Unkown
HY-143407	FAK-IN-3	Inhibitor	/	Unkown
HY-147867	MMP-2/9-IN-1	Inhibitor	/	Unkown
HY-147936	TP0556351	Inhibitor	/	Unkown
HY-149378	MMP13-IN-5	Inhibitor	/	Unkown
HY-152030	Tubulin/MMP-IN-2		/	Unkown
HY-154698	Homouridine		/	Unkown
HY-155201	YJ182	Inhibitor	/	Unkown
HY-155721	22-(4′-py)-JA	Inhibitor	/	Unkown
HY-156247	IVMT-Rx-3	Inhibitor	/	Unkown
HY-15668	ST09		/	Unkown
HY-157382	AChE-IN-51	Inhibitor	/	Unkown
HY-160720	ASPH-IN-1	Inhibitor	/	Unkown
HY-161707	MMP2-IN-4	Inhibitor	/	Unkown
HY-162344	Ir-CA	Inducer	/	Unkown
HY-168560	MMP Inhibitor 4	Inhibitor	/	Unkown
HY-168605	DH-18		/	Unkown
HY-170604	MMP-2 Inhibitor-4	Inhibitor	/	Unkown
HY-171776	OPB-3206	Inhibitor	/	Unkown
HY-172088	Tubulin/MMP-IN-3		/	Unkown
HY-172551	anti-TNBC agent-9		/	Unkown
HY-175291	Cystatin B agonist 1		/	Unkown
HY-175815	Apoptosis inducer 44		/	Unkown
HY-176149	Fluoxetine-Conjugated Platinum(IV) prodrug-1		/	Unkown
HY-180117	MMP-2/9-IN-2		/	Unkown
HY-180765	Colchicine-O-CO-Enyl(Me)-Enyl-Enyl(Me)-Enyl-1,3,3-trimethylcyclohex-1-ene	Activator	/	Unkown
HY-181272	MMP-9-IN-14		/	Unkown
HY-182795	Colchicine derivative-1		/	Unkown
HY-184501	UE01		/	Unkown
HY-184926	PEG9MA10-PAB10-GalMA10		/	Unkown
HY-18694	CGS 27023A	Inhibitor	/	Unkown
HY-18694A	CGS 27023A free base	Inhibitor	/	Unkown
HY-B0916R	Propoxur (Standard)		99.04%	Unkown
HY-B0916S	Propoxur-d3		/	Unkown
HY-N10176	D-Isofloridoside	Inhibitor	98.59%	Unkown
HY-N15588	Smyrindiol	Inhibitor	/	Unkown
HY-N17617	S-Petasin		/	Unkown
HY-N19029	Vernodalin		/	Unkown
HY-P11746	GPLGIAGQC		/	Unkown
HY-P1789	CTTHWGFTLC, CYCLIC	Inhibitor	/	Unkown
HY-P3477	Mca-PLA-Nva-Dap(Dnp)-AR-NH2		/	Unkown
HY-P3513A	β-Neo-Endorphin acetate	Activator	/	Unkown
HY-P3699	TNO003	Substrate	/	Unkown
HY-P4574	VPLSLYSG		/	Unkown
HY-P5764	TRAP-14 amide		/	Unkown
HY-RS08538	Mmp2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08539	Mmp2 Rat Pre-designed siRNA Set A		/	Unkown
HY-W012856	3-Ethyltoluene		/	Unkown
HY-W095774	(E)-N-(3-Methoxyphenyl)cinnamamide	Inhibitor	/	Unkown
HY-W277900	2-Methoxy-2,4-diphenylfuran-3-one		/	Unkown
HY-W750153	Propoxur-d7		/	Unkown
HY-105854A	Pipoxolan		/	Unkown
HY-113440R	5-Methoxytryptophol (Standard)		/	Unkown
HY-119110	LY52	Inhibitor	/	Unkown
HY-123130	ABT-770	Inhibitor	/	Unkown
HY-124341	ND-378	Inhibitor	/	Unkown
HY-128393S1	Trilinolein-13C54		/	Unkown
HY-133845	CIL-102		/	Unkown
HY-164525	SD-7300	Inhibitor	/	Unkown
HY-183408	MMI-166		/	Unkown
HY-35513	3-Aminobenzene-1,2-diol	Inhibitor	98.0%	Unkown
HY-43586	BR351 precursor	Inhibitor	/	Unkown
HY-B0689S1	Indinavir-13C4,15N		/	Unkown
HY-N13208	Stevia Powder		/	Unkown
HY-P3699A	TNO003 TFA	Substrate	/	Unkown
HY-W1058004	(E)-N-(2-Fluorophenyl)cinnamamide	Inhibitor	/	Unkown
HY-P0273	Histatin 5	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991609	ABX-MA1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MMP2	RGD	RGD:621316
Felis catus	MMP2	VGNC	VGNC:68287
Macaca mulatta	MMP2	VGNC	VGNC:74897
Mus musculus	MMP2	MGD	MGI:97009
Canis familiaris	MMP2	VGNC	VGNC:43280
Bos taurus	MMP2	VGNC	VGNC:31524
Others	MMP2	NCBI