Mmp2 - matrix metallopeptidase 2 Gene

Also Known as GelA; Clg4a; MMP-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17390

About Mmp2

Chromosome 8: 93,553,919-93,580,048 forward strand.GRCm39:CM001001.3

This gene has 4 transcripts (splice variants), 210 orthologues, 23 paralogues and is associated with 73 phenotypes. Broad expression in mammary gland adult (RPKM 186.), subcutaneous fat pad adult (RPKM 13.) and 15 other tissues.

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that hydrolyzes collagens, gelatins, laminin, fibronectin and elastin. Mice lacking the encoded protein exhibit suppressed angiogenesis and attenuated features of human multicentric osteolysis with arthritis including abnormal skeletal and craniofacial development. [provided by RefSeq, Feb 2016]

Mmp2 Products (1)

mRNA Protein Name
NM_008610.3 NP_032636.1 72 kDa type IV collagenase preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
12419962 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel maturation IGI
IGI: Inferred from genetic interaction
11747814 MGI
acts upstream of or within bone trabecula formation IGI
IGI: Inferred from genetic interaction
17440987 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
acts upstream of or within cellular response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
17561096 MGI
acts upstream of or within collagen catabolic process IMP
IMP: Inferred from mutant phenotype
17440987 MGI
acts upstream of or within embryo implantation IDA
IDA: Inferred from direct assay
18556655 MGI
acts upstream of or within face morphogenesis IGI
IGI: Inferred from genetic interaction
17440987 MGI
acts upstream of or within intramembranous ossification IGI
IGI: Inferred from genetic interaction
17440987 MGI
acts upstream of or within positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17561096 MGI
involved in response to amyloid-beta IDA
IDA: Inferred from direct assay
28912710 MGI
acts upstream of or within response to hypoxia IDA
IDA: Inferred from direct assay
17382917 MGI
acts upstream of or within skeletal system morphogenesis IGI
IGI: Inferred from genetic interaction
17440987 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
17349656 MGI
located in sarcomere IDA
IDA: Inferred from direct assay
17349656 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp2 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (69 - 96)

Peptidase_M10

Peptidase_M10: pfam00413 (117 - 445)

FN2

FN2: smart00059 (225 - 273)

FN2

FN2: smart00059 (283 - 331)

FN2

FN2: smart00059 (341 - 389)

HX

HX: cd00094 (467 - 661)

  • 0
  • 200
  • 400
  • 600
  • 662 a.a.
Protein Preferred Names Protein Names

72 kDa type IV collagenase

  • 72 kDa gelatinase

  • 72kD gelatinase

  • 72kD type IV collagenase

  • 72kDa gelatinase

  • 72kDa type IV collagenase

  • gelatinase A

  • matrix metalloproteinase 2

Recombinant Mmp2 Proteins

Cat. No. Product Name Accession Purity
HY-P73810 MMP-2 Protein, Mouse (HEK293, His) NP_032636.1 (M409-C662) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0493 Niflumic acid Inhibitor 99.61% Unkown
HY-B0689A Indinavir sulfate 99.97% Yes
HY-B0689 Indinavir 99.96% Yes
HY-B0493R Niflumic acid (Standard) Inhibitor 99.93% Unkown
HY-B0689B Indinavir sulfate ethanolate / Unkown

Clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-12169 Marimastat Inhibitor 99.90% Phase 3
HY-12170 Prinomastat 98.41% Phase 3
HY-12168 Tanomastat Inhibitor 99.74% Phase 3
HY-B0916 Propoxur 99.43% Phase 3
HY-15768 Ilomastat Inhibitor 99.14% Phase 2
HY-10398 CTS-1027 Inhibitor 99.24% Phase 2
HY-106992 S 3304 Inhibitor 99.75% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
HY-165386 TU-100 Inhibitor / Phase 2
HY-160822 AGG-523 Inhibitor 99.32% Phase 1
HY-114214 CKD-712 / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991419 MSB-0254 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (153)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0431 Astragaloside IV Inhibitor 99.93% Unkown
HY-13564 Batimastat Inhibitor 98.92% Unkown
HY-12354 SB-3CT Inhibitor 99.84% Unkown
HY-122022 JR-AB2-011 Inhibitor 98.15% Unkown
HY-110397 KP-457 Inhibitor 98.88% Unkown
HY-W068119A N-(2-Aminoethyl)maleimide hydrochloride 99.97% Unkown
HY-122214 AC-73 Inducer 99.91% Unkown
HY-N0069 Solamargine 99.87% Unkown
HY-103444 ARP-100 Inhibitor ≥99.0% Unkown
HY-N0532 Morroniside Inhibitor 99.94% Unkown
HY-N2593 Isorhapontigenin 99.82% Unkown
HY-W591424 m-PEG2000-NHS ester Ligand 95.89% Unkown
HY-N0805 Alisol B 23-acetate 99.65% Unkown
HY-112546 MMP-2 Inhibitor I Inhibitor 99.24% Unkown
HY-N0853 Alisol A 99.59% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-124373 ND-336 Inhibitor 97.16% Unkown
HY-164159 α-Glucosylrutin Inhibitor 96.32% Unkown
HY-120149 Inotodiol 98.29% Unkown
HY-144707 AK-778-XXMU 99.96% Unkown
HY-N0249 Saikosaponin C Inducer 98.09% Unkown
HY-N0419 Quercimeritrin 99.48% Unkown
HY-146754 MMP2-IN-1 99.24% Unkown
HY-113440 5-Methoxytryptophol 99.95% Unkown
HY-128393 Trilinolein 98.0% Unkown
HY-124813 PDZ1i Inhibitor 99.29% Unkown
HY-162038 RXP03 Inhibitor 98.82% Unkown
HY-N0084 Betulinaldehyde Inhibitor 98.72% Unkown
HY-P3513 β-Neo-Endorphin Activator 98.97% Unkown
HY-N0566 23-Hydroxybetulinic acid 99.44% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-116474 Viridicatol 99.93% Unkown
HY-N7627 Regaloside C 99.62% Unkown
HY-P2213 GPLGIAGQ Inducer 99.74% Unkown
HY-116399 MMP-2/MMP-9-IN-1 Inhibitor 99.48% Unkown
HY-P5982 PTPσ Inhibitor, ISP Inhibitor 97.31% Unkown
HY-107428 PD-166793 Inhibitor 99.21% Unkown
HY-117970 MMPI-1154 Inhibitor 99.76% Unkown
HY-12170A Prinomastat hydrochloride 98.53% Unkown
HY-122506 Salviolone Inhibitor 99.32% Unkown
HY-W001925 7-Methoxy-1-tetralone 99.93% Unkown
HY-101535 ARP101 Inhibitor ≥99.0% Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-120213 YH-306 98.34% Unkown
HY-19485 XL-784 Inhibitor 98.25% Unkown
HY-W011085 CP-471474 Inhibitor 99.2% Unkown
HY-143657 Myoferlin inhibitor 1 Inhibitor 99.88% Unkown
HY-P2213A GPLGIAGQ TFA Inducer 99.89% Unkown
HY-148571 TP0597850 Inhibitor 99.47% Unkown
HY-114785 BPHA Inhibitor 99.88% Unkown
HY-126941 Hecogenin acetate 98.57% Unkown
HY-176184 PROTAC DDR1 degrader-1 98.69% Unkown
HY-N5136 25(R,S)-Ruscogenin Inhibitor 99.83% Unkown
HY-N6896 Isoviolanthin Inhibitor 99.87% Unkown
HY-P10143 MMP-2/MMP-9 Substrate Substrate 98.48% Unkown
HY-114911 Feprazone Inhibitor 99.88% Unkown
HY-119979 Cardanol monoene Inducer 99.51% Unkown
HY-147745 MMP2-IN-2 Inhibitor 98.80% Unkown
HY-181654 Snail IN-1 Inhibitor 98.27% Unkown
HY-N7385 Nudol 99.60% Unkown
HY-P0273A Histatin 5 TFA Inhibitor 99.98% Unkown
HY-13564A Batimastat sodium salt Inhibitor 99.04% Unkown
HY-N16129 Diplacone 98.38% Unkown
HY-110116 SD-2590 hydrochloride Inhibitor 99.4% Unkown
HY-120349 LL-Z1640-4 Inhibitor 99.0% Unkown
HY-130076 MMP-2 Inhibitor II Inhibitor 98.0% Unkown
HY-131417 cis-ACCP Inhibitor 97.0% Unkown
HY-147031 JAMM protein inhibitor 2 Inhibitor 98.20% Unkown
HY-147746 MMP2-IN-3 Inhibitor 99.64% Unkown
HY-P1789A CTTHWGFTLC, CYCLIC TFA Inhibitor 98.52% Unkown
HY-160187A (Rac)-AAA 99.02% Unkown
HY-RS08537 MMP2 Human Pre-designed siRNA Set A / Unkown
HY-77813S Benzyl isothiocyanate-d7 / Unkown
HY-105854 Pipoxolan hydrochloride / Unkown
HY-109747 RO-28-2653 Inhibitor / Unkown
HY-111172 Inotilone Inhibitor 95.26% Unkown
HY-113621B Ageladine A dihydrochloride Inhibitor / Unkown
HY-114396 BR351 Inhibitor / Unkown
HY-116474R Viridicatol (Standard) / Unkown
HY-119185 AZD-6605 / Unkown
HY-120339 STK899704 / Unkown
HY-12168B (Rac)-Tanomastat Inhibitor / Unkown
HY-124373A (R)-ND-336 Inhibitor / Unkown
HY-128393S2 Trilinolein-d5 / Unkown
HY-136699 Excisanin A Inhibitor / Unkown
HY-138195 NEO212 / Unkown
HY-14237 SC-77964 Inhibitor / Unkown
HY-143407 FAK-IN-3 Inhibitor / Unkown
HY-147867 MMP-2/9-IN-1 Inhibitor / Unkown
HY-147936 TP0556351 Inhibitor / Unkown
HY-149378 MMP13-IN-5 Inhibitor / Unkown
HY-152030 Tubulin/MMP-IN-2 / Unkown
HY-154698 Homouridine / Unkown
HY-155201 YJ182 Inhibitor / Unkown
HY-155721 22-(4′-py)-JA Inhibitor / Unkown
HY-156247 IVMT-Rx-3 Inhibitor / Unkown
HY-15668 ST09 / Unkown
HY-157382 AChE-IN-51 Inhibitor / Unkown
HY-160720 ASPH-IN-1 Inhibitor / Unkown
HY-161707 MMP2-IN-4 Inhibitor / Unkown
HY-162344 Ir-CA Inducer / Unkown
HY-168560 MMP Inhibitor 4 Inhibitor / Unkown
HY-168605 DH-18 / Unkown
HY-170604 MMP-2 Inhibitor-4 Inhibitor / Unkown
HY-171776 OPB-3206 Inhibitor / Unkown
HY-172088 Tubulin/MMP-IN-3 / Unkown
HY-172551 anti-TNBC agent-9 / Unkown
HY-175291 Cystatin B agonist 1 / Unkown
HY-175815 Apoptosis inducer 44 / Unkown
HY-176149 Fluoxetine-Conjugated Platinum(IV) prodrug-1 / Unkown
HY-180117 MMP-2/9-IN-2 / Unkown
HY-180765 Colchicine-O-CO-Enyl(Me)-Enyl-Enyl(Me)-Enyl-1,3,3-trimethylcyclohex-1-ene Activator / Unkown
HY-181272 MMP-9-IN-14 / Unkown
HY-182795 Colchicine derivative-1 / Unkown
HY-184501 UE01 / Unkown
HY-184926 PEG9MA10-PAB10-GalMA10 / Unkown
HY-18694 CGS 27023A Inhibitor / Unkown
HY-18694A CGS 27023A free base Inhibitor / Unkown
HY-B0916R Propoxur (Standard) 99.04% Unkown
HY-B0916S Propoxur-d3 / Unkown
HY-N10176 D-Isofloridoside Inhibitor 98.59% Unkown
HY-N15588 Smyrindiol Inhibitor / Unkown
HY-N17617 S-Petasin / Unkown
HY-N19029 Vernodalin / Unkown
HY-P11746 GPLGIAGQC / Unkown
HY-P1789 CTTHWGFTLC, CYCLIC Inhibitor / Unkown
HY-P3477 Mca-PLA-Nva-Dap(Dnp)-AR-NH2 / Unkown
HY-P3513A β-Neo-Endorphin acetate Activator / Unkown
HY-P3699 TNO003 Substrate / Unkown
HY-P4574 VPLSLYSG / Unkown
HY-P5764 TRAP-14 amide / Unkown
HY-RS08538 Mmp2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08539 Mmp2 Rat Pre-designed siRNA Set A / Unkown
HY-W012856 3-Ethyltoluene / Unkown
HY-W095774 (E)-N-(3-Methoxyphenyl)cinnamamide Inhibitor / Unkown
HY-W277900 2-Methoxy-2,4-diphenylfuran-3-one / Unkown
HY-W750153 Propoxur-d7 / Unkown
HY-105854A Pipoxolan / Unkown
HY-113440R 5-Methoxytryptophol (Standard) / Unkown
HY-119110 LY52 Inhibitor / Unkown
HY-123130 ABT-770 Inhibitor / Unkown
HY-124341 ND-378 Inhibitor / Unkown
HY-128393S1 Trilinolein-13C54 / Unkown
HY-133845 CIL-102 / Unkown
HY-164525 SD-7300 Inhibitor / Unkown
HY-183408 MMI-166 / Unkown
HY-35513 3-Aminobenzene-1,2-diol Inhibitor 98.0% Unkown
HY-43586 BR351 precursor Inhibitor / Unkown
HY-B0689S1 Indinavir-13C4,15N / Unkown
HY-N13208 Stevia Powder / Unkown
HY-P3699A TNO003 TFA Substrate / Unkown
HY-W1058004 (E)-N-(2-Fluorophenyl)cinnamamide Inhibitor / Unkown
HY-P0273 Histatin 5 Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991609 ABX-MA1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp2 NCBI NCBI:4313