2. Gene
  3. Mmp2 - matrix metallopeptidase 2 Gene

Mmp2 - matrix metallopeptidase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as GelA; Clg4a; MMP-2

Gene ID: 17390 | Gene type: protein coding

About Mmp2

Chromosome 8: 93,553,919-93,580,048 forward strand.GRCm39:CM001001.3

This gene has 4 transcripts (splice variants), 210 orthologues, 23 paralogues and is associated with 73 phenotypes. Broad expression in mammary gland adult (RPKM 186.), subcutaneous fat pad adult (RPKM 13.) and 15 other tissues.

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme that hydrolyzes collagens, gelatins, laminin, fibronectin and elastin. Mice lacking the encoded protein exhibit suppressed angiogenesis and attenuated features of human multicentric osteolysis with arthritis including abnormal skeletal and craniofacial development. [provided by RefSeq, Feb 2016]

Mmp2 Products(1)

mRNA Protein Name
NM_008610.3 NP_032636.1 72 kDa type IV collagenase preproprotein

Mmp2 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (69 - 96)

Peptidase_M10

Peptidase_M10: pfam00413 (117 - 445)

FN2

FN2: smart00059 (225 - 273)

FN2

FN2: smart00059 (283 - 331)

FN2

FN2: smart00059 (341 - 389)

HX

HX: cd00094 (467 - 661)

  • 0
  • 200
  • 400
  • 600
  • 662 a.a.
Protein Preferred Names Protein Names

72 kDa type IV collagenase

72 kDa gelatinase

72kD gelatinase

72kD type IV collagenase

72kDa gelatinase

72kDa type IV collagenase

gelatinase A

matrix metalloproteinase 2

Recombinant Mmp2 Proteins

Cat. No. Product Name Accession Purity
HY-P73810 MMP-2 Protein, Mouse (HEK293, His) P33434 (M409-C662) ≥95%

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0689A Indinavir sulfate 99.96% Yes
HY-B0493 Niflumic acid Inhibitor 99.88% Unkown
HY-B0689 Indinavir / Unkown
HY-B0689B Indinavir sulfate ethanolate / Unkown
Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-12169 Marimastat Inhibitor ≥98.0% Phase 3
HY-12170 Prinomastat ≥98.0% Phase 3
HY-12170A Prinomastat hydrochloride 98.18% Phase 3
HY-10398 CTS-1027 Inhibitor 99.19% Phase 2
HY-106992 S 3304 Inhibitor 99.11% Phase 2
HY-19485 XL-784 98.13% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (76)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15768 Ilomastat Inhibitor 98.33% Yes
HY-N0431 Astragaloside IV Inhibitor ≥98.0% Unkown
HY-122022 JR-AB2-011 Inhibitor 99.16% Unkown
HY-13564 Batimastat Inhibitor 98.92% Unkown
HY-12354 SB-3CT Inhibitor 99.59% Unkown
HY-122214 AC-73 Inducer 99.89% Unkown
HY-103444 ARP-100 Inhibitor ≥99.0% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-N0069 Solamargine 99.97% Unkown
HY-N2388 Auraptene Inhibitor 99.86% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-W068119A N-(2-Aminoethyl)maleimide hydrochloride 99.97% Unkown
HY-N0084 Betulinaldehyde Inhibitor 98.72% Unkown
HY-107428 PD-166793 Inhibitor 99.45% Unkown
HY-77813 Benzyl isothiocyanate 99.29% Unkown
HY-N0532 Morroniside Inhibitor 98.55% Unkown
HY-P3513 β-Neo-Endorphin Activator 98.22% Unkown
HY-120213 YH-306 98.01% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-112546 MMP-2 Inhibitor I Inhibitor 99.23% Unkown
HY-P0273A Histatin 5 TFA Inhibitor 99.89% Unkown
HY-131498 MOCAc-PLGL(Dpa)AR 99.86% Unkown
HY-146754 MMP2-IN-1 99.18% Unkown
HY-101535 ARP101 Inhibitor 99.39% Unkown
HY-122506 Salviolone Inhibitor 99.61% Unkown
HY-P1789A CTTHWGFTLC, CYCLIC TFA Inhibitor 98.60% Unkown
HY-P2213A GPLGIAGQ TFA Inducer 98.40% Unkown
HY-110116 SD-2590 hydrochloride Inhibitor ≥99.0% Unkown
HY-116399 MMP-2/MMP-9-IN-1 Inhibitor 99.25% Unkown
HY-117970 MMPI-1154 Inhibitor 99.87% Unkown
HY-12168 Tanomastat Inhibitor ≥99.0% Unkown
HY-124373 ND-336 Inhibitor ≥95.0% Unkown
HY-131417 cis-ACCP Inhibitor / Unkown
HY-147031 JAMM protein inhibitor 2 Inhibitor 98.20% Unkown
HY-147745 MMP2-IN-2 Inhibitor 98.80% Unkown
HY-147746 MMP2-IN-3 Inhibitor 99.64% Unkown
HY-148571 TP0597850 Inhibitor 99.09% Unkown
HY-111172 Inotilone Inhibitor / Unkown
HY-114396 BR351 Inhibitor / Unkown
HY-114785 BPHA Inhibitor / Unkown
HY-114911 Feprazone Inhibitor 99.88% Unkown
HY-120349 LL-Z1640-4 Inhibitor / Unkown
HY-12168B (Rac)-Tanomastat Inhibitor / Unkown
HY-124373A (R)-ND-336 Inhibitor / Unkown
HY-130076 MMP-2 Inhibitor II Inhibitor / Unkown
HY-136699 Excisanin A / Unkown
HY-14240 PG 116800 Inhibitor / Unkown
HY-143407 FAK-IN-3 Inhibitor / Unkown
HY-147867 MMP-2/9-IN-1 Inhibitor / Unkown
HY-147936 TP0556351 Inhibitor / Unkown
HY-149378 MMP13-IN-5 Inhibitor / Unkown
HY-152030 Tubulin/MMP-IN-2 / Unkown
HY-154698 Homouridine / Unkown
HY-155201 YJ182 Inhibitor / Unkown
HY-155721 22-(4′-py)-JA Inhibitor / Unkown
HY-156247 IVMT-Rx-3 Inhibitor / Unkown
HY-157382 AChE-IN-51 Inhibitor / Unkown
HY-162038 RXP03 Inhibitor / Unkown
HY-162344 Ir-CA Inducer / Unkown
HY-77813S Benzyl isothiocyanate-d7 / Unkown
HY-N10176 D-Isofloridoside Inhibitor / Unkown
HY-N5136 25(R,S)-Ruscogenin Inhibitor 99.84% Unkown
HY-N7385 Nudol / Unkown
HY-P1789 CTTHWGFTLC, CYCLIC Inhibitor / Unkown
HY-P2213 GPLGIAGQ Activator / Unkown
HY-P3477 Mca-PLA-Nva-Dap(Dnp)-AR-NH2 / Unkown
HY-P4574 VPLSLYSG / Unkown
HY-P5380 TNO211 / Unkown
HY-RS08537 MMP2 Human Pre-designed siRNA Set A / Unkown
HY-RS08538 Mmp2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08539 Mmp2 Rat Pre-designed siRNA Set A / Unkown
HY-W011085 CP-471474 Inhibitor / Unkown
HY-W277900 2-Methoxy-2,4-diphenylfuran-3-one / Unkown
HY-13564A Batimastat sodium salt Inhibitor / Unkown
HY-43586 BR351 precursor Inhibitor / Unkown
HY-P0273 Histatin 5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp2 NCBI NCBI:4313
Rattus norvegicus Mmp2 NCBI NCBI:81686