BTK - Bruton tyrosine kinase Gene

Also Known as AT; ATK; BPK; XLA; IMD1; AGMX1; IGHD3; PSCTK1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 695

About BTK

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:101,349,450-101,390,796 (from NCBI)

This gene has 31 transcripts (splice variants), 206 orthologues, 32 paralogues and is associated with 78 phenotypes. Biased expression in lymph node (RPKM 25.2), spleen (RPKM 18.4) and 13 other tissues.

Summary

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

BTK Products (3)

mRNA	Protein	Name
NM_000061.3	NP_000052.1	tyrosine-protein kinase BTK isoform 1
NM_001287345.2	NP_001274274.1	tyrosine-protein kinase BTK isoform 2
NM_001287344.2	NP_001274273.1	tyrosine-protein kinase BTK isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	11577348	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	11606584	GOA
enables non-membrane spanning protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	14656219	GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	17823121	GOA
enables phospholipase activator activity	IDA IDA: Inferred from direct assay	11606584	GOA
enables phospholipase binding	IPI IPI: Inferred from physical interaction	11606584	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8892607	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	7518558	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	34554188	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	15509800	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	11606584	GOA
involved in intracellular signal transduction	IGI IGI: Inferred from genetic interaction	14656219	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	11606584	GOA
involved in peptidyl-tyrosine phosphorylation	IGI IGI: Inferred from genetic interaction	14656219	GOA
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	34554188	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	17823121	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	15046600	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17823121	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTK Protein Structure

BTK

SH3_1

SH2

Pkinase_Tyr

0
200
400
600
659 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase BTK	B-cell progenitor kinase Bruton agammaglobulinemia tyrosine kinase Bruton's tyrosine kinase agammaglobulinaemia tyrosine kinase dominant-negative kinase-deficient Brutons tyrosine kinase

BTK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BTK	Q06187	BLNK	Homo sapiens	Q8WV28	NMR	16969585
Intra	BTK	Q06187	WAS	Homo sapiens	P42768	Pull Down	8892607
Intra	BTK	Q06187	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	BTK	Q06187	GTF2I	Homo sapiens	P78347	Anti Bait CoIP	9012831
Intra	BTK	Q06187	GTF2I	Homo sapiens	P78347	Pull Down	9012831
Intra	BTK	Q06187	GTF2I	Homo sapiens	P78347	Anti Bait CoIP	19214191
Intra	BTK	Q06187	GTF2I	Homo sapiens	P78347	Protein Kinase Assay	9012831
Intra	BTK	Q06187	GTF2I	Homo sapiens	P78347	Anti Tag CoIP	9012831
Intra	BTK	Q06187	PRKCQ	Homo sapiens	Q04759	Anti Bait CoIP	11788586
Intra	BTK	Q06187	PRKCQ	Homo sapiens	Q04759	Pull Down	11788586
Intra	BTK	Q06187	MAL	Homo sapiens	P21145	Anti Bait CoIP	22366891
Intra	BTK	Q06187	MAL	Homo sapiens	P21145	Confocal	22366891
Intra	BTK	Q06187	MAL	Homo sapiens	P21145	Pull Down	22366891
Intra	BTK	Q06187	ARID3A	Homo sapiens	Q99856	Anti Bait CoIP	19214191
Intra	BTK	Q06187	BTK	Homo sapiens	Q06187	X-Ray Diffraction	11231015
Intra	BTK	Q06187	ANKRD54	Homo sapiens	Q6NXT1	Pull Down	32707033
Intra	BTK	Q06187	ebi-1521221	Homo sapiens	EBI-1521221	Y2H	11577348
Intra	BTK	Q06187	ANKRD54	Homo sapiens	Q6NXT1	Anti Tag CoIP	33961781
Intra	BTK	Q06187	ANKRD54	Homo sapiens	Q6NXT1	Anti Tag CoIP	28514442
Intra	BTK	Q06187	BTK	Homo sapiens	Q06187	Protein Kinase Assay	11577348
Intra	BTK	Q06187	SH3BP5	Homo sapiens	O60239	Anti Tag CoIP	9571151
Intra	BTK	Q06187	SH3BP5	Homo sapiens	O60239	Pull Down	9571151
Intra	BTK	Q06187	MEOX2	Homo sapiens	P50222	Validated Y2H	25910212
Intra	BTK	Q06187	MEOX2	Homo sapiens	P50222	Y2H Array	25910212
Intra	BTK	Q06187	MEOX2	Homo sapiens	P50222	Y2H Bait-Prey Pool	25910212

Cross: Cross-species interaction Intra: Intraspecies interaction

BTK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80454	Phospho-BTK(Y223) Antibody (YA221)	WB, IP	Human
HY-P80576	BTK Antibody (YA816)	WB, IP	Human
HY-P80576A	BTK Antibody (YA816)(PBS only)	WB, IP	Human
HY-P84493	BTK Antibody (YA4190)	WB, IHC-P, ICC/IF, ELISA	Human, Monkey
HY-P84493A	BTK Antibody (YA4190)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human, Monkey
HY-P86215	BTK Antibody (YA5907)	WB, IHC-P, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Marginal Zone B-Cell Lymphoma	Marginal Zone Lymphoma Mzl Mucosa-Associated Lymphoid Tissue Lymphoma
Waldenstroem'S Macroglobulinemia	Waldenstrom Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstrom'S Macroglobulinaemia Waldenstrom'S Syndrome Waldenström Macroglobulinemia Waldenstrom'S Macroglobulinemia Wm Waldenström'S Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic
Cd40 Ligand Deficiency	X-Linked Hyper Igm Syndrome Hyperimmunoglobulin M Syndrome Higm1 Hyper-Igm Syndrome Type 1 X-Linked Hyper-Igm Syndrome Xhigm Higmx-1 X-Linked Hyper-Igm Immunodeficiency Hyper-Igm Syndrome 1 Immunodeficiency With Hyper-Igm, Type 1 Hyper-Igm Syndrome Due To Cd40 Ligand Deficiency Hyper-Igm Syndrome Due To Cd40l Deficiency Hyper-Igm Immunodeficiency Syndrome Hyper-Igm Immunodeficiency Syndrome, Type 1
X-Linked Recessive Disease
Transient Hypogammaglobulinemia Of Infancy	Immunoglobulin Maturational Delay Thi - [Transient Hypogammaglobulinaemia Of Infancy]
Immunodeficiency 7	Tcr-Alpha-Beta-Positive T-Cell Deficiency IMD7 T-Cell Receptor-Alpha/Beta Deficiency Immunodeficiency 7, Tcr-Alpha/Beta Deficient Tcr-Alpha/Beta Deficiency Tcr-Alpha-Beta+ T-Cell Deficiency T-Cell Receptor Alpha/Beta Deficiency
Isolated Growth Hormone Deficiency Type Iii	Congenital Ighd Type Iii Congenital Isolated Gh Deficiency Type Iii Congenital Isolated Growth Hormone Deficiency Type Iii Fleisher Syndrome Growth Hormone Deficiency With Hypogammaglobulinemia Ighd Iii X-Linked Ighd X-Linked Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 3 X-Linked Agammaglobulinemia And Isolated Growth Hormone Deficiency X-Linked Hypogammaglobulinemia And Isolated Growth Hormone Deficiency Agammaglobulinemia And Isolated Growth Hormone Deficiency, X-Linked Hypogammaglobulinemia And Isolated Growth Hormone Deficiency, X-Linked Ighd3 Growth Hormone Deficiency, Isolated, Type Iii )
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws
Selective Immunoglobulin Deficiency Disease
X-Linked Monogenic Disease
Agammaglobulinemia 1, Autosomal Recessive	AGM1 Agammaglobulinemia 1 Autosomal Recessive Agammaglobulinemia 1 Agammaglobulinemia, Autosomal Recessive, Due To Ighm Defect Agammaglobulinemia Autosomal Recessive Due To Ighm Defect Agammaglobulinemia, Type 1, Autosomal Recessive )
Congenital Hypogammaglobulinemia	Congenital Hypogammaglobulinaemia
Bn2 Diffuse Large B-Cell Lymphoma	Bn2 Dlbcl Doid:0081064
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Immunodeficiency 45	IMD45
Macroglobulinemia	Primary Macroglobulinemia Waldenstrom Macroglobulinemia
Omenn Syndrome	Histiocytic Medullary Reticulosis Severe Combined Immunodeficiency With Hypereosinophilia Combined Immunodeficiency With Hypereosinophilia Reticuloendotheliosis, Familial, With Eosinophilia Reticuloendotheliosis Familial With Eosinophilia Familial Reticuloendotheliosis Omenn'S Syndrome OS Malignant Histiocytosis
Pneumocystosis	Pneumocystis Jirovecii Pneumonia Pneumocystis Carinii Pneumonia Pneumocystis Pneumonia Pulmonary Pneumocystosis PCP Pneumocystosis Pneumonia Pneumonia Pneumocystis Carinii Pneumonia, Pneumocystis Pneumocystis Jiroveci Pneumonia
Lymphopenia	Lymphocytopenia
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
B Cell Deficiency	Immunoglobulin Heavy Chain Deficiency B Cell Deficiencies Immunoglobulin Heavy Chain Deletion Humoral Immune Defect
Central Nervous System Hematologic Cancer	Cns Hematopoietic Tumor Hematopoietic Neoplasm Of Central Nervous System Central Nervous System Hematopoietic Neoplasm
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Acquired Hypogammaglobulinemia Common Variable Immune Deficiency Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Tibial Nerve Palsy
Immunodeficiency With Hyper-Igm, Type 1	Immunodeficiency, X-Linked, With Hyper-Igm Hyper Igm Syndrome HIGM1 Xhim Hyper-Igm Syndrome Higm Hyper-Igm Syndrome 1 Immunodeficiency 3 Imd3 Immunodeficiency With Hyper-Igm Immunodeficiency With Hyper Igm Type 1 Ihis X-Linked Hyper Igm Syndrome Hyper-Igm Immunodeficiency, X-Linked Hyper Igm Immunodeficiency, X-Linked Hyper Igm Syndrome 1 X-Linked Immunodeficiency With Hyper-Igm 1 Immunodeficiency, With Hyper Igm Immunodeficiency, With Hyper Igm, Type 1 Hyper-Igm Immunodeficiency Syndrome, Type 1 Hyperimmunoglobulin M Syndrome
Testicular Lymphoma	Malignant Lymphoma Of Testis Lymphoma Of The Testis
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Refractory Plasma Cell Neoplasm
Lambda 5 Deficiency
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Transient Hypogammaglobulinemia
Immunodeficiency 46	Tfrc-Related Combined Immunodeficiency IMD46 Cid Due To Tfrc Deficiency Combined Immunodeficiency Due To Tfrc Deficiency
Hairy Cell Leukemia	Hcl-V Hairy Cell Leukemia Variant Hairy Cell Leukaemia Variant Hcl Leukemic Reticuloendotheliosis Leukemic Reticuloendotheliosis Variant Prolymphocytic Variant Of Hcl Prolymphocytic Variant Of Hairy Cell Leukemia Leukemia Hairy Cell Leukemia, Hairy Cell Leukaemic Reticuloendotheliosis Lre - [Leukemic Reticuloendotheliosis] Hairy-Cell Leukaemia, Nos Hcl - [Hairy Cell Leukaemia] Hairy-Cell Leukaemia Without Mention Of Remission
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Plasma Protein Metabolism Disease
Anemia, Autoimmune Hemolytic	Autoimmune Hemolytic Anemia Idiopathic Autoimmune Hemolytic Anemia Immuno-Hemolytic Anemia Anemia, Hemolytic, Autoimmune Autoimmune Haemolytic Anaemia Autoimmune Hemolytic Anaemia Acquired Autoimmune Hemolytic Anemia Anemia Hemolytic Autoimmune Familial Auto-Immune Hemolytic Anemia Aha Aiha
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia	IGHD3 Ighd Iii Fleisher Syndrome Growth Hormone Deficiency With Hypogammaglobulinemia, X-Linked Hypogammaglobulinemia And Isolated Growth Hormone Deficiency, X-Linked Agammaglobulinemia And Isolated Growth Hormone Deficiency, X-Linked Short Stature Due To Isolated Growth Hormone Deficiency With X-Linked Hypogammaglobulinemia Growth Hormone Deficiency, Isolated, 3, With Agammaglobulinemia Agammaglobulinemia And Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 3 X-Linked Hypogammaglobulinemia And Isolated Growth Hormone Deficiency
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Ecthyma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Aneurysm, Intracranial Berry, 12	ANIB12 Intracranial Berry Aneurysm 12
N1 Diffuse Large B-Cell Lymphoma	N1 Dlbcl Doid:0081067
Paralytic Poliomyelitis	Poliomyelitis, Paralytic
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Mcd Diffuse Large B-Cell Lymphoma	Mcd Dlbcl Doid:0081066
Mohr-Tranebjaerg Syndrome	Deafness-Dystonia-Optic Neuronopathy Syndrome Jensen Syndrome Deafness Dystonia Syndrome MTS Dds Deafness-Dystonia-Optic Atrophy Syndrome Deafness Syndrome, Progressive, With Blindness, Dystonia, Fractures, And Mental Deficiency Opticoacoustic Nerve Atrophy With Dementia Dystonia-Deafness Syndrome Ddp Ddon Syndrome Mohr-Tranebjærg Syndrome Deafness Dystonia Optic Atrophy Syndrome Deafness Dystonia Optic Neuronopathy Syndrome Dystonia Deafness Syndrome Ddon Deafness - Dystonia - Optic Neuronopathy Syndrome Deafness-Dystonia-Optic Neuronopathy Syndrome Hearing Loss-Dystonia-Optic Neuronopathy Syndrome Dfn-1 X-Linked Progressive Deafness Type 1
Panniculitis	Nodular Panniculitis
Agammaglobulinemia, X-Linked	X-Linked Agammaglobulinemia XLA Bruton Type Agammaglobulinemia Bruton'S Agammaglobulinemia Bruton-Type Agammaglobulinemia Agmx1 Imd1 Agammaglobulinemia, X-Linked 1 Btk-Deficiency Agammaglobulinemia Hypogammaglobulinemia Agammaglobulinemia, X-Linked, Type 1 Immunodeficiency 1 Bruton Agammaglobulinemia Tyrosine Kinase Deficiency Bruton'S Agammaglobulinaemia Bruton'S Sex-Linked Agammaglobulinemia Bruton'S Type Agammaglobulinemia Btk Deficiency Agammaglobulinemia, Btk Agammaglobulinemia, Bruton Tyrosine Kinase Congenital Agammaglobulinemia Immunodeficiency Type 1 X-Linked Agammaglobulinemia Type 1
Mast-Cell Leukemia	Mast Cell Leukemia Leukemia, Mast-Cell Leukemia Mast Cell Mast Cell Leukaemia Nos Mast Cell Leukaemia Without Mention Of Remission
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Lymphoplasmacytic Lymphoma	Waldenstrom Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic Waldenström Macroglobulinaemia Waldenström Macroglobulinaemia Without Mention Of Remission Idiopathic Macroglobulinaemia Primary Macroglobulinaemia
Diffuse Large B-Cell Lymphoma Activated B-Cell Type	Dlbcl Abc Type
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Central Nervous System Lymphoma	Microglioma Primary Cns Lymphoma Cns Lymphoma Primary Central Nervous System Lymphoma
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Richter'S Syndrome	Richter Syndrome Richter Transformation
Poliomyelitis	Infantile Paralysis Polio
Conjunctivitis	Madras Eye Adenoviral Conjunctivitis Acute Adenoviral Follicular Conjunctivitis Inclusion Conjunctivitis Of The Adult Swimming-Pool Conjunctivitis Inflammation Of Conjunctiva Ophthalmia Acute Conjunctivitis Eye Catarrh Catarrhal Ophthalmia Koch-Weeks Conjunctivitis
Pyoderma
Immunoglobulin A Deficiency 1	Immunoglobulin A Deficiency Selective Iga Deficiency Disease IGAD1 Selective Immunoglobulin A Deficiency Immunoglobulin A, Selective Deficiency Of Iga, Selective Deficiency Of Gamma-A-Globulin, Selective Deficiency Of Selective Iga Immunodeficiency Selective Iga Deficiency Iga Deficiency Selective
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma	Cll/Sll B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma Icdo:9823/3 Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission Small Cell B-Cell Lymphoma
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10997	Ibrutinib	Inhibitor	99.97%	Yes
HY-17600	Acalabrutinib	Inhibitor	99.88%	Yes
HY-131328	Pirtobrutinib	Inhibitor	99.90%	Unkown
HY-101474A	Zanubrutinib	Inhibitor	99.71%	Yes
HY-128757	Remibrutinib	Inhibitor	99.76%	Yes
HY-109192	Tolebrutinib	Inhibitor	99.12%	Yes
HY-129390	Orelabrutinib	Inhibitor	99.97%	Yes
HY-132842	Sunvozertinib	Inhibitor	99.62%	Unkown
HY-15771	Tirabrutinib	Inhibitor	99.71%	Yes
HY-10997A	Ibrutinib Racemate	Inhibitor	95.39%	Unkown
HY-15771A	Tirabrutinib hydrochloride	Inhibitor	99.66%	Yes
HY-101474AR	Zanubrutinib (Standard)	Inhibitor	99.90%	Unkown
HY-151232	(E/Z)-Rilzabrutinib	Inhibitor	/	Unkown
HY-109192R	Tolebrutinib (Standard)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17600A	Acalabrutinib maleate	Inhibitor	/	Phase 4
HY-19834	Fenebrutinib	Inhibitor	99.89%	Phase 3
HY-153321	Bexobrutideg	Degrader	99.33%	Phase 3
HY-112166	Rilzabrutinib	Inhibitor	98.97%	Phase 3
HY-101215	Evobrutinib	Inhibitor	99.60%	Phase 3
HY-112215	Nemtabrutinib	Inhibitor	99.32%	Phase 3
HY-19816A	Avitinib maleate	Inhibitor	99.86%	Phase 3
HY-160167	Birelentinib	Inhibitor	/	Phase 3
HY-112161	Branebrutinib	Inhibitor	99.78%	Phase 2
HY-109078	Vecabrutinib	Inhibitor	99.76%	Phase 2
HY-139984	Corubrutinib	Inhibitor	99.85%	Phase 2
HY-109010	Poseltinib	Inhibitor	98.11%	Phase 2
HY-109143	Elsubrutinib	Inhibitor	98.0%	Phase 2
HY-101856	BMS-986142	Inhibitor	99.38%	Phase 2
HY-139481	Flixebrutinib	Inhibitor	99.86%	Phase 2
HY-132808	Atuzabrutinib	Inhibitor	98.00%	Phase 2
HY-18012A	Spebrutinib besylate	Inhibitor	/	Phase 2
HY-153220	Zelebrudomide	Inhibitor	99.72%	Phase 1
HY-139535	Luxeptinib	Inhibitor	98.95%	Phase 1
HY-137438	Edralbrutinib	Inhibitor	99.75%	Phase 1
HY-153110	Larotinib	Inhibitor	99.50%	Phase 1
HY-132879	TAK-020	Inhibitor	99.93%	Phase 1
HY-153245	JNJ-64264681	Inhibitor	98.14%	Phase 1
HY-131342	BIIB068	Inhibitor	98.35%	Phase 1
HY-163827	ABBV-992	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (217)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160141	Catadegbrutinib	Degrader	99.18%	Unkown
HY-19816	Avitinib	Inhibitor	99.95%	Unkown
HY-18012	Spebrutinib	Inhibitor	99.22%	Unkown
HY-100342	Ibrutinib-biotin	Inhibitor	99.66%	Unkown
HY-80002	BMX-IN-1	Inhibitor	99.04%	Unkown
HY-11999	CGI-1746	Inhibitor	99.25%	Unkown
HY-108691	PF-06465469	Inhibitor	99.48%	Unkown
HY-13036A	IBT6A	Inhibitor	99.59%	Unkown
HY-122562	MT-802	Degrader	98.35%	Unkown
HY-147943	PROTAC BTK Degrader-1		99.92%	Unkown
HY-100335	PCI-33380	Inhibitor	98.0%	Unkown
HY-153803	GBD-9	Degrader	99.91%	Unkown
HY-12679	PF-06658607	Inhibitor	99.69%	Unkown
HY-15805	KIN-8194	Inhibitor	99.26%	Unkown
HY-80003	QL47	Inhibitor	99.50%	Unkown
HY-169396	TAE648	Ligand	99.50%	Unkown
HY-107447	N-Deshydroxyethyl Dasatinib	Ligand	97.19%	Unkown
HY-133137	SJF620	Inhibitor	98.98%	Unkown
HY-153357	NRX-0492	Degrader	98.30%	Unkown
HY-144288	BLK-IN-2	Inhibitor	98.61%	Unkown
HY-78727	Ibrutinib deacryloylpiperidine	Inhibitor	99.96%	Unkown
HY-163962	L18I	Degrader	99.89%	Unkown
HY-15427	GDC-0834	Inhibitor	98.05%	Unkown
HY-18009	(Z)-LFM-A13	Inhibitor	99.80%	Unkown
HY-100338	CNX-500	Inhibitor	99.86%	Unkown
HY-49421	BTK ligand 12	Ligand	98.23%	Unkown
HY-163295	BTK degrader-1	Degrader	99.40%	Unkown
HY-122830	DD-03-171	Degrader	98.72%	Unkown
HY-18951	ONO-4059 analog	Inhibitor	99.81%	Unkown
HY-13943	CNX-774	Inhibitor	99.54%	Unkown
HY-163565	BIIB129	Inhibitor	99.54%	Unkown
HY-P5438	Srctide	Substrate	99.71%	Unkown
HY-124645	QL-X-138	Inhibitor	98.17%	Unkown
HY-18018	RN486	Inhibitor	98.91%	Unkown
HY-135334	ACP-5862	Inhibitor	98.32%	Unkown
HY-101474	(±)-Zanubrutinib	Inhibitor	99.70%	Unkown
HY-43521	Ibrutinib-MPEA	Inhibitor	99.71%	Unkown
HY-18010	PCI 29732	Inhibitor	99.59%	Unkown
HY-10644	Lck inhibitor 2	Inhibitor	99.73%	Unkown
HY-122828	PROTAC BTK Degrader-2	Degrader	99.93%	Unkown
HY-15809	(Rac)-Ibrutinib alkyne	Inhibitor	99.35%	Unkown
HY-101474B	(R)-Zanubrutinib		98.97%	Unkown
HY-153220A	(R)-Zelebrudomide	Degrader	98.93%	Unkown
HY-101793	BMS-935177	Inhibitor	98.35%	Unkown
HY-150023	BI-1622	Inhibitor	98.02%	Unkown
HY-130983	N-piperidine Ibrutinib hydrochloride	Inhibitor	98.06%	Unkown
HY-149391	PROTAC BTK Degrader-6	Degrader	99.24%	Unkown
HY-160142	UBX-382	Degrader	96.20%	Unkown
HY-110002	LFM-A13	Inhibitor	99.65%	Unkown
HY-101941	BTK IN-1	Inhibitor	98.09%	Unkown
HY-101766	Btk inhibitor 2	Inhibitor	99.53%	Unkown
HY-17600S	Acalabrutinib-d4	Inhibitor	99.50%	Unkown
HY-136531	XMU-MP-3	Inhibitor	95.78%	Unkown
HY-153110A	Larotinib mesylate hydrate	Inhibitor	98.66%	Unkown
HY-149051	BGB-8035	Inhibitor	99.00%	Unkown
HY-100659	Dihydrodiol-Ibrutinib	Inhibitor	99.91%	Unkown
HY-10997S	Ibrutinib-d5	Inhibitor	98.08%	Unkown
HY-101522	CHMFL-EGFR-202	Inhibitor	99.75%	Unkown
HY-148066	DB0662	Degrader	99.66%	Unkown
HY-160966	Omtebrutideg	Degrader	99.24%	Unkown
HY-157763	Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1	Degrader	/	Unkown
HY-125997	BTK inhibitor 10	Inhibitor	99.66%	Unkown
HY-15427B	GDC-0834 (S-enantiomer)		/	Unkown
HY-131705	BTK inhibitor 17	Inhibitor	99.53%	Unkown
HY-132842A	(S)-Sunvozertinib	Inhibitor	99.05%	Unkown
HY-133137A	SJF620 hydrochloride	Inhibitor	99.28%	Unkown
HY-131328A	(R)-Pirtobrutinib		99.88%	Unkown
HY-15427A	GDC-0834 Racemate		98.04%	Unkown
HY-101474S	Zanubrutinib-d5	Inhibitor	99.0%	Unkown
HY-160246	QL47B	Inhibitor	/	Unkown
HY-136113	Ibrutinib dimer	Inhibitor	98.27%	Unkown
HY-109143B	(R)-Elsubrutinib	Inhibitor	98.0%	Unkown
HY-110013	Terreic acid	Inhibitor	/	Unkown
HY-154860	PTD10	Degrader	97.38%	Unkown
HY-100659S	Dihydrodiol-Ibrutinib-d5	Inhibitor	99.19%	Unkown
HY-13036B	IBT6A hydrochloride	Inhibitor	99.35%	Unkown
HY-13036	(Rac)-IBT6A	Inhibitor	98.03%	Unkown
HY-160245	QL47R		99.94%	Unkown
HY-160246A	QL47B TFA	Inhibitor	96.03%	Unkown
HY-115876	BTK-IN-5	Inhibitor	/	Unkown
HY-132196	BTK inhibitor 18	Inhibitor	/	Unkown
HY-111781	Civorebrutinib	Inhibitor	/	Unkown
HY-156746	DBt-10	Degrader	/	Unkown
HY-130255	BTK inhibitor 13	Inhibitor	/	Unkown
HY-174129	TM471-1	Inhibitor	/	Unkown
HY-151808	JS25	Inhibitor	98.06%	Unkown
HY-174850	CFON-026	Inhibitor	/	Unkown
HY-181050	DFCI-002-06	Degrader	/	Unkown
HY-145373	BMS-986143	Inhibitor	/	Unkown
HY-102036	G-744	Inhibitor	/	Unkown
HY-156604	Cinsebrutinib	Inhibitor	/	Unkown
HY-117900	PF-06250112	Inhibitor	/	Unkown
HY-101521	CHMFL-BTK-01	Inhibitor	/	Unkown
HY-170758	BTK ligand 13		/	Unkown
HY-169228	WS-11	Inhibitor	/	Unkown
HY-147754	JAK3/BTK-IN-6	Inhibitor	/	Unkown
HY-159947	PROTAC BTK Degrader-11	Degrader	/	Unkown
HY-168302	BTK ligand 10		99.49%	Unkown
HY-176131	AMX5160	Inhibitor	/	Unkown
HY-162257	BTK-IN-34	Inhibitor	/	Unkown
HY-181547	HBC-12551	Inhibitor	/	Unkown
HY-152212	BTK-IN-19	Inhibitor	/	Unkown
HY-147584	BTK-IN-14	Inhibitor	/	Unkown
HY-161876	GSTO1-IN-2	Inhibitor	/	Unkown
HY-151211	BTK-IN-16	Inhibitor	98.93%	Unkown
HY-175541	TQ-3959	Degrader	/	Unkown
HY-156745	PROTAC DDa-1	Degrader	/	Unkown
HY-173143	BTK-IN-42	Inhibitor	/	Unkown
HY-164002	PF-303	Inhibitor	/	Unkown
HY-184940	BTK-IN-50	Inhibitor	/	Unkown
HY-175909	BTK ligand-18	Ligand	/	Unkown
HY-117900A	(Rac)-PF-06250112		/	Unkown
HY-168965	BTK ligand 15	Ligand	/	Unkown
HY-179948	BTK-IN-45	Inhibitor	/	Unkown
HY-170413	PROTAC BTK Degrader-12	Degrader	/	Unkown
HY-P10609	Btk substrate peptide		/	Unkown
HY-158064	BTK-IN-36	Inhibitor	/	Unkown
HY-141689	BTK-IN-3	Inhibitor	/	Unkown
HY-162081	BTK-IN-32	Inhibitor	/	Unkown
HY-173125	FDU73	Degrader	/	Unkown
HY-175788	BTK ligand-17	Ligand	/	Unkown
HY-181996	BTK-IN-47	Inhibitor	/	Unkown
HY-153951S	BTK-IN-26	Inhibitor	/	Unkown
HY-179076	BTK/IKZF1/3 ligand 1	Ligand	/	Unkown
HY-151920	BTK-IN-17	Inhibitor	/	Unkown
HY-143717	JAK3/BTK-IN-2	Inhibitor	/	Unkown
HY-182910	PROTAC BTK Degrader-15	Degrader	/	Unkown
HY-182943	BTK-IN-49	Inhibitor	/	Unkown
HY-148584	BTK-IN-21	Inhibitor	/	Unkown
HY-177103	Midobrutinib	Inhibitor	/	Unkown
HY-E70808	BTK C481R Recombinant Human Active Protein Kinase		/	Unkown
HY-182293	BTK-IN-48	Inhibitor	/	Unkown
HY-171893	CRBN ligand-185	Ligand	/	Unkown
HY-142932	BTK-IN-6	Inhibitor	/	Unkown
HY-143719	JAK3/BTK-IN-4	Inhibitor	/	Unkown
HY-101474BS	(R)-Zanubrutinib-d5		/	Unkown
HY-143718	JAK3/BTK-IN-3	Inhibitor	/	Unkown
HY-152201	BTK-IN-18	Inhibitor	/	Unkown
HY-172589	BTK-IN-43	Inhibitor	/	Unkown
HY-124605	IQS-019	Inhibitor	/	Unkown
HY-150885	BTK ligand 1	Degrader	/	Unkown
HY-128408	PROTAC BTK Degrader-4	Degrader	/	Unkown
HY-147580	BTK-IN-10	Inhibitor	/	Unkown
HY-151961	RSH-7	Inhibitor	98.74%	Unkown
HY-148832	BTK-IN-20	Inhibitor	/	Unkown
HY-153536	PROTAC BTK Degrader-3	Degrader	/	Unkown
HY-143720	JAK3/BTK-IN-5	Inhibitor	/	Unkown
HY-147784	HZ-A-005	Inhibitor	/	Unkown
HY-182933	BTK ligand-20	Ligand	/	Unkown
HY-153705	BTK-IN-25	Inhibitor	/	Unkown
HY-147741	DPPY	Inhibitor	/	Unkown
HY-110113	CTA056	Inhibitor	/	Unkown
HY-120406	PLS-123	Inhibitor	/	Unkown
HY-172822	TLT8	Degrader	/	Unkown
HY-159956	BTK-IN-39	Ligand	/	Unkown
HY-143900	BTK-IN-7	Inhibitor	/	Unkown
HY-145884	BTK-IN-8	Inhibitor	/	Unkown
HY-150898	BTK ligand 3	Ligand	/	Unkown
HY-180884	BTK-IN-46	Inhibitor	/	Unkown
HY-171131	BTK-IN-41	Inhibitor	/	Unkown
HY-170324	BTK-IN-40	Inhibitor	/	Unkown
HY-160168	BTK-IN-31	Inhibitor	/	Unkown
HY-143730	BTK inhibitor 20	Inhibitor	/	Unkown
HY-W062695	(R)-Acalabrutinib	Inhibitor	/	Unkown
HY-123117	VA5	Inhibitor	/	Unkown
HY-162280	PROTAC BTK Degrader-9	Degrader	/	Unkown
HY-117499	RN941	Inhibitor	/	Unkown
HY-179077	PROTAC BTK/IKZF1/3 Degrader-1	Degrader	/	Unkown
HY-181546	Ibt-DOX	Inhibitor	/	Unkown
HY-144170	RET-IN-14	Inhibitor	/	Unkown
HY-183103	PDD-87	Inhibitor	/	Unkown
HY-184792	CA/PRAK-IN-1	Inhibitor	/	Unkown
HY-181624	BTK ligand-19	Ligand	/	Unkown
HY-160219S	BTK-IN-33	Inhibitor	/	Unkown
HY-173126	BTK ligand-14	Inhibitor	/	Unkown
HY-144283	BLK-IN-1	Inhibitor	/	Unkown
HY-143901	EGFR-IN-40	Inhibitor	/	Unkown
HY-124153	GNE-431	Inhibitor	/	Unkown
HY-175543	BTK ligand 16	Ligand	/	Unkown
HY-182671	SRX3305	Inhibitor	/	Unkown
HY-147581	BTK-IN-11	Inhibitor	/	Unkown
HY-163183	JAK3/BTK-IN-7	Inhibitor	/	Unkown
HY-148594	BTK-IN-23	Inhibitor	/	Unkown
HY-155072	PROTAC BTK Degrader-5	Degrader	/	Unkown
HY-157159	BTK-IN-28	Inhibitor	/	Unkown
HY-147582	BTK-IN-12	Inhibitor	/	Unkown
HY-179562	BTK degrader-2	Degrader	/	Unkown
HY-E70809	BTK V416L Recombinant Human Active Protein Kinase		/	Unkown
HY-168427	Avitinib maleate dihydrate	Inhibitor	/	Unkown
HY-176172	BTK-IN-44	Inhibitor	/	Unkown
HY-150752	BTK-IN-15	Inhibitor	/	Unkown
HY-169307	BTK-IN-38	Inhibitor	/	Unkown
HY-156553	BTK-IN-27	Inhibitor	/	Unkown
HY-148585	BTK-IN-22	Inhibitor	/	Unkown
HY-139881	BTK inhibitor 19	Inhibitor	/	Unkown
HY-162407	I-As-1	Inhibitor	/	Unkown
HY-143716	JAK3/BTK-IN-1	Inhibitor	/	Unkown
HY-168314	BTK ligand 11	Ligand	/	Unkown
HY-153321A	(R,R)-Bexobrutideg	Degrader	98.83%	Unkown
HY-142621	BCPyr	Degrader	/	Unkown
HY-159589	BTK-IN-37	Inhibitor	/	Unkown
HY-117628	RN983	Inhibitor	/	Unkown
HY-168963	PROTAC BTK Degrader-13	Degrader	/	Unkown
HY-156969	Topoisomerase I inhibitor 11		/	Unkown
HY-131328S	Pirtobrutinib-13C,d3	Inhibitor	/	Unkown
HY-115944	BTK-IN-9	Inhibitor	/	Unkown
HY-181623	PROTAC BTK degrader-14	Degrader	/	Unkown
HY-101474R	(±)-Zanubrutinib (Standard)	Inhibitor	/	Unkown
HY-18016	CGI 560	Inhibitor	/	Unkown
HY-13036C	(Rac)-IBT6A hydrochloride	Inhibitor	/	Unkown
HY-128403	BTK inhibitor 8	Inhibitor	99.96%	Unkown
HY-160167A	(R,R)-Birelentinib	Inhibitor	/	Unkown
HY-168292	BTK ligand 9		/	Unkown
HY-135334S	ACP-5862-d4	Inhibitor	/	Unkown
HY-176526	BTK degrader-1 intermediate	Degrader	/	Unkown
HY-183397	Avitinib dihydrochloride	Inhibitor	/	Unkown
HY-101766R	Btk inhibitor 2 (Standard)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BTK	VGNC	VGNC:38560
Macaca mulatta	BTK	VGNC	VGNC:82111
Felis catus	BTK	VGNC	VGNC:82460
Rattus norvegicus	BTK	RGD	RGD:1359683
Mus musculus	BTK	MGD	MGI:88216
Bos taurus	BTK	VGNC	VGNC:26601
Others	BTK	NCBI