BCR - BCR activator of RhoGEF and GTPase Gene

Also Known as ALL; CML; PHL; BCR1; D22S11; D22S662

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 613

About BCR

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,180,509-23,318,037 (from NCBI)

This gene has 15 transcripts (splice variants), 265 orthologues, 1 paralogue and is associated with 104 phenotypes. Ubiquitous expression in testis (RPKM 14.9), brain (RPKM 14.5) and 25 other tissues.

Summary

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the Bcr-Abl fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and Other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]

BCR Products (2)

mRNA	Protein	Name
NM_004327.4	NP_004318.3	breakpoint cluster region protein isoform 1
NM_021574.3	NP_067585.2	breakpoint cluster region protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	1903516	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	7479768	GOA
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	23940119	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8112292	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of GTPase activity	IDA IDA: Inferred from direct assay	7479768	GOA
involved in activation of GTPase activity	IMP IMP: Inferred from mutant phenotype	23940119	GOA
involved in focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	23940119	GOA
involved in keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	23940119	GOA
involved in regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	23940119	GOA
involved in small GTPase-mediated signal transduction	IMP IMP: Inferred from mutant phenotype	23940119	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCR Protein Structure

Bcr-Abl_Oligo

RhoGEF

RhoGAP

0
200
400
600
800
1000
1200
1271 a.a.

Protein Preferred Names	Protein Names
breakpoint cluster region protein	BCR, RhoGEF and GTPase activating protein

BCR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	BCR	P11274	Sh2d5	Mus musculus	Q8JZW5	Anti Tag CoIP	25331951
Cross	BCR	P11274	Sh2d5	Mus musculus	A2AM67	Anti Tag CoIP	25331951
Intra	BCR	P11274	GRB2	Homo sapiens	P62993	Pull Down	8995379
Intra	BCR	P11274	GRB2	Homo sapiens	P62993	CoIP	10887132
Intra	BCR	P11274	GRB2	Homo sapiens	P62993	Pull Down	8955135
Intra	BCR	P11274	TNKS2	Homo sapiens	Q9H2K2	FPS	22153077

Cross: Cross-species interaction Intra: Intraspecies interaction

BCR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83001	BCR Antibody (YA2746)	WB, IHC-P, IP	Human, Rat
HY-P83001A	BCR Antibody (YA2746)(PBS only)	WB, IHC-P, IP	Human, Rat
HY-P84057	BCR Antibody (YA3754)	WB, FC, ELISA	Human
HY-P84057A	BCR Antibody (YA3754)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Chromosome 8p11 Myeloproliferative Syndrome	Stem Cell Leukemia/Lymphoma Scll Myeloid/Lymphoid Neoplasm Associated With Fgfr1 Rearrangement 8p11 Myeloproliferative Syndrome Myeloid And Lymphoid Neoplasms With Fgfr1 Rearrangement
B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality
Precursor T-Cell Acute Lymphoblastic Leukemia	T-All Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma Precursor T-Cell Acute Lymphocytic Leukemia Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Adult T-Cell Lymphoma/Leukemia
Chronic Myelogenous Leukemia, Bcr-Abl1 Positive	Chronic Myelogenous Leukemia, Bcr/Abl Positive Chronic Myelosis Chronic Myeloid Leukaemia, Bcr-Abl-Positive Without Mention Of Remission
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome 22q11.2 Distal Deletion Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2, Distal
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Denture Stomatitis	Stomatitis, Denture Denture Sore Mouth
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
B-Lymphoblastic Leukemia/Lymphoma	B Lymphoblastic Leukemia/Lymphoma B-All Precursor B Lymphoblastic Lymphoma/Leukemia C-All Lymphoblastic Lymphoma, Nos Common Precursor B All Lymphoblastic B-Cell Lymphoma Pro-B All B-Precursor Lymphoma Lbl - [Lymphoblastic Lymphoma]
Cryoglobulinemia, Familial Mixed	Cryoglobulinemic Vasculitis Essential Mixed Cryoglobulinemia Mixed Cryoglobulinemia Essential Cryoglobulinemia Primary Cryoglobulinemia Meltzer Syndrome Familial Mixed Cryoglobulinemia
Agammaglobulinemia, X-Linked	X-Linked Agammaglobulinemia XLA Bruton Type Agammaglobulinemia Bruton'S Agammaglobulinemia Bruton-Type Agammaglobulinemia Agmx1 Imd1 Agammaglobulinemia, X-Linked 1 Btk-Deficiency Agammaglobulinemia Hypogammaglobulinemia Agammaglobulinemia, X-Linked, Type 1 Immunodeficiency 1 Bruton Agammaglobulinemia Tyrosine Kinase Deficiency Bruton Disease Bruton'S Agammaglobulinaemia Bruton'S Sex-Linked Agammaglobulinemia Bruton'S Type Agammaglobulinemia Btk Deficiency Agammaglobulinemia, Btk Agammaglobulinemia, Bruton Tyrosine Kinase Congenital Agammaglobulinemia Immunodeficiency Type 1 X-Linked Agammaglobulinemia Type 1
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
B-Cell Adult Acute Lymphocytic Leukemia	Adult B Acute Lymphoblastic Leukemia Adult B Acute Lymphoblastic Leukaemia Adult B-Cell Acute Lymphoblastic Leukaemia Adult B-Cell Acute Lymphoblastic Leukemia Adult B-Cell Lymphocytic Leukaemia Adult B-Cell Lymphocytic Leukemia Adult B-Lymphoblastic Leukaemia Adult B-Lymphoblastic Leukemia B-Cell Adult Acute Lymphocytic Leukaemia B-Cell Adult Acute Lymphoblastic Leukemia
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
B-Cell Expansion With Nfkb And T-Cell Anergy	Benta Disease BENTA B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease Persistent Polyclonal B-Cell Lymphocytosis Lymphocytosis
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10181	Dasatinib		99.85%	Yes
HY-15463	Imatinib		99.95%	Yes
HY-10159	Nilotinib		99.94%	Yes
HY-50946	Imatinib Mesylate		99.97%	Yes
HY-104010	Asciminib	Inhibitor	99.61%	Yes
HY-15666	Olverembatinib	Inhibitor	99.47%	Yes
HY-10181A	Dasatinib hydrochloride		99.67%	Yes
HY-129390	Orelabrutinib	Inhibitor	99.97%	Yes
HY-10159A	Nilotinib monohydrochloride monohydrate		99.91%	Yes
HY-13904	Flumatinib	Inhibitor	99.94%	Unkown
HY-10181B	Dasatinib monohydrate		99.58%	Yes
HY-104010A	Asciminib hydrochloride	Inhibitor	99.79%	Yes
HY-15728	Radotinib		99.19%	Yes
HY-15666A	Olverembatinib dimesylate	Inhibitor	99.80%	Yes
HY-13905	Flumatinib mesylate	Inhibitor	99.80%	Unkown
HY-50946R	Imatinib Mesylate (Standard)		99.98%	Unkown
HY-10159B	Nilotinib hydrochloride		99.17%	Yes

Clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13024	Rebastinib		99.84%	Phase 2
HY-50868	Bafetinib		99.18%	Phase 2
HY-13468	KW-2478		99.53%	Phase 2
HY-137460	Vodobatinib	Inhibitor	98.09%	Phase 2
HY-109010	Poseltinib	Inhibitor	98.11%	Phase 2
HY-156640	Rocbrutinib	Inhibitor	99.76%	Phase 2
HY-109082	Cevidoplenib	Inhibitor	99.58%	Phase 2
HY-120508	Pivanex		95.0%	Phase 2
HY-15493	AN-019	Inhibitor	/	Phase 2
HY-15749	XL228	Inhibitor	99.64%	Phase 1
HY-103275	Adaphostin		99.02%	Phase 1
HY-118084	LS-104		/	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99761	Obexelimab		99.99%	Phase 3
HY-P991900	LY3541860	Inhibitor	≥99.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (160)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13520	Nocodazole		99.59%	Unkown
HY-13264	Degrasyn		99.70%	Unkown
HY-147308	Zelenirstat	Inhibitor	99.76%	Unkown
HY-125845	(S,R,S)-AHPC		99.13%	Unkown
HY-160141	Catadegbrutinib		99.18%	Unkown
HY-158145	DS55980254	Inhibitor	99.25%	Unkown
HY-157562	DS68591889		99.18%	Unkown
HY-118144	PD166326	Inhibitor	99.99%	Unkown
HY-11007	GNF-2	Inhibitor	99.82%	Unkown
HY-152036A	SIAIS100 TFA	Degrader	99.75%	Unkown
HY-125834	GMB-475		98.69%	Unkown
HY-15738	GNF-5	Inhibitor	99.95%	Unkown
HY-128756	SIAIS178	Inhibitor	98.64%	Unkown
HY-10181S	Dasatinib-d8		99.15%	Unkown
HY-10943	GNF-7	Inhibitor	99.70%	Unkown
HY-107447	N-Deshydroxyethyl Dasatinib		97.19%	Unkown
HY-153357	NRX-0492	Degrader	98.30%	Unkown
HY-10159S	Nilotinib-d6		99.95%	Unkown
HY-103274	PD180970		99.27%	Unkown
HY-15814	HG-7-85-01		98.14%	Unkown
HY-100338	CNX-500	Inhibitor	99.86%	Unkown
HY-153415	PROTAC BCR-ABL Degrader-1	Degrader	98.73%	Unkown
HY-13943	CNX-774	Inhibitor	99.92%	Unkown
HY-147414	Vamotinib	Inhibitor	99.89%	Unkown
HY-15463S1	Imatinib-d4		99.82%	Unkown
HY-18010	PCI 29732	Inhibitor	99.59%	Unkown
HY-103032	Multi-kinase inhibitor 1	Inhibitor	99.05%	Unkown
HY-15463S	Imatinib-d8		99.88%	Unkown
HY-136268	AQX-435	Activator	99.15%	Unkown
HY-153996	CT1113		99.61%	Unkown
HY-10159C	Nilotinib hydrochloride dihydrate		99.89%	Unkown
HY-101489A	GZD856 formic		95.36%	Unkown
HY-117718	AG957	Inhibitor	99.30%	Unkown
HY-123450	S116836		99.78%	Unkown
HY-13904S	Flumatinib-d3	Inhibitor	99.9%	Unkown
HY-145887	BCR-ABL1-IN-1		99.82%	Unkown
HY-157327	AKE-72	Inhibitor	98.29%	Unkown
HY-164393	ON044580		99.11%	Unkown
HY-123159	AKI603	Inhibitor	98.03%	Unkown
HY-133794	Dasatinib N-oxide		99.24%	Unkown
HY-111872	SNIPER(ABL)-020	Inhibitor	99.79%	Unkown
HY-10181G	Dasatinib (GMP)		/	Unkown
HY-108486	Herbimycin A	Inhibitor	99%	Unkown
HY-123390	DB07107	Inhibitor	/	Unkown
HY-130297	PROTAC BCR-ABL1 ligand 1	Inhibitor	99.17%	Unkown
HY-153008	BCR-ABL-IN-7	Inhibitor	99.66%	Unkown
HY-15463S2	Imatinib-d3 hydrochloride		95.19%	Unkown
HY-154860	PTD10		97.38%	Unkown
HY-156148	BCR-ABL-IN-8	Inhibitor	/	Unkown
HY-180982	Asciminib-NH2	Degrader	/	Unkown
HY-10181S1	Dasatinib-d4		97.54%	Unkown
HY-41940	Dasatinib intermediate-1	Control	≥98.0%	Unkown
HY-101489	GZD856		/	Unkown
HY-108704	CT-721	Inhibitor	/	Unkown
HY-110402	(S,R,S)-AHPC TFA		/	Unkown
HY-111871	SNIPER(ABL)-033	Inhibitor	/	Unkown
HY-128607	Mcl1-IN-9	Inhibitor	/	Unkown
HY-136526	BCR-ABL-IN-3	Inhibitor	/	Unkown
HY-111851	SNIPER(ABL)-049	Inhibitor	/	Unkown
HY-111854	SNIPER(ABL)-015	Inhibitor	/	Unkown
HY-111858	SNIPER(ABL)-050	Inhibitor	/	Unkown
HY-111859	SNIPER(ABL)-058	Inhibitor	/	Unkown
HY-111860	SNIPER(ABL)-013	Inhibitor	/	Unkown
HY-111861	SNIPER(ABL)-024	Inhibitor	/	Unkown
HY-111862	SNIPER(ABL)-044	Inhibitor	/	Unkown
HY-111873	SNIPER(ABL)-019	Inhibitor	/	Unkown
HY-13024A	Rebastinib tosylate		/	Unkown
HY-165532	SGX393	Inhibitor	/	Unkown
HY-133794S	Dasatinib N-oxide-d8		/	Unkown
HY-100314	BCR-ABL-IN-1	Inhibitor	/	Unkown
HY-101268	CHMFL-ABL-053	Inhibitor	/	Unkown
HY-10159S1	Nilotinib-13C,d3		/	Unkown
HY-101763B	(S,R,S)-AHPC dihydrochloride		/	Unkown
HY-10181GL	Dasatinib (GMP Like)		/	Unkown
HY-10212A	BIIB021 mesylate		/	Unkown
HY-10364	AP24163	Inhibitor	/	Unkown
HY-111863	SNIPER(ABL)-047	Inhibitor	/	Unkown
HY-111874	SNIPER(ABL)-039	Inhibitor	/	Unkown
HY-112404	BCR-ABL-IN-13	Inhibitor	99.86%	Unkown
HY-119177	PD173956	Inhibitor	/	Unkown
HY-120036	Tyrphostin AG1112	Inhibitor	/	Unkown
HY-12292G	IM-12 (GMP)		/	Unkown
HY-124605	IQS-019		/	Unkown
HY-124792	MRLB-223		/	Unkown
HY-125090	PHA-680626		/	Unkown
HY-126143	CHMFL-ABL-039	Inhibitor	/	Unkown
HY-131275	Imatinib Impurity E		96.05%	Unkown
HY-13468A	KW-2478 hydrochloride		/	Unkown
HY-142922	BCR-ABL-IN-4	Inhibitor	/	Unkown
HY-147581	BTK-IN-11	Inhibitor	/	Unkown
HY-147584	BTK-IN-14	Inhibitor	/	Unkown
HY-150566	BCR-ABL-IN-5	Inhibitor	/	Unkown
HY-150569	BCR-ABL-IN-6	Inhibitor	/	Unkown
HY-150908	Brigatinib A	Ligand	/	Unkown
HY-152036	SIAIS100	Degrader	/	Unkown
HY-153085	CD19 CAR circRNA		/	Unkown
HY-153582	ML 2-23	Degrader	/	Unkown
HY-15728S	Radotinib-d6		/	Unkown
HY-157389	AK-HW-90	Inhibitor	/	Unkown
HY-160167	Birelentinib	Inhibitor	/	Unkown
HY-160478	GNF-6	Inhibitor	/	Unkown
HY-161323	FLT3-ITD/D835Y-IN-1		/	Unkown
HY-161445	(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH		/	Unkown
HY-162257	BTK-IN-34	Inhibitor	/	Unkown
HY-162489	Tyrosine kinase-IN-8	Inhibitor	/	Unkown
HY-162698	JMF4073	Inhibitor	/	Unkown
HY-162952	cSRC/BCR-ABL1-IN-1	Inhibitor	/	Unkown
HY-168963	PROTAC BTK Degrader-13		/	Unkown
HY-169230	BCR-ABL-IN-9	Inhibitor	/	Unkown
HY-169231	BCR-ABL-IN-10	Inhibitor	/	Unkown
HY-171184	EAPB0503		/	Unkown
HY-172096	cSRC/BCR-ABL-IN-1	Inhibitor	/	Unkown
HY-176269	VS1150		/	Unkown
HY-177273	Kinase modulator-1	Inhibitor	/	Unkown
HY-179247	BCR-ABL1-IN-2	Inhibitor	/	Unkown
HY-179460	Radotinib dihydrochloride		/	Unkown
HY-180218	DS-PPE-GW	Degrader	/	Unkown
HY-180798	BCR-ABL degrader 1	Degrader	/	Unkown
HY-180925	Leu-PEG1-Dasa	Degrader	/	Unkown
HY-180962	Phe-PEG1-Dasa	Degrader	/	Unkown
HY-180963	Lys-PEG1-Dasa	Degrader	/	Unkown
HY-180967	PROTAC BCR-ABL Degrader-2		/	Unkown
HY-180968	GMB-805	Degrader	/	Unkown
HY-180969	SIAIS056	Degrader	/	Unkown
HY-180977	P19P	Degrader	/	Unkown
HY-180979	P22D	Degrader	/	Unkown
HY-180981	P19As	Degrader	/	Unkown
HY-180983	Azo-PROTAC-4C-trans	Degrader	/	Unkown
HY-180984	trans-Lenalidomide-CO-Ph-N2-Ph-O-C4-Cl		/	Unkown
HY-180985	Azo-PROTAC-4C-cis	Degrader	/	Unkown
HY-181546	Ibt-DOX		/	Unkown
HY-182792	Embibatinib	Inhibitor	/	Unkown
HY-185658	3'-BPANeuGc	Inhibitor	/	Unkown
HY-185659	6'-BPANeuGc		/	Unkown
HY-186016	Arg-PEG1-Dasa	Degrader	/	Unkown
HY-186166	(S)-Embibatinib	Inhibitor	/	Unkown
HY-18819	BCR-ABL-IN-2	Inhibitor	/	Unkown
HY-E70634	ABL1 E255K Recombinant Human Active Protein Kinase		/	Unkown
HY-E70635	ABL1 F317I Recombinant Human Active Protein Kinase		/	Unkown
HY-E70636	ABL1 G250E Recombinant Human Active Protein Kinase		/	Unkown
HY-E70637	ABL1 H396P Recombinant Human Active Protein Kinase		/	Unkown
HY-E70638	ABL1 M351T Recombinant Human Active Protein Kinase		/	Unkown
HY-E70639	ABL1 Q252H Recombinant Human Active Protein Kinase		/	Unkown
HY-E70640	ABL1 T315I Recombinant Human Active Protein Kinase		/	Unkown
HY-E70641	ABL1 Y253F Recombinant Human Active Protein Kinase		/	Unkown
HY-E70789	BCR-RET Recombinant Human Active Protein Kinase		/	Unkown
HY-E70808	BTK C481R Recombinant Human Active Protein Kinase		/	Unkown
HY-E70809	BTK V416L Recombinant Human Active Protein Kinase		/	Unkown
HY-RS01450	BCR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-123486	HS-438		/	Unkown
HY-132549S	Nilotinib-d3		/	Unkown
HY-15463S3	Imatinib-13C,d3		/	Unkown
HY-160174	BCR-ABL kinase-IN-3	Inhibitor	/	Unkown
HY-160174A	BCR-ABL kinase-IN-3 (dihydrocholide)	Inhibitor	/	Unkown
HY-164469	CHMFL-48	Inhibitor	/	Unkown
HY-169608	BCR-ABL-IN-11	Inhibitor	/	Unkown
HY-185595	N,3-BisBoc-L-Histidine		/	Unkown
HY-186223	Enzyme modulator-1	Modulator	/	Unkown
HY-RS16598	Bcr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23032	Bcr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991086	MGD010	Inhibitor	99.06%	Unkown
HY-P991804	Anti-Mouse CD79b Antibody (HM79b)	Inhibitor	/	Unkown
HY-P991820	Anti-Mouse CD45 Antibody (I3/2.3)	Inhibitor	/	Unkown
HY-P991996	SM201	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BCR	VGNC	VGNC:38420
Mus musculus	BCR	MGD	MGI:88141
Felis catus	BCR	VGNC	VGNC:60094
Rattus norvegicus	BCR	RGD	RGD:1307993
Macaca mulatta	BCR	VGNC	VGNC:97739
Bos taurus	BCR	VGNC	VGNC:56808
Others	BCR	NCBI