Quinalizarin

Quinalizarin (1-100 μM; 24 h) potently inhibits the viability of SW480 and HCT-116 colorectal cancer cells in a dose-dependent manner^[1].
Quinalizarin (10 μM; 3-24 h) reduces the protein expression levels of cyclin B1 and CDK1/2 in a time-dependent manner, and induces G₂/M phase cell cycle arrest in SW480 colon cancer cells^[1].
Quinalizarin (10 μM; 3-24 h) induces caspase-3-dependent apoptosis in SW480 colorectal cancer cells, which is characterized by upregulated expression of p-p53, Bad, activated caspase-3 and activated PARP, as well as downregulated expression of Bcl-2^[1].
Quinalizarin (10 μmol/L; 3-24 h) reduces the phosphorylation levels of Akt, ERK and STAT3, and increases the phosphorylation levels of JNK and p38 in SW480 colon cancer cells^[1].
Quinalizarin (5, 20 μM; 4-24 h) is cell-permeable and inhibits endogenous CK2 activity in HEK-293T and Jurkat cells^[2].
Quinalizarin (1-100 µM; 24 h) potently inhibits the viability of human lung cancer A549, NCI-H23 and NCI-H460 cells, with IC₅₀ values of 12.1, 20.24 and 27.94 µM, respectively, and exerts no significant cytotoxicity against normal liver QSG-7701 cells^[3].
Quinalizarin (12.1 µM; 0-24 h) induces time-dependent G₀/G₁ cell cycle arrest and apoptosis in human lung cancer A549 cells^[3].
Quinalizarin (12.1 µM; 0-24 h) regulates the Akt, MAPK, STAT3 and p53 signaling pathways in human lung cancer A549 cells, and promotes cell apoptosis by inhibiting the phosphorylation of Akt, ERK and STAT3 and activating the phosphorylation of JNK, p38 and p53^[3].
Quinalizarin (12.1 µM; 0-24 h) induces time-dependent intracellular ROS production in human lung cancer A549 cells^[3].
Quinalizarin (0.5-128 µg/mL; 24 h) exhibits antifungal activity against a variety of pathogenic yeast strains, including Fluconazole (HY-B0101)-resistant clinical Candida albicans isolates, with MIC values ranging from 0.5 to 128 µg/mL^[4].
Quinalizarin (2-4 µg/mL; 10-24 h) inhibits hyphal growth of Candida albicans ATCC 10231 in a concentration-dependent manner^[4].
Quinalizarin (8-80 µg/mL; 24 h) reduces the viability and biomass of preformed mature Candida albicans biofilms^[4].
Quinalizarin (2-16 µg/mL; 5 h) significantly increases intracellular ROS levels in Candida albicans cells^[4].
Quinalizarin (2-16 µg/mL; 5 h) can significantly dissipate the mitochondrial membrane potential of Candida albicans^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.