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Dehydrocorydaline (hydroxyl)

(Synonyms: 13-Methylpalmatine (hydroxyl))
46 Cited Publications
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Based on 46 publication(s) in Google Scholar

Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

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  • Pureté: 99.52%
  • Formule: C22H25NO5
  • Masse moléculaire:383.44
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Dehydrocorydaline (hydroxyl) Chemical Structure
    Dehydrocorydaline (hydroxyl) Chemical Structure
  • Experimental Validation Results for Dehydrocorydaline (hydroxyl)
  • Experimental Validation Results for Dehydrocorydaline (hydroxyl)
  • Experimental Validation Results for Dehydrocorydaline (hydroxyl)
  • Experimental Validation Results for Dehydrocorydaline (hydroxyl)
  • Experimental Validation Results for Dehydrocorydaline (hydroxyl)
  • Experimental Validation Results for Dehydrocorydaline (hydroxyl)
  • Experimental Validation Results for Dehydrocorydaline (hydroxyl)
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  • Dehydrocorydaline (hydroxyl) Chemical Structure
    Dehydrocorydaline (hydroxyl) Chemical Structure
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    Dehydrocorydaline (hydroxyl) purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]

    Customer Validation
     Images of mice lung tissue slices stained with H&E, Masson, and Sirius Red treated with L-DHC (Dehydrocorydaline) 5 mg/kg, H-DHC: 10 mg/kg.

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    Dehydrocorydaline (hydroxyl) purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]

    Customer Validation
     RT-qPCR results for Col1a1 and Fn1 expression levels of mice lung tissue treated with L-DHC (Dehydrocorydaline) 5 mg/kg, H-DHC: 10 mg/kg.

  • 1/16

    Dehydrocorydaline (hydroxyl) purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]

    Customer Validation
     Collagen 1 and Fibronectin of mice lung tissues are analyzed using Western blot treated with L-DHC (Dehydrocorydaline) 5 mg/kg, H-DHC: 10 mg/kg.

  • 1/16

    Dehydrocorydaline (hydroxyl) purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]

    Customer Validation
     Immunofluorescence images of α-SMA, Collagen 1, and Fibronectin in mice lung tissue slices treated with L-DHC (Dehydrocorydaline) 5 mg/kg, H-DHC: 10 mg/kg.

  • 1/16

    Dehydrocorydaline (hydroxyl) purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 Apr 12;26(1):136. [Abstract]

    Customer Validation
     CCK8 assay to determine the impact of Dehydrocorydaline (DHC) (5, 10, 30, 50, 80, 100, 150 μM) on HPFs viability.

  • 1/16

    Dehydrocorydaline (hydroxyl) purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 May 23;499(4):743-750. [Abstract]

    Customer Validation
     Astrocytes are cultured with p38 and JNK activator of DHC and ANS, respectively, at the indicated concentrations for 24 h. Then, all cells are harvested for western blot analysis of p-p38 and p-JNK. Astrocytes are pretreated with DHC (500 nM) or ANS (10 mM) for 24 h, followed by Fru (5 mM) for an additional 24 h.

  • 1/16

    Dehydrocorydaline (hydroxyl) purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 5;503(2):467-473. [Abstract]

    Customer Validation
     The increase of Bcl-2 and decrease of Bax, cleaved Caspase-3 and PARP induced by Ulk1- inhibition in LPS-exposed AST are abrogated by the Dehydrocorydaline chloride (DHC) or Anisomycin (ANS) pre-treatment

  • Dehydrocorydaline (hydroxyl)