FES - FES proto-oncogene, tyrosine kinase Gene

Also Known as FPS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2242

About FES

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,884,504-90,895,776 (from NCBI)

This gene has 17 transcripts (splice variants), 193 orthologues, 32 paralogues and is associated with 56 phenotypes. Broad expression in spleen (RPKM 39.1), bone marrow (RPKM 25.6) and 23 other tissues.

Summary

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]

FES Products (4)

mRNA Protein Name
NM_001143783.1 NP_001137255.1 tyrosine-protein kinase Fes/Fps isoform 2
NM_001143784.1 NP_001137256.1 tyrosine-protein kinase Fes/Fps isoform 3
NM_001143785.2 NP_001137257.1 tyrosine-protein kinase Fes/Fps isoform 4
NM_002005.4 NP_001996.1 tyrosine-protein kinase Fes/Fps isoform 1
Molecular Function GO Annotation Evidence Verweise Source
enables immunoglobulin receptor binding IDA
IDA: Inferred from direct assay
19001085 GOA
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
15485904 GOA
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
19001085 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18046454 GOA
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
11509660 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to vitamin D IMP
IMP: Inferred from mutant phenotype
28389358 GOA
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
11509660 GOA
involved in positive regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
15485904 GOA
involved in positive regulation of monocyte differentiation IMP
IMP: Inferred from mutant phenotype
28389358 GOA
involved in positive regulation of myeloid cell differentiation IMP
IMP: Inferred from mutant phenotype
2656706 GOA
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
15302586 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
7687763 GOA
involved in regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
11509660 GOA
involved in regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
15302586 GOA
involved in regulation of cell motility IMP
IMP: Inferred from mutant phenotype
18046454 GOA
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11509660 GOA
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
11509660 GOA
involved in regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
19001085 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11339827 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
18046454 GOA
colocalizes with cytoplasmic vesicle IDA
IDA: Inferred from direct assay
11339827 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
18046454 GOA
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
15485904 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FES Protein Structure

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (1 - 94)

SH2

SH2: SH2 domain (460 - 529)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (561 - 814)

  • 0
  • 200
  • 400
  • 600
  • 822 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase Fes/Fps

  • Oncogene FES, feline sarcoma virus

FES Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
FES P07332 EZR Homo sapiens P15311 18046454
Intra
FES P07332 EZR Homo sapiens P15311 18046454
Intra
FES P07332 KIT Homo sapiens P10721
FPS
24728074
Intra
FES P07332 DSP Homo sapiens P15924 32707033
Intra
FES P07332 GAB1 Homo sapiens Q13480
FPS
24728074
Intra
FES P07332 AR Homo sapiens P10275
FPS
24728074
Intra
FES P07332 TERF1 Homo sapiens P54274 21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FES Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P73050 FES Protein, Human (Active, sf9, His-GST) P07332-1 (M1-R822) ≥ 80%, as determined by reducing SDS-PAGE.

FES Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P83075 FES Antibody (YA2820) WB Human
HY-P83075A FES Antibody (YA2820)(PBS only) WB Human
HY-P85159 FES Antibody (YA4851) WB, IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Sarcoma
  • Connective And Soft Tissue Neoplasm

  • Tumor Of Soft Tissue And Skeleton

  • Sarcomas

  • Sarcoma - Category

Myeloid Leukemia
  • Myeloid Leukaemia

  • Leukaemia Myelogenous

  • Leukemia Myelogenous

  • Myeloid Granulocytic Leukaemia

  • Myeloid Granulocytic Leukemia

  • Non-Lymphocytic Leukemia

  • Leukemia, Myeloid

  • Granulocytic Leukaemia

  • Myelogenous Leukaemia

  • Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Leukemia
  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos

Acute Promyelocytic Leukemia
  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic

Ewing Sarcoma Of Bone
  • Ewing'S Sarcoma Of Bone

  • Bone Ewing Sarcoma

  • Bone Ewing'S Sarcoma

  • Bone Localized Ewing Sarcoma

  • Bone Localized Ewing'S Sarcoma

  • Ewing'S Sarcoma/Bone Peripheral Primitive Neuroectodermal Tumor

  • Localized Skeletal Ewing'S Sarcoma

  • Localized Bone Ewing Sarcoma

Myopathy, Centronuclear, 2
  • Myopathy, Centronuclear, Autosomal Recessive

  • Autosomal Recessive Centronuclear Myopathy

  • CNM2

  • Centronuclear Myopathy 2

  • Ar-Cnm

  • Myotubular Myopathy, Autosomal Recessive

  • Autosomal Recessive Myotubular Myopathy

  • Centronuclear Myopathy Autosomal Recessive

  • Myopathy, Centronuclear, Type 2

Melanoma
  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas

Leukemia, Chronic Myeloid
  • Chronic Myeloid Leukemia

  • Chronic Myelogenous Leukemia

  • CML

  • Chronic Granulocytic Leukemia

  • Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

  • Chronic Myeloid Leukaemia

  • Chronic Granulocytic Leukaemia

  • Chronic Myelogenous Leukaemia

  • Myeloid Leukemia, Chronic

  • Leukemia, Chronic Myelogenous

  • Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

  • Cml - Chronic Myelogenous Leukemia

  • Cgl

  • Chronic Myelocytic Leukemia

  • Leukemia, Chronic Myeloid, Atypical

  • ACML

  • Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

  • Myeloid Leukemia Chronic

  • Leukemia, Myeloid, Chronic

  • Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

  • Cml- [Chronic Myeloid Leukaemia]

  • Cgl - [Chronic Granulocytic Leukaemia]

  • Chronic Myelocytic Leukaemia

Prostate Cancer
  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus FES MGD MGI:95514
Bos taurus FES VGNC VGNC:28954
Macaca mulatta FES VGNC VGNC:72637
Rattus norvegicus FES RGD RGD:1564385
Felis catus FES VGNC VGNC:62232
Canis familiaris FES VGNC VGNC:40825
Others FES NCBI