Btk - Bruton tyrosine kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 367901

About Btk

Primary_assembly X: 97,722,802-97,761,853 reverse strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 206 orthologues, 32 paralogues and is associated with 36 phenotypes. Biased expression in Spleen (RPKM 217.2), Thymus (RPKM 46.2) and 3 other tissues.

Summary

Enables protein tyrosine kinase activity. Involved in several processes, including cellular response to molecule of Fungal origin; histamine secretion by mast cell; and positive regulation of hypersensitivity. Located in perinuclear region of cytoplasm. Used to study arthus reaction. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; and lymphoma (multiple). Orthologous to human Btk (Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Btk Products (1)

mRNA Protein Name
NM_001007798.2 NP_001007799.2 tyrosine-protein kinase BTK

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
7696342 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to molecule of fungal origin IDA
IDA: Inferred from direct assay
10744701 RGD
involved in cellular response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
10744701 RGD
involved in eosinophil homeostasis IMP
IMP: Inferred from mutant phenotype
32484067 RGD
involved in histamine secretion by mast cell IMP
IMP: Inferred from mutant phenotype
12220673 RGD
involved in monocyte proliferation IMP
IMP: Inferred from mutant phenotype
32484067 RGD
involved in negative regulation of B cell activation IMP
IMP: Inferred from mutant phenotype
25545336 RGD
involved in negative regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
28352114 RGD
involved in negative regulation of leukocyte proliferation IMP
IMP: Inferred from mutant phenotype
32484067 RGD
involved in neutrophil homeostasis IMP
IMP: Inferred from mutant phenotype
32484067 RGD
involved in peptidyl-tyrosine autophosphorylation IMP
IMP: Inferred from mutant phenotype
21521773 RGD
involved in positive regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
28352114 RGD
involved in positive regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
28352114 RGD
involved in positive regulation of interleukin-17A production IMP
IMP: Inferred from mutant phenotype
28352114 RGD
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
28352114 RGD
involved in positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
28352114 RGD
involved in positive regulation of synoviocyte proliferation IMP
IMP: Inferred from mutant phenotype
28352114 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
28352114 RGD
involved in positive regulation of type I hypersensitivity IMP
IMP: Inferred from mutant phenotype
22228807 RGD
involved in positive regulation of type III hypersensitivity IMP
IMP: Inferred from mutant phenotype
22228807 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
7696342 RGD
involved in proteoglycan catabolic process IMP
IMP: Inferred from mutant phenotype
32083858 RGD
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
28352114 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12220673 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Btk Protein Structure

PH_Btk

PH_Btk: cd01238 (5 - 167)

SH3_BTK

SH3_BTK: cd11906 (218 - 272)

SH2_Tec_Btk

SH2_Tec_Btk: cd10397 (275 - 379)

PTKc_Btk_Bmx

PTKc_Btk_Bmx: cd05113 (398 - 653)

  • 0
  • 200
  • 400
  • 600
  • 661 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase BTK

  • Bruton agammaglobulinemia tyrosine kinase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10997 Ibrutinib Inhibitor 99.97% Yes
HY-17600 Acalabrutinib Inhibitor 99.88% Yes
HY-131328 Pirtobrutinib Inhibitor 99.90% Unkown
HY-101474A Zanubrutinib Inhibitor 99.71% Yes
HY-128757 Remibrutinib Inhibitor 99.76% Yes
HY-109192 Tolebrutinib Inhibitor 99.12% Yes
HY-129390 Orelabrutinib Inhibitor 99.97% Yes
HY-132842 Sunvozertinib Inhibitor 99.62% Unkown
HY-15771 Tirabrutinib Inhibitor 99.71% Yes
HY-10997A Ibrutinib Racemate Inhibitor 95.39% Unkown
HY-15771A Tirabrutinib hydrochloride Inhibitor 99.66% Yes
HY-101474AR Zanubrutinib (Standard) Inhibitor 99.90% Unkown
HY-151232 (E/Z)-Rilzabrutinib Inhibitor / Unkown
HY-109192R Tolebrutinib (Standard) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name Effect
Purity Phase
HY-17600A Acalabrutinib maleate Inhibitor / Phase 4
HY-19834 Fenebrutinib Inhibitor 99.89% Phase 3
HY-153321 Bexobrutideg Degrader 99.33% Phase 3
HY-112166 Rilzabrutinib Inhibitor 98.97% Phase 3
HY-101215 Evobrutinib Inhibitor 99.60% Phase 3
HY-112215 Nemtabrutinib Inhibitor 99.32% Phase 3
HY-19816A Avitinib maleate Inhibitor 99.86% Phase 3
HY-160167 Birelentinib Inhibitor / Phase 3
HY-112161 Branebrutinib Inhibitor 99.78% Phase 2
HY-109078 Vecabrutinib Inhibitor 99.76% Phase 2
HY-139984 Corubrutinib Inhibitor 99.85% Phase 2
HY-109010 Poseltinib Inhibitor 98.11% Phase 2
HY-109143 Elsubrutinib Inhibitor 98.0% Phase 2
HY-101856 BMS-986142 Inhibitor 99.38% Phase 2
HY-139481 Flixebrutinib Inhibitor 99.86% Phase 2
HY-132808 Atuzabrutinib Inhibitor 98.00% Phase 2
HY-18012A Spebrutinib besylate Inhibitor / Phase 2
HY-153220 Zelebrudomide Inhibitor 99.72% Phase 1
HY-139535 Luxeptinib Inhibitor 98.95% Phase 1
HY-137438 Edralbrutinib Inhibitor 99.75% Phase 1
HY-153110 Larotinib Inhibitor 99.50% Phase 1
HY-132879 TAK-020 Inhibitor 99.93% Phase 1
HY-153245 JNJ-64264681 Inhibitor 98.14% Phase 1
HY-131342 BIIB068 Inhibitor 98.35% Phase 1
HY-163827 ABBV-992 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (217)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160141 Catadegbrutinib Degrader 99.18% Unkown
HY-19816 Avitinib Inhibitor 99.95% Unkown
HY-18012 Spebrutinib Inhibitor 99.22% Unkown
HY-100342 Ibrutinib-biotin Inhibitor 99.66% Unkown
HY-80002 BMX-IN-1 Inhibitor 99.04% Unkown
HY-11999 CGI-1746 Inhibitor 99.25% Unkown
HY-108691 PF-06465469 Inhibitor 99.48% Unkown
HY-13036A IBT6A Inhibitor 99.59% Unkown
HY-122562 MT-802 Degrader 98.35% Unkown
HY-147943 PROTAC BTK Degrader-1 99.92% Unkown
HY-100335 PCI-33380 Inhibitor 98.0% Unkown
HY-153803 GBD-9 Degrader 99.91% Unkown
HY-12679 PF-06658607 Inhibitor 99.69% Unkown
HY-15805 KIN-8194 Inhibitor 99.26% Unkown
HY-80003 QL47 Inhibitor 99.50% Unkown
HY-169396 TAE648 Ligand 99.50% Unkown
HY-107447 N-Deshydroxyethyl Dasatinib Ligand 97.19% Unkown
HY-133137 SJF620 Inhibitor 98.98% Unkown
HY-153357 NRX-0492 Degrader 98.30% Unkown
HY-144288 BLK-IN-2 Inhibitor 98.61% Unkown
HY-78727 Ibrutinib deacryloylpiperidine Inhibitor 99.96% Unkown
HY-163962 L18I Degrader 99.89% Unkown
HY-15427 GDC-0834 Inhibitor 98.05% Unkown
HY-18009 (Z)-LFM-A13 Inhibitor 99.80% Unkown
HY-49421 BTK ligand 12 Ligand 98.23% Unkown
HY-163295 BTK degrader-1 Degrader 99.40% Unkown
HY-100338 CNX-500 Inhibitor 99.86% Unkown
HY-122830 DD-03-171 Degrader 98.72% Unkown
HY-18951 ONO-4059 analog Inhibitor 99.81% Unkown
HY-13943 CNX-774 Inhibitor 99.54% Unkown
HY-163565 BIIB129 Inhibitor 99.54% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-124645 QL-X-138 Inhibitor 98.17% Unkown
HY-18018 RN486 Inhibitor 98.91% Unkown
HY-135334 ACP-5862 Inhibitor 98.32% Unkown
HY-101474 (±)-Zanubrutinib Inhibitor 99.70% Unkown
HY-43521 Ibrutinib-MPEA Inhibitor 99.71% Unkown
HY-18010 PCI 29732 Inhibitor 99.59% Unkown
HY-10644 Lck inhibitor 2 Inhibitor 99.73% Unkown
HY-122828 PROTAC BTK Degrader-2 Degrader 99.93% Unkown
HY-15809 (Rac)-Ibrutinib alkyne Inhibitor 99.35% Unkown
HY-101474B (R)-Zanubrutinib 98.97% Unkown
HY-153220A (R)-Zelebrudomide Degrader 98.93% Unkown
HY-101793 BMS-935177 Inhibitor 98.35% Unkown
HY-150023 BI-1622 Inhibitor 98.02% Unkown
HY-130983 N-piperidine Ibrutinib hydrochloride Inhibitor 98.06% Unkown
HY-149391 PROTAC BTK Degrader-6 Degrader 99.24% Unkown
HY-160142 UBX-382 Degrader 96.20% Unkown
HY-110002 LFM-A13 Inhibitor 99.65% Unkown
HY-101941 BTK IN-1 Inhibitor 98.09% Unkown
HY-101766 Btk inhibitor 2 Inhibitor 99.53% Unkown
HY-17600S Acalabrutinib-d4 Inhibitor 99.50% Unkown
HY-136531 XMU-MP-3 Inhibitor 95.78% Unkown
HY-153110A Larotinib mesylate hydrate Inhibitor 98.66% Unkown
HY-149051 BGB-8035 Inhibitor 99.00% Unkown
HY-100659 Dihydrodiol-Ibrutinib Inhibitor 99.91% Unkown
HY-10997S Ibrutinib-d5 Inhibitor 98.08% Unkown
HY-101522 CHMFL-EGFR-202 Inhibitor 99.75% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-160966 Omtebrutideg Degrader 99.24% Unkown
HY-157763 Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 Degrader / Unkown
HY-125997 BTK inhibitor 10 Inhibitor 99.66% Unkown
HY-15427B GDC-0834 (S-enantiomer) / Unkown
HY-131705 BTK inhibitor 17 Inhibitor 99.53% Unkown
HY-132842A (S)-Sunvozertinib Inhibitor 99.05% Unkown
HY-133137A SJF620 hydrochloride Inhibitor 99.28% Unkown
HY-131328A (R)-Pirtobrutinib 99.88% Unkown
HY-15427A GDC-0834 Racemate 98.04% Unkown
HY-101474S Zanubrutinib-d5 Inhibitor 99.0% Unkown
HY-160246 QL47B Inhibitor / Unkown
HY-136113 Ibrutinib dimer Inhibitor 98.47% Unkown
HY-109143B (R)-Elsubrutinib Inhibitor 98.0% Unkown
HY-110013 Terreic acid Inhibitor / Unkown
HY-154860 PTD10 Degrader 97.38% Unkown
HY-100659S Dihydrodiol-Ibrutinib-d5 Inhibitor 99.19% Unkown
HY-13036B IBT6A hydrochloride Inhibitor 99.35% Unkown
HY-13036 (Rac)-IBT6A Inhibitor 98.03% Unkown
HY-160245 QL47R 99.94% Unkown
HY-160246A QL47B TFA Inhibitor 96.03% Unkown
HY-115876 BTK-IN-5 Inhibitor / Unkown
HY-132196 BTK inhibitor 18 Inhibitor / Unkown
HY-111781 Civorebrutinib Inhibitor / Unkown
HY-156746 DBt-10 Degrader / Unkown
HY-130255 BTK inhibitor 13 Inhibitor / Unkown
HY-151808 JS25 Inhibitor 98.06% Unkown
HY-174129 TM471-1 Inhibitor / Unkown
HY-174850 CFON-026 Inhibitor / Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-181050 DFCI-002-06 Degrader / Unkown
HY-102036 G-744 Inhibitor / Unkown
HY-156604 Cinsebrutinib Inhibitor / Unkown
HY-117900 PF-06250112 Inhibitor / Unkown
HY-101521 CHMFL-BTK-01 Inhibitor / Unkown
HY-170758 BTK ligand 13 / Unkown
HY-147754 JAK3/BTK-IN-6 Inhibitor / Unkown
HY-159947 PROTAC BTK Degrader-11 Degrader / Unkown
HY-169228 WS-11 Inhibitor / Unkown
HY-168302 BTK ligand 10 99.49% Unkown
HY-176131 AMX5160 Inhibitor / Unkown
HY-152212 BTK-IN-19 Inhibitor / Unkown
HY-162257 BTK-IN-34 Inhibitor / Unkown
HY-181547 HBC-12551 Inhibitor / Unkown
HY-175541 TQ-3959 Degrader / Unkown
HY-151211 BTK-IN-16 Inhibitor 98.93% Unkown
HY-175909 BTK ligand-18 Ligand / Unkown
HY-173143 BTK-IN-42 Inhibitor / Unkown
HY-147584 BTK-IN-14 Inhibitor / Unkown
HY-179948 BTK-IN-45 Inhibitor / Unkown
HY-117900A (Rac)-PF-06250112 / Unkown
HY-161876 GSTO1-IN-2 Inhibitor / Unkown
HY-170413 PROTAC BTK Degrader-12 Degrader / Unkown
HY-156745 PROTAC DDa-1 Degrader / Unkown
HY-164002 PF-303 Inhibitor / Unkown
HY-184940 BTK-IN-50 Inhibitor / Unkown
HY-168965 BTK ligand 15 Ligand / Unkown
HY-158064 BTK-IN-36 Inhibitor / Unkown
HY-P10609 Btk substrate peptide / Unkown
HY-162081 BTK-IN-32 Inhibitor / Unkown
HY-141689 BTK-IN-3 Inhibitor / Unkown
HY-175788 BTK ligand-17 Ligand / Unkown
HY-179076 BTK/IKZF1/3 ligand 1 Ligand / Unkown
HY-173125 FDU73 Degrader / Unkown
HY-182910 PROTAC BTK Degrader-15 Degrader / Unkown
HY-181996 BTK-IN-47 Inhibitor / Unkown
HY-153951S BTK-IN-26 Inhibitor / Unkown
HY-151920 BTK-IN-17 Inhibitor / Unkown
HY-143717 JAK3/BTK-IN-2 Inhibitor / Unkown
HY-182943 BTK-IN-49 Inhibitor / Unkown
HY-171893 CRBN ligand-185 Ligand / Unkown
HY-148584 BTK-IN-21 Inhibitor / Unkown
HY-182293 BTK-IN-48 Inhibitor / Unkown
HY-E70808 BTK C481R Recombinant Human Active Protein Kinase / Unkown
HY-142932 BTK-IN-6 Inhibitor / Unkown
HY-143719 JAK3/BTK-IN-4 Inhibitor / Unkown
HY-177103 Midobrutinib Inhibitor / Unkown
HY-101474BS (R)-Zanubrutinib-d5 / Unkown
HY-172589 BTK-IN-43 Inhibitor / Unkown
HY-150885 BTK ligand 1 Degrader / Unkown
HY-124605 IQS-019 Inhibitor / Unkown
HY-128408 PROTAC BTK Degrader-4 Degrader / Unkown
HY-143718 JAK3/BTK-IN-3 Inhibitor / Unkown
HY-152201 BTK-IN-18 Inhibitor / Unkown
HY-151961 RSH-7 Inhibitor 98.74% Unkown
HY-147580 BTK-IN-10 Inhibitor / Unkown
HY-143720 JAK3/BTK-IN-5 Inhibitor / Unkown
HY-153536 PROTAC BTK Degrader-3 Degrader / Unkown
HY-147784 HZ-A-005 Inhibitor / Unkown
HY-153705 BTK-IN-25 Inhibitor / Unkown
HY-148832 BTK-IN-20 Inhibitor / Unkown
HY-110113 CTA056 Inhibitor / Unkown
HY-147741 DPPY Inhibitor / Unkown
HY-120406 PLS-123 Inhibitor / Unkown
HY-182933 BTK ligand-20 Ligand / Unkown
HY-143900 BTK-IN-7 Inhibitor / Unkown
HY-145884 BTK-IN-8 Inhibitor / Unkown
HY-172822 TLT8 Degrader / Unkown
HY-159956 BTK-IN-39 Ligand / Unkown
HY-180884 BTK-IN-46 Inhibitor / Unkown
HY-150898 BTK ligand 3 Ligand / Unkown
HY-143730 BTK inhibitor 20 Inhibitor / Unkown
HY-W062695 (R)-Acalabrutinib Inhibitor / Unkown
HY-171131 BTK-IN-41 Inhibitor / Unkown
HY-123117 VA5 Inhibitor / Unkown
HY-170324 BTK-IN-40 Inhibitor / Unkown
HY-160168 BTK-IN-31 Inhibitor / Unkown
HY-162280 PROTAC BTK Degrader-9 Degrader / Unkown
HY-179077 PROTAC BTK/IKZF1/3 Degrader-1 Degrader / Unkown
HY-117499 RN941 Inhibitor / Unkown
HY-144170 RET-IN-14 Inhibitor / Unkown
HY-181546 Ibt-DOX Inhibitor / Unkown
HY-183103 PDD-87 Inhibitor / Unkown
HY-181624 BTK ligand-19 Ligand / Unkown
HY-173126 BTK ligand-14 Inhibitor / Unkown
HY-143901 EGFR-IN-40 Inhibitor / Unkown
HY-184792 CA/PRAK-IN-1 Inhibitor / Unkown
HY-175543 BTK ligand 16 Ligand / Unkown
HY-160219S BTK-IN-33 Inhibitor / Unkown
HY-144283 BLK-IN-1 Inhibitor / Unkown
HY-124153 GNE-431 Inhibitor / Unkown
HY-182671 SRX3305 Inhibitor / Unkown
HY-155072 PROTAC BTK Degrader-5 Degrader / Unkown
HY-148594 BTK-IN-23 Inhibitor / Unkown
HY-147582 BTK-IN-12 Inhibitor / Unkown
HY-157159 BTK-IN-28 Inhibitor / Unkown
HY-147581 BTK-IN-11 Inhibitor / Unkown
HY-163183 JAK3/BTK-IN-7 Inhibitor / Unkown
HY-179562 BTK degrader-2 Degrader / Unkown
HY-E70809 BTK V416L Recombinant Human Active Protein Kinase / Unkown
HY-168427 Avitinib maleate dihydrate Inhibitor / Unkown
HY-176172 BTK-IN-44 Inhibitor / Unkown
HY-150752 BTK-IN-15 Inhibitor / Unkown
HY-169307 BTK-IN-38 Inhibitor / Unkown
HY-162407 I-As-1 Inhibitor / Unkown
HY-142621 BCPyr Degrader / Unkown
HY-168314 BTK ligand 11 Ligand / Unkown
HY-139881 BTK inhibitor 19 Inhibitor / Unkown
HY-156553 BTK-IN-27 Inhibitor / Unkown
HY-143716 JAK3/BTK-IN-1 Inhibitor / Unkown
HY-159589 BTK-IN-37 Inhibitor / Unkown
HY-153321A (R,R)-Bexobrutideg Degrader 98.83% Unkown
HY-148585 BTK-IN-22 Inhibitor / Unkown
HY-117628 RN983 Inhibitor / Unkown
HY-168963 PROTAC BTK Degrader-13 Degrader / Unkown
HY-131328S Pirtobrutinib-13C,d3 Inhibitor / Unkown
HY-156969 Topoisomerase I inhibitor 11 / Unkown
HY-115944 BTK-IN-9 Inhibitor / Unkown
HY-181623 PROTAC BTK degrader-14 Degrader / Unkown
HY-18016 CGI 560 Inhibitor / Unkown
HY-101474R (±)-Zanubrutinib (Standard) Inhibitor / Unkown
HY-13036C (Rac)-IBT6A hydrochloride Inhibitor / Unkown
HY-128403 BTK inhibitor 8 Inhibitor 99.96% Unkown
HY-160167A (R,R)-Birelentinib Inhibitor / Unkown
HY-168292 BTK ligand 9 / Unkown
HY-135334S ACP-5862-d4 Inhibitor / Unkown
HY-176526 BTK degrader-1 intermediate Degrader / Unkown
HY-183397 Avitinib dihydrochloride Inhibitor / Unkown
HY-101766R Btk inhibitor 2 (Standard) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Btk NCBI NCBI:695