2. Gene
  3. Cdk1 - cyclin-dependent kinase 1 Gene

Cdk1 - cyclin-dependent kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cdc2; Cdc2a

Gene ID: 54237 | Gene type: protein coding

About Cdk1

Biased expression in Thymus (RPKM 28.3), Spleen (RPKM 193.1) and 8 other tissues.

Summary

Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and histone kinase activity. Involved in several processes, including Golgi disassembly; positive regulation of protein import into nucleus; and ventricular cardiac muscle cell development. Acts upstream of or within negative regulation of gene expression. Located in cytoplasm and nucleus. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder Cancer. Orthologous to human CDK1 (cyclin dependent kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdk1 Products(1)

mRNA Protein Name
NM_019296.2 NP_062169.1 cyclin-dependent kinase 1

Cdk1 Protein Structure

STKc_CDK1_euk

STKc_CDK1_euk: cd07861 (2 - 286)

  • 0
  • 100
  • 200
  • 297 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 1

Cell division cycle control protein 2

cell division control protein 2 homolog

cell division cycle 2 homolog A

cell division cycle 2, G1 to S and G2 to M

cell division protein kinase 1

p34 protein kinase

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16297A Abemaciclib Inhibitor 99.96% Yes
HY-10492 Dinaciclib Inhibitor 99.44% Yes
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-B0263 Thiabendazole Inhibitor 99.72% Unkown
Clinical Phase
Bioactive Molecules (25)
Cat. No. Product Name Effect
Purity Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.74% Phase 4
HY-10005 Flavopiridol Inhibitor 99.72% Phase 2
HY-30237 (R)-Roscovitine Inhibitor 99.84% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-10006 Flavopiridol Hydrochloride Inhibitor 98.95% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-13914 Roniciclib Inhibitor 98.03% Phase 2
HY-10424 Milciclib Inhibitor 99.90% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-103712B Samuraciclib hydrochloride hydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-137432A Avotaciclib trihydrochloride Inhibitor 99.75% Phase 2
HY-112272 Lerociclib Inhibitor / Phase 2
HY-137432 Avotaciclib Inhibitor / Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10008 SNS-032 Inhibitor 99.51% Phase 1
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-12871B Atuveciclib Inhibitor 99.80% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-10032 PF 477736 Inhibitor 99.21% Phase 1
HY-15504 RGB-286638 Inhibitor 99.84% Phase 1
HY-12422 Voruciclib Inhibitor 99.77% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.07% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.23% Phase 1
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 1
Pre-clinical Phase
Bioactive Molecules (73)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12529 Ro-3306 Inhibitor 99.04% Unkown
HY-12302 Kenpaullone Inhibitor 98.16% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.91% Unkown
HY-124719 hSMG-1 inhibitor 11j Inhibitor 99.81% Unkown
HY-15154 NG 52 Inhibitor 99.97% Unkown
HY-15339 CVT-313 Inhibitor 99.76% Unkown
HY-11009 CGP60474 Inhibitor 99.23% Unkown
HY-N0417 Cucurbitacin E Inhibitor 99.92% Unkown
HY-10014 R547 Inhibitor 99.57% Unkown
HY-124760 hSMG-1 inhibitor 11e Inhibitor 99.81% Unkown
HY-13461A PHA-767491 hydrochloride Inhibitor 98.06% Unkown
HY-18340 (R)​-​CR8 Inhibitor 99.21% Unkown
HY-18299A Purvalanol A Inhibitor 98.30% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.80% Unkown
HY-15275 BMS-265246 Inhibitor 98.92% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-15878 LDC000067 Inhibitor 98.00% Unkown
HY-18299 Purvalanol B Inhibitor ≥97.0% Unkown
HY-18629 SU9516 Inhibitor 99.81% Unkown
HY-18340A (R)-CR8 trihydrochloride Inhibitor 98.95% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-117535 CDK2-IN-4 Inhibitor 98.07% Unkown
HY-119940 MC180295 Inhibitor 98.89% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-129478 TC11 Activator 98.04% Unkown
HY-16559 Riviciclib hydrochloride 99.01% Unkown
HY-15889 AMG 925 Inhibitor 98.20% Unkown
HY-107419 NU6140 Inhibitor 99.07% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.91% Unkown
HY-103647 K00546 Inhibitor 98.08% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-108359 Alsterpaullone Inhibitor 98.38% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-103221 MeBIO Inhibitor ≥98.0% Unkown
HY-19316 NU2058 Inhibitor 98.78% Unkown
HY-112463 CDK1-IN-2 Inhibitor 97.17% Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-13816 NU6027 Inhibitor 99.04% Unkown
HY-N5072 Desmethylglycitein Inhibitor 98.98% Unkown
HY-111237 Butyrolactone I Inhibitor 98.03% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.22% Unkown
HY-111930 5-Iodo-indirubin-3'-monoxime Inhibitor 99.50% Unkown
HY-112462 Cdk1/2 Inhibitor III Inhibitor 99.69% Unkown
HY-15889A AMG 925 HCl Inhibitor / Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-14372 BS-194 Inhibitor 99.36% Unkown
HY-114903 (E/Z)-BIO-acetoxime Inhibitor / Unkown
HY-112346 RGB-286147 Inhibitor ≥98.0% Unkown
HY-103381 NSC693868 Inhibitor ≥99.0% Unkown
HY-136726 CGP-82996 Inhibitor / Unkown
HY-13461 PHA-767491 Inhibitor / Unkown
HY-151407 CDK1-IN-3 Inhibitor / Unkown
HY-151409 CDK1-IN-5 Inhibitor / Unkown
HY-103712 Samuraciclib Inhibitor / Unkown
HY-126244 CDK4/6-IN-3 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-111932 Indirubin-5-sulfonate Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-111931 Indirubin-3'-monoxime-5-sulphonic acid Inhibitor / Unkown
HY-151408 CDK1-IN-4 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-141685 3-Methylthienyl-carbonyl-JNJ-7706621 Inhibitor / Unkown
HY-147901 KDM1/CDK1-IN-1 Inhibitor / Unkown
HY-146253 CDK1/2/4-IN-1 Inhibitor / Unkown
HY-112336 Aloisine RP106 Inhibitor / Unkown
HY-115924 CDK1-IN-1 Inhibitor / Unkown
HY-155787 SHR5428 Inhibitor / Unkown
HY-112363 Aloisine A Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-147646 CDK1/Cyc B-IN-1 Inhibitor / Unkown
HY-160643 CDK2-IN-27 Inhibitor / Unkown
HY-103383 (R)-DRF053 dihydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk1 NCBI NCBI:983
Mus musculus Cdk1 NCBI NCBI:12534