Cdk1 - cyclin-dependent kinase 1 Gene

Also Known as Cdc2; Cdc2a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54237

About Cdk1

Biased expression in Thymus (RPKM 28.3), Spleen (RPKM 193.1) and 8 other tissues.

Summary

Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and histone kinase activity. Involved in several processes, including Golgi disassembly; positive regulation of protein import into nucleus; and ventricular cardiac muscle cell development. Acts upstream of or within negative regulation of gene expression. Located in cytoplasm and nucleus. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder Cancer. Orthologous to human CDK1 (cyclin dependent kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdk1 Products (1)

mRNA Protein Name
NM_019296.2 NP_062169.1 cyclin-dependent kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Referencias Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
15696186 RGD
enables cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9753325 RGD
enables histone kinase activity IDA
IDA: Inferred from direct assay
19821535 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9753325 RGD
Biological Process GO Annotation Evidence Referencias Source
involved in Golgi disassembly IDA
IDA: Inferred from direct assay
9753325 RGD
involved in animal organ regeneration IMP
IMP: Inferred from mutant phenotype
15696186 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
16179908 RGD
involved in cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
15695611 RGD
involved in chromosome condensation IMP
IMP: Inferred from mutant phenotype
15695611 RGD
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28350193 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
9753325 RGD
involved in positive regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
19821535 RGD
involved in positive regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
15253691 RGD
acts upstream of positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28350193 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18356527 RGD
involved in positive regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
15696186 RGD
involved in positive regulation of protein import into nucleus IMP
IMP: Inferred from mutant phenotype
18356527 RGD
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
19136513 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
16826023 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
16155410 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
17200138 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
16730872 RGD
involved in response to copper ion IEP
IEP: Inferred from expression pattern
19497425 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
18181150 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
16963227 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16427046 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
19237604 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16427046 RGD
involved in ventricular cardiac muscle cell development IEP
IEP: Inferred from expression pattern
15253691 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk1 Protein Structure

STKc_CDK1_euk

STKc_CDK1_euk: cd07861 (2 - 286)

  • 0
  • 100
  • 200
  • 297 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 1

  • Cell division cycle control protein 2

  • cell division control protein 2 homolog

  • cell division cycle 2 homolog A

  • cell division cycle 2, G1 to S and G2 to M

  • cell division protein kinase 1

  • p34 protein kinase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Referencia número Nombre del producto Efecto
Pureza Rare Diseases
HY-16297A Abemaciclib Inhibitor 99.97% Yes
HY-10492 Dinaciclib Inhibitor 99.80% Yes
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-B0263 Thiabendazole 99.94% Unkown
HY-B1165 Cyproheptadine (hydrochloride sesquihydrate) 99.74% Unkown

Clinical Phase

Bioactive Molecules (22)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-10005 Flavopiridol Inhibitor 99.72% Phase 2
HY-30237 (R)-Roscovitine Inhibitor 99.53% Phase 2
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-13914 Roniciclib Inhibitor 98.00% Phase 2
HY-10424 Milciclib Inhibitor 99.89% Phase 2
HY-137432 Avotaciclib Inhibitor 99.72% Phase 2
HY-N2424 Flavone Inhibitor 99.85% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10008 SNS-032 Inhibitor 99.91% Phase 1
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-10032 PF 477736 Inhibitor 99.04% Phase 1
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-12871B Atuveciclib Inhibitor 99.75% Phase 1
HY-15504 RGB-286638 Inhibitor 99.67% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.26% Phase 1
HY-182906 XL495 Inhibitor / Phase 1
HY-114214 CKD-712 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (151)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-12529 Ro-3306 Inhibitor 99.83% Unkown
HY-124719 hSMG-1 inhibitor 11j Inhibitor 99.82% Unkown
HY-12302 Kenpaullone Inhibitor 98.20% Unkown
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.73% Unkown
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.39% Unkown
HY-15339 CVT-313 Inhibitor 99.90% Unkown
HY-15154 NG 52 Inhibitor 99.88% Unkown
HY-10006 Flavopiridol Hydrochloride Inhibitor 99.73% Yes
HY-124760 hSMG-1 inhibitor 11e Inhibitor 99.94% Unkown
HY-18340 (R)​-​CR8 Inhibitor 99.52% Unkown
HY-122609 XO44 99.73% Unkown
HY-18299A Purvalanol A Inhibitor 98.61% Unkown
HY-15275 BMS-265246 Inhibitor 99.59% Unkown
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Unkown
HY-108359 Alsterpaullone Inhibitor 99.85% Unkown
HY-15878 LDC000067 Inhibitor 99.00% Unkown
HY-18629 SU9516 Inhibitor 99.85% Unkown
HY-N0417 Cucurbitacin E Inhibitor 99.92% Unkown
HY-11009 CGP60474 Inhibitor 98.90% Unkown
HY-13461A PHA-767491 hydrochloride Inhibitor 99.49% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-117535 CDK2-IN-4 Inhibitor 99.85% Unkown
HY-X0150 JSH-150 Inhibitor 98.36% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-103221 MeBIO Inhibitor 98.0% Unkown
HY-18340A (R)-CR8 trihydrochloride Inhibitor 99.37% Unkown
HY-12422 Voruciclib Inhibitor 99.76% Unkown
HY-13461 PHA-767491 Inhibitor 99.97% Unkown
HY-103712 Samuraciclib Inhibitor 99.55% Unkown
HY-18299 Purvalanol B Inhibitor 97.0% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-16559 Riviciclib hydrochloride 99.08% Unkown
HY-175842 CDK2 degrader 7 Degrader 99.51% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.93% Unkown
HY-119940 MC180295 Inhibitor 98.07% Unkown
HY-112272 Lerociclib Inhibitor 96.42% Unkown
HY-103647 K00546 Inhibitor 99.48% Unkown
HY-129478 TC11 Activator 99.55% Unkown
HY-162919 YK-2168 Inhibitor 98.05% Unkown
HY-151071 TMX-3013 Inhibitor 98.02% Unkown
HY-50914 AZD5597 Inhibitor 98.9% Unkown
HY-N5072 Desmethylglycitein Inhibitor 99.99% Unkown
HY-15889 AMG 925 Inhibitor 99.02% Unkown
HY-50943 AT7519 Hydrochloride Inhibitor 99.16% Unkown
HY-112403 (S)-Roscovitine Inhibitor 99.15% Unkown
HY-15504A RGB-286638 free base Inhibitor 98.09% Unkown
HY-115924 CDK1-IN-1 Inhibitor 99.33% Unkown
HY-111237 Butyrolactone I Inhibitor 99.80% Unkown
HY-115565 CGP-74514 Inhibitor 98.02% Unkown
HY-151069 TMX-2039 Inhibitor 99.42% Unkown
HY-13816 NU6027 Inhibitor 98.01% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.94% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-148070 FLT3-IN-17 99.11% Unkown
HY-107419 NU6140 Inhibitor 99.53% Unkown
HY-14372 BS-194 Inhibitor 99.13% Unkown
HY-148062 RSS0680 99.85% Unkown
HY-112462 Cdk1/2 Inhibitor III Inhibitor 99.69% Unkown
HY-137432A Avotaciclib trihydrochloride Inhibitor 99.60% Unkown
HY-123045 PNU-292137 Inhibitor 99.95% Unkown
HY-100429 CAN508 Inhibitor 99.71% Unkown
HY-137432B Avotaciclib hydrochloride Inhibitor 99.75% Unkown
HY-136726 CGP-82996 Inhibitor 98.12% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.88% Unkown
HY-112463 CDK1-IN-2 Inhibitor 98.89% Unkown
HY-119715 AG-012986 Inhibitor 99.78% Unkown
HY-155787 SHR5428 Inhibitor 99.80% Unkown
HY-19316 NU2058 Inhibitor 99.66% Unkown
HY-111930 5-Iodo-indirubin-3'-monoxime Inhibitor 98.12% Unkown
HY-50940A AT7519 TFA Inhibitor 99.75% Unkown
HY-X0009A Tambiciclib dimaleate Inhibitor 99.53% Unkown
HY-168673 CDK1-IN-6 Inhibitor 99.96% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-147646 CDK1/Cyc B-IN-1 Inhibitor 98.47% Unkown
HY-114903 (E/Z)-BIO-acetoxime Inhibitor 99.9% Unkown
HY-103381 NSC693868 Inhibitor 99.0% Unkown
HY-103383 (R)-DRF053 dihydrochloride Inhibitor 99.30% Unkown
HY-180485 PROTAC D16-M1P2 Inhibitor / Unkown
HY-112346 RGB-286147 Inhibitor 98.60% Unkown
HY-178227 KY19334 Inhibitor 99.78% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-15889A AMG 925 (HCl) Inhibitor / Unkown
HY-164906 TMX-2138 Degrader 98.99% Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-121989 cis-Trismethoxy resveratrol Inhibitor 99.87% Unkown
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor 98.67% Unkown
HY-112450 Olomoucine II Inhibitor 98.0% Unkown
HY-151409 CDK1-IN-5 Inhibitor / Unkown
HY-151407 CDK1-IN-3 Inhibitor / Unkown
HY-126244 CDK4/6-IN-3 Inhibitor / Unkown
HY-179012 CDC20/HSP90-IN-1 Inhibitor / Unkown
HY-151408 CDK1-IN-4 Inhibitor / Unkown
HY-123034 CDKI-83 Inhibitor / Unkown
HY-161826 Antitumor agent-174 Inhibitor / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-183547 WEE1/PKMYT1-IN-4 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-184444 CDK4-IN-7 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-182470 AG-012986 dihydrochloride Inhibitor / Unkown
HY-180817 CDK2-IN-55 Inhibitor 98.91% Unkown
HY-146253 CDK1/2/4-IN-1 Inhibitor / Unkown
HY-178112 CDK2-IN-47 Inhibitor / Unkown
HY-208742 ZNL-02-096 Inhibitor / Unkown
HY-181004 PKMYT1-IN-13 Inhibitor / Unkown
HY-112471 TrkA Inhibitor Inhibitor / Unkown
HY-177780 Cyclin K degrader 2 Degrader / Unkown
HY-180820 Dimethyl bisphenolate Inhibitor / Unkown
HY-179023 CDK9-IN-45 Inhibitor / Unkown
HY-110359 CGP-74514 dihydrochloride Inhibitor / Unkown
HY-181098 FKA-9i Inhibitor / Unkown
HY-182752 CDK1-IN-9 Inhibitor / Unkown
HY-179052 Apoptosis inducer 50 Inhibitor / Unkown
HY-P11028 M1-20 Inhibitor / Unkown
HY-111932 Indirubin-5-sulfonate Inhibitor / Unkown
HY-137432D Avotaciclib sulfate Inhibitor / Unkown
HY-181763 Tubulin-IN-65 Activator / Unkown
HY-170306 LZ9 Inhibitor / Unkown
HY-112336 Aloisine RP106 Inhibitor 99.76% Unkown
HY-173347 BLINK11 Inhibitor / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-147901 KDM1/CDK1-IN-1 Inhibitor / Unkown
HY-141685 3-Methylthienyl-carbonyl-JNJ-7706621 Inhibitor / Unkown
HY-112363 Aloisine A Inhibitor / Unkown
HY-118976 CGP-74514 hydrochloride Inhibitor / Unkown
HY-180484 PKMYT1-IN-12 Inhibitor / Unkown
HY-123369 BMI-1026 Inhibitor / Unkown
HY-181838 CIRc-014 Inhibitor / Unkown
HY-167237 Calactin Inhibitor / Unkown
HY-173348 BLINK15 Inhibitor / Unkown
HY-111931 Indirubin-3'-monoxime-5-sulphonic acid Inhibitor / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-183787 PI3Kα-IN-33 Inhibitor / Unkown
HY-178756 CDK2-IN-48 Inhibitor / Unkown
HY-170965 Anticancer agent 264 Inhibitor / Unkown
HY-170651 CDK4/6/HDAC-IN-1 Inhibitor / Unkown
HY-183854 AG-12286 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-182734 BMS-357075 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-181140 UNPD139734 Inhibitor / Unkown
HY-182986 LS-Q2 Inhibitor / Unkown
HY-179614 PARP1-IN-50 Inhibitor / Unkown
HY-179521 CDK1-IN-8 Inhibitor / Unkown
HY-181978 GIT1-IN-1 Inhibitor / Unkown
HY-11001A PHA-793887 hydrochloride Inhibitor / Unkown
HY-112394 2-Cyanoethylalsterpaullone Inhibitor / Unkown
HY-181030 BDE30671203 Inhibitor / Unkown
HY-19926A GDC-0425 hydrochloride Inhibitor / Unkown
HY-160643 CDK2-IN-27 Inhibitor / Unkown
Inhibitory Antibodies (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-P991218 Anti-IL11 Antibody (X203) Modulator 98.53% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk1 NCBI NCBI:983