SRC - SRC proto-oncogene, non-receptor tyrosine kinase Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 485864

About SRC

Primary_assembly 24: 26,666,617-26,717,074 forward strand.ROS_Cfam_1.0:CM025123.1

This gene has 3 transcripts (splice variants), 261 orthologues and 32 paralogues.

SRC Products (6)

mRNA Protein Name
XM_038433794.1 XP_038289722.1 proto-oncogene tyrosine-protein kinase Src isoform X2
XM_038433791.1 XP_038289719.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_038433790.1 XP_038289718.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_038433792.1 XP_038289720.1 proto-oncogene tyrosine-protein kinase Src isoform X1
XM_038433793.1 XP_038289721.1 proto-oncogene tyrosine-protein kinase Src isoform X3
XM_038433789.1 XP_038289717.1 proto-oncogene tyrosine-protein kinase Src isoform X1

SRC Protein Structure

SH3_Src

SH3_Src: cd12008 (87 - 159)

SH2_Src_Src

SH2_Src_Src: cd10365 (163 - 263)

PTKc_Src

PTKc_Src: cd05071 (276 - 552)

  • 0
  • 100
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  • 400
  • 500
  • 553 a.a.
Protein Preferred Names Protein Names

LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src

proto-oncogene tyrosine-protein kinase Src

  • src oncogene

  • tyrosine protein kinase pp60-c-src

  • v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10181 Dasatinib Inhibitor 99.85% Yes
HY-12047 Ponatinib Inhibitor 99.67% Yes
HY-10158 Bosutinib Inhibitor 99.97% Yes
HY-10181A Dasatinib hydrochloride Inhibitor 99.67% Yes
HY-10340 Tirbanibulin Inhibitor 99.45% Unkown
HY-10209 Masitinib Inhibitor 99.94% Yes
HY-108766 Ponatinib hydrochloride Inhibitor 99.76% Yes
HY-10181B Dasatinib monohydrate Inhibitor 99.58% Yes
HY-10209A Masitinib mesylate Inhibitor 99.98% Yes
HY-10158A Bosutinib hydrate Inhibitor 99.97% Yes
HY-10340B Tirbanibulin Mesylate Inhibitor 99.94% Unkown

Clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Phase
HY-10234 Saracatinib Inhibitor 99.23% Phase 3
HY-10234A Saracatinib difumarate Inhibitor 99.93% Phase 3
HY-10340A Tirbanibulin dihydrochloride Inhibitor 98.02% Phase 3
HY-13024 Rebastinib Inhibitor 99.84% Phase 2
HY-50868 Bafetinib Inhibitor 99.18% Phase 2
HY-59047 Tolimidone Activator 99.98% Phase 2
HY-32718 Pelitinib Inhibitor 99.13% Phase 2
HY-15323 PRT062607 Hydrochloride Inhibitor 98.07% Phase 2
HY-10987A ENMD-2076 Inhibitor 99.99% Phase 2
HY-10186 TG 100801 Inhibitor 98.61% Phase 2
HY-10987 ENMD-2076 Tartrate Inhibitor 99.66% Phase 2
HY-10187 TG 100801 Hydrochloride Inhibitor / Phase 2
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1
HY-10032 PF 477736 Inhibitor 99.04% Phase 1
HY-111787 Elzovantinib Inhibitor 99.93% Phase 1
HY-15749 XL228 Inhibitor 99.64% Phase 1
HY-112809 GSK2646264 Inhibitor 99.74% Phase 1
HY-112314 AZD0424 Inhibitor / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991664 AG01 Inhibitor 95.10% Phase 1

Pre-clinical Phase

Bioactive Molecules (272)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13805 PP2 Inhibitor 99.14% Unkown
HY-15176A Pyridostatin hydrochloride Inhibitor 99.95% Unkown
HY-N0752 Scutellarein Inhibitor 99.39% Unkown
HY-12299 WH-4-023 Inhibitor 99.87% Unkown
HY-101053 Src Inhibitor 1 Inhibitor 99.97% Unkown
HY-112096 eCF506 Inhibitor 99.77% Unkown
HY-B0789 SU6656 Inhibitor 99.01% Unkown
HY-N7264 7α-Hydroxycholesterol 99.99% Unkown
HY-N0031 Plantamajoside 99.80% Unkown
HY-W062835 CGP77675 Inhibitor 99.46% Unkown
HY-135299 CH6953755 Inhibitor 99.75% Unkown
HY-12072 Lck Inhibitor Inhibitor 99.65% Unkown
HY-11011 A-770041 Inhibitor 99.89% Unkown
HY-15764 A 419259 Inhibitor 99.88% Unkown
HY-130254 CSK-IN-1 Inhibitor 98.61% Unkown
HY-10395 PD173955 Inhibitor 99.12% Unkown
HY-15764A A 419259 trihydrochloride Inhibitor 98.28% Unkown
HY-132166 Velzatinib Inhibitor 99.40% Unkown
HY-13804 PP1 Inhibitor 99.57% Unkown
HY-15176B Pyridostatin TFA Inhibitor 99.17% Unkown
HY-13942 1-NM-PP1 Inhibitor 98.93% Unkown
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-N0202 Atractylenolide II Inhibitor 99.89% Unkown
HY-112852 TL02-59 Inhibitor 99.86% Unkown
HY-W040055 Neopterin Inhibitor 99.95% Unkown
HY-13941 1-Naphthyl PP1 Inhibitor 99.36% Unkown
HY-139147 iHCK-37 Inhibitor 99.52% Unkown
HY-122113 PD173952 Inhibitor 99.58% Unkown
HY-10372 PP121 Inhibitor 99.51% Unkown
HY-118144 PD166326 Inhibitor 99.99% Unkown
HY-P3279 EPQpYEEIPIYL Activator 99.49% Unkown
HY-121705 Propionyl-L-carnitine Activator 95.0% Unkown
HY-18303 AMG-47a Inhibitor 99.19% Unkown
HY-100434 PD-161570 Inhibitor 99.82% Unkown
HY-108318 RK-24466 Inhibitor 99.91% Unkown
HY-12039 Lyn-IN-1 Inhibitor 98.07% Unkown
HY-78263 MNS Inhibitor 99.55% Unkown
HY-N0442 5-O-Methylvisammioside Inhibitor 99.90% Unkown
HY-148385 Ganglioside GM2 Activator 98.0% Unkown
HY-N0701 (-)-Asarinin Inhibitor 99.90% Unkown
HY-155657 BT424 Inhibitor 98.89% Unkown
HY-159480 AD1058 Inhibitor 98.11% Unkown
HY-101963 AD80 Inhibitor 99.88% Unkown
HY-120417 JP-153 Inhibitor 99.45% Unkown
HY-108488 KB SRC 4 Inhibitor 99.22% Unkown
HY-136605 DGY-06-116 Inhibitor 98.62% Unkown
HY-163144 DAS-5-oCRBN Degrader 99.21% Unkown
HY-101795 Larixyl acetate Inhibitor 99.44% Unkown
HY-N0909 Notoginsenoside R2 Inhibitor 99.80% Unkown
HY-15805 KIN-8194 Inhibitor 99.26% Unkown
HY-131669 Dasatinib metabolite M6 Inhibitor 99.39% Unkown
HY-18622 PP58 Inhibitor 98.70% Unkown
HY-10181S Dasatinib-d8 Inhibitor 99.15% Unkown
HY-112182 UM-164 Inhibitor 98.74% Unkown
HY-146127A Grb2 SH2 domain inhibitor 1 TFA Inhibitor 99.62% Unkown
HY-108016 Peruvoside Inhibitor 99.32% Unkown
HY-13561 AZM475271 Inhibitor 99.89% Unkown
HY-10185 TG 100572 Hydrochloride Inhibitor 98.76% Unkown
HY-107447 N-Deshydroxyethyl Dasatinib Ligand 97.19% Unkown
HY-103274 PD180970 Inhibitor 99.27% Unkown
HY-15176C Pyridostatin trihydrochloride Inhibitor 99.85% Unkown
HY-107024 Osteogenic Growth Peptide (10-14) Inhibitor 99.51% Unkown
HY-13314 Tesevatinib Inhibitor 99.41% Yes
HY-N6596 7-Hydroxy-4H-chromen-4-one Inhibitor 99.85% Unkown
HY-15814 HG-7-85-01 Inhibitor 98.14% Unkown
HY-112291 SB 220025 Inhibitor 99.90% Unkown
HY-137345 DB-3-291 Degrader 99.08% Unkown
HY-127002 Squarunkin A Inhibitor 99.49% Unkown
HY-N4201 β-Hydroxyisovalerylshikonin Inhibitor 99.83% Unkown
HY-120595 JNJ-49095397 Inhibitor 99.55% Unkown
HY-P6442 Chemerin15 Inhibitor 99.65% Unkown
HY-137342 SB1-G-187 Degrader 98.70% Unkown
HY-108485 Damnacanthal Inhibitor 99.40% Unkown
HY-N4127 3'-Demethylnobiletin 99.98% Unkown
HY-13342AS Apatinib-d8 free base 92.5% Unkown
HY-13941B 1-Naphthyl PP1 hydrochloride Inhibitor 99.83% Unkown
HY-10644 Lck inhibitor 2 Inhibitor 99.73% Unkown
HY-120213 YH-306 Inhibitor 98.34% Unkown
HY-137918 TGF-βRI inhibitor 3 Inhibitor 99.16% Unkown
HY-155582 BLK degrader 1 Degrader 98.94% Unkown
HY-N7160 2-Hydroxy-3-methylanthraquinone Inhibitor 99.60% Unkown
HY-15324 PRT062607 acetate Inhibitor 99.83% Unkown
HY-132150A HPK1-IN-2 dihydrochloride Inhibitor 98.03% Unkown
HY-18507 AD57 Inhibitor 98.27% Unkown
HY-W013857 Lavendustin C Inhibitor 98.17% Unkown
HY-125028 Hck-IN-1 Inhibitor 98.10% Unkown
HY-N0046 Notoginsenoside Fe Inhibitor 99.99% Unkown
HY-176892A Papaveroline hydrochloride Inhibitor 99.04% Unkown
HY-163469 SRC-3-IN-2 Inhibitor 96.32% Unkown
HY-111187 KX2-361 Inhibitor 99.09% Unkown
HY-P1377A Caffeic acid-pYEEIE TFA 98.47% Unkown
HY-18623 VI 16832 Ligand 99.09% Unkown
HY-W744699 Larixol Inhibitor 95.52% Unkown
HY-P1111 Lyn peptide inhibitor Inhibitor 99.35% Unkown
HY-122949 Momordicine I Inhibitor 97.0% Unkown
HY-136849 TL13-68 Inhibitor 98.31% Unkown
HY-176461 Pro-Dasatinib Inhibitor / Unkown
HY-175451 MRT-10350 Degrader 99.10% Unkown
HY-12847 CCT241161 Inhibitor 99.77% Unkown
HY-156914 IGF-1R/SRC-IN-1 Inhibitor 99.86% Unkown
HY-147314 HIV-IN-6 98.14% Unkown
HY-P2547A Tyrosine Kinase Peptide 1 acetate 99.51% Unkown
HY-102073 TG53 Inhibitor 98.6% Unkown
HY-112345 PD-089828 Inhibitor 98.07% Unkown
HY-137343 DB-0646 Degrader 98.0% Unkown
HY-P10665 pYEEI Inhibitor 99.01% Unkown
HY-123298 Chrysotoxine Inhibitor 99.52% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-15764G A 419259 (GMP) Inhibitor / Unkown
HY-162676 SJ45566 Degrader 98.41% Unkown
HY-176892 Papaveroline Inhibitor / Unkown
HY-116028 15-deoxy-Δ12,14-Prostaglandin D2 Activator 98.0% Unkown
HY-155587 Hydroxy-PP Inhibitor 99.66% Unkown
HY-123506 Fenlean Inhibitor 99.56% Unkown
HY-10181G Dasatinib (GMP) Inhibitor / Unkown
HY-180888 Lck-IN-5 Inhibitor 98.09% Unkown
HY-138202 Lck-IN-1 Inhibitor 98.54% Unkown
HY-179433 PROTAC AR Degrader-12 Inhibitor / Unkown
HY-P11147 IL13Rα2 D1 Inhibitor 99.17% Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-12047S Ponatinib-d8 Inhibitor 99.16% Unkown
HY-10158S Bosutinib-d8 Inhibitor ≥99.0% Unkown
HY-16906 T338C Src-IN-2 Inhibitor 98.41% Unkown
HY-10181S1 Dasatinib-d4 Inhibitor 97.54% Unkown
HY-10184 TG 100572 Inhibitor / Unkown
HY-18237 KX1-004 Inhibitor 99.75% Unkown
HY-108649A MRS2768 tetrasodium salt Activator 98.70% Unkown
HY-117123 Convulxin Activator / Unkown
HY-118105 RK-20448 Inhibitor 99.38% Unkown
HY-16905 T338C Src-IN-1 Inhibitor / Unkown
HY-13805R PP2 (Standard) Inhibitor 99.05% Unkown
HY-10158S1 Bosutinib-13C,d3 Inhibitor / Unkown
HY-13024A Rebastinib tosylate Inhibitor / Unkown
HY-181050 DFCI-002-06 Degrader / Unkown
HY-157998 mG2N001 / Unkown
HY-112852A TL02-59 dihydrochloride Inhibitor / Unkown
HY-P2547 Tyrosine Kinase Peptide 1 / Unkown
HY-E70725 FRK Recombinant Human Active Protein Kinase / Unkown
HY-P10372 pFYN peptide / Unkown
HY-101268 CHMFL-ABL-053 Inhibitor / Unkown
HY-170971 Src Inhibitor 4 Inhibitor / Unkown
HY-10181GL Dasatinib (GMP Like) Inhibitor / Unkown
HY-162413 (R)-LW-Srci-8 Inhibitor / Unkown
HY-12299G WH-4-023 (GMP) Inhibitor / Unkown
HY-P1377 Caffeic acid-pYEEIE / Unkown
HY-127002A Squarunkin A hydrochloride Inhibitor / Unkown
HY-10363 AP 24149 Inhibitor / Unkown
HY-108649 MRS2768 Activator / Unkown
HY-178120 Lck-IN-4 Inhibitor / Unkown
HY-138195 NEO212 Inhibitor / Unkown
HY-P2372 P60v-src(137-157) Inhibitor / Unkown
HY-180834 Tyrosine kinase-IN-11 Inhibitor 98.75% Unkown
HY-P3743 p60c-src Substrate / Unkown
HY-110367 LCB 03-0110 dihydrochloride Inhibitor / Unkown
HY-182614 BJ-2302 Inhibitor / Unkown
HY-108487 N-Acetyl-O-phosphono-Tyr-Glu dipentylamide Inhibitor / Unkown
HY-123394 AP-22161 Inhibitor / Unkown
HY-168893 K882 Inhibitor / Unkown
HY-132150C HPK1-IN-2 TFA Inhibitor / Unkown
HY-182293 BTK-IN-48 Inhibitor / Unkown
HY-175281 SJ11646 Degrader / Unkown
HY-185227 EphB4-IN-1 Inhibitor / Unkown
HY-146014 Multi-kinase-IN-1 Inhibitor / Unkown
HY-E70862 Src-ZAP70 Recombinant Human Active Protein Kinase / Unkown
HY-168187 Src Inhibitor 3 Inhibitor / Unkown
HY-18507A AD57 hydrochloride Inhibitor / Unkown
HY-177272 HPK1-IN-61 Inhibitor / Unkown
HY-175845 Scr-IN-2 Inhibitor / Unkown
HY-125500 TOP1362 Inhibitor / Unkown
HY-110367A LCB 03-0110 Inhibitor / Unkown
HY-175809 SRT6 Inhibitor / Unkown
HY-112404 BCR-ABL-IN-13 Inhibitor 99.86% Unkown
HY-150026 Multi-kinase-IN-2 Inhibitor / Unkown
HY-183103 PDD-87 Inhibitor / Unkown
HY-121849 KL-1156 Inhibitor / Unkown
HY-163278 Lck-IN-2 Inhibitor / Unkown
HY-100824 PP2 Analog Inhibitor / Unkown
HY-125142 AP-24567 Inhibitor / Unkown
HY-179948 BTK-IN-45 Inhibitor / Unkown
HY-112369 LDDN-0003499 Inhibitor / Unkown
HY-114980 BMS-279700 Inhibitor / Unkown
HY-125718 MLS-2384 free base Inhibitor / Unkown
HY-101447 SI-2 Inhibitor / Unkown
HY-172096 cSRC/BCR-ABL-IN-1 Inhibitor / Unkown
HY-136699 Excisanin A Inhibitor / Unkown
HY-161687 Cisplatin/Dasatinib prodrug-1 Inhibitor / Unkown
HY-112335 Lck Inhibitor III Inhibitor / Unkown
HY-P1200A Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA Inhibitor / Unkown
HY-13314A Tesevatinib tosylate Inhibitor / Unkown
HY-116028S1 15-deoxy-Δ12,14-Prostaglandin D2-d4 Activator / Unkown
HY-P3773 p60c-src substrate II / Unkown
HY-122860 SKLB-C05 / Unkown
HY-176225 BY13 Degrader / Unkown
HY-176367 Multi kinase ligand 4 Inhibitor / Unkown
HY-175437 MRT-7612 Degrader / Unkown
HY-P2413 Ac-PPPHPHARIK-NH2 Inhibitor / Unkown
HY-149921 Antiangiogenic agent 3 Inhibitor / Unkown
HY-P3771 p60c-src substrate II, phosphorylated / Unkown
HY-112393 TX-1918 Inhibitor / Unkown
HY-W745090 Isomaltulose monohydrate Inhibitor / Unkown
HY-121828 TX-1123 Inhibitor / Unkown
HY-180928 LCK degrader-3 Degrader / Unkown
HY-162879 FAK inhibitor 7 Inhibitor / Unkown
HY-175298 STAT-3/c-Src-IN-1 Inhibitor / Unkown
HY-170958 Scr-IN-1 Inhibitor / Unkown
HY-178950 Hck-IN-3 Inhibitor / Unkown
HY-176194 Antifibrotic agent 1 Inhibitor / Unkown
HY-131931 Lysoganglioside-GM1 potassium Inhibitor / Unkown
HY-175916 LCK ligand-1 Ligand / Unkown
HY-163468 SRC-3-IN-1 Inhibitor / Unkown
HY-162291 Lck-IN-3 Inhibitor / Unkown
HY-10188 SKS-927 Inhibitor / Unkown
HY-E70726 FYN Y531F Recombinant Human Active Protein Kinase / Unkown
HY-160167 Birelentinib Inhibitor / Unkown
HY-112096S eCF506-d5 Inhibitor / Unkown
HY-183584 ARN25699 Inhibitor / Unkown
HY-W769935 5-POHSA Modulator / Unkown
HY-157290 HL403 Inhibitor / Unkown
HY-18692 Multi-kinase-IN-12 Inhibitor / Unkown
HY-P1111A Lyn peptide inhibitor TFA Inhibitor / Unkown
HY-10158AR Bosutinib hydrate (Standard) Inhibitor / Unkown
HY-175280 Lck degrader-1 Degrader / Unkown
HY-128397 CpCDPK1/TgCDPK1-IN-1 Inhibitor / Unkown
HY-115723 Antiallergic agent-1 Inhibitor / Unkown
HY-125387 TOP1210 / Unkown
HY-157497 DA5-HTL Inhibitor 98.69% Unkown
HY-P0200 RR-SRC / Unkown
HY-P1200 Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH Inhibitor / Unkown
HY-184274 EGFR/c-SRC-IN-1 Chemical / Unkown
HY-180938 Fyn-IN-1 Inhibitor / Unkown
HY-168901 Hck-IN-2 Inhibitor / Unkown
HY-W844558 Protein kinase inhibitor 11 Inhibitor 98.28% Unkown
HY-P10527 CSK substrate / Unkown
HY-139890 DC-Srci-6649 Inhibitor / Unkown
HY-15268 PP487 Inhibitor / Unkown
HY-175463 LCK degrader-2 Degrader / Unkown
HY-135216 Antiproliferative agent-54 Inhibitor / Unkown
HY-131931A Lysoganglioside-GM1 ammonium Inhibitor / Unkown
HY-W062835A CGP77675 hydrate Inhibitor / Unkown
HY-181732 PROTAC TG2 Degrader-3 Modulator / Unkown
HY-W714853 (+)-Theta-cypermethrin Ligand / Unkown
HY-112448 Lck-IN-6 Inhibitor / Unkown
HY-175193 N-Deshydroxyethyl Dasatinib-C3-NH2 Inhibitor / Unkown
HY-N0442R 5-O-Methylvisammioside (Standard) Inhibitor / Unkown
HY-N12166 2,3,4,6,8-Pentahydroxy-1-methylxanthone Inhibitor / Unkown
HY-122585 proMMP-9 inhibitor-3c Inhibitor / Unkown
HY-171217 TG-100435 Inhibitor / Unkown
HY-W700620 Hydroxymethyl dasatinib Inhibitor 99.92% Unkown
HY-D3058 FITC-amide-C2 Lck inhibitor 2 Inhibitor / Unkown
HY-N14271 Hibarimicin B Inhibitor / Unkown
HY-N14267 Hibarimicin A Inhibitor / Unkown
HY-164527 Si306 Inhibitor / Unkown
HY-18909 Multi-kinase-IN-11 Inhibitor / Unkown
HY-164530 SKLB646 Inhibitor / Unkown
HY-178014 SIK1-IN-1 Inhibitor / Unkown
HY-171218 CGP062464 Inhibitor / Unkown
HY-N14689 Hibarimicin D Inhibitor / Unkown
HY-133184 Aminogenistein Inhibitor / Unkown
HY-W994722 ISO24 Ligand / Unkown
HY-136622 A-420983 Inhibitor / Unkown
HY-120622 BMS-243117 Inhibitor / Unkown
HY-10234S Saracatinib-d3 Inhibitor / Unkown
HY-N14279 Hibarimicin G Inhibitor / Unkown
HY-32718S Pelitinib-d6 / Unkown
HY-112852S TL02-59-d5 / Unkown
HY-112291A SB 220025 (tri(hydrochloride)) Inhibitor / Unkown
HY-N14273 Hibarimicin C Inhibitor / Unkown
HY-160930 TOP1288 Inhibitor / Unkown
HY-N15076 Herbimycin B Inhibitor / Unkown
HY-N14618 Rhodomycin A Inhibitor / Unkown
HY-169670 Protein kinase inhibitor 13 Inhibitor / Unkown
HY-125064 AP22408 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SRC NCBI NCBI:6714