FES - FES proto-oncogene, tyrosine kinase Gene
Also Known as FPS
Species: Homo sapiens
About FES
This gene has 17 transcripts (splice variants), 193 orthologues, 32 paralogues and is associated with 56 phenotypes. Broad expression in spleen (RPKM 39.1), bone marrow (RPKM 25.6) and 23 other tissues.
Summary
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
FES Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001143783.1 | NP_001137255.1 | tyrosine-protein kinase Fes/Fps isoform 2 |
| NM_001143784.1 | NP_001137256.1 | tyrosine-protein kinase Fes/Fps isoform 3 |
| NM_001143785.2 | NP_001137257.1 | tyrosine-protein kinase Fes/Fps isoform 4 |
| NM_002005.4 | NP_001996.1 | tyrosine-protein kinase Fes/Fps isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables immunoglobulin receptor binding |
IDA
IDA: Inferred from direct assay
|
19001085 | GOA |
| enables non-membrane spanning protein tyrosine kinase activity |
IDA
IDA: Inferred from direct assay
|
15485904 | GOA |
| enables phosphatidylinositol binding |
IDA
IDA: Inferred from direct assay
|
19001085 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
18046454 | GOA |
| enables protein tyrosine kinase activity |
IDA
IDA: Inferred from direct assay
|
11509660 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
11339827 | GOA |
| located in cytoplasmic side of plasma membrane |
IDA
IDA: Inferred from direct assay
|
18046454 | GOA |
| colocalizes with cytoplasmic vesicle |
IDA
IDA: Inferred from direct assay
|
11339827 | GOA |
| located in focal adhesion |
IDA
IDA: Inferred from direct assay
|
18046454 | GOA |
| located in microtubule cytoskeleton |
IDA
IDA: Inferred from direct assay
|
15485904 | GOA |
FES Protein Structure
FCH: Fes/CIP4, and EFC/F-BAR homology domain (1 - 94)
SH2: SH2 domain (460 - 529)
Pkinase_Tyr: Protein tyrosine kinase (561 - 814)
- 0
- 200
- 400
- 600
- 822 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
tyrosine-protein kinase Fes/Fps |
|
FES Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
FES | P07332 | EZR | Homo sapiens | P15311 | 18046454 | |
|
Intra
|
FES | P07332 | EZR | Homo sapiens | P15311 | 18046454 | |
|
Intra
|
FES | P07332 | KIT | Homo sapiens | P10721 | 24728074 | |
|
Intra
|
FES | P07332 | DSP | Homo sapiens | P15924 | 32707033 | |
|
Intra
|
FES | P07332 | GAB1 | Homo sapiens | Q13480 | 24728074 | |
|
Intra
|
FES | P07332 | AR | Homo sapiens | P10275 | 24728074 | |
|
Intra
|
FES | P07332 | TERF1 | Homo sapiens | P54274 | 21044950 |
Recombinant FES Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P73050 | FES Protein, Human (Active, sf9, His-GST) | P07332-1 (M1-R822) | ≥ 80%, as determined by reducing SDS-PAGE. |
FES Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83075 | FES Antibody (YA2820) | WB | Human |
| HY-P83075A | FES Antibody (YA2820)(PBS only) | WB | Human |
| HY-P85159 | FES Antibody (YA4851) | WB, IHC-P, ICC/IF, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Sarcoma |
|
|
| Myeloid Leukemia |
|
|
| Leukemia |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Ewing Sarcoma Of Bone |
|
|
| Myopathy, Centronuclear, 2 |
|
|
| Melanoma |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Prostate Cancer |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | FES | MGD | MGI:95514 |
| Bos taurus | FES | VGNC | VGNC:28954 |
| Macaca mulatta | FES | VGNC | VGNC:72637 |
| Rattus norvegicus | FES | RGD | RGD:1564385 |
| Felis catus | FES | VGNC | VGNC:62232 |
| Canis familiaris | FES | VGNC | VGNC:40825 |
| Others | FES | NCBI |