Ahr - aryl-hydrocarbon receptor Gene

Also Known as Ah; In; Ahh; Ahre; bHLHe76

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11622

Summary

The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing Enzymes such as Cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Ahr Products (2)

mRNA	Protein	Name
NM_001314027.1	NP_001300956.1	aryl hydrocarbon receptor isoform 2
NM_013464.4	NP_038492.1	aryl hydrocarbon receptor isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	1313028	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	1313028	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18223155	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	20106950	MGI
enables aryl hydrocarbon receptor binding	IPI IPI: Inferred from physical interaction	24001774	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	24001774	MGI
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	1314586	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8657146	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	24001774	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11230806	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	24001774	MGI
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	15581363	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1605850	MGI
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28396409	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in B cell homeostasis	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in T cell homeostasis	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in blood circulation	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in blood vessel development	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in camera-type eye development	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in cardiac left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	14644620	MGI
involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine	IDA IDA: Inferred from direct assay	33436590	MGI
involved in cellular response to 3-methylcholanthrene	IDA IDA: Inferred from direct assay	1314586	MGI
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	20106950	MGI
involved in circumferential growth involved in left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	14644620	MGI
acts upstream of or within gland development	IMP IMP: Inferred from mutant phenotype	12151645	MGI
involved in glomerulus morphogenesis	IMP IMP: Inferred from mutant phenotype	14644620	MGI
involved in immune system process	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in kidney morphogenesis	IMP IMP: Inferred from mutant phenotype	14644620	MGI
involved in liver development	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in lymphocyte homeostasis	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20106950	MGI
involved in negative regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	14644620	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18223155	MGI
involved in negative regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	14644620	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1313028	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20106950	MGI
acts upstream of or within positive regulation of RNA polymerase II transcription preinitiation complex assembly	IDA IDA: Inferred from direct assay	8215422	MGI
involved in positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	10973493	MGI
involved in positive regulation of growth rate	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in post-embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	8692887	MGI
acts upstream of or within prostate gland development	IMP IMP: Inferred from mutant phenotype	12151645	MGI
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1314586	MGI
acts upstream of or within reproductive structure development	IMP IMP: Inferred from mutant phenotype	12151645	MGI
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	7961644	MGI
involved in spleen development	IMP IMP: Inferred from mutant phenotype	7732381	MGI
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1314586	MGI
involved in vasculature development	IMP IMP: Inferred from mutant phenotype	16443691	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12215427	MGI
located in cytosol	IDA IDA: Inferred from direct assay	17569696	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	33436590	MGI
located in nucleus	IDA IDA: Inferred from direct assay	1314586	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
aryl hydrocarbon receptor	ah receptor dioxin receptor

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109044	Tapinarof	Agonist	99.95%	Unkown
HY-A0083	Methacholine chloride	Agonist	≥98.0%	Yes
HY-N0178	Diosmin	Agonist	98.62%	Yes
HY-B0311	Carbidopa	Modulator	99.84%	Yes
HY-W017113	2-Mercaptobenzothiazole		99.85%	Yes
HY-B0311A	Carbidopa monohydrate	Modulator	99.84%	Yes
HY-B0678	Metaxalone		99.77%	Unkown
HY-17357	Nepafenac	Inhibitor	99.56%	Unkown
HY-17479	Amfenac		/	Unkown
HY-A0083B	Methacholine bromide	Agonist	/	Unkown
HY-B0678R	Metaxalone (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0170	Indole-3-carbinol		99.16%	Phase 3
HY-B2132	Tryptamine		99.89%	Phase 3
HY-W013053	Dibenz[a,h]anthracene	Inducer	98.0%	Phase 3
HY-15001	Stemregenin 1	Antagonist	99.95%	Phase 2
HY-16031B	AFP464 dihydrochloride		99.45%	Phase 2
HY-16031	AFP464 free base		/	Phase 2
HY-16031A	AFP464		/	Phase 2
HY-135829	BAY 2416964	Antagonist	99.59%	Phase 1
HY-111449	BAY-218	Antagonist	99.78%	Phase 1
HY-N0170R	Indole-3-carbinol (Standard)		98.31%	Phase 1
HY-136220	AHR antagonist 5	Antagonist	98.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (169)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12684	CH-223191	Antagonist	99.82%	Unkown
HY-12028	PD98059		99.94%	Unkown
HY-15484	Pifithrin-α hydrobromide		99.94%	Unkown
HY-12451	FICZ	Agonist	99.42%	Unkown
HY-W028393	Indole-3-pyruvic acid	Agonist	99.55%	Unkown
HY-19317	ITE	Agonist	99.27%	Unkown
HY-102023	GNF351	Antagonist	99.87%	Unkown
HY-W011910	Potassium 1H-indol-3-yl sulfate		99.95%	Unkown
HY-W015273A	trans-3-Indoleacrylic acid	Inhibitor	99.77%	Unkown
HY-114740	β-Naphthoflavone		99.86%	Unkown
HY-W007355	Skatole		99.99%	Unkown
HY-141609	IK-175	Inhibitor	99.89%	Unkown
HY-122208	SGA360	Inhibitor	99.93%	Unkown
HY-133677	Mono(2-ethyl-5-hydroxyhexyl) phthalate		99.03%	Unkown
HY-103220	6,2',4'-Trimethoxyflavone	Antagonist	98.02%	Unkown
HY-W011338	Benzyl butyl phthalate	Activator	97.0%	Unkown
HY-134217	KYN-101	Inhibitor	98.03%	Unkown
HY-119019	ASB14780	Inhibitor	99.58%	Unkown
HY-B0845	Prochloraz		99.85%	Unkown
HY-W014502	D-Kynurenine	Agonist	99.94%	Unkown
HY-W014075	1-Hydroxypyrene		99.38%	Unkown
HY-103221	MeBIO		98.0%	Unkown
HY-18619	YL-109	Modulator	98.91%	Unkown
HY-132429S	Potassium 1H-indol-3-yl sulfate-d5		99.77%	Unkown
HY-112628	CAY10464	Antagonist	99.77%	Unkown
HY-N1939	Icariside I		98.76%	Unkown
HY-144339	AhR agonist 2		99.89%	Unkown
HY-135750	VAF347	Agonist	99.75%	Unkown
HY-12545	Brevetoxin-3	Activator	95.0%	Unkown
HY-112629	PDM2	Antagonist	98.96%	Unkown
HY-117532	PenCB	Inducer	99.82%	Unkown
HY-77278	25-Hydroxytachysterol3	Agonist	98.07%	Unkown
HY-15001G	Stemregenin 1 (GMP)	Antagonist	/	Unkown
HY-N0914	Ajugol		99.80%	Unkown
HY-111450	CB7993113	Antagonist	98.0%	Unkown
HY-D0932	Sudan IV		98.0%	Unkown
HY-G0006	Omeprazole sulfide		99.88%	Unkown
HY-W014701	1,4-Dihydroxy-2-naphthoic acid		99.60%	Unkown
HY-117102	ANI-7	Activator	99.01%	Unkown
HY-G0007	Omeprazole sulfone	Control	99.23%	Unkown
HY-118438	10-Cl-BBQ	Agonist	99.46%	Unkown
HY-W718300	Indole-3-pyruvic acid-d5		96.31%	Unkown
HY-W011910S	Potassium 1H-indol-3-yl sulfate-d4	Activator	99.9%	Unkown
HY-17663	KMR-206		98.86%	Unkown
HY-W011338S	Benzyl butyl phthalate-d4		98.38%	Unkown
HY-N0586A	Norisoboldine hydrochloride	Agonist	99.72%	Unkown
HY-124421	5F-203	Inducer	98.04%	Unkown
HY-RS00483	AHR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-B0973	Dibenzothiophene	Inhibitor	99.92%	Unkown
HY-112627	CAY 10465	Agonist	98.30%	Unkown
HY-114682	Lenperone	Antagonist	98.11%	Unkown
HY-N4095	Brevifolincarboxylic acid	Inhibitor	99.90%	Unkown
HY-130256	β-NF-JQ1	Degrader	98.05%	Unkown
HY-105791	Sulazepam		99.56%	Unkown
HY-147128	PY109	Agonist	99.15%	Unkown
HY-34505	1-Methyl-5-pyrazolecarboxylic acid		99.83%	Unkown
HY-W012278	Benz[a]anthracene	Ligand	99.90%	Unkown
HY-111441	1,4-Chrysenequinone	Activator	99.97%	Unkown
HY-120377	CYP1A1 inhibitor 8a	Inhibitor	98.00%	Unkown
HY-124404	12(R)-HETE		99.90%	Unkown
HY-125019	iJak-381	Inhibitor	99.86%	Unkown
HY-135831	AHR antagonist 2	Antagonist	99.30%	Unkown
HY-B0311AS	Carbidopa-d3 monohydrate	Modulator	98.53%	Unkown
HY-W014075S	1-Hydroxypyrene-d9		99.95%	Unkown
HY-W764758	3-OH-Kynurenamine dihydroiodide	Activator	99.56%	Unkown
HY-12028R	PD98059 (Standard)		99.72%	Unkown
HY-103222	DiMNF	Modulator	98.46%	Unkown
HY-103223	Phortress	Inducer	98.19%	Unkown
HY-N0586	Norisoboldine	Agonist	99.65%	Unkown
HY-W251708	AHR 10240		/	Unkown
HY-114740R	β-Naphthoflavone (Standard)		99.49%	Unkown
HY-RS16533	Ahr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-100242	Mivotilate	Activator	99.58%	Unkown
HY-104026CS	L-Kynurenine-13C10 sulfate hemihydrate	Agonist	99.90%	Unkown
HY-118474	GW 610	Activator	99.78%	Unkown
HY-118780	CHD-5	Antagonist	98.0%	Unkown
HY-17357S	Nepafenac-d5	Inhibitor	98.84%	Unkown
HY-N10123	Indolokine A5	Agonist	98.0%	Unkown
HY-N6264	26-Deoxyactein	Inhibitor	99.76%	Unkown
HY-W014502R	D-Kynurenine (Standard)	Agonist	99.99%	Unkown
HY-W046846	Corannulene	Agonist	97.31%	Unkown
HY-W338764	AHR agonist 3		99.79%	Unkown
HY-133677S	Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4		96.23%	Unkown
HY-154825	20-Hydroxyvitamin D3		≥98.0%	Unkown
HY-W095381	N-Methylscatole	Agonist	98.45%	Unkown
HY-131340	LASSBio-1632	Inhibitor	/	Unkown
HY-136220A	AHR antagonist 5 hemimaleate	Antagonist	/	Unkown
HY-101745B	Rocastine fumarate		/	Unkown
HY-101802	Fluzinamide		/	Unkown
HY-104026B	L-Kynurenine sulfate	Agonist	/	Unkown
HY-106487	Pridefine	Inhibitor	/	Unkown
HY-111157	Dezinamide		/	Unkown
HY-114682A	Lenperone hydrochloride	Antagonist	/	Unkown
HY-116148	AHR-11797		/	Unkown
HY-116638	AHR-5333	Inhibitor	/	Unkown
HY-116638A	AHR-5333 mandelate	Inhibitor	/	Unkown
HY-117774	AHR-2244 hydrochloride		/	Unkown
HY-118792	AHR activator 1		/	Unkown
HY-119018	AHR-6293	Inhibitor	/	Unkown
HY-119960	AHR-10037	Inhibitor	/	Unkown
HY-120677	AHR-15010	Inhibitor	/	Unkown
HY-123432	AHR-13268D	Inhibitor	/	Unkown
HY-123461	Sul-121 hydrochloride	Inhibitor	/	Unkown
HY-124021	Benzyl 2-naphthyl ether		99.44%	Unkown
HY-125926A	(S)-2-Ketodoxapram		/	Unkown
HY-125926S	2-Ketodoxapram-d5		/	Unkown
HY-129305	Tampramine fumarate	Inhibitor	/	Unkown
HY-130269	β-Naphthoflavone-CH2-OH		/	Unkown
HY-130270	AhR Ligand-Linker Conjugates 1		/	Unkown
HY-130842	β-Naphthoflavone-CH2-Br		/	Unkown
HY-132974	Aminoflavone		/	Unkown
HY-135671	AhR modulator-1		/	Unkown
HY-135830	AHR antagonist 4	Antagonist	/	Unkown
HY-136876	AHR-12234 citrate		/	Unkown
HY-136891	AHR-16303B		/	Unkown
HY-139117	6,2′,4′-Trimethoxyflavone	Antagonist	/	Unkown
HY-155505	AHR agonist 4	Agonist	/	Unkown
HY-156908	3-OH-Kynurenamine	Activator	/	Unkown
HY-158167	AhR agonist 5	Agonist	/	Unkown
HY-158168	AhR agonist 6	Agonist	/	Unkown
HY-158169	AhR agonist 7	Agonist	/	Unkown
HY-161649	hCYP1B1-IN-2	Inhibitor	/	Unkown
HY-168033	AhR agonist 8	Agonist	/	Unkown
HY-169753	AHR-IN-1	Inhibitor	/	Unkown
HY-173393	LXRα agonist 1	Agonist	/	Unkown
HY-17479B	Amfenac sodium		/	Unkown
HY-175785	X15695		98.45%	Unkown
HY-176771	Tapinarof prodrug-1		/	Unkown
HY-178053	AHR agonist 10		/	Unkown
HY-181472	10(11)-Cl-BBQ		/	Unkown
HY-181629	ZSTK3744		/	Unkown
HY-181629A	ZSTK3744 hydrochloride		/	Unkown
HY-182495	Penisimplicissin	Inhibitor	/	Unkown
HY-19826	Isofistularin-3		/	Unkown
HY-A0083C	Methacholine iodide	Agonist	/	Unkown
HY-B0311D	Carbidopa hydrochloride	Modulator	/	Unkown
HY-B0311S1	Carbidopa-d3-1	Modulator	/	Unkown
HY-B0678S	Metaxalone-d3		98.0%	Unkown
HY-B0678S1	Metaxalone-d6		/	Unkown
HY-B0973S	Dibenzothiophene-d8	Inhibitor	/	Unkown
HY-G0007S	Omeprazole sulfone-d3	Control	/	Unkown
HY-G0007S1	Omeprazole sulfone-13C,d3	Control	/	Unkown
HY-N12537A	(2R,3S)-PD-1/PD-L1-IN-38		/	Unkown
HY-N16465	Cinnamtannin D1	Inhibitor	/	Unkown
HY-W716464	Prochloraz-d7		/	Unkown
HY-101745	Rocastine	Antagonist	/	Unkown
HY-104026BS	L-Kynurenine-13C10 sulfate	Agonist	/	Unkown
HY-107063	AHR-1911	Activator	99.66%	Unkown
HY-109044S	Tapinarof-d5	Agonist	/	Unkown
HY-118910	AHR-14310C	Antagonist	/	Unkown
HY-119991	AHR-9294	Inhibitor	/	Unkown
HY-125926S1	2-Ketodoxapram-d4		/	Unkown
HY-128229	AHR antagonist 6	Antagonist	/	Unkown
HY-129247	Versicolorin A		/	Unkown
HY-130456	AHR 10718	Inhibitor	/	Unkown
HY-148637	Picoberin	Agonist	/	Unkown
HY-163665	AHR antagonist 8		/	Unkown
HY-167214	(+)-Ketodoxapram		/	Unkown
HY-170514	1,2,3,7,8,9-Hexachlorodibenzofuran	Ligand	/	Unkown
HY-177563	AhR modulator-2	Activator	/	Unkown
HY-20888	3'-Methoxy-4'-nitroflavone		/	Unkown
HY-B0845R	Prochloraz (Standard)		/	Unkown
HY-D0932S	Sudan IV-d6		/	Unkown
HY-N16435	Plumericin		/	Unkown
HY-RS22964	Ahr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-U00010	Dazopride		/	Unkown
HY-W007355S2	Skatole-13C6		/	Unkown
HY-W587465	9,10-Dichlorophenanthrene		/	Unkown
HY-W714200	Neburon		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ahr	NCBI	NCBI:196