Lox - lysyl oxidase Gene

Also Known as rrg; TSC-160

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16948

Summary

This gene encodes a precursor protein that belongs to the Lysyl Oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of Collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Lox Products (3)

mRNA Protein Name
NM_001286181.1 NP_001273110.1 protein-lysine 6-oxidase preproprotein
NM_001286182.1 NP_001273111.1 protein-lysine 6-oxidase preproprotein
NM_010728.4 NP_034858.2 protein-lysine 6-oxidase preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16251195 MGI
enables protein-lysine 6-oxidase activity IDA
IDA: Inferred from direct assay
14140 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
19458888 MGI
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within ascending aorta development IMP
IMP: Inferred from mutant phenotype
28550176 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
12417550 MGI
involved in blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
27432961 MGI
acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
19458888 MGI
acts upstream of or within cell chemotaxis IMP
IMP: Inferred from mutant phenotype
18586678 MGI
acts upstream of or within cellular response to chemokine IMP
IMP: Inferred from mutant phenotype
18586678 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
26700732 MGI
acts upstream of or within connective tissue development IGI
IGI: Inferred from genetic interaction
25715398 MGI
acts upstream of or within descending aorta development IMP
IMP: Inferred from mutant phenotype
28550176 MGI
acts upstream of or within elastic fiber assembly IMP
IMP: Inferred from mutant phenotype
12417550 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
16192629 MGI
acts upstream of or within muscle cell cellular homeostasis IGI
IGI: Inferred from genetic interaction
25715398 MGI
acts upstream of or within muscle cell development IMP
IMP: Inferred from mutant phenotype
25715398 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
28538980 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
28538980 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
19458888 MGI
acts upstream of or within platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: Inferred from mutant phenotype
18586678 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
28538980 MGI
acts upstream of or within regulation of bone development IMP
IMP: Inferred from mutant phenotype
21665949 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28285904 MGI
acts upstream of or within regulation of megakaryocyte differentiation IMP
IMP: Inferred from mutant phenotype
21665949 MGI
acts upstream of or within regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: Inferred from mutant phenotype
21665949 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
18835815 MGI
acts upstream of or within regulation of receptor binding IMP
IMP: Inferred from mutant phenotype
18586678 MGI
acts upstream of or within regulation of striated muscle tissue development IMP
IMP: Inferred from mutant phenotype
25715398 MGI
acts upstream of or within regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25715398 MGI
Cellular Component GO Annotation Evidence References Source
part of collagen trimer IDA
IDA: Inferred from direct assay
7901452 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
9382709 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
27432961 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein-lysine 6-oxidase

  • ras excision protein

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13948 Angiotensin II human 99.98% Unkown
HY-13948A Angiotensin II human acetate 99.81% Unkown
HY-A0060 Malotilate Inhibitor 99.47% Unkown
HY-13948B Angiotensin II human TFA 98.29% Unkown

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-105028 Tenidap 99.93% Phase 3
HY-105024 FPL 62064 Inhibitor 99.25% Phase 3
HY-106835 Flobufen Inhibitor / Phase 3
HY-N0198 Nordihydroguaiaretic acid 99.93% Phase 2
HY-117048 PF-4191834 Inhibitor 99.48% Phase 2
HY-138625B PXS-5505 Inhibitor / Phase 2
HY-B1452 Licofelone 99.84% Phase 1

Pre-clinical Phase

Bioactive Molecules (171)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Y1750 β-Aminopropionitrile Inhibitor 99.99% Unkown
HY-12341 ML355 Inhibitor 98.11% Unkown
HY-N0551 Wedelolactone 99.93% Unkown
HY-138153 JKE-1674 99.97% Unkown
HY-111310 ML351 Inhibitor 99.16% Unkown
HY-23999 BI-0115 99.72% Unkown
HY-113439 12-HETE Inhibitor 95.70% Unkown
HY-138625 PXS-5505 free base Inhibitor 99.97% Unkown
HY-42484 ER-076349 Inhibitor 99.72% Unkown
HY-138625A PXS-5505 anhydrous Inhibitor 99.90% Unkown
HY-N0232 Psoralidin 99.90% Unkown
HY-N2176 S-(+)-Marmesin Inhibitor 99.9% Unkown
HY-108448 N-Oleoyldopamine 99.47% Unkown
HY-N0493 Pectolinarigenin 99.98% Unkown
HY-N1996 Chebulagic acid Inhibitor 99.85% Unkown
HY-N7108 7-Hydroxyflavone 99.89% Unkown
HY-N2056 11-​Keto-​beta-​boswellic acid Inhibitor 99.90% Unkown
HY-13568 Benoxaprofen Inhibitor 99.03% Unkown
HY-138989 15-LOX-1 inhibitor 1 Inhibitor 98.81% Unkown
HY-W020955 Triphenylphosphinechlorogold 99.93% Unkown
HY-113884B (S)-Coriolic acid Activator 99.0% Unkown
HY-N1881 4',5-Dihydroxyflavone Inhibitor 99.95% Unkown
HY-170538 SNT-5382 Inhibitor 99.96% Unkown
HY-10439 HPGDS inhibitor 1 Inhibitor 99.42% Unkown
HY-133159 Resolvin E2 98.5% Unkown
HY-151499A PXS-6302 hydrochloride Inhibitor 99.57% Unkown
HY-W010144 Phenidone Inhibitor 98.96% Unkown
HY-126421 Kansuinine A 99.81% Unkown
HY-N10549 Gigantol 99.79% Unkown
HY-151498A PXS-4787 hydrochloride Inhibitor 99.71% Unkown
HY-171955 LXG6403 99.85% Unkown
HY-W009248 Phenethyl ferulate Inhibitor 99.66% Unkown
HY-124108 Eicosatetraynoic acid Inhibitor 99.9% Unkown
HY-N1942 5-O-Demethylnobiletin Inhibitor 99.91% Unkown
HY-W041193 3-Hydroxy-2-pyrone Inhibitor 99.61% Unkown
HY-113439S 12-HETE-d8 Inhibitor 98.03% Unkown
HY-128171 Diflapolin Inhibitor 99.33% Unkown
HY-139196 ThioLox Inhibitor 99.74% Unkown
HY-170573A LOXL2-IN-1 tosylate Inhibitor 99.90% Unkown
HY-N3270 Methyl orsellinate Inhibitor 99.91% Unkown
HY-N7012 7,3',4'-Tri-O-methylluteolin 99.28% Unkown
HY-124674A CCT365623 hydrochloride 98.07% Unkown
HY-138939 5-LOX-IN-2 Inhibitor 98.12% Unkown
HY-149922 DKI5 Inhibitor 98.12% Unkown
HY-169021 JNK-1-IN-3 Inhibitor 98.44% Unkown
HY-127170 3-Hydroxycoumarin Inhibitor 99.30% Unkown
HY-W089800 trans-2-Nonenal 98.99% Unkown
HY-111140 YS121 99.74% Unkown
HY-118480 4-MMPB 98.54% Unkown
HY-121585 CAY10698 Inhibitor 99.28% Unkown
HY-Y1750A β-Aminopropionitrile hydrochloride Inhibitor 99.76% Unkown
HY-155244 12R-LOX-IN-2 Inhibitor 99.85% Unkown
HY-W028263 6-Hydroxyflavanone Inhibitor 99.87% Unkown
HY-116124 17(S)-HpDHA 99.48% Unkown
HY-116919 MLS000536924 Inhibitor 98.20% Unkown
HY-118110 MLS000545091 Inhibitor 99.92% Unkown
HY-125770 5(S)​-​HPETE 98.0% Unkown
HY-125975 1-Naphthyl 3,5-dinitrobenzoate Inhibitor 99.49% Unkown
HY-139055 NCTT-956 Inhibitor 97% Unkown
HY-148134 5-LOX-IN-1 Inhibitor 98.04% Unkown
HY-151498 PXS-4787 Inhibitor / Unkown
HY-151499 PXS-6302 Inhibitor / Unkown
HY-158204 CNB-001 Inhibitor / Unkown
HY-N1965 Gaultherin Inhibitor 99.44% Unkown
HY-P2976 Lipoxygenase, general / Unkown
HY-W488004 KKII5 Inhibitor 98.60% Unkown
HY-N9551 Eriodictyol chalcone Inhibitor 97.25% Unkown
HY-U00308 5-LOX-IN-4 Inhibitor 98.06% Unkown
HY-W009671 3-Chloroiminodibenzyl Inhibitor 99.60% Unkown
HY-105504 CI-986 Inhibitor / Unkown
HY-111033 RO5068760 / Unkown
HY-114796 tHGA Inhibitor / Unkown
HY-114873 LY256548 Inhibitor / Unkown
HY-116763 COX-2/5-LOX-IN-4 Inhibitor / Unkown
HY-116866 Sclerotiorin Inhibitor / Unkown
HY-117317 BLX-2477 Inhibitor / Unkown
HY-117514 5-LOX-IN-7 Inhibitor / Unkown
HY-118506 BRP-7 Inhibitor / Unkown
HY-119462 Tagorizine Inhibitor / Unkown
HY-120502 5-LOX-IN-6 Inhibitor / Unkown
HY-124674 CCT365623 / Unkown
HY-124722 OHM1 Inhibitor / Unkown
HY-145473 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE / Unkown
HY-146294 COX-2/5-LOX-IN-1 Inhibitor / Unkown
HY-146295 COX-2/5-LOX-IN-2 / Unkown
HY-147870 COX-2-IN-22 Inhibitor / Unkown
HY-147951 COX-2/5-LOX-IN-3 Inhibitor / Unkown
HY-149269 COX-2-IN-30 Inhibitor / Unkown
HY-149270 COX-2-IN-31 Inhibitor / Unkown
HY-149476 5-LOX-IN-5 Inhibitor / Unkown
HY-150548 COX-2/15-LOX-IN-1 Inhibitor / Unkown
HY-150550 COX-2-IN-26 Inhibitor / Unkown
HY-150551 COX-2-IN-27 Inhibitor / Unkown
HY-150553 COX-2-IN-28 Inhibitor / Unkown
HY-151173 XO/COX/LOX-IN-1 Inhibitor / Unkown
HY-151426 Anticancer agent 83 Inducer / Unkown
HY-153279 5-LOX-IN-3 Inhibitor / Unkown
HY-153930 h15-LOX-2 inhibitor 1 Inhibitor / Unkown
HY-155123 Antioxidant agent-13 Inhibitor / Unkown
HY-155159 COX-2/15-LOX-IN-2 Inhibitor / Unkown
HY-155160 COX-2/15-LOX-IN-3 Inhibitor / Unkown
HY-155161 COX-2/15-LOX-IN-4 Inhibitor / Unkown
HY-155243 12R-LOX-IN-1 Inhibitor / Unkown
HY-155409 ALR-38 Antagonist / Unkown
HY-155522 WES-1 Inhibitor / Unkown
HY-156329 sEH/FLAP-IN-1 Inhibitor / Unkown
HY-159169 5-LOX/sEH-IN-1 Inhibitor / Unkown
HY-161315 15-LOX-IN-1 Inhibitor / Unkown
HY-162166 COX-2/15-LOX/mPGES1-IN-1 Inhibitor / Unkown
HY-162523 hMAO-B-IN-8 Inhibitor / Unkown
HY-162830 5-LOX/MAOs-IN-1 Inhibitor / Unkown
HY-163187 COX-2/LOX-IN-1 Inhibitor / Unkown
HY-163188 COX-2/LOX-IN-2 Inhibitor / Unkown
HY-163355 COX-2/15-LOX-IN-5 Inhibitor / Unkown
HY-163736 mPGES-1/5-LOX-IN-1 Inhibitor / Unkown
HY-168340 COX-2/15-LOX-IN-6 Inhibitor / Unkown
HY-168632 Topoisomerase I/II inhibitor 6 / Unkown
HY-170573 LOXL2-IN-1 Inhibitor / Unkown
HY-170938 AChE-IN-82 Inhibitor / Unkown
HY-170957 5-LOX/NO-IN-1 Inhibitor / Unkown
HY-172790 Cbz-(S,S)-Pro-Pro-allyl Inhibitor / Unkown
HY-172877 EGFR/BRAFV600E-IN-5 / Unkown
HY-173056 Ruthenoleuton Inhibitor / Unkown
HY-173115 15-LOX-IN-2 / Unkown
HY-173180 5-LOX-IN-8 Inhibitor / Unkown
HY-173332 15-LOX-1 inhibitor 2 Inhibitor / Unkown
HY-175034 Topoisomerase I/II-IN-1 / Unkown
HY-175245 hCA-IN-1 Inhibitor / Unkown
HY-175970 MLS000099089 Inhibitor / Unkown
HY-179021 COX-2/15-LOX-IN-7 Inhibitor / Unkown
HY-179441 sEH/FLAP-IN-2 Inhibitor / Unkown
HY-180363 E 6080 Inhibitor / Unkown
HY-180581 LOXL2/sGC modulator-1 / Unkown
HY-181044 COX-2/5-LOX-IN-6 Inhibitor / Unkown
HY-181061 COX/5-LO-IN-2 / Unkown
HY-181273 COX-2/5-LOX-IN-7 Inhibitor / Unkown
HY-183764 COX-2/5-LOX-IN-8 Inhibitor / Unkown
HY-B1452S1 Licofelone-d6 / Unkown
HY-N16694 6,7-Dehydroferruginol Control / Unkown
HY-N17462 Methyl 9-hydroxyoctadeca-10,12,15-trienoate Inhibitor / Unkown
HY-N18218 Speranskoside Inhibitor / Unkown
HY-N18235 (1Z)-Atractylodinol Inhibitor / Unkown
HY-N19723 Buddlejasaponin I Inhibitor / Unkown
HY-N19724 Buddledin A Inhibitor / Unkown
HY-N2266 Benzoylgomisin O Inhibitor / Unkown
HY-N8480 Atractylochromene Inhibitor / Unkown
HY-N8764 Decaffeoylacteoside Inhibitor / Unkown
HY-P10458 5-Lipoxygenase blocking peptide Inhibitor / Unkown
HY-RS07739 LOX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W009640 Mofebutazone Inhibitor 98.42% Unkown
HY-W009640A Mofebutazone sodium Inhibitor / Unkown
HY-W676872 Dihydroflavokawin B Inhibitor / Unkown
HY-W778179 Benoxaprofen-13C,d3 Inhibitor / Unkown
HY-113807 ZLJ-6 Inhibitor / Unkown
HY-118268 RG 6866 Inhibitor / Unkown
HY-118848 A63162 Inhibitor / Unkown
HY-133215 Zileuton sulfoxide Inhibitor / Unkown
HY-155407 ALR-6 Antagonist / Unkown
HY-155408 ALR-27 Antagonist / Unkown
HY-161907 h15-LOX-2 inhibitor 2 Inhibitor / Unkown
HY-161908 h15-LOX-2 inhibitor 3 Inhibitor / Unkown
HY-168768 FerroLOXIN-1 Inhibitor / Unkown
HY-N0493R Pectolinarigenin (Standard) / Unkown
HY-N11072 Tremulacin Inhibitor 96.41% Unkown
HY-N15453 Asperenone Inhibitor / Unkown
HY-N2056R 11-Keto-beta-boswellic acid (Standard) Inhibitor / Unkown
HY-RS16507 Lox Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22939 Lox Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W036566 2-Phenylcyclopropanamine Inhibitor / Unkown
HY-W836666 5-LOX-IN-9 Inhibitor / Unkown
HY-Y1750R β-Aminopropionitrile (Standard) Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99646 Golocdacimab Inhibitor 99.11% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lox NCBI NCBI:4015