LOX - lysyl oxidase Gene
Also Known as AAT10
Species: Homo sapiens
About LOX
This gene has 6 transcripts (splice variants), 263 orthologues, 15 paralogues and is associated with 2 phenotypes. Broad expression in fat (RPKM 18.5), gall bladder (RPKM 11.6) and 21 other tissues.
Summary
This gene encodes a member of the Lysyl Oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016]
LOX Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001178102.2 | NP_001171573.1 | protein-lysine 6-oxidase isoform 2 |
| NM_001317073.1 | NP_001304002.1 | protein-lysine 6-oxidase isoform 3 |
| NM_002317.7 | NP_002308.2 | protein-lysine 6-oxidase isoform 1 preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables collagen binding |
IDA
IDA: Inferred from direct assay
|
31152061 | GOA |
| enables molecular adaptor activity |
IPI
IPI: Inferred from physical interaction
|
30082873 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
19570982 | GOA |
| enables protein-lysine 6-oxidase activity |
IDA
IDA: Inferred from direct assay
|
31152061 | GOA |
| enables small molecule binding |
IPI
IPI: Inferred from physical interaction
|
30082873 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in peptidyl-lysine oxidation |
IDA
IDA: Inferred from direct assay
|
31152061 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
31152061 | GOA |
LOX Protein Structure
Lysyl_oxidase: Lysyl oxidase (213 - 416)
- 0
- 100
- 200
- 300
- 417 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein-lysine 6-oxidase |
|
LOX Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
LOX | P28300 | ELN | Homo sapiens | P15502 | 19570982 | |
|
Intra
|
LOX | P28300 | FBN1 | Homo sapiens | P35555 | 19570982 | |
|
Intra
|
LOX | P28300 | FBN1 | Homo sapiens | P35555 | 19570982 | |
|
Intra
|
LOX | P28300 | PTPRK | Homo sapiens | Q15262 | 21690299 | |
|
Intra
|
LOX | P28300 | PTPRK | Homo sapiens | Q15262 | 21690299 | |
|
Intra
|
LOX | P28300 | EFEMP2 | Homo sapiens | O95967 | 19570982 |
LOX Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83408 | LOX Antibody (YA3153) | WB, IHC-P, ICC/IF, IP, FC | Human, Mouse, Rat |
| HY-P83408A | LOX Antibody (YA3153)(PBS only) | WB, IHC-P, ICC/IF, IP, FC | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Aortic Aneurysm, Familial Thoracic 10 |
|
|
| Aortic Aneurysm, Familial Thoracic 1 |
|
|
| Oral Submucous Fibrosis |
|
|
| Cutis Laxa |
|
|
| Occipital Horn Syndrome |
|
|
| Menkes Disease |
|
|
| Aortic Aneurysm |
|
|
| Aortic Aneurysm, Familial Thoracic 4 |
|
|
| Exfoliation Syndrome |
|
|
| Pelvic Organ Prolapse |
|
|
| Marfan Syndrome |
|
|
| Wilson Disease |
|
|
| Localized Scleroderma |
|
|
| Anovulation |
|
|
| Ehlers-Danlos Syndrome |
|
|
| Posterolateral Myocardial Infarction |
|
|
| Keratoconus |
|
|
| Arteriosclerosis |
|
|
| Phacogenic Glaucoma |
|
|
| Retinal Detachment |
|
|
| Homocystinuria |
|
|
| Colorectal Cancer |
|
|
| Corneal Ectasia |
|
|
| Ichthyosis, Congenital, Autosomal Recessive 3 |
|
|
| Bladder Diverticulum |
|
|
| Bronchiolo-Alveolar Adenocarcinoma |
|
|
| Osteoporosis |
|
|
| Irregular Astigmatism |
|
|
| Pancreatic Cancer |
|
|
| Myelofibrosis |
|
|
| Autosomal Recessive Cutis Laxa Type I |
|
|
| Prostate Cancer |
|
|
| Aortic Dissection |
|
|
| Bruck Syndrome |
|
|
| Lung Adenoma |
|
|
| Vascular Disease |
|
|
| Ureteric Orifice Cancer |
|
|
| Lung Cancer |
|
|
| Scoliosis |
|
|
| Connective Tissue Disease |
|
|
| Melanoma |
|
|
| Breast Cancer |
|
|
| Alzheimer Disease 13 |
|
|
| Loeys-Dietz Syndrome |
|
|
| Ovarian Cancer |
|
|
| Asthma |
|
|
| Gastric Cancer |
|
|
| Muscular Dystrophy |
|
|
| Eye Disease |
|
|
| Rhabdomyosarcoma |
|
|
| Aortic Aneurysm, Familial Abdominal, 1 |
|
|
| Aortic Valve Disease 1 |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Inflammatory Bowel Disease |
|
|
| Skin Disease |
|
|
| Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3 |
|
|
| Diabetes Mellitus |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Autosomal Recessive Congenital Ichthyosis |
|
|
| Hypertension, Essential |
|
|
| Brittle Bone Disorder |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Interstitial Lung Disease 2 |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | LOX | VGNC | VGNC:102245 |
| Rattus norvegicus | LOX | RGD | RGD:3015 |
| Macaca mulatta | LOX | VGNC | VGNC:110455 |
| Bos taurus | LOX | VGNC | VGNC:30951 |
| Canis familiaris | LOX | VGNC | VGNC:42737 |
| Mus musculus | LOX | MGD | MGI:96817 |
| Others | LOX | NCBI |