HDAC2 - histone deacetylase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84577

About HDAC2

Primary_assembly 20: 40,548,250-40,571,609 forward strand.mRatBN7.2:CM026993.1

This gene has 2 transcripts (splice variants), 205 orthologues, 12 paralogues and is associated with 42 phenotypes. Biased expression in Muscle (RPKM 329.9), Thymus (RPKM 38.1) and 9 other tissues.

Summary

Enables several functions, including deacetylase activity; heat shock protein binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of macromolecule metabolic process; and response to alkaloid. Located in chromatin; cytoplasm; and nucleus. Used to study Peyronie's disease; alcohol use disorder; and anxiety disorder. Biomarker of bronchitis; chronic obstructive pulmonary disease; endometriosis; pulmonary emphysema; and visual epilepsy. Human ortholog(s) of this gene implicated in stomach Cancer. Orthologous to human HDAC2 (histone deacetylase 2). [provided by Alliance of Genome Resources, Apr 2022]

HDAC2 Products (1)

mRNA Protein Name
NM_053447.1 NP_445899.1 histone deacetylase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
24441681 RGD
enables deacetylase activity IDA
IDA: Inferred from direct assay
23868068 RGD
enables heat shock protein binding IDA
IDA: Inferred from direct assay
18849323 RGD
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
21586557 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11516394 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to ethanol IEP
IEP: Inferred from expression pattern
23485013 RGD
involved in cardiac muscle hypertrophy IEP
IEP: Inferred from expression pattern
19713680 RGD
involved in cellular response to dopamine IEP
IEP: Inferred from expression pattern
15731170 RGD
involved in cellular response to heat IEP
IEP: Inferred from expression pattern
18849323 RGD
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
19553350 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
19486889 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
19553350 RGD
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
11516394 RGD
involved in negative regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
23485013 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
18754010 RGD
involved in negative regulation of peptidyl-lysine acetylation IMP
IMP: Inferred from mutant phenotype
19486889 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21465537 RGD
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
19553350 RGD
involved in positive regulation of interleukin-1 production IMP
IMP: Inferred from mutant phenotype
22772764 RGD
involved in positive regulation of male mating behavior IMP
IMP: Inferred from mutant phenotype
21586557 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
22573687 RGD
involved in positive regulation of protein modification process IMP
IMP: Inferred from mutant phenotype
21465537 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
22772764 RGD
involved in protein modification process IMP
IMP: Inferred from mutant phenotype
24441681 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
26509893 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
22470541 RGD
involved in response to amyloid-beta IEP
IEP: Inferred from expression pattern
24441681 RGD
involved in response to caffeine IEP
IEP: Inferred from expression pattern
24717552 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
16670375 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
21905265 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
24595367 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
24709674 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16670375 RGD
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
11516394 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC2 Protein Structure

HDAC2

HDAC2: cd10011 (8 - 373)

CobT2

CobT2: cl34772 (385 - 478)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

histone deacetylase 2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10221 Vorinostat Inhibitor 99.96% Yes
HY-10585 Valproic acid Inhibitor 99.90% Unkown
HY-15149 Romidepsin Inhibitor 99.98% Unkown
HY-10585A Valproic acid sodium Inhibitor 99.65% Unkown
HY-109015 Tucidinostat Inhibitor 98.74% Unkown
HY-12164 Mocetinostat Inhibitor 99.68% Yes
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes
HY-10585B Valproic acid sodium (2:1) Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Phase
HY-12163 Entinostat Inhibitor 99.98% Phase 3
HY-50934 Tacedinaline Inhibitor 99.32% Phase 3
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-101780 Tinostamustine Inhibitor 99.64% Phase 3
HY-150109 Purinostat mesylate Inhibitor 99.45% Phase 3
HY-175513 ZWZH-21 Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-100748 Zabadinostat Inhibitor 99.83% Phase 2
HY-13432 Nanatinostat Inhibitor 99.67% Phase 2
HY-124295 Imofinostat Inhibitor 99.40% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-15994 Citarinostat Inhibitor 99.55% Phase 1

Pre-clinical Phase

Bioactive Molecules (180)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0931 Santacruzamate A Inhibitor 99.54% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-19618 BRD3308 Inhibitor 98.34% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-100719 BRD-6929 Inhibitor 99.01% Unkown
HY-19327 ACY-738 Inhibitor 99.92% Unkown
HY-18613 CAY10603 Inhibitor 99.76% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-111400 SR-4370 Inhibitor 98.38% Unkown
HY-103596 Thalidomide-4-OH Degrader 99.62% Unkown
HY-19328 ACY-775 Inhibitor 99.71% Unkown
HY-16012A Domatinostat Inhibitor 99.34% Unkown
HY-104008 ACY-957 Inhibitor 99.63% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-102083 BRD4884 Inhibitor 99.14% Unkown
HY-164782 PT3 Inhibitor 99.94% Unkown
HY-18976 UF010 99.83% Unkown
HY-10585R Valproic acid (Standard) Inhibitor 99.97% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% Unkown
HY-145815A JPS014 TFA 98.12% Unkown
HY-18712 BG45 Inhibitor 99.95% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-172762 S234984 99.46% Unkown
HY-117709 BRD6688 Inhibitor 98.06% Unkown
HY-116818 Crebinostat Inhibitor 98.83% Unkown
HY-100871 WT-161 Inhibitor 98.04% Unkown
HY-124053 BRD2492 Inhibitor 99.22% Unkown
HY-146346 HD-TAC7 Degrader 98.53% Unkown
HY-150109A Purinostat Inhibitor 98.04% Unkown
HY-100384 NKL 22 Inhibitor 97.26% Unkown
HY-19747 HPOB Inhibitor 99.54% Unkown
HY-18700 BRD73954 Inhibitor 99.13% Unkown
HY-156422 KPZ560 Inhibitor 99.72% Unkown
HY-142690A HDAC-IN-27 dihydrochloride Inhibitor 99.08% Unkown
HY-110280 MC1742 Inhibitor 98.95% Unkown
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.63% Unkown
HY-124337 BG48 Inhibitor 99.09% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-149721 HDAC4-IN-1 Inhibitor 98.11% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-152174 HDAC-IN-52 Inhibitor 99.46% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-157388 CARM1/HDAC2-IN-1 Inhibitor 95.17% Unkown
HY-W103792 4-Phenylcinnamic acid Inhibitor ≥97.0% Unkown
HY-117374 HDAC3-IN-1 Inhibitor 99.28% Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.12% Unkown
HY-109015S Tucidinostat-d4 Inhibitor 98.63% Unkown
HY-P3364A Ac-QPKK(Ac)-AMC acetate Substrate 99.38% Unkown
HY-169938 LSD1/HDAC-IN-2 Inhibitor / Unkown
HY-117583 cis-BG47 Inhibitor 98.02% Unkown
HY-151261 HDAC6-IN-13 Inhibitor 98.08% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-143497 HDAC1/2 and CDK2-IN-1 Inhibitor / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-168863 FF2049 Degrader / Unkown
HY-151464 SHP2/HDAC-IN-1 Inhibitor / Unkown
HY-128582 PI3K/HDAC-IN-1 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-145816 JPS016 / Unkown
HY-172394 ZSNI-21 Inhibitor / Unkown
HY-176904 JPS004 Degrader / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-133147 HDAC3/6-IN-2 Inhibitor / Unkown
HY-181009 HDAC-IN-98 Inhibitor 98.36% Unkown
HY-162769 HDAC3-IN-5 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-12487 NL-103 Inhibitor / Unkown
HY-181768 HDAC3-IN-8 Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-173160 HDAC1-IN-10 Inhibitor / Unkown
HY-149946 HDAC-IN-57 Inhibitor / Unkown
HY-182747 HDAC6-IN-79 Inhibitor / Unkown
HY-146160 PARP-1/HDAC-IN-1 Inhibitor / Unkown
HY-183150 HDAC1-IN-13 Inhibitor / Unkown
HY-185554B (R)-HDAC-IN-102 Inhibitor / Unkown
HY-175021 HDAC-IN-91 Inhibitor / Unkown
HY-178161 HDAC degrader-2 Degrader / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-157481 HDAC1-IN-6 Inhibitor / Unkown
HY-173330 HDAC-IN-89 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-172889 PI3K/HDAC-IN-4 Inhibitor / Unkown
HY-184705 HDAC-IN-105 Inhibitor / Unkown
HY-176733 HDAC6-IN-61 Inhibitor / Unkown
HY-169226 HDAC6-IN-51 Inhibitor / Unkown
HY-179374 Aurora kinase/HDAC-IN-1 Inhibitor / Unkown
HY-142690 HDAC-IN-27 Inhibitor 98.12% Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-147840 HDAC-IN-41 Inhibitor / Unkown
HY-176561 IOR-160 Inhibitor / Unkown
HY-151248 HDAC2-IN-1 Inhibitor / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-179655 ST17 / Unkown
HY-108919 CG-1521 Inhibitor 95.71% Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-168962 HDAC-IN-88 Inhibitor / Unkown
HY-124792 MRLB-223 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-154855 HDAC-IN-56 Inhibitor / Unkown
HY-144332 PHD2/HDACs-IN-1 Inhibitor / Unkown
HY-182321 HDAC2-IN-3 Inhibitor / Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-184415 Syk/HDAC6-IN-1 Inhibitor / Unkown
HY-P11678 HDAC-IN-100 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-161783 HDAC6-IN-45 Inhibitor / Unkown
HY-174398 GSK-3β/HDAC-IN-2 Inhibitor / Unkown
HY-162487 HDAC-IN-72 Inhibitor / Unkown
HY-13432A Nanatinostat TFA Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-181843 HDAC-IN-99 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-145818 JPS035 Degrader / Unkown
HY-119316A CM-545 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-172159 FF2039 Inhibitor / Unkown
HY-152146 HDAC-IN-50 Inhibitor / Unkown
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / Unkown
HY-125645 M122 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-172359 PROTAC HDAC6 degrader 4 Degrader / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-173064 DS-103 Inhibitor / Unkown
HY-170379 HDAC-IN-84 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-179216 KTT-1 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-175671 LSD1/HDAC-IN-3 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-145815 JPS014 / Unkown
HY-115941 HDAC-IN-9 Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-168175 PROTAC HDAC8 Degrader-2 Degrader / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-180224 HDAC6-IN-70 Inhibitor / Unkown
HY-162955 LSD1/HDAC-IN-1 Inhibitor / Unkown
HY-187382 HDAC8-IN-17 Inhibitor / Unkown
HY-178336 AC-340 Inhibitor / Unkown
HY-153514 HDAC-IN-54 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-177768 HDAC-IN-96 Inhibitor / Unkown
HY-161667 GSK-3β/HDAC-IN-1 Inhibitor / Unkown
HY-161524 HDAC6-IN-43 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-184574 HDAC-IN-104 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-13906 Largazole Inhibitor / Unkown
HY-162910 HDAC-IN-79 Inhibitor / Unkown
HY-119316 CM-414 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-179654 ST13 Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown
HY-172167 PD-L1/HDAC-IN-1 Inhibitor / Unkown
HY-117583A BG47 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens HDAC2 NCBI NCBI:3066