CDK4 - cyclin-dependent kinase 4 Gene

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 94201

About CDK4

Primary_assembly 7: 62,883,105-62,942,403 forward strand.mRatBN7.2:CM026980.1

This gene has 4 transcripts (splice variants), 229 orthologues, 24 paralogues and is associated with 48 phenotypes. Biased expression in Thymus (RPKM 573.2), Adrenal (RPKM 371.5) and 9 other tissues.

Summary

Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell size; response to hyperoxia; and response to testosterone. Located in nucleus and perinuclear region of cytoplasm. Biomarker of pancreatic cancer; prostatic hypertrophy; and urinary bladder Cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

CDK4 Products (2)

mRNA Protein Name
NM_053593.3 NP_446045.1 cyclin-dependent kinase 4 isoform 1
NM_001402395.1 NP_001389324.1 cyclin-dependent kinase 4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables cyclin binding IPI
IPI: Inferred from physical interaction
15809057 RGD
enables cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12163013 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
8651753 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
16534847 RGD
involved in cellular response to polyamine macromolecule IEP
IEP: Inferred from expression pattern
21737690 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
11598123 RGD
involved in lens development in camera-type eye IEP
IEP: Inferred from expression pattern
10620399 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18353414 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17635516 RGD
involved in positive regulation of cell size IMP
IMP: Inferred from mutant phenotype
12163013 RGD
involved in positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
21737690 RGD
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
12163013 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
18082050 RGD
involved in response to testosterone IDA
IDA: Inferred from direct assay
17962342 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
17343987 RGD
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
18353414 RGD
located in nucleus IDA
IDA: Inferred from direct assay
18353414 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15161838 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase 4

  • PSK-J3

  • cell division protein kinase 4

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (14)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-50767 Palbociclib Inhibitor 99.94% Unkown
HY-16297A Abemaciclib Inhibitor 99.97% Yes
HY-15777 Ribociclib Inhibitor 99.94% Unkown
HY-50767C Palbociclib hydrochloride Inhibitor 99.96% Unkown
HY-50767A Palbociclib monohydrochloride Inhibitor 99.98% Unkown
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
HY-A0065 Palbociclib isethionate Inhibitor 99.98% Unkown
HY-15777B Ribociclib succinate Inhibitor 99.93% Unkown
HY-15777A Ribociclib hydrochloride Inhibitor 99.95% Unkown
HY-114338 Dalpiciclib Inhibitor 99.70% Unkown
HY-101467A Trilaciclib hydrochloride Inhibitor 99.69% Unkown
HY-15777C Ribociclib succinate hydrate Inhibitor 99.94% Unkown
HY-50767D Palbociclib orotate Inhibitor / Unkown
HY-50767B Palbociclib dihydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (24)
製品番号 製品名 製品効果
純度 Phase
HY-125101A Rafutrombopag diolamine Agonist / Phase 4
HY-112272A Lerociclib dihydrochloride Inhibitor 98.51% Phase 3
HY-175538 USP10-IN-4 Inhibitor / Phase 3
HY-10005 Flavopiridol Inhibitor 99.72% Phase 2
HY-101563 GSK3326595 99.83% Phase 2
HY-50940 AT7519 Inhibitor 99.69% Phase 2
HY-114177 Ebvaciclib Inhibitor 99.98% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-13914 Roniciclib Inhibitor 98.00% Phase 2
HY-10424 Milciclib Inhibitor 99.89% Phase 2
HY-12624 Narazaciclib Inhibitor 98.66% Phase 2
HY-103712B Samuraciclib hydrochloride dihydrate Inhibitor 99.90% Phase 2
HY-45661 Inixaciclib Inhibitor 99.93% Phase 2
HY-201330 GDC-4198 Inhibitor 99.9% Phase 2
HY-16559A Riviciclib Inhibitor / Phase 2
HY-10008 SNS-032 Inhibitor 99.91% Phase 1
HY-10012 AZD-5438 Inhibitor 99.91% Phase 1
HY-10014 R547 Inhibitor 99.57% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-15504 RGB-286638 Inhibitor 99.67% Phase 1
HY-111361 FN-1501 Inhibitor 98.72% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.26% Phase 1
HY-153336 PRT3645 Inhibitor / Phase 1
HY-172234 PF-06842874 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (182)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.73% Unkown
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Unkown
HY-103248 Toyocamycin Inhibitor 99.27% Unkown
HY-10329 JNJ-7706621 Inhibitor 99.39% Unkown
HY-15339 CVT-313 Inhibitor 99.90% Unkown
HY-136250 BSJ-03-204 Inhibitor 99.76% Unkown
HY-10006 Flavopiridol Hydrochloride Inhibitor 99.73% Yes
HY-116035 Nimbolide Inhibitor 99.79% Unkown
HY-122609 XO44 99.73% Unkown
HY-138946 XY028-140 Inhibitor 98.52% Unkown
HY-18299A Purvalanol A Inhibitor 98.61% Unkown
HY-15275 BMS-265246 Inhibitor 99.59% Unkown
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Unkown
HY-N0404 Sinigrin Inhibitor 99.97% Unkown
HY-114338A Dalpiciclib hydrochloride Inhibitor 99.41% Unkown
HY-136252 BSJ-04-132 Inhibitor 99.07% Unkown
HY-15878 LDC000067 Inhibitor 99.00% Unkown
HY-18629 SU9516 Inhibitor 99.85% Unkown
HY-122620 Rafutrombopag (tautomerism) Agonist 98.33% Unkown
HY-11009 CGP60474 Inhibitor 98.90% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-N0805 Alisol B 23-acetate Inhibitor 99.65% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-12422 Voruciclib Inhibitor 99.76% Unkown
HY-128669 Abemaciclib metabolite M2 Inhibitor 99.75% Unkown
HY-103712 Samuraciclib Inhibitor 99.55% Unkown
HY-126534A Abemaciclib metabolite M18 hydrochloride Inhibitor 98.18% Unkown
HY-168664 CPD-39 Degrader 98.06% Unkown
HY-16559 Riviciclib hydrochloride 99.08% Unkown
HY-163786 PROTAC CDK4/6 degrader 1 Degrader 98.88% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.93% Unkown
HY-119940 MC180295 Inhibitor 98.07% Unkown
HY-112272 Lerociclib Inhibitor 96.42% Unkown
HY-N1431 Tabersonine Inhibitor 98.13% Unkown
HY-129336 Abemaciclib metabolite M20 Inhibitor 95.92% Unkown
HY-147007 β-catenin-IN-3 Inhibitor 95.64% Unkown
HY-129180 XY028-133 Inhibitor 99.07% Unkown
HY-151071 TMX-3013 Inhibitor 98.02% Unkown
HY-100624 Ryuvidine Inhibitor 99.23% Unkown
HY-15889 AMG 925 Inhibitor 99.02% Unkown
HY-126534 Abemaciclib metabolite M18 Inhibitor 98.01% Unkown
HY-50943 AT7519 Hydrochloride Inhibitor 99.16% Unkown
HY-50767S Palbociclib-d8 Inhibitor 99.84% Unkown
HY-144995 BSJ-02-162 Degrader 98.07% Unkown
HY-163640 CDK4 degrader 1 Degrader 99.83% Unkown
HY-150280 Ironomycin Inhibitor 99.85% Unkown
HY-168660 CPD-10 Degrader 98.59% Unkown
HY-15504A RGB-286638 free base Inhibitor 98.09% Unkown
HY-148214 CDK2/4/6-IN-2 Inhibitor 98.20% Unkown
HY-151069 TMX-2039 Inhibitor 99.42% Unkown
HY-142076 CDK4/6-IN-15 Inhibitor 99.32% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-153894 SRX3177 Inhibitor 99.33% Unkown
HY-164129 CDK4-IN-3 Inhibitor 98.07% Unkown
HY-N7045 Isosilybin B Inhibitor 99.32% Unkown
HY-152263 HEMTAC CDK4/6 degrader 1 Inhibitor 98.18% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148070 FLT3-IN-17 99.11% Unkown
HY-107419 NU6140 Inhibitor 99.53% Unkown
HY-148062 RSS0680 99.85% Unkown
HY-114339 CDK4/6-IN-2 Inhibitor 99.67% Unkown
HY-16942 Damulin B Inhibitor 96.62% Unkown
HY-123045 PNU-292137 Inhibitor 99.95% Unkown
HY-126251 CDK9-IN-7 Inhibitor 98.05% Unkown
HY-100429 CAN508 Inhibitor 99.71% Unkown
HY-155787 SHR5428 Inhibitor 99.80% Unkown
HY-129336S Abemaciclib metabolite M20-d8 Inhibitor 99.26% Unkown
HY-103380 NSC 625987 Inhibitor 98.01% Unkown
HY-112822 ON-013100 Inhibitor 99.66% Unkown
HY-119715 AG-012986 Inhibitor 99.78% Unkown
HY-136726 CGP-82996 Inhibitor 98.12% Unkown
HY-50940A AT7519 TFA Inhibitor 99.75% Unkown
HY-168996 LA-CB1 Degrader 98.20% Unkown
HY-115992 CDK4/6-IN-9 Inhibitor 99.46% Unkown
HY-112328 Fascaplysin Inhibitor 95.64% Unkown
HY-142696A CDK6/PIM1-IN-1 hydrochloride Inhibitor 99.38% Unkown
HY-108420 INK4C-IN-2 Activator 98.35% Unkown
HY-146213 CDK4/6-IN-12 Inhibitor 99.76% Unkown
HY-179688 PROTAC CDK2/4 Degrader-1 Degrader 98.10% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-145589 Rafutrombopag Agonist 95.29% Unkown
HY-168440 Aurora-A ligand 1 Ligand 98.75% Unkown
HY-115909 ZDLD20 Inhibitor 99.84% Unkown
HY-148366 NecroIr2 Inhibitor 98.02% Unkown
HY-148365 NecroIr1 Inhibitor 98.53% Unkown
HY-185121 PROTAC CDK2/4/6 Degrader-2 Degrader 97.22% Unkown
HY-123535 P18IN003 Activator 99.49% Unkown
HY-112243A Cimpuciclib tosylate Inhibitor 99.65% Unkown
HY-161708 PROTAC FLT3/CDKs degrader-1 Degrader 98.00% Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-164906 TMX-2138 Degrader 98.99% Unkown
HY-112346 RGB-286147 Inhibitor 98.60% Unkown
HY-112418 CDK4/6-IN-18 Inhibitor 98.9% Unkown
HY-147125 DDO-6600 Inhibitor 99.2% Unkown
HY-15889A AMG 925 (HCl) Inhibitor / Unkown
HY-N2423 Sinigrin hydrate Inhibitor 99.92% Unkown
HY-112450 Olomoucine II Inhibitor 98.0% Unkown
HY-111207 CA224 Inhibitor 99.94% Unkown
HY-112243 Cimpuciclib Inhibitor / Unkown
HY-126244 CDK4/6-IN-3 Inhibitor / Unkown
HY-164376 CDK4/6-IN-21 Inhibitor / Unkown
HY-160941 CDK2-IN-29 Inhibitor / Unkown
HY-159155 CDK2/4-IN-1 Inhibitor / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-171656 G721-0282 Inhibitor 99.96% Unkown
HY-114338B Dalpiciclib isethionate Inhibitor / Unkown
HY-115942 Anticancer agent 29 Inhibitor / Unkown
HY-162530 CDK4/6-IN-20 Inhibitor / Unkown
HY-171740 CDK4-IN-4 Inhibitor / Unkown
HY-134303 CST651 Degrader / Unkown
HY-163856 CDK7-IN-30 Inhibitor / Unkown
HY-183571 JD128 Inhibitor / Unkown
HY-171826 PROTAC CDK2/4/6 Degrader-1 Inhibitor / Unkown
HY-176718 VEGFR-2-IN-69 Inhibitor / Unkown
HY-184418 CDK4-IN-6 Inhibitor / Unkown
HY-183297 CDK4-IN-5 Inhibitor / Unkown
HY-185487 CDK4/6-IN-27 Inhibitor / Unkown
HY-179375 LCI133 Inhibitor / Unkown
HY-155602 CDK2-IN-18 Inhibitor / Unkown
HY-178516 PROTAC CDK4/6/9 degrader 2 Degrader / Unkown
HY-143327 PROTAC BRD4 Degrader-16 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-123034 CDKI-83 Inhibitor / Unkown
HY-115993 CDK4/6-IN-10 Inhibitor / Unkown
HY-115904 FLT3/CDK4-IN-1 Inhibitor / Unkown
HY-168444 CDK4/6-IN-23 Inhibitor / Unkown
HY-153088 CDK4/6-IN-16 Inhibitor / Unkown
HY-171481 Thio-acridone Inhibitor / Unkown
HY-162529 CDK4/6-IN-19 Inhibitor / Unkown
HY-150609 SHP2/CDK4-IN-1 Inhibitor / Unkown
HY-128491 UNC10112785 Inhibitor / Unkown
HY-141685 3-Methylthienyl-carbonyl-JNJ-7706621 Inhibitor / Unkown
HY-161709 FLT3/CDKs ligand-1 Degrader / Unkown
HY-182986 LS-Q2 Inhibitor / Unkown
HY-178168 ARUK2010694 Inhibitor / Unkown
HY-143257 CDK4/6-IN-7 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown
HY-182752 CDK1-IN-9 Inhibitor / Unkown
HY-170992 Autophagy agonist-1 Inhibitor / Unkown
HY-W1047040 CDK2/4 ligand 1 Inhibitor / Unkown
HY-181062 VWK147 Inhibitor / Unkown
HY-170651 CDK4/6/HDAC-IN-1 Inhibitor / Unkown
HY-182734 BMS-357075 Inhibitor / Unkown
HY-111932 Indirubin-5-sulfonate Inhibitor / Unkown
HY-178112 CDK2-IN-47 Inhibitor / Unkown
HY-182447 Contragestazol Inhibitor / Unkown
HY-176365 Palbociclib-C4-Boc Inhibitor / Unkown
HY-178452 PROTAC CDK4/6/9 degrader 1 Degrader / Unkown
HY-182470 AG-012986 dihydrochloride Inhibitor / Unkown
HY-164376A CDK4/6-IN-21 maleate Inhibitor / Unkown
HY-172127 NUAK1-IN-1 Inhibitor / Unkown
HY-183854 AG-12286 Inhibitor / Unkown
HY-181501 CDK2/4/6-IN-3 Inhibitor / Unkown
HY-162875 PROTAC BRD4 Degrader-27 Inhibitor / Unkown
HY-123859 SR-2890 Inhibitor / Unkown
HY-184707 CDK4/6-IN-29 Inhibitor / Unkown
HY-146253 CDK1/2/4-IN-1 Inhibitor / Unkown
HY-178171 ARUK2010489 Inhibitor 96.64% Unkown
HY-182044 MRTX849-amide-C4-(o)-carborane Inhibitor / Unkown
HY-183771 CDK4/6-IN-28 Inhibitor / Unkown
HY-179151 CDK4/6-IN-26 Inhibitor / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-163787 YY173 Inhibitor / Unkown
HY-115908 ZDLD13 Inhibitor / Unkown
HY-170815 CDK4/9-IN-1 Inhibitor / Unkown
HY-148213 CDK2/4/6-IN-1 Inhibitor / Unkown
HY-172198 GSK3-IN-10 Inhibitor / Unkown
HY-184444 CDK4-IN-7 Inhibitor / Unkown
HY-173237 CDK4/6/BRD4-IN-1 Inhibitor / Unkown
HY-172128 NUAK1-IN-2 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-143258 CDK4/6-IN-8 Inhibitor / Unkown
HY-162619 CDK9-IN-33 Inhibitor / Unkown
HY-184877 CDK4-IN-8 Inhibitor / Unkown
HY-183529 Antitrypanosomal agent 31 Inhibitor / Unkown
HY-11001A PHA-793887 hydrochloride Inhibitor / Unkown
HY-173172 MG-002 Inhibitor / Unkown
HY-102088 P18IN011 Inhibitor / Unkown
HY-118447 RO0505124 / Unkown
HY-N11852 Momilactone B Inhibitor 99.47% Unkown
HY-N1431A Tabersonine hydrochloride Inhibitor 98.55% Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens CDK4 NCBI NCBI:1019