Hdac8 - histone deacetylase 8 Gene

Also Known as 2610007D20Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 70315

About Hdac8

Chromosome X: 101,328,245-101,548,965 reverse strand.GRCm39:CM001013.3

This gene has 5 transcripts (splice variants), 202 orthologues, 10 paralogues and is associated with 18 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 1.2), bladder adult (RPKM 1.) and 28 other tissues.

Summary

Predicted to enable chromatin binding activity; heat shock protein binding activity; and histone deacetylase activity. Predicted to be involved in several processes, including histone deacetylation; negative regulation of macromolecule metabolic process; and regulation of chromosome organization. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including 2-cell stage embryo; brain; embryo ectoderm; foregut; and retina. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Apr 2022]

Hdac8 Products (2)

mRNA Protein Name
NM_027382.4 NP_081658.1 histone deacetylase 8 isoform 1
NM_001313742.1 NP_001300671.1 histone deacetylase 8 isoform 2

Hdac8 Protein Structure

HDAC8

HDAC8: cd10000 (15 - 376)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
Protein Preferred Names Protein Names

histone deacetylase 8

  • HD8

  • protein deacetylase HDAC8

  • protein decrotonylase HDAC8

Recombinant Hdac8 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P75144 HDAC8 Protein, Mouse (sf9, His) Q8VH37-1 (M1-V377) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
製品番号 製品名 製品効果
純度 Rare Diseases
HY-109015 Tucidinostat Inhibitor 98.74% Unkown
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-B0494 Bufexamac Inhibitor 98.47% Unkown
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (13)
製品番号 製品名 製品効果
純度 Phase
HY-14718 Resminostat Inhibitor 99.44% Phase 4
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-101780 Tinostamustine Inhibitor 99.64% Phase 3
HY-150109 Puzerinostat mesylate Inhibitor 99.45% Phase 3
HY-175513 ZWZH-21 Inhibitor / Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-138799 KA2507 Inhibitor 99.17% Phase 2
HY-124295 Imofinostat Inhibitor 99.40% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-15994 Citarinostat Inhibitor 99.55% Phase 1
HY-10226 JNJ-16241199 Inhibitor 99.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (166)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-13271A Tubastatin A Inhibitor 99.07% Unkown
HY-18361 TMP195 Inhibitor 99.82% Unkown
HY-15224 PCI-34051 Inhibitor 99.84% Unkown
HY-13428 Tubacin Inhibitor 98.71% Unkown
HY-13271 Tubastatin A Hydrochloride Inhibitor 99.31% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-N6735 Apicidin Inhibitor 99.87% Unkown
HY-18360 TMP269 Inhibitor 98.16% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-18613 CAY10603 Inhibitor 99.76% Unkown
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Unkown
HY-111400 SR-4370 Inhibitor 98.38% Unkown
HY-103596 Thalidomide-4-OH Degrader 99.62% Unkown
HY-111818 TH34 Inhibitor 99.52% Unkown
HY-111342 HDAC8-IN-1 Inhibitor 99.77% Unkown
HY-144779 HDAC10-IN-1 Inhibitor 99.87% Unkown
HY-13267 Droxinostat Inhibitor 99.08% Unkown
HY-119939 CHDI-390576 Inhibitor 98.10% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-164782 PT3 Inhibitor 99.94% Unkown
HY-164233 YX968 Degrader 98.06% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.91% Unkown
HY-18976 UF010 99.83% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% Unkown
HY-14718A Resminostat hydrochloride Inhibitor 99.67% Yes
HY-117348 NCC-149 Inhibitor 99.29% Unkown
HY-135714 Bavarostat Inhibitor 99.51% Unkown
HY-152147 SZUH280 Degrader 99.38% Unkown
HY-100871 WT-161 Inhibitor 98.04% Unkown
HY-172157 HDAC11-IN-2 Inhibitor 99.52% Unkown
HY-150109A Puzerinostat Inhibitor 98.04% Unkown
HY-114483 AES-135 Inhibitor 98.68% Unkown
HY-19747 HPOB Inhibitor 99.54% Unkown
HY-100384 NKL 22 Inhibitor 97.26% Unkown
HY-156027 SIRT6-IN-3 Inhibitor 98.19% Unkown
HY-18700 BRD73954 Inhibitor 99.13% Unkown
HY-110280 MC1742 Inhibitor 98.95% Unkown
HY-126141 JAK/HDAC-IN-1 Inhibitor 98.63% Unkown
HY-162616 SelSA Inhibitor 99.83% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-149721 HDAC4-IN-1 Inhibitor 98.11% Unkown
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.59% Unkown
HY-178948A HDAC10-IN-3 formic Inhibitor 97.16% Unkown
HY-146153 HDAC-IN-40 Inhibitor 98.71% Unkown
HY-178948 HDAC10-IN-3 Inhibitor / Unkown
HY-124782 HDAC8-IN-8 Inhibitor 99.01% Unkown
HY-148624 CHDI-00484077 Inhibitor 98.38% Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.12% Unkown
HY-169938 LSD1/HDAC-IN-2 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-149208 HDAC-IN-53 Inhibitor 95.73% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-168287 HDAC3/8 ligand-1 / Unkown
HY-126829 Coumarin-SAHA 99.9% Unkown
HY-W274807 TM-2-51 Activator 99.95% Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-128582 PI3K/HDAC-IN-1 Inhibitor / Unkown
HY-187005 HDAC8 ligand 2 Ligand / Unkown
HY-157314 HDAC6-IN-27 Inhibitor / Unkown
HY-169226 HDAC6-IN-51 Inhibitor / Unkown
HY-163846 HDAC8-IN-10 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-170379 HDAC-IN-84 Inhibitor / Unkown
HY-184525 HDAC6-IN-85 Inhibitor 97.58% Unkown
HY-152146 HDAC-IN-50 Inhibitor / Unkown
HY-144782 HDAC10-IN-2 Inhibitor / Unkown
HY-168175 PROTAC HDAC8 Degrader-2 Degrader / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-161524 HDAC6-IN-43 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-158308 HDAC6-IN-41 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-149372 HDAC6-IN-17 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-153583 HDAC8-IN-4 Inhibitor / Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-173064 DS-103 Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-141701 mTOR/HDAC-IN-1 Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-163143 HDAC8-IN-6 Inhibitor / Unkown
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-182035 HDAC8-IN-16 Inhibitor / Unkown
HY-183565 HYF031 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-181009 HDAC-IN-98 Inhibitor 98.36% Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-163920 PROTAC HDAC8 Degrader-1 Degrader / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-182720 FT108 Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-151248 HDAC2-IN-1 Inhibitor / Unkown
HY-147991 PDE5/HDAC-IN-1 Inhibitor / Unkown
HY-115941 HDAC-IN-9 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-181979 HDAC8-IN-15 Inhibitor / Unkown
HY-168477 HDAC1-IN-8 Inhibitor / Unkown
HY-181023 PROTAC HDAC8 Degrader-3 Degrader / Unkown
HY-181024 PROTAC HDAC8 Degrader-4 Degrader / Unkown
HY-174401 PROTAC HDAC6 degrader 5 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / Unkown
HY-115442 NHNB Inhibitor / Unkown
HY-181086 FLT3/HDAC-IN-3 Inhibitor / Unkown
HY-178104 HDAC-IN-93 Inhibitor / Unkown
HY-168962 HDAC-IN-88 Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-176733 HDAC6-IN-61 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-168176 HDAC8 ligand 1 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-187382 HDAC8-IN-17 Inhibitor / Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-184574 HDAC-IN-104 Inhibitor / Unkown
HY-182747 HDAC6-IN-79 Inhibitor / Unkown
HY-150694 HDAC6-IN-11 Inhibitor / Unkown
HY-151366 HDAC8/BRPF1-IN-1 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-173330 HDAC-IN-89 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-179227 HDAC6 ligand-7 Inhibitor / Unkown
HY-180214 HDAC6-IN-69 Inhibitor / Unkown
HY-174398 GSK-3β/HDAC-IN-2 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-178380 HDAC8-IN-14 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-179271 CA/HDAC-IN-1 Inhibitor / Unkown
HY-181577 HDAC6-IN-73 Inhibitor / Unkown
HY-149946 HDAC-IN-57 Inhibitor 99.61% Unkown
HY-162955 LSD1/HDAC-IN-1 Inhibitor / Unkown
HY-150772 Tubulin/HDAC-IN-1 Inhibitor / Unkown
HY-144098 HDAC8-IN-2 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-146539 HDAC-IN-35 Inhibitor / Unkown
HY-161350 ALK/HDAC-IN-1 Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown
HY-185554A (S)-HDAC-IN-102 Inhibitor / Unkown
HY-139815 ZYJ-34c Inhibitor / Unkown
HY-119550 J1075 Inhibitor / Unkown
HY-187346 HDAC1-IN-15 Inhibitor / Unkown
HY-139795 ZYJ-25e Inhibitor / Unkown
HY-183426 MMH409 Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Hdac8 NCBI NCBI:55869