CDK2 - cyclin dependent kinase 2 Gene

Also Known as CDKN2; p33(CDK2)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1017

About CDK2

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,966,830-55,972,789 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and 26 paralogues. Ubiquitous expression in placenta (RPKM 29.3), bone marrow (RPKM 14.9) and 24 other tissues.

Summary

This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by Other subunits of the complex including cyclin A or E, CDK Inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

CDK2 Products (4)

mRNA	Protein	Name
NM_001798.5	NP_001789.2	cyclin-dependent kinase 2 isoform 1
NM_001290230.2	NP_001277159.1	cyclin-dependent kinase 2 isoform 3
XM_011537732.2	XP_011536034.1	cyclin-dependent kinase 2 isoform X1
NM_052827.4	NP_439892.2	cyclin-dependent kinase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cyclin binding	IDA IDA: Inferred from direct assay	1653904	GOA
enables cyclin binding	IPI IPI: Inferred from physical interaction	1312467	GOA
enables cyclin-dependent protein kinase activity	IDA IDA: Inferred from direct assay	1312467	GOA
enables cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	21596315	GOA
contributes to histone kinase activity	IDA IDA: Inferred from direct assay	8692841	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	2227411	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	8876165	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11953320	GOA
enables protein serine/threonine kinase activity	IGI IGI: Inferred from genetic interaction	26996940	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Ras protein signal transduction	IEP IEP: Inferred from expression pattern	9054499	GOA
involved in centriole replication	IMP IMP: Inferred from mutant phenotype	26297806	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	23184662	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10767298	GOA
involved in positive regulation of heterochromatin formation	IDA IDA: Inferred from direct assay	20935635	GOA
involved in post-translational protein modification	IDA IDA: Inferred from direct assay	11746698	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12944431	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	29203878	GOA
involved in telomere maintenance in response to DNA damage	IDA IDA: Inferred from direct assay	28216226	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Cajal body	IDA IDA: Inferred from direct assay	10995387	GOA
part of cyclin A2-CDK2 complex	IDA IDA: Inferred from direct assay	1312467	GOA
part of cyclin A2-CDK2 complex	IPI IPI: Inferred from physical interaction	12244298	GOA
part of cyclin E1-CDK2 complex	IPI IPI: Inferred from physical interaction	8756624	GOA
part of cyclin E2-CDK2 complex	IPI IPI: Inferred from physical interaction	15232106	GOA
part of cyclin-dependent protein kinase holoenzyme complex	IDA IDA: Inferred from direct assay	1312467	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10767298	GOA
located in endosome	IDA IDA: Inferred from direct assay	21262353	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	8245034	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10767298	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK2 Protein Structure

Pkinase

0
100
200
298 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 2	cdc2-related protein kinase cell division protein kinase 2 p33 protein kinase

CDK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDK2	P24941	CDKN3	Homo sapiens	Q16667	Anti Tag CoIP	33961781
Intra	CDK2	P24941	CDKN3	Homo sapiens	Q16667	Y2H	8242750
Intra	CDK2	P24941	CDKN3	Homo sapiens	Q16667	Anti Tag CoIP	25852190
Intra	CDK2	P24941	CDKN3	Homo sapiens	Q16667	X-Ray Diffraction	11463386
Intra	CDK2	P24941	CDK7	Homo sapiens	P50613	Protein Kinase Assay	15530371
Intra	CDK2	P24941	CDK7	Homo sapiens	P50613	TAP	23455922
Intra	CDK2	P24941	MAPK15	Homo sapiens	Q8TD08	Anti Tag CoIP	33961781
Intra	CDK2	P24941	MAPK15	Homo sapiens	Q8TD08	Anti Tag CoIP	25852190
Intra	CDK2	P24941	MAPK15	Homo sapiens	Q8TD08	TAP	23455922
Intra	CDK2	P24941	SCML2	Homo sapiens	Q9UQR0-1	Anti Bait CoIP	24358021
Intra	CDK2	P24941	SCML2	Homo sapiens	Q9UQR0-1	GMS	24358021
Intra	CDK2	P24941	SCML2	Homo sapiens	Q9UQR0	Anti Bait CoIP	24358021
Intra	CDK2	P24941	STOML1	Homo sapiens	Q9UBI4	Anti Tag CoIP	23082202
Intra	CDK2	P24941	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	CDK2	P24941	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	CDK2	P24941	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	CDK2	P24941	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	CDK2	P24941	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	CDK2	P24941	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	CDK2	P24941	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	CDK2	P24941	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	CDK2	P24941	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	CDK2	P24941	CCND1	Homo sapiens	P24385	TAP	23455922
Intra	CDK2	P24941	CCND1	Homo sapiens	P24385	Anti Tag CoIP	33961781
Intra	CDK2	P24941	CCND1	Homo sapiens	P24385	Anti Tag CoIP	26496610
Intra	CDK2	P24941	CCNB2	Homo sapiens	O95067	Anti Tag CoIP	33961781
Intra	CDK2	P24941	CCNB2	Homo sapiens	O95067	TAP	23455922
Intra	CDK2	P24941	CCNB2	Homo sapiens	O95067	Anti Tag CoIP	28514442
Intra	CDK2	P24941	CCNB2	Homo sapiens	O95067	Protein Array	15232106
Intra	CDK2	P24941	CCNE2	Homo sapiens	O96020	TAP	23455922
Intra	CDK2	P24941	CCNE2	Homo sapiens	O96020	Y2H	9840943
Intra	CDK2	P24941	CCNE2	Homo sapiens	O96020	Protein Array	15232106
Intra	CDK2	P24941	CCNE2	Homo sapiens	O96020	Anti Tag CoIP	35271311
Intra	CDK2	P24941	CCNE2	Homo sapiens	O96020	Anti Tag CoIP	25852190
Intra	CDK2	P24941	CCNE2	Homo sapiens	O96020	TAP	23602568
Intra	CDK2	P24941	CCNE2	Homo sapiens	O96020	Anti Tag CoIP	26496610
Intra	CDK2	P24941	CCNE2	Homo sapiens	O96020	Anti Tag CoIP	33961781
Intra	CDK2	P24941	CCNE2	Homo sapiens	O96020	Anti Tag CoIP	28514442
Intra	CDK2	P24941	CDKN1A	Homo sapiens	P38936	MAPPIT	25416956
Intra	CDK2	P24941	CDKN1A	Homo sapiens	P38936	SPR	15890360
Intra	CDK2	P24941	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	33961781
Intra	CDK2	P24941	CDKN1A	Homo sapiens	P38936	Anti Bait CoIP	17698606
Intra	CDK2	P24941	CDKN1A	Homo sapiens	P38936	Anti Bait CoIP	16962592
Intra	CDK2	P24941	CDKN1A	Homo sapiens	P38936	Anti Bait CoIP	24358021
Intra	CDK2	P24941	CDKN1A	Homo sapiens	P38936	Pull Down	9284049
Intra	CDK2	P24941	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	26496610
Intra	CDK2	P24941	CDKN1A	Homo sapiens	P38936	TAP	23602568
Intra	CDK2	P24941	CDKN1A	Homo sapiens	P38936	Pull Down	8756624
Intra	CDK2	P24941	CDKN1A	Homo sapiens	P38936	TAP	23455922
Intra	CDK2	P24941	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	28514442
Intra	CDK2	P24941	LATS1	Homo sapiens	O95835	Anti Tag CoIP	25218637
Intra	CDK2	P24941	EP300	Homo sapiens	Q09472	TAP	23455922
Intra	CDK2	P24941	EP300	Homo sapiens	Q09472	Anti Tag CoIP	33961781
Intra	CDK2	P24941	EP300	Homo sapiens	Q09472	Pull Down	10330164
Intra	CDK2	P24941	EP300	Homo sapiens	Q09472	Anti Tag CoIP	28514442
Intra	CDK2	P24941	CKS1B	Homo sapiens	P61024	BRET	37398436
Intra	CDK2	P24941	CKS1B	Homo sapiens	P61024	Anti Tag CoIP	33961781
Intra	CDK2	P24941	CKS1B	Homo sapiens	P61024	Anti Tag CoIP	25852190
Intra	CDK2	P24941	CKS1B	Homo sapiens	P61024	TAP	23602568
Intra	CDK2	P24941	CKS1B	Homo sapiens	P61024	Anti Tag CoIP	26496610
Intra	CDK2	P24941	CKS1B	Homo sapiens	P61024	TAP	23455922
Intra	CDK2	P24941	CKS1B	Homo sapiens	P61024	Y2H Array	31467278
Intra	CDK2	P24941	CKS1B	Homo sapiens	P61024	BRET	29997244
Intra	CDK2	P24941	CKS1B	Homo sapiens	P61024	SLC	31467278
Intra	CDK2	P24941	CKS1B	Homo sapiens	P61024	Complementation	31467278
Intra	CDK2	P24941	CKS1B	Homo sapiens	P61024	MAPPIT	31467278
Intra	CDK2	P24941	CCNA2	Homo sapiens	P20248	Anti Bait CoIP	16431923
Intra	CDK2	P24941	CCNA2	Homo sapiens	P20248	Pull Down	24358021
Intra	CDK2	P24941	CCNA2	Homo sapiens	P20248	TAP	23602568
Intra	CDK2	P24941	CCNA2	Homo sapiens	P20248	X-Ray Diffraction	12244298
Intra	CDK2	P24941	CCNA2	Homo sapiens	P20248	TAP	23455922
Intra	CDK2	P24941	CCNA2	Homo sapiens	P20248	X-Ray Diffraction	15239650
Intra	CDK2	P24941	CCNA2	Homo sapiens	P20248	Anti Bait CoIP	17254966
Intra	CDK2	P24941	CCNA2	Homo sapiens	P20248	Anti Tag CoIP	25852190
Intra	CDK2	P24941	RB1	Homo sapiens	P06400	Protein Kinase Assay	8756624
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	Anti Bait CoIP	17053782
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	PLA	25241761
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	Anti Bait CoIP	17418410
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	Anti Bait CoIP	24358021
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	GMS	24358021
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	Anti Tag CoIP	35271311
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	SPR	17254966
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	Anti Tag CoIP	33961781
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	Anti Bait CoIP	17698606
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	Anti Tag CoIP	26496610
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	Anti Tag CoIP	28514442
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	Anti Bait CoIP	17254967
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	Anti Tag CoIP	25852190
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	TAP	23602568
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	SPR	15890360
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	TAP	23455922
Intra	CDK2	P24941	CDKN1B	Homo sapiens	P46527	Anti Bait CoIP	17254966
Intra	CDK2	P24941	CCNE1	Homo sapiens	P24864	Protein Kinase Assay	23853094
Intra	CDK2	P24941	CCNE1	Homo sapiens	P24864	Anti Tag CoIP	28514442
Intra	CDK2	P24941	CCNE1	Homo sapiens	P24864	Anti Tag CoIP	21092281
Intra	CDK2	P24941	CCNE1	Homo sapiens	P24864	Anti Tag CoIP	33961781
Intra	CDK2	P24941	CCNE1	Homo sapiens	P24864	TAP	23602568
Intra	CDK2	P24941	CCNE1	Homo sapiens	P24864	TAP	23455922
Intra	CDK2	P24941	CCNE1	Homo sapiens	P24864	Anti Bait CoIP	17254967
Intra	CDK2	P24941	CCNE1	Homo sapiens	P24864	Anti Tag CoIP	16223725
Intra	CDK2	P24941	CCNE1	Homo sapiens	P24864	Pull Down	24358021
Intra	CDK2	P24941	CCNE1	Homo sapiens	P24864	Anti Bait CoIP	16431923
Intra	CDK2	P24941	CCNE1	Homo sapiens	P24864	Anti Tag CoIP	25852190
Intra	CDK2	P24941	UHRF2	Homo sapiens	Q96PU4	Antibody Array	21952639
Intra	CDK2	P24941	UHRF2	Homo sapiens	Q96PU4	Anti Tag CoIP	15178429
Intra	CDK2	P24941	FBXW7	Homo sapiens	Q969H0-4	Anti Tag CoIP	23082202
Intra	CDK2	P24941	CCNH	Homo sapiens	P51946	Anti Tag CoIP	28514442
Intra	CDK2	P24941	CCNH	Homo sapiens	P51946	Y2H	9840943
Intra	CDK2	P24941	CCNH	Homo sapiens	P51946	Anti Tag CoIP	33961781
Intra	CDK2	P24941	CCNH	Homo sapiens	P51946	Anti Tag CoIP	26496610
Intra	CDK2	P24941	IKBKG	Homo sapiens	Q9Y6K9	Pull Down	20098747
Cross	CDK2	P24941	E7	Human papillomavirus	P03129	Affinity Chrom	16061792

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDK2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70014	CDK2 Protein, Human (His)	P24941 (E2-L298)	≥ 95%, as determined by reducing SDS-PAGE.

CDK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80076	CDK2 Antibody (YA514)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
HY-P80797	Phospho-CDK1/2/3 (Thr14) Antibody (YA218)	WB, IP	Human, Hamster
HY-P80797A	Phospho-CDK1/2/3 (Thr14) Antibody (YA218)(PBS only)	WB, IP	Human, Hamster
HY-P84206	CDK2 Antibody (YA3903)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P84206A	CDK2 Antibody (YA3903)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P86535	CDK2 Antibody (YA6227)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Cecum Adenoma	Caecum Adenoma
Retinal Cancer	Malignant Neoplasm Of Retina Retinal Neoplasms Malignant Retinal Neoplasm Malignant Tumor Of Retina Neoplasm Of Retina Retinal Tumor Retinal Neoplasm Cancer Of The Retina Malignant Retinal Tumour Malignant Tumour Of Retina Primary Malignant Neoplasm Of Retina
Leiomyosarcoma	Leiomyosarcomas
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Sensory System Disease
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 CMM1 Melanoma, Cutaneous Malignant Cmm Melanoma, Malignant Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Retinal Disease	Retinal Diseases Retinal Disorder Retinal Disorders
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Robinow Syndrome, Autosomal Dominant 3	Autosomal Dominant Robinow Syndrome 3 DRS3 Robinow, Autosomal Dominant Syndrome, Type 3
Large Cell Carcinoma	Carcinoma, Large Cell Carcinoma Large Cell
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Leiomyoma	Leiomyomatous Neoplasm Leiomyomatous Tumor Leiomyomas Fibroid Tumor Uterine Fibroids
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Cecal Benign Neoplasm	Cecal Neoplasms Cecum Neoplasm Neoplasm Of Caecum Cecal Neoplasm Cecum Carcinoma Malignant Neoplasm Of Cecum
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Endometrial Hyperplasia
Ocular Cancer	Eye Carcinoma Eye Neoplasm Eye Cancer Eye Neoplasms Malignant Eye Neoplasm Neoplasm Of Eye Neoplasm Of Eye Proper Ocular Tumor Carcinoma Of Eye Ocular Carcinoma Malignant Tumor Of Eye
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Tetraploidy	Tetraploidy Syndrome
Pancreatic Adenocarcinoma	Adenocarcinoma Of Pancreas Adenocarcinoma Of The Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-10492	Dinaciclib	Inhibitor	99.80%	Yes
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes
HY-B0402	Amantadine	Inhibitor	99.90%	Unkown
HY-B0402A	Amantadine hydrochloride	Inhibitor	98.0%	Yes
HY-B0263	Thiabendazole		99.94%	Unkown
HY-B1165	Cyproheptadine (hydrochloride sesquihydrate)		99.74%	Unkown
HY-B0402B	Amantadine sulfate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (33)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10580	GSK 3 Inhibitor IX	Inhibitor	99.73%	Phase 4
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.51%	Phase 3
HY-112272	Lerociclib	Inhibitor	96.42%	Phase 3
HY-10005	Flavopiridol	Inhibitor	99.72%	Phase 2
HY-30237	(R)-Roscovitine	Inhibitor	99.53%	Phase 2
HY-137894A	Tagtociclib hydrate	Inhibitor	99.73%	Phase 2
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-X0009	Tambiciclib	Inhibitor	99.68%	Phase 2
HY-50940	AT7519	Inhibitor	99.69%	Phase 2
HY-101212	Fadraciclib	Inhibitor	99.77%	Phase 2
HY-10006	Flavopiridol Hydrochloride	Inhibitor	99.73%	Phase 2
HY-137478	KB-0742	Inhibitor	99.63%	Phase 2
HY-137478A	KB-0742 dihydrochloride	Inhibitor	98.77%	Phase 2
HY-10424	Milciclib	Inhibitor	99.89%	Phase 2
HY-103712	Samuraciclib	Inhibitor	99.55%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.90%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.16%	Phase 2
HY-15163	Zotiraciclib	Inhibitor	99.88%	Phase 2
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Phase 2
HY-50940A	AT7519 TFA	Inhibitor	99.75%	Phase 2
HY-X0009A	Tambiciclib dimaleate	Inhibitor	99.53%	Phase 2
HY-16559A	Riviciclib	Inhibitor	/	Phase 2
HY-10008	SNS-032	Inhibitor	99.91%	Phase 1
HY-138293	SY-5609	Inhibitor	99.93%	Phase 1
HY-141680	CPS2	Inhibitor	99.33%	Phase 1
HY-10012	AZD-5438	Inhibitor	99.91%	Phase 1
HY-10014	R547	Inhibitor	99.57%	Phase 1
HY-11001	PHA-793887	Inhibitor	99.25%	Phase 1
HY-12871B	Atuveciclib	Inhibitor	99.75%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.67%	Phase 1
HY-111361	FN-1501	Inhibitor	98.72%	Phase 1
HY-137443	Ipivivint	Inhibitor	99.95%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.09%	Phase 1

Pre-clinical Phase

Bioactive Molecules (247)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12529	Ro-3306	Inhibitor	99.83%	Unkown
HY-124719	hSMG-1 inhibitor 11j	Inhibitor	99.82%	Unkown
HY-12302	Kenpaullone	Inhibitor	98.20%	Unkown
HY-103248	Toyocamycin	Inhibitor	99.27%	Unkown
HY-101257	YKL-5-124	Inhibitor	99.53%	Unkown
HY-10329	JNJ-7706621	Inhibitor	99.39%	Unkown
HY-15339	CVT-313	Inhibitor	99.90%	Unkown
HY-114177	Ebvaciclib	Inhibitor	99.98%	Unkown
HY-124760	hSMG-1 inhibitor 11e	Inhibitor	99.94%	Unkown
HY-18340	(R)-CR8	Inhibitor	99.52%	Unkown
HY-122609	XO44		99.73%	Unkown
HY-18930	NU6300	Inhibitor	98.44%	Unkown
HY-15004	AUZ 454	Inhibitor	99.15%	Unkown
HY-18299A	Purvalanol A	Inhibitor	98.61%	Unkown
HY-15275	BMS-265246	Inhibitor	99.59%	Unkown
HY-130709	PROTAC CDK2/9 Degrader-1	Degrader	99.85%	Unkown
HY-130665	TL12-186	Inhibitor	99.23%	Unkown
HY-127104	FMF-04-159-2	Inhibitor	99.64%	Unkown
HY-13914	Roniciclib	Inhibitor	98.00%	Unkown
HY-163814	CDK2 degrader 1	Degrader	99.74%	Unkown
HY-15166	(E/Z)-Zotiraciclib	Inhibitor	99.96%	Unkown
HY-108359	Alsterpaullone	Inhibitor	99.85%	Unkown
HY-15878	LDC000067	Inhibitor	99.00%	Unkown
HY-18629	SU9516	Inhibitor	99.85%	Unkown
HY-144117	GFB-12811	Inhibitor	98.04%	Unkown
HY-11009	CGP60474	Inhibitor	98.90%	Unkown
HY-13461A	PHA-767491 hydrochloride	Inhibitor	99.49%	Unkown
HY-12445	Asnuciclib	Inhibitor	99.76%	Unkown
HY-117535	CDK2-IN-4	Inhibitor	99.85%	Unkown
HY-X0150	JSH-150	Inhibitor	98.36%	Unkown
HY-15569	NU6102	Inhibitor	99.23%	Unkown
HY-W019806	Lacto-N-fucopentaose I	Activator	99.92%	Unkown
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	99.37%	Unkown
HY-13461	PHA-767491	Inhibitor	99.97%	Unkown
HY-123772	CDK5 inhibitor 20-223	Inhibitor	99.62%	Unkown
HY-N0260	Epmedin C	Inhibitor	99.47%	Unkown
HY-176444	CDK2 degrader 6	Degrader	99.81%	Unkown
HY-18299	Purvalanol B	Inhibitor	97.0%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-16559	Riviciclib hydrochloride		99.08%	Unkown
HY-175842	CDK2 degrader 7	Degrader	99.51%	Unkown
HY-112626	CDK12-IN-2	Inhibitor	99.36%	Unkown
HY-112358	GW8510	Inhibitor	99.04%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.93%	Unkown
HY-119940	MC180295	Inhibitor	98.07%	Unkown
HY-108136A	Bisindolylmaleimide X hydrochloride	Antagonist	98.90%	Unkown
HY-145694	CDK5-IN-3	Inhibitor	99.49%	Unkown
HY-164664	CDK2-IN-30	Inhibitor	98.40%	Unkown
HY-103647	K00546	Inhibitor	99.48%	Unkown
HY-120497	PKCζ-IN-1	Inhibitor	99.1%	Unkown
HY-162919	YK-2168	Inhibitor	98.05%	Unkown
HY-164827	CDK2 degrader 3	Degrader	99.91%	Unkown
HY-101257B	YKL-5-124 TFA	Inhibitor	99.74%	Unkown
HY-151071	TMX-3013	Inhibitor	98.02%	Unkown
HY-50914	AZD5597	Inhibitor	98.09%	Unkown
HY-170442	ECI830	Inhibitor	98.01%	Unkown
HY-N5072	Desmethylglycitein	Inhibitor	99.99%	Unkown
HY-15889	AMG 925	Inhibitor	99.02%	Unkown
HY-W011428	Olomoucine	Inhibitor	99.88%	Unkown
HY-15166A	(E/Z)-Zotiraciclib hydrochloride	Inhibitor	99.90%	Unkown
HY-112403	(S)-Roscovitine	Inhibitor	99.15%	Unkown
HY-N0699	Daphnoretin	Inhibitor	99.83%	Unkown
HY-169912	CDK2 degrader 5	Degrader	99.17%	Unkown
HY-155218	TMX-2172	Degrader	99.38%	Unkown
HY-148214	CDK2/4/6-IN-2	Inhibitor	98.20%	Unkown
HY-13816	NU6027	Inhibitor	98.01%	Unkown
HY-142076	CDK4/6-IN-15	Inhibitor	99.32%	Unkown
HY-151069	TMX-2039	Inhibitor	99.42%	Unkown
HY-139329	CDK12-IN-6	Inhibitor	99.15%	Unkown
HY-139980	CDK9-IN-13	Inhibitor	99.94%	Unkown
HY-N1465	Aristolochic acid D	Inhibitor	99.74%	Unkown
HY-159805	CDK2-IN-31	Inhibitor	98.22%	Unkown
HY-N7045	Isosilybin B	Inhibitor	99.32%	Unkown
HY-107419	NU6140	Inhibitor	99.53%	Unkown
HY-117203A	CDK12-IN-E9	Inhibitor	99.71%	Unkown
HY-169910	CDK2 degrader 4	Inhibitor	99.71%	Unkown
HY-15166B	(E/Z)-Zotiraciclib citrate	Inhibitor	99.83%	Unkown
HY-112462	Cdk1/2 Inhibitor III	Inhibitor	99.69%	Unkown
HY-14372	BS-194	Inhibitor	99.13%	Unkown
HY-154851	GSK-3 inhibitor 3	Inhibitor	99.10%	Unkown
HY-148062	RSS0680		99.85%	Unkown
HY-112460	CDK2-IN-3	Inhibitor	95.12%	Unkown
HY-100600	BGG463	Inhibitor	98.0%	Unkown
HY-123045	PNU-292137	Inhibitor	99.95%	Unkown
HY-41076	Ca2+ channel agonist 1	Inhibitor	98.87%	Unkown
HY-100429	CAN508	Inhibitor	99.71%	Unkown
HY-157516	CDK2-IN-22	Inhibitor	98.64%	Unkown
HY-45661	Inixaciclib	Inhibitor	99.93%	Unkown
HY-136726	CGP-82996	Inhibitor	98.12%	Unkown
HY-176444A	(R)-CDK2 degrader 6	Degrader	99.55%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.88%	Unkown
HY-119715	AG-012986	Inhibitor	99.78%	Unkown
HY-19316	NU2058	Inhibitor	99.66%	Unkown
HY-155787	SHR5428	Inhibitor	99.80%	Unkown
HY-103646	CK7	Inhibitor	99.72%	Unkown
HY-139328	CDK12-IN-5	Inhibitor	98.03%	Unkown
HY-117393	Bisindolylmaleimide III	Inhibitor	98.95%	Unkown
HY-179688	PROTAC CDK2/4 Degrader-1	Degrader	/	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-168440	Aurora-A ligand 1	Ligand	98.75%	Unkown
HY-170897	CDK2-IN-40	Inhibitor	99.80%	Unkown
HY-114903	(E/Z)-BIO-acetoxime	Inhibitor	99.9%	Unkown
HY-170820	XYD049	Inhibitor	99.46%	Unkown
HY-119979	Cardanol monoene		98.02%	Unkown
HY-154852	GSK-3 inhibitor 4	Inhibitor	99.02%	Unkown
HY-185121	PROTAC CDK2/4/6 Degrader-2	Degrader	97.22%	Unkown
HY-201330	GDC-4198	Inhibitor	/	Unkown
HY-139011	IV-361	Inhibitor	99.60%	Unkown
HY-112346	RGB-286147	Inhibitor	98.60%	Unkown
HY-148868A	Akt1&PKA-IN-2	Inhibitor	/	Unkown
HY-148868	Akt1&PKA-IN-1	Inhibitor	/	Unkown
HY-149636	Multi-target kinase inhibitor 2	Inhibitor	99.82%	Unkown
HY-161708	PROTAC FLT3/CDKs degrader-1	Degrader	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-12843	Bohemine	Inhibitor	98.93%	Unkown
HY-100035	PT-262	Inhibitor	99.21%	Unkown
HY-153556	GW297361	Inhibitor	98.13%	Unkown
HY-158170	CDK7-IN-28	Inhibitor	/	Unkown
HY-164906	TMX-2138	Degrader	/	Unkown
HY-15889A	AMG 925 (HCl)	Inhibitor	/	Unkown
HY-112468	PNU112455A hydrochloride	Inhibitor	99.56%	Unkown
HY-112450	Olomoucine II	Inhibitor	98.0%	Unkown
HY-111207	CA224	Inhibitor	99.94%	Unkown
HY-151436	ZLMT-12	Inhibitor	/	Unkown
HY-110368	BS-181 dihydrochloride	Inhibitor	/	Unkown
HY-151409	CDK1-IN-5	Inhibitor	/	Unkown
HY-143497	HDAC1/2 and CDK2-IN-1	Inhibitor	/	Unkown
HY-151407	CDK1-IN-3	Inhibitor	/	Unkown
HY-130980	N-Desmethyl FN-1501	Ligand	/	Unkown
HY-130981	FN-1501-propionic acid		/	Unkown
HY-130001	CDK9-IN-9	Inhibitor	/	Unkown
HY-111356	IIIM-290	Inhibitor	/	Unkown
HY-160556	RLY-2139	Inhibitor	/	Unkown
HY-178112	CDK2-IN-47	Inhibitor	/	Unkown
HY-15570	NU6301	Inhibitor	/	Unkown
HY-150641	CDK-IN-9	Inhibitor	/	Unkown
HY-180355	SY-5102	Inhibitor	/	Unkown
HY-151580S	CDK2-IN-14-d3	Inhibitor	/	Unkown
HY-147771	ZLWT-37	Inhibitor	/	Unkown
HY-182605	NU6310	Inhibitor	/	Unkown
HY-178168	ARUK2010694	Inhibitor	/	Unkown
HY-181501	CDK2/4/6-IN-3	Inhibitor	/	Unkown
HY-151408	CDK1-IN-4	Inhibitor	/	Unkown
HY-139327	CDK12-IN-4	Inhibitor	/	Unkown
HY-176124	CDK2 ligand-2	Ligand	/	Unkown
HY-183710	CDK9-IN-50	Inhibitor	/	Unkown
HY-148213	CDK2/4/6-IN-1	Inhibitor	/	Unkown
HY-172872	CDK2-IN-45	Inhibitor	/	Unkown
HY-168845	CDK2/9-IN-1	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-112363	Aloisine A	Inhibitor	/	Unkown
HY-184649	CDK2-IN-60	Inhibitor	/	Unkown
HY-145693	CDK5-IN-2	Inhibitor	/	Unkown
HY-123034	CDKI-83	Inhibitor	/	Unkown
HY-156470	Multi-kinase-IN-6	Inhibitor	/	Unkown
HY-168067	CDK-IN-14	Inhibitor	/	Unkown
HY-178171	ARUK2010489	Inhibitor	96.64%	Unkown
HY-162528	CDK12-IN-7	Inhibitor	/	Unkown
HY-182470	AG-012986 dihydrochloride	Inhibitor	/	Unkown
HY-180157	CDK2-IN-51	Inhibitor	/	Unkown
HY-160941	CDK2-IN-29	Inhibitor	/	Unkown
HY-144810	CDK2-IN-8	Inhibitor	/	Unkown
HY-168513	ALK-IN-29	Inhibitor	/	Unkown
HY-173203	CDK2-IN-43	Inhibitor	/	Unkown
HY-115942	Anticancer agent 29	Inhibitor	/	Unkown
HY-115943	Anticancer agent 30	Inhibitor	/	Unkown
HY-176281	PI3Kα-IN-26	Inhibitor	/	Unkown
HY-181838	CIRc-014	Inhibitor	/	Unkown
HY-180817	CDK2-IN-55	Inhibitor	98.91%	Unkown
HY-182734	BMS-357075	Inhibitor	/	Unkown
HY-155441	CDK2-IN-20	Inhibitor	/	Unkown
HY-173310	CDK2-IN-44	Inhibitor	/	Unkown
HY-172128	NUAK1-IN-2	Inhibitor	/	Unkown
HY-150570	Carbonic anhydrase inhibitor 14	Inhibitor	/	Unkown
HY-178142	Multi-kinase-IN-7	Inhibitor	/	Unkown
HY-W1047040	CDK2/4 ligand 1	Inhibitor	/	Unkown
HY-179633	ZLMT-72	Inhibitor	/	Unkown
HY-151984	CDK9-IN-22	Inhibitor	/	Unkown
HY-181645	CDK12-IN-9	Inhibitor	/	Unkown
HY-173224	CDK2/PIM1-IN-1	Inhibitor	/	Unkown
HY-128491	UNC10112785	Inhibitor	/	Unkown
HY-139651	CDK2-IN-7	Inhibitor	/	Unkown
HY-161595	CDK5-IN-4	Inhibitor	/	Unkown
HY-171826	PROTAC CDK2/4/6 Degrader-1	Inhibitor	/	Unkown
HY-179022	CAIX/CDK-2-IN-1	Inhibitor	/	Unkown
HY-162416	CDK7-IN-27	Inhibitor	/	Unkown
HY-183854	AG-12286	Inhibitor	/	Unkown
HY-180912	HS-36	Inhibitor	/	Unkown
HY-180242	EGFR/CDK2-IN-5	Inhibitor	/	Unkown
HY-183273	BRD4/AKT-IN-1	Inhibitor	/	Unkown
HY-170965	Anticancer agent 264	Inhibitor	/	Unkown
HY-145867	EGFR-IN-45	Inhibitor	/	Unkown
HY-112471	TrkA Inhibitor	Inhibitor	/	Unkown
HY-177957	CDK2-IN-52	Inhibitor	/	Unkown
HY-179231	CDK2-IN-50	Inhibitor	/	Unkown
HY-172153	CDK2-IN-41	Inhibitor	/	Unkown
HY-173347	BLINK11	Inhibitor	/	Unkown
HY-10793	CDK2-IN-56	Inhibitor	/	Unkown
HY-183146	CDK2-IN-57	Inhibitor	/	Unkown
HY-141685	3-Methylthienyl-carbonyl-JNJ-7706621	Inhibitor	/	Unkown
HY-150573	CDK2-IN-12	Inhibitor	/	Unkown
HY-144811	CDK2-IN-9	Inhibitor	/	Unkown
HY-182986	LS-Q2	Inhibitor	/	Unkown
HY-155602	CDK2-IN-18	Inhibitor	/	Unkown
HY-178756	CDK2-IN-48	Inhibitor	/	Unkown
HY-180546	CDK2-IN-53	Inhibitor	/	Unkown
HY-176282	CDK8-IN-19	Inhibitor	/	Unkown
HY-162619	CDK9-IN-33	Inhibitor	/	Unkown
HY-178157	Multi-target kinase-IN-7	Inhibitor	/	Unkown
HY-184657	CDK2 degrader 10	Degrader	/	Unkown
HY-170441	CDK2-IN-36	Inhibitor	/	Unkown
HY-183789	CDK2-IN-59	Inhibitor	/	Unkown
HY-149407	Multi-kinase-IN-4	Inhibitor	/	Unkown
HY-151898	CDK4/6-IN-14	Inhibitor	/	Unkown
HY-181906	ZnPc-PEG2-VH032	Inhibitor	/	Unkown
HY-182789	VEGFR2-IN-86	Inhibitor	/	Unkown
HY-186126	CDK2 modulator 1	Modulator	/	Unkown
HY-161690	EF-4-177	Inhibitor	/	Unkown
HY-147698	ZLHQ-5f	Inhibitor	/	Unkown
HY-146253	CDK1/2/4-IN-1	Inhibitor	/	Unkown
HY-112454	Bisindolylmaleimide III hydrochloride	Inhibitor	/	Unkown
HY-173348	BLINK15	Inhibitor	/	Unkown
HY-161776	P-gp/CDK2-IN-1	Inhibitor	/	Unkown
HY-186132	PROTAC CDK2-pRb degrader-1	Degrader	/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-182752	CDK1-IN-9	Inhibitor	/	Unkown
HY-137478B	KB-0742 hydrochloride	Inhibitor	/	Unkown
HY-119831	Rohitukine	Inhibitor	/	Unkown
HY-180630	CDK2-IN-54	Inhibitor	/	Unkown
HY-148651	CDK2-IN-15	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-181116	Anticancer agent 298		/	Unkown
HY-159155	CDK2/4-IN-1	Inhibitor	/	Unkown
HY-181620	CDK2 degrader 9	Degrader	/	Unkown
HY-178084	CDK2 ligand-3		/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-176718	VEGFR-2-IN-69	Inhibitor	/	Unkown
HY-147409	Ulecaciclib	Inhibitor	/	Unkown
HY-111932	Indirubin-5-sulfonate	Inhibitor	/	Unkown
HY-183534	CDK2-IN-58	Inhibitor	/	Unkown
HY-160185	CDK2-IN-21	Inhibitor	/	Unkown
HY-160643	CDK2-IN-27	Inhibitor	/	Unkown
HY-183529	Antitrypanosomal agent 31	Inhibitor	/	Unkown
HY-11001A	PHA-793887 hydrochloride	Inhibitor	/	Unkown
HY-19926A	GDC-0425 hydrochloride	Inhibitor	/	Unkown
HY-183456	Tyrphostin AG17	Inhibitor	/	Unkown
HY-123826	CCT68127	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDK2	RGD	RGD:70486
Felis catus	CDK2	VGNC	VGNC:60697
Bos taurus	CDK2	VGNC	VGNC:27123
Canis familiaris	CDK2	VGNC	VGNC:39051
Mus musculus	CDK2	MGD	MGI:104772
Macaca mulatta	CDK2	VGNC	VGNC:70979
Others	CDK2	NCBI